Exploring the molecular interface between hypoxia-inducible factor signalling and mitochondria (Q64227126)

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Exploring the molecular interface between hypoxia-inducible factor signalling and mitochondria (English)

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hypoxia-inducible factor 1

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Luke W Thomas

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14 February 2019

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Cellular and Molecular Life Sciences

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76

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Creative Commons Attribution 4.0 International

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4 references

4 July 2020

22 December 2020

5 July 2021

Lipid accumulation of hypoxic tissue culture cells

19 July 2021

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

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Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

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Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene expression

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Targeted disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal perinuclear clustering of mitochondria

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Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

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12 December 2020

The genome sequence of Rickettsia prowazekii and the origin of mitochondria

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12 December 2020

Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway

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12 December 2020

Effect of AMPK activation on muscle glucose metabolism in conscious rats

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12 December 2020

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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12 December 2020

The dynamin-like protein DLP1 is essential for normal distribution and morphology of the endoplasmic reticulum and mitochondria in mammalian cells

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12 December 2020

Hypoxia induces hexokinase II gene expression in human lung cell line A549.

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Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing

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Creatine and creatinine metabolism

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Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia

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Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia

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Control of mitochondrial morphology by a human mitofusin

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

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Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

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HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors.

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A conserved family of prolyl-4-hydroxylases that modify HIF

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12 December 2020

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

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12 December 2020

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

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12 December 2020

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

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12 December 2020

Germ-line mutations in nonsyndromic pheochromocytoma

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12 December 2020

Inhibitors of mitochondrial complex I attenuate the accumulation of hypoxia-inducible factor-1 during hypoxia in Hep3B cells

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12 December 2020

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

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12 December 2020

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

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12 December 2020

Cellular glutathione and thiols metabolism.

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Lactate and glucose interactions during rest and exercise in men: effect of exogenous lactate infusion

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Axonal transport of mitochondria to synapses depends on milton, a novel Drosophila protein

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Essential role of complex II of the respiratory chain in hypoxia-induced ROS generation in the pulmonary vasculature.

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Molecular pathology of von HippelLindau disease and the VHL tumour suppressor gene

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Oxygen sensing by HIF hydroxylases

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Energy transfer from astrocytes to axons: the role of CNS glycogen

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Peroxisomal proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1 alpha) enhances the thyroid hormone induction of carnitine palmitoyltransferase I (CPT-I alpha).

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12 December 2020

REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase.

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12 December 2020

Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity

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12 December 2020

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

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12 December 2020

Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators

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12 December 2020

Stimulation of HIF-1alpha, HIF-2alpha, and VEGF by prolyl 4-hydroxylase inhibition in human lung endothelial and epithelial cells.

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12 December 2020

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12 December 2020

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12 December 2020

Phosphorylation of the 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase/PFKFB3 family of glycolytic regulators in human cancer

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12 December 2020

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12 December 2020

Genome Phylogenies Indicate a Meaningful α-Proteobacterial Phylogeny and Support a Grouping of the Mitochondria with the Rickettsiales

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12 December 2020

The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism.

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12 December 2020

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12 December 2020

AMP-activated Protein Kinase and the Regulation of Autophagic Proteolysis

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12 December 2020

Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro

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12 December 2020

Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells

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12 December 2020

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12 December 2020

HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells

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12 December 2020

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The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production

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12 December 2020

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12 December 2020

Hypoxia regulates the expression of fatty acid-binding proteins in primary term human trophoblasts

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Hypoxia-inducible factor-1alpha under the control of nitric oxide

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12 December 2020

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12 December 2020

Nuclear respiratory factor 1 regulates all ten nuclear-encoded subunits of cytochrome c oxidase in neurons

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12 December 2020

Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia

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12 December 2020

N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking

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12 December 2020

Induction of HIF-2alpha is dependent on mitochondrial O2 consumption in an O2-sensitive adrenomedullary chromaffin cell line

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12 December 2020

MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3

1 reference

12 December 2020

AMPK phosphorylation of raptor mediates a metabolic checkpoint

1 reference

12 December 2020

Dynamin-like protein 1 reduction underlies mitochondrial morphology and distribution abnormalities in fibroblasts from sporadic Alzheimer's disease patients

1 reference

12 December 2020

HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma

1 reference

12 December 2020

PGC-1alpha is coupled to HIF-1alpha-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells

1 reference

12 December 2020

IDH1 and IDH2 mutations in gliomas

1 reference

12 December 2020

Role of BNIP3 and NIX in cell death, autophagy, and mitophagy

1 reference

12 December 2020

Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains

1 reference

12 December 2020

Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use.

1 reference

12 December 2020

Hypoxia-inducible factor 2 regulates hepatic lipid metabolism

1 reference

12 December 2020

HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport

1 reference

12 December 2020

SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma

1 reference

12 December 2020

MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2

1 reference

12 December 2020

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

1 reference

12 December 2020

Hypoxic enlarged mitochondria protect cancer cells from apoptotic stimuli

1 reference

12 December 2020

Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling

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12 December 2020

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

1 reference

12 December 2020

A general introduction to the biochemistry of mitochondrial fatty acid β-oxidation

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12 December 2020

IDH1 and IDH2 mutations in gliomas and the associated induction of hypoxia-inducible factor and production of 2-hydroxyglutarate

1 reference

12 December 2020

Lactate kinetics in human tissues at rest and during exercise

1 reference

12 December 2020

Hypoxia-regulated microRNA-210 modulates mitochondrial function and decreases ISCU and COX10 expression

1 reference

12 December 2020

Stabilization of hypoxia-inducible factor-1alpha protein in hypoxia occurs independently of mitochondrial reactive oxygen species production.

1 reference

12 December 2020

IDH2 mutations in patients with D-2-hydroxyglutaric aciduria

1 reference

12 December 2020

Altered fusion dynamics underlie unique morphological changes in mitochondria during hypoxia-reoxygenation stress

1 reference

12 December 2020

Hypoxia induces peroxisome proliferator-activated receptor α (PPARα) and lipid metabolism peroxisomal enzymes in human glioblastoma cells.

1 reference

12 December 2020

Hypoxia-inducible factor-1 (HIF-1) promotes LDL and VLDL uptake through inducing VLDLR under hypoxia

1 reference

12 December 2020

Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling

1 reference

12 December 2020

Fine-tuning of Drp1/Fis1 availability by AKAP121/Siah2 regulates mitochondrial adaptation to hypoxia

1 reference

12 December 2020

Induction of the mitochondrial NDUFA4L2 protein by HIF-1α decreases oxygen consumption by inhibiting Complex I activity.

1 reference

12 December 2020

HIF-1α localization with mitochondria: a new role for an old favorite?

1 reference

12 December 2020

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

1 reference

12 December 2020

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

1 reference

12 December 2020

Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression

1 reference

12 December 2020

IDH mutation impairs histone demethylation and results in a block to cell differentiation

1 reference

12 December 2020

Hypoxia causes triglyceride accumulation by HIF-1-mediated stimulation of lipin 1 expression

1 reference

12 December 2020

Perinuclear mitochondrial clustering creates an oxidant-rich nuclear domain required for hypoxia-induced transcription

1 reference

12 December 2020

Identification of a signaling axis HIF-1α/microRNA-210/ISCU independent of SDH mutation that defines a subgroup of head and neck paragangliomas

1 reference

12 December 2020

Hypoxia-inducible factor 1α mediates the down-regulation of superoxide dismutase 2 in von Hippel-Lindau deficient renal clear cell carcinoma

1 reference

12 December 2020

Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells

1 reference

12 December 2020

MicroRNAs as regulators of mitochondrial function: role in cancer suppression.

1 reference

12 December 2020

Unearthing the secrets of mitochondrial ROS and glutathione in bioenergetics

1 reference

12 December 2020

MGARP regulates mouse neocortical development via mitochondrial positioning

1 reference

12 December 2020

HIF-1α and HIF-2α are critically involved in hypoxia-induced lipid accumulation in hepatocytes through reducing PGC-1α-mediated fatty acid β-oxidation

1 reference

12 December 2020

Hypoxic regulation of glutamine metabolism through HIF1 and SIAH2 supports lipid synthesis that is necessary for tumor growth

1 reference

12 December 2020

The 2-oxoacid dehydrogenase complexes in mitochondria can produce superoxide/hydrogen peroxide at much higher rates than complex I

1 reference

12 December 2020

Serine and glycine metabolism in cancer

1 reference

12 December 2020

Comprehensive review on lactate metabolism in human health

1 reference

12 December 2020

Serine catabolism regulates mitochondrial redox control during hypoxia

1 reference

12 December 2020

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

1 reference

12 December 2020

Fatty acid uptake and lipid storage induced by HIF-1α contribute to cell growth and survival after hypoxia-reoxygenation

1 reference

12 December 2020

Human high-altitude adaptation: forward genetics meets the HIF pathway.

1 reference

12 December 2020

Remote ischemic conditioning.

1 reference

12 December 2020

Mitochondrial biogenesis: cell-cycle-dependent investment in making mitochondria.

1 reference

12 December 2020

Distinct von Hippel-Lindau gene and hypoxia-regulated alterations in gene and protein expression patterns of renal cell carcinoma and their effects on metabolism

1 reference

12 December 2020

High resolution imaging of intracellular oxygen concentration by phosphorescence lifetime.

1 reference

12 December 2020

Suppression of PGC-1α Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma

1 reference

12 December 2020

Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype

1 reference

12 December 2020

Balancing mitochondrial biogenesis and mitophagy to maintain energy metabolism homeostasis

1 reference

12 December 2020

HIF-1α Promotes Glutamine-Mediated Redox Homeostasis and Glycogen-Dependent Bioenergetics to Support Postimplantation Bone Cell Survival

1 reference

12 December 2020

Mitochondrial ROS regulation of proliferating cells

1 reference

12 December 2020

AMPK and HIF signaling pathways regulate both longevity and cancer growth: the good news and the bad news about survival mechanisms

1 reference

12 December 2020

PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis

1 reference

12 December 2020

Acidic pH Is a Metabolic Switch for 2-Hydroxyglutarate Generation and Signaling.

1 reference

12 December 2020

Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

1 reference

12 December 2020

Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions.

1 reference

12 December 2020

CHCHD4 Regulates Intracellular Oxygenation and Perinuclear Distribution of Mitochondria

1 reference

12 December 2020

Metabolic reprogramming ensures cancer cell survival despite oncogenic signaling blockade.

1 reference

12 December 2020

Microtubule-Organizing Centers: Towards a Minimal Parts List.

1 reference

12 December 2020

VHL-Mediated Regulation of CHCHD4 and Mitochondrial Function

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12 December 2020

10.1007/S00018-019-03039-Y

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30767037%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

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23 April 2020

PubMed publication ID

30767037

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