MEK-ERK signaling controls Hdm2 oncoprotein expression by regulating hdm2 mRNA export to the cytoplasm. (Q40455851)

20 September 2017

MEK-ERK signaling controls Hdm2 oncoprotein expression by regulating hdm2 mRNA export to the cytoplasm. (English)

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20 September 2017

Monika Phelps

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20 September 2017

Anna Phillips

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2

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20 September 2017

Matthew Darley

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3

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20 September 2017

Jeremy P Blaydes

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4

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20 September 2017

language of work or name

English

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publication date

21 February 2005

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Journal of Biological Chemistry

20 September 2017

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20 September 2017

280

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20 September 2017

17

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20 September 2017

16651-16658

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20 September 2017

Surfing the p53 network

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PUMA induces the rapid apoptosis of colorectal cancer cells

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PUMA, a novel proapoptotic gene, is induced by p53

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A functional p53-responsive intronic promoter is contained within the human mdm2 gene

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MDM2--master regulator of the p53 tumor suppressor protein

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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

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Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

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The proliferation of normal human fibroblasts is dependent upon negative regulation of p53 function by mdm2.

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Tolerance of high levels of wild-type p53 in transformed epithelial cells dependent on auto-regulation by mdm-2.

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Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

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Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

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The p53-Mdm2 module and the ubiquitin system.

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ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

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DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

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The evolution of diverse biological responses to DNA damage: insights from yeast and p53.

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A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

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Phosphorylation of HDM2 by Akt.

21 January 2018

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Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation

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The dark side of Ras: regulation of apoptosis

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Induction of Mdm2 and enhancement of cell survival by bFGF.

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Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF.

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mdm2 Is critical for inhibition of p53 during lymphopoiesis and the response to ionizing irradiation

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Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

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Amplification of a gene encoding a p53-associated protein in human sarcomas

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The p53 tumor suppressor protein does not regulate expression of its own inhibitor, MDM2, except under conditions of stress

21 January 2018

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Role of two upstream open reading frames in the translational control of oncogene mdm2.

21 January 2018

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BCR/ABL activates mdm2 mRNA translation via the La antigen

21 January 2018

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Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation

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Mapping of the p53 and mdm-2 interaction domains

21 January 2018

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Messenger RNA turnover in cell-free extracts

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Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study

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Specificity and mechanism of action of some commonly used protein kinase inhibitors

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ATM complexes with HDM2 and promotes its rapid phosphorylation in a p53-independent manner in normal and tumor human cells exposed to ionizing radiation

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The human Y4 small cytoplasmic RNA gene is controlled by upstream elements and resides on chromosome 7 with all other hY scRNA genes.

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Oncogenic Ras and Akt Signaling Contribute to Glioblastoma Formation by Differential Recruitment of Existing mRNAs to Polysomes

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Ras inhibition leads to transcriptional activation of p53 and down-regulation of Mdm2: two mechanisms that cooperatively increase p53 function in colon cancer cells

21 January 2018

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Effect of extracellular signal-regulated kinase on p53 accumulation in response to cisplatin

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ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

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Phospholipase D elevates the level of MDM2 and suppresses DNA damage-induced increases in p53.

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Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes

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Nuclear export of mRNA: from the site of transcription to the cytoplasm

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RNA metabolism in nuclei: adenovirus and heat shock alter intranuclear RNA compartmentalization

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Delineation of mRNA export pathways by the use of cell-permeable peptides

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Fibroblast growth factor-2 induces translational regulation of Bcl-XL and Bcl-2 via a MEK-dependent pathway: correlation with resistance to etoposide-induced apoptosis

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Fibroblast growth factor 2-mediated translational control of IAPs blocks mitochondrial release of Smac/DIABLO and apoptosis in small cell lung cancer cells

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Disruption of p53 in human cancer cells alters the responses to therapeutic agents

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Regulation of p53 expression by the RAS-MAP kinase pathway

21 January 2018

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Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

21 January 2018

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Unraveling the complexities of the Raf/MAP kinase pathway for pharmacological intervention

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The role of MAPK pathways in the action of chemotherapeutic drugs

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The blood-brain barrier and cerebral angiogenesis: lessons from the cold-injury model

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The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M412334200

1 reference

20 September 2017

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