Dysregulation of the autophagy-endolysosomal system in amyotrophic lateral sclerosis and related motor neuron diseases (Q21285051)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22852081%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

title

Dysregulation of the autophagy-endolysosomal system in amyotrophic lateral sclerosis and related motor neuron diseases (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22852081%20AND%20SRC:MED&resulttype=core&format=json

amyotrophic lateral sclerosis

9 February 2020

main subject

autophagy

0 references

0 references

1

Asako Otomo

Asako

Otomo

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22852081%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Lei Pan

2

Lei

Pan

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22852081%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Shinji Hadano

series ordinal

3

author given names

Shinji

author last names

Hadano

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22852081%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

language of work or name

English

0 references

publication date

17 July 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22852081%20AND%20SRC:MED&resulttype=core&format=json

Neurology Research International

9 February 2020

published in

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22852081%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

volume

2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22852081%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

page(s)

498428

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22852081%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 3.0 Unported

9 February 2020

copyright license

start time

1 January 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

1 reference

April 2022 Public Data File from Crossref

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19 March 2017

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12 September 2017

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12 September 2017

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p62 at the crossroads of autophagy, apoptosis, and cancer

12 September 2017

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12 September 2017

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12 September 2017

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The cellular pathways of neuronal autophagy and their implication in neurodegenerative diseases

12 September 2017

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Redox modifier genes and pathways in amyotrophic lateral sclerosis

12 September 2017

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Deleterious variants of FIG4, a phosphoinositide phosphatase, in patients with ALS.

12 September 2017

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Autophagy and multivesicular bodies: two closely related partners

12 September 2017

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Ubiquitin, the proteasome and protein degradation in neuronal function and dysfunction

12 September 2017

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Network inference algorithms elucidate Nrf2 regulation of mouse lung oxidative stress

12 September 2017

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Mutant dynein (Loa) triggers proprioceptive axon loss that extends survival only in the SOD1 ALS model with highest motor neuron death

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407648

Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407648

Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407648

Retrograde axonal transport and motor neuron disease

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407648

Lithium delays progression of amyotrophic lateral sclerosis

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407648

Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407648

Molecular and cellular function of ALS2/alsin: implication of membrane dynamics in neuronal development and degeneration.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407648

Constitutive autophagy: vital role in clearance of unfavorable proteins in neurons.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407648

Molecular biology of amyotrophic lateral sclerosis: insights from genetics

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407648

Oxidative stress in ALS: a mechanism of neurodegeneration and a therapeutic target

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407648

Calcium-permeable AMPA channels in neurodegenerative disease and ischemia

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407648

Dynein mutations impair autophagic clearance of aggregate-prone proteins

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407648

Mutations in the small GTP-ase late endosomal protein RAB7 cause Charcot-Marie-Tooth type 2B neuropathy

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407648

Recurrent mutation of the gene encoding sequestosome 1 (SQSTM1/p62) in Paget disease of bone

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407648

UBQLN2/P62 cellular recycling pathways in amyotrophic lateral sclerosis and frontotemporal dementia

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407648

Early endosomes and endosomal coatomer are required for autophagy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407648

Interaction between familial amyotrophic lateral sclerosis (ALS)-linked SOD1 mutants and the dynein complex

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407648

p62 accumulates and enhances aggregate formation in model systems of familial amyotrophic lateral sclerosis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407648

An MND/ALS phenotype associated with C9orf72 repeat expansion: abundant p62-positive, TDP-43-negative inclusions in cerebral cortex, hippocampus and cerebellum but without associated cognitive decline.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407648

Interaction between small GTPase Rab7 and PI3KC3 links autophagy and endocytosis: A new Rab7 effector protein sheds light on membrane trafficking pathways

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407648

Lysosomal positioning coordinates cellular nutrient responses.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407648

Dynein- and activity-dependent retrograde transport of autophagosomes in neuronal axons

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407648

Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407648

Rab5 and Rab7 control endocytic sorting along the axonal retrograde transport pathway

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407648

In search of an "autophagomometer".

30 May 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F498428

Monitoring autophagic degradation of p62/SQSTM1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F498428

The phagocytic capacity of neurones

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F498428

Annexin A5 stimulates autophagy and inhibits endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F498428

Microtubule and kinesin/dynein-dependent, bi-directional transport of autolysosomes in neurites of PC12 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F498428

SQSTM1 mutations in familial and sporadic amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F498428

Mutant dynactin in motor neuron disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F498428

Variation in the biochemical/biophysical properties of mutant superoxide dismutase 1 enzymes and the rate of disease progression in familial amyotrophic lateral sclerosis kindreds.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F498428

Degradation of Amyotrophic Lateral Sclerosis-linked Mutant Cu,Zn-Superoxide Dismutase Proteins by Macroautophagy and the Proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F498428

In vivo optical imaging of motor neuron autophagy in a mouse model of amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F498428

Mutations in dynein link motor neuron degeneration to defects in retrograde transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F498428

Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F498428

Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F498428

Reversible disruption of dynactin 1-mediated retrograde axonal transport in polyglutamine-induced motor neuron degeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F498428

Disruption of dynein/dynactin inhibits axonal transport in motor neurons causing late-onset progressive degeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F498428

CMT2B-associated Rab7 mutants inhibit neurite outgrowth

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F498428

A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F498428

Rapamycin treatment augments motor neuron degeneration in SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F498428

The Rab5 Activator ALS2/alsin Acts as a Novel Rac1 Effector through Rac1-activated Endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F498428

p62 positive, TDP-43 negative, neuronal cytoplasmic and intranuclear inclusions in the cerebellum and hippocampus define the pathology of C9orf72-linked FTLD and MND/ALS

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F498428

Autophagy in spinal cord motor neurons in sporadic amyotrophic lateral sclerosis

21 January 2018

1 reference

12 December 2020

ALS pathogenesis: recent insights from genetics and mouse models

1 reference

12 December 2020

Increased autophagy in transgenic mice with a G93A mutant SOD1 gene

1 reference

12 December 2020

ALS2/alsin deficiency in neurons leads to mild defects in macropinocytosis and axonal growth

1 reference

12 December 2020

Altered macroautophagy in the spinal cord of SOD1 mutant mice

1 reference

12 December 2020

Identifiers

DOI

10.1155/2012/498428

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22852081%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22852081%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

PubMed publication ID

22852081

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22852081%20AND%20SRC:MED&resulttype=core&format=json