Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes (Q37785490)

23 August 2017

Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes (English)

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23 August 2017

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F Al-Ejeh

1

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Sunil R Lakhani

4

object named as

S R Lakhani

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23 August 2017

R Kumar

2

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23 August 2017

A Wiegmans

3

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23 August 2017

M P Brown

5

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23 August 2017

K K Khanna

6

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23 August 2017

language of work or name

English

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publication date

6 September 2010

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23 August 2017

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23 August 2017

29

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23 August 2017

46

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23 August 2017

6085-6098

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https://scigraph.springernature.com/pub.10.1038/onc.2010.407

23 August 2017

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Tumour biology: senescence in premalignant tumours

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Sensitization of breast carcinoma cells to ionizing radiation by small molecule inhibitors of DNA-dependent protein kinase and ataxia telangiectsia mutated

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Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics

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Novel poly(ADP-ribose) polymerase-1 inhibitor, AG14361, restores sensitivity to temozolomide in mismatch repair-deficient cells.

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Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

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Survivin: a promising tumor biomarker

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Life and death partners: apoptosis, autophagy and the cross-talk between them

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Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin.

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H2AX phosphorylation marks gemcitabine-induced stalled replication forks and their collapse upon S-phase checkpoint abrogation

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

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How nucleotide excision repair protects against cancer

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Absence of specific cell killing of the BRCA2-deficient human cancer cell line CAPAN1 by poly(ADP-ribose) polymerase inhibition

21 January 2018

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Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs.

21 January 2018

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Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation

21 January 2018

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BH3 peptidomimetics potently activate apoptosis and demonstrate single agent efficacy in neuroblastoma

21 January 2018

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Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.

21 January 2018

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Targeting poly(ADP-ribosyl)ation: a promising approach in cancer therapy

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The Hallmarks of Cancer

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Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach

21 January 2018

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The DNA damage response: ten years after

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Evidence that DNA damage detection machinery participates in DNA repair

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Restoration of an absent G1 arrest and protection from apoptosis in embryonic stem cells after ionizing radiation

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The inhibitors of apoptosis (IAPs) as cancer targets

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DNA and its associated processes as targets for cancer therapy

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SU11752 inhibits the DNA-dependent protein kinase and DNA double-strand break repair resulting in ionizing radiation sensitization

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ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

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How does radiation kill cells?

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Prognostic significance of 99mTc Hynic-rh-annexin V scintigraphy during platinum-based chemotherapy in advanced lung cancer.

21 January 2018

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Loss of 53BP1 is a gain for BRCA1 mutant cells.

21 January 2018

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DNA repair proteins as molecular targets for cancer therapeutics

21 January 2018

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DNA repair pathways in clinical practice: lessons from pediatric cancer susceptibility syndromes

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DNA double-strand breaks: signaling, repair and the cancer connection

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Recent advances in understanding the cell death pathways activated by anticancer therapy

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Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

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BH3-only proteins in cell death initiation, malignant disease and anticancer therapy.

21 January 2018

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IAP-targeted therapies for cancer

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p38 Mitogen-activated protein kinase- and HuR-dependent stabilization of p21(Cip1) mRNA mediates the G(1)/S checkpoint

21 January 2018

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Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland

21 January 2018

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Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries

21 January 2018

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DNA damage repair and response proteins as targets for cancer therapy

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19F-NMR detection of lacZ gene expression via the enzymic hydrolysis of 2-fluoro-4-nitrophenyl beta-D-galactopyranoside in vivo in PC3 prostate tumor xenografts in the mouse

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Dial 9-1-1 for p53: mechanisms of p53 activation by cellular stress

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Targeted therapy for cancer using PARP inhibitors

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Targeting the double-strand DNA break repair pathway as a therapeutic strategy

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Cell survival, cell death and cell cycle pathways are interconnected: implications for cancer therapy

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p21 Waf1/Cip1 can protect human colon carcinoma cells against p53-dependent and p53-independent apoptosis induced by natural chemopreventive and therapeutic agents

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Targeting phosphoinositide 3-kinase: moving towards therapy

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RAD51 up-regulation bypasses BRCA1 function and is a common feature of BRCA1-deficient breast tumors

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Cleavage-mediated activation of Chk1 during apoptosis

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Pharmacological abrogation of S-phase checkpoint enhances the anti-tumor activity of gemcitabine in vivo

21 January 2018

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BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of Poly (ADP-Ribose) polymerase: an issue of potency

21 January 2018

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p53: a guide to apoptosis

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BRAFE600-associated senescence-like cell cycle arrest of human naevi

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Role of checkpoint kinase 1 in preventing premature mitosis in response to gemcitabine

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The Plk3-Cdc25 circuit

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ATR and Chk1 suppress a caspase-3-dependent apoptotic response following DNA replication stress

21 January 2018

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Radiosensitization by the poly(ADP-ribose) polymerase inhibitor 4-amino-1,8-naphthalimide is specific of the S phase of the cell cycle and involves arrest of DNA synthesis

21 January 2018

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Targeted cancer therapies based on the inhibition of DNA strand break repair

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Validation of the Royal Marsden hospital prognostic index in advanced esophagogastric cancer using individual patient data from the REAL 2 study

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Checkpoint kinase 1 is cleaved in a caspase-dependent pathway during genotoxic stress-induced apoptosis.

21 January 2018

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Ku70 corrupts DNA repair in the absence of the Fanconi anemia pathway

21 January 2018

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Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells

21 January 2018

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Inhibition of poly(ADP-ribose) polymerase in cancer

21 January 2018

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Targeting poly(ADP-ribose) polymerase: a two-armed strategy for cancer therapy

21 January 2018

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Mechanisms of drug-induced mitotic catastrophe in cancer cells

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Targeting the DNA damage response for cancer therapy

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Stem cells, senescence, neosis and self-renewal in cancer

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Current development of clinical inhibitors of poly(ADP-ribose) polymerase in oncology

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Drug insight: cancer therapy strategies based on restoration of endogenous cell death mechanisms

21 January 2018

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Proapoptotic multidomain Bcl-2/Bax-family proteins: mechanisms, physiological roles, and therapeutic opportunities

21 January 2018

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p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage

21 January 2018

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Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2.

21 January 2018

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Escape from therapy-induced accelerated cellular senescence in p53-null lung cancer cells and in human lung cancers.

21 January 2018

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Parp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/c-myc translocations during immunoglobulin class switch recombination

21 January 2018

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Apoptosis induced by replication inhibitors in Chk1-depleted cells is dependent upon the helicase cofactor Cdc45.

21 January 2018

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Chk1 and p21 cooperate to prevent apoptosis during DNA replication fork stress

21 January 2018

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Tumor senescence as a determinant of drug response in vivo

21 January 2018

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If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells

21 January 2018

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Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

21 January 2018

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Inactivation of DNA-dependent protein kinase leads to spindle disruption and mitotic catastrophe with attenuated checkpoint protein 2 Phosphorylation in response to DNA damage.

21 January 2018

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DNA-dependent protein kinase is a molecular target for the development of noncytotoxic radiation-sensitizing drugs

21 January 2018

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Regulation of DNA double-strand break repair pathway choice

21 January 2018

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Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3.

21 January 2018

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Role of senescence and mitotic catastrophe in cancer therapy

21 January 2018

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ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling

21 January 2018

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Effect of combined DNA repair inhibition and G2 checkpoint inhibition on cell cycle progression after DNA damage

21 January 2018

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Chk1 inhibitors for novel cancer treatment

21 January 2018

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p53 suppression of arsenite-induced mitotic catastrophe is mediated by p21CIP1/WAF1.

21 January 2018

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Non-classical p38 map kinase functions: cell cycle checkpoints and survival

21 January 2018

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CHIR-124, a novel potent inhibitor of Chk1, potentiates the cytotoxicity of topoisomerase I poisons in vitro and in vivo

21 January 2018

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In vivo imaging of beta-galactosidase activity using far red fluorescent switch

21 January 2018

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p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2.

21 January 2018

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DNA damage induces two distinct modes of cell death in ovarian carcinomas

21 January 2018

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Death through a tragedy: mitotic catastrophe

21 January 2018

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Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repair.

21 January 2018

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BCL-2 in the crosshairs: tipping the balance of life and death

21 January 2018

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DNA ligase III as a candidate component of backup pathways of nonhomologous end joining

21 January 2018

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PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways

21 January 2018

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Centrosome-associated regulators of the G(2)/M checkpoint as targets for cancer therapy

21 January 2018

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The increment of micronucleus frequency in cervical carcinoma during irradiation in vivo and its prognostic value for tumour radiocurability.

21 January 2018

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A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia

21 January 2018

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DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemia.

21 January 2018

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Repair of radiation induced DNA double strand breaks by backup NHEJ is enhanced in G2.

21 January 2018

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PF-00477736 mediates checkpoint kinase 1 signaling pathway and potentiates docetaxel-induced efficacy in xenografts

21 January 2018

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BH3 mimetics to improve cancer therapy; mechanisms and examples

21 January 2018

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Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441.

21 January 2018

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Targeting the checkpoint kinases: chemosensitization versus chemoprotection

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The DNA damage response: putting checkpoints in perspective

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BCL2 family in DNA damage and cell cycle control

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Immunotargeting of Functional Nanoparticles for MRI detection of Apoptotic Tumor Cells

21 January 2018

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Effect of double-strand break DNA sequence on the PARP-1 NHEJ pathway

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Prediction of radiosensitivity of oral cancers by serial cytological assay of nuclear changes

31 March 2020

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Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs

31 March 2020

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Monitoring of chemotherapy-induced cell death in melanoma tumors by N,N'-Didansyl-L-cystine

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What drives success for specialty pharmaceuticals?

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Deficiency in the Repair of DNA Damage by Homologous Recombination and Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.407

Radiation-induced centrosome overduplication and multiple mitotic spindles in human tumor cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.407

A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.407

Predictive assays for the therapy of rectum carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.407

Micronuclei and nuclear abnormalities observed in erythroblasts in myelodysplastic syndromes and in de novo acute leukemia after treatment

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.407

Changes in S-phase fraction and micronucleus frequency as prognostic factors in radiotherapy of cervical carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.407

31 March 2020

Identifiers

DOI

10.1038/ONC.2010.407

1 reference

23 August 2017

1 reference