CHK1 inhibitors in combination chemotherapy: thinking beyond the cell cycle (Q24622357)

Europe PubMed Central

title

CHK1 inhibitors in combination chemotherapy: thinking beyond the cell cycle (English)

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1

Paul Dent

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author name string

Yong Tang

2

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Adly Yacoub

3

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Yun Dai

4

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Paul B Fisher

5

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Steven Grant

Molecular Interventions: pharmacological perspectives from biology, chemistry and genomics

6

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language of work or name

English

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publication date

April 2011

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published in

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volume

11

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issue

2

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page(s)

133-40

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cites work

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Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK.

28 November 2018

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28 November 2018

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Coadministration of UCN-01 with MEK1/2 inhibitors potently induces apoptosis in BCR/ABL+ leukemia cells sensitive and resistant to ST1571.

28 November 2018

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The E2F-Cdc2 cell-cycle pathway specifically mediates activity deprivation-induced apoptosis of postmitotic neurons.

28 November 2018

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Combined treatment with the checkpoint abrogator UCN-01 and MEK1/2 inhibitors potently induces apoptosis in drug-sensitive and -resistant myeloma cells through an IL-6-independent mechanism

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Abrogation of the Chk1-mediated G(2) checkpoint pathway potentiates temozolomide-induced toxicity in a p53-independent manner in human glioblastoma cells

28 November 2018

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Pharmacological inhibitors of the mitogen-activated protein kinase (MAPK) kinase/MAPK cascade interact synergistically with UCN-01 to induce mitochondrial dysfunction and apoptosis in human leukemia cells

28 November 2018

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Physiological modeling of altered pharmacokinetics of a novel anticancer drug, UCN-01 (7-hydroxystaurosporine), caused by slow dissociation of UCN-01 from human alpha1-acid glycoprotein.

28 November 2018

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Dominant negative EGFR-CD533 and inhibition of MAPK modify JNK1 activation and enhance radiation toxicity of human mammary carcinoma cells.Miko

28 November 2018

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28 November 2018

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Activation of p34cdc2 coincident with taxol-induced apoptosis.

28 November 2018

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Biochemical and cellular characterization of VRX0466617, a novel and selective inhibitor for the checkpoint kinase Chk2

28 November 2018

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12 December 2020

Bendamustine induces G2 cell cycle arrest and apoptosis in myeloma cells: the role of ATM-Chk2-Cdc25A and ATM-p53-p21-pathways

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12 December 2020

Keeping checkpoint kinases in line: new selective inhibitors in clinical trials

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12 December 2020

The effect of different dosing schedules of UCN-01 on its pharmacokinetics and cardiohaemodynamics in dogs

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12 December 2020

p34cdc2 and apoptosis

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12 December 2020

Apoptosis in 7-hydroxystaurosporine-treated T lymphoblasts correlates with activation of cyclin-dependent kinases 1 and 2

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12 December 2020

Enhancement of cisplatin-induced cytotoxicity by 7-hydroxystaurosporine (UCN-01), a new G2-checkpoint inhibitor

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12 December 2020

Identifiers

DOI

10.1124/MI.11.2.11

1 reference

1 reference

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PubMed publication ID

21540473

1 reference