Multiple roles of ATM in monitoring and maintaining DNA integrity (Q24594847)

ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2

Europe PubMed Central

title

Multiple roles of ATM in monitoring and maintaining DNA integrity (English)

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Frederick A Derheimer

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1

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Michael B Kastan

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2

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language of work or name

English

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publication date

10 September 2010

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published in

FEBS Letters

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volume

584

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issue

17

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page(s)

3675-81

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cites work

1 reference

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RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

24 March 2017

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Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity

24 March 2017

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Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

24 March 2017

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RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly

24 March 2017

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RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

24 March 2017

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The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response

24 March 2017

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Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention

24 March 2017

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Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

24 March 2017

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ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

24 March 2017

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Megabase chromatin domains involved in DNA double-strand breaks in vivo

24 March 2017

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Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

24 March 2017

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A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.

24 March 2017

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Double-strand break repair in yeast requires both leading and lagging strand DNA polymerases

24 March 2017

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DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

24 March 2017

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A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM

24 March 2017

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DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion

24 March 2017

1 reference

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Cell-cycle checkpoints and cancer

24 March 2017

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MDC1/NFBD1: a key regulator of the DNA damage response in higher eukaryotes

24 March 2017

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

24 March 2017

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Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways

24 March 2017

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ATM phosphorylates histone H2AX in response to DNA double-strand breaks

24 March 2017

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The many substrates and functions of ATM

24 March 2017

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Substrate specificities and identification of putative substrates of ATM kinase family members

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950315

The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species

24 March 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950315

Enhanced phosphorylation of p53 by ATM in response to DNA damage

24 March 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950315

How shelterin protects mammalian telomeres

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950315

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

7 April 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950315

DNA damage foci at dysfunctional telomeres

7 April 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950315

Participation of p53 protein in the cellular response to DNA damage

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950315

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

7 April 2017

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gammaH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization

7 April 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950315

Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites

27 September 2017

1 reference

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Multiple roles for MRE11 at uncapped telomeres

27 September 2017

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Kinase-independent functions of TEL1 in telomere maintenance

27 September 2017

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Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950315

Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950315

Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950315

Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950315

ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950315

A novel Tel1/ATM N-terminal motif, TAN, is essential for telomere length maintenance and a DNA damage response

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950315

Irreversible chromosome damage accumulates rapidly in the absence of ATM kinase activity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950315

ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950315

Activation and regulation of ATM kinase activity in response to DNA double-strand breaks

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950315

Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950315

ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950315

Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950315

Involvement of novel autophosphorylation sites in ATM activation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950315

Ataxia telangiectasia mutated (Atm) is not required for telomerase-mediated elongation of short telomeres

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950315

DNA damage-induced phosphorylation of the human telomere-associated protein TRF2.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950315

Human telomeric protein TRF2 associates with genomic double-strand breaks as an early response to DNA damage.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950315

Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950315

Role of DNA replication proteins in double-strand break-induced recombination in Saccharomyces cerevisiae

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950315

Chromatin association of rad17 is required for an ataxia telangiectasia and rad-related kinase-mediated S-phase checkpoint in response to low-dose ultraviolet radiation.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950315

Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950315

Requirement of the MRN complex for ATM activation by DNA damage

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950315

Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950315

Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950315

Radiosensitivity in ataxia-telangiectasia: a new explanation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950315

The genetic defect in ataxia-telangiectasia

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950315

Chromosome end associations, telomeres and telomerase activity in ataxia telangiectasia cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950315

Initial chromosome damage but not DNA damage is greater in ataxia telangiectasia cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950315

Assessment of protein dynamics and DNA repair following generation of DNA double-strand breaks at defined genomic sites.

30 May 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.05.031

DNA damage-induced phosphorylation of TRF2 is required for the fast pathway of DNA double-strand break repair.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.05.031

Ataxia-telangiectasia; a familial syndrome of progressive cerebellar ataxia, oculocutaneous telangiectasia and frequent pulmonary infection.

21 January 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950315

Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation

28 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950315

Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo

28 November 2018

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Ataxia telangiectasia. Neoplasia, untoward response to x-irradiation, and tuberous sclerosis

21 January 2018

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12 December 2020

Wip1 Phosphatase Modulates ATM-Dependent Signaling Pathways

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12 December 2020

Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo

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12 December 2020

DNA double-strand breaks are not sufficient to initiate recruitment of TRF2

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12 December 2020

10.1016/J.FEBSLET.2010.05.031

Identifiers

DOI

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PubMed publication ID

20580718

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