Presenilins: members of the gamma-secretase quartets, but part-time soloists too. (Q37242236)

19 August 2017

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title

Presenilins: members of the gamma-secretase quartets, but part-time soloists too. (English)

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19 August 2017

2

Bart De Strooper

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19 August 2017

Tomoko Wakabayashi

1

1 reference

19 August 2017

1 August 2008

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19 August 2017

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19 August 2017

23

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19 August 2017

194-204

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The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families

19 August 2017

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Enzymatic analysis of a rhomboid intramembrane protease implicates transmembrane helix 5 as the lateral substrate gate

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Where Notch and Wnt signaling meet. The presenilin hub

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Novel therapeutic strategies provide the real test for the amyloid hypothesis of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Structure of a site-2 protease family intramembrane metalloprotease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Membrane Topology and Nicastrin-enhanced Endoproteolysis of APH-1, a Component of the γ-Secretase Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Dimerization of presenilin-1 in vivo: suggestion of novel regulatory mechanisms leading to higher order complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

A novel transmembrane topology of presenilin based on reconciling experimental and computational evidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

APP processing and synaptic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Moonlighting activity of presenilin in plants is independent of gamma-secretase and evolutionarily conserved

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Gamma-secretase: proteasome of the membrane?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

A nine-transmembrane domain topology for presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Presenilin-2 mutations modulate amplitude and kinetics of inositol 1, 4,5-trisphosphate-mediated calcium signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Cutting proteins within lipid bilayers: rhomboid structure and mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Presenilins in memory, Alzheimer's disease, and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

A C-terminal region of signal peptide peptidase defines a functional domain for intramembrane aspartic protease catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Effects of PS1 deficiency on membrane protein trafficking in neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Notch1 functions as a tumor suppressor in mouse skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Identification of a novel family of presenilin homologues

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

The SREBP pathway--insights from Insigs and insects

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

The amyloid-beta precursor protein: integrating structure with biological function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Analysis of the 5' sequence, genomic structure, and alternative splicing of the presenilin-1 gene (PSEN1) associated with early onset Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Active gamma-secretase complexes contain only one of each component

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Adipsin, a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Nicastrin functions as a gamma-secretase-substrate receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Skeletal and CNS defects in Presenilin-1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Identification of distinct gamma-secretase complexes with different APH-1 variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Presenilin-1 maintains a nine-transmembrane topology throughout the secretory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Presenilin is required for activity and nuclear access of Notch in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

The role of presenilin cofactors in the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Rhomboid proteins: conserved membrane proteases with divergent biological functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Regulation of tyrosinase trafficking and processing by presenilins: partial loss of function by familial Alzheimer's disease mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Crystal structure of a rhomboid family intramembrane protease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Identification of signal peptide peptidase, a presenilin-type aspartic protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Targeting presenilin-type aspartic protease signal peptide peptidase with gamma-secretase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

Presenilin 1 interaction in the brain with a novel member of the Armadillo family

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00009.2008

10.1152/PHYSIOL.00009.2008

21 January 2018

Identifiers

DOI

1 reference

19 August 2017

1 reference

PubMed ID

18697993