MEK-ERK signaling dictates DNA-repair gene MGMT expression and temozolomide resistance of stem-like glioblastoma cells via the MDM2-p53 axis (Q48873373)

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English	MEK-ERK signaling dictates DNA-repair gene MGMT expression and temozolomide resistance of stem-like glioblastoma cells via the MDM2-p53 axis	scientific article

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Europe PubMed Central

PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/21957016

MEK-ERK signaling dictates DNA-repair gene MGMT expression and temozolomide resistance of stem-like glioblastoma cells via the MDM2-p53 axis (English)

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Europe PubMed Central

PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/21957016

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16 February 2018

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author name string

Atsushi Sato

1

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PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/21957016

Jun Sunayama

2

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Europe PubMed Central

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16 February 2018

http://europepmc.org/abstract/MED/21957016

Ken-ichiro Matsuda

3

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Europe PubMed Central

PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/21957016

Shizuka Seino

4

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Europe PubMed Central

PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/21957016

Kaori Suzuki

5

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Europe PubMed Central

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16 February 2018

http://europepmc.org/abstract/MED/21957016

Eriko Watanabe

6

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Europe PubMed Central

PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/21957016

Ken Tachibana

7

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Europe PubMed Central

PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/21957016

Takamasa Kayama

9

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16 February 2018

http://europepmc.org/abstract/MED/21957016

Chifumi Kitanaka

10

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16 February 2018

http://europepmc.org/abstract/MED/21957016

publication date

1 December 2011

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16 February 2018

http://europepmc.org/abstract/MED/21957016

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Europe PubMed Central

PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/21957016

29

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PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/21957016

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16 February 2018

http://europepmc.org/abstract/MED/21957016

1942-1951

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Europe PubMed Central

PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/21957016

Malignant gliomas in adults

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.753

21 January 2018

Advances in the treatment of malignant gliomas

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.753

21 January 2018

Temozolomide in malignant gliomas: current use and future targets

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.753

21 January 2018

Standard Therapy for Glioblastoma- A Review of Where We Are

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.753

21 January 2018

Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.753

21 January 2018

O6-methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.753

21 January 2018

Sensitivity to temozolomide in brain tumor initiating cells

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.753

21 January 2018

O6-Methylguanine DNA methyltransferase protein expression in tumor cells predicts outcome of temozolomide therapy in glioblastoma patients

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.753

21 January 2018

Efficient delivery of liposome-mediated MGMT-siRNA reinforces the cytotoxity of temozolomide in GBM-initiating cells

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.753

21 January 2018

Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.753

21 January 2018

A distinct subset of glioma cell lines with stem cell-like properties reflects the transcriptional phenotype of glioblastomas and overexpresses CXCR4 as therapeutic target.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.753

21 January 2018

The cancer stem cell: premises, promises and challenges

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.753

21 January 2018

Crosstalk between the PI3K/mTOR and MEK/ERK pathways involved in the maintenance of self-renewal and tumorigenicity of glioblastoma stem-like cells.

1 reference

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21 January 2018

Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens

1 reference

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21 January 2018

An efficient method for derivation and propagation of glioblastoma cell lines that conserves the molecular profile of their original tumours

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.753

21 January 2018

Autocrine TGF-beta signaling maintains tumorigenicity of glioma-initiating cells through Sry-related HMG-box factors.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.753

21 January 2018

Plasma and cerebrospinal fluid population pharmacokinetics of temozolomide in malignant glioma patients

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.753

21 January 2018

Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.753

21 January 2018

p53 is involved in regulation of the DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) by DNA damaging agents

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.753

21 January 2018

Regulation of the p53 pathway by ubiquitin and related proteins

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.753

21 January 2018

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.753

21 January 2018

Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.753

21 January 2018

MEK-ERK signaling controls Hdm2 oncoprotein expression by regulating hdm2 mRNA export to the cytoplasm.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.753

21 January 2018

Association between MGMT promoter hypermethylation and p53 mutation in glioblastoma.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.753

21 January 2018

MGMT promoter hypermethylation is a frequent, early, and consistent event in astrocytoma progression, and not correlated with TP53 mutation.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.753

21 January 2018

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.753

21 January 2018

Effect of aberrant p53 function on temozolomide sensitivity of glioma cell lines and brain tumor initiating cells from glioblastoma

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.753

21 January 2018

Genomic and expression profiling of glioblastoma stem cell-like spheroid cultures identifies novel tumor-relevant genes associated with survival

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.753

21 January 2018

Temozolomide preferentially depletes cancer stem cells in glioblastoma

1 reference

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21 January 2018

Local intracerebral administration of O(6)-benzylguanine combined with systemic chemotherapy with temozolomide of a patient suffering from a recurrent glioblastoma

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.753

21 January 2018

Expression of activated epidermal growth factor receptors, Ras-guanosine triphosphate, and mitogen-activated protein kinase in human glioblastoma multiforme specimens

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.753

21 January 2018

The activation of ERK1/2 MAP kinases in glioblastoma pathobiology and its relationship with EGFR amplification.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.753

21 January 2018

Levetiracetam enhances p53-mediated MGMT inhibition and sensitizes glioblastoma cells to temozolomide

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.753

21 January 2018

Identifiers

10.1002/STEM.753

1 reference

Europe PubMed Central

PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/21957016

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

16 February 2018

http://europepmc.org/abstract/MED/21957016

ResearchGate publication ID

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