"Inflammaging" as a Druggable Target: A Senescence-Associated Secretory Phenotype-Centered View of Type 2 Diabetes (Q26747251)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27340505%20AND%20SRC:MED&resulttype=core&format=json

15 March 2020

review article

2 references

4 February 2021

"Inflammaging" as a Druggable Target: A Senescence-Associated Secretory Phenotype-Centered View of Type 2 Diabetes (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27340505%20AND%20SRC:MED&resulttype=core&format=json

15 March 2020

2 references

20 August 2019

4 February 2021

1 reference

20 August 2019

1 reference

1 reference

1 reference

Francesco Prattichizzo

1

1 reference

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15 March 2020

Valeria De Nigris

2

1 reference

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15 March 2020

Valeria De Nigris

3

1 reference

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15 March 2020

Lucia La Sala

4

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15 March 2020

Fabiola Olivieri

6

1 reference

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15 March 2020

Antonio Ceriello

7

1 reference

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15 March 2020

Antonio Ceriello

8

1 reference

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15 March 2020

author name string

Antonio Domenico Procopio

5

1 reference

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language of work or name

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publication date

1 June 2016

6 references

13 March 2019

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24 March 2019

20 August 2019

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15 March 2020

4 February 2021

Oxidative medicine and cellular longevity

7 references

13 March 2019

14 March 2019

24 March 2019

20 August 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27340505%20AND%20SRC:MED&resulttype=core&format=json

15 March 2020

4 February 2021

2016

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15 March 2020

page(s)

1810327

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Creative Commons Attribution 4.0 International

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28 September 2017

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mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

28 September 2017

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28 September 2017

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Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity.

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Short telomere length is associated with arterial aging in patients with type 2 diabetes mellitus

28 September 2017

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Epigenetic mechanisms of endothelial dysfunction in type 2 diabetes

28 September 2017

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50 years forward: mechanisms of hyperglycaemia-driven diabetic complications

28 September 2017

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Metabolic syndrome, aging and involvement of oxidative stress

28 September 2017

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Inflammation: a culprit for vascular calcification in atherosclerosis and diabetes

28 September 2017

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Age-independent rise of inflammatory scores may contribute to accelerated aging in multi-morbidity

28 September 2017

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NLRP3 inflammasome: from a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases.

28 September 2017

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Metformin beyond diabetes: pleiotropic benefits of metformin in attenuation of atherosclerosis

28 September 2017

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28 September 2017

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Diabetes and the brain: oxidative stress, inflammation, and autophagy

28 September 2017

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Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers.

28 September 2017

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Chronic inflammation induces telomere dysfunction and accelerates ageing in mice.

28 September 2017

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28 September 2017

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28 September 2017

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Targeting inflammation in the treatment of type 2 diabetes: time to start

28 September 2017

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Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases

28 September 2017

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Understanding and modulating the Toll like Receptors (TLRs) and NOD like Receptors (NLRs) cross talk in type 2 diabetes.

28 September 2017

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28 September 2017

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Endothelial cellular senescence is inhibited by liver X receptor activation with an additional mechanism for its atheroprotection in diabetes

28 September 2017

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TOR-centric view on insulin resistance and diabetic complications: perspective for endocrinologists and gerontologists

28 September 2017

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Rates of complications and mortality in older patients with diabetes mellitus: the diabetes and aging study

28 September 2017

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Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet.

28 September 2017

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Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging

28 September 2017

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Redox control of the senescence regulator interleukin-1α and the secretory phenotype

28 September 2017

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Short leukocyte telomere length predicts risk of diabetes in american indians: the strong heart family study

28 September 2017

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Omics technologies and the study of human ageing

28 September 2017

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A complex secretory program orchestrated by the inflammasome controls paracrine senescence

28 September 2017

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Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

28 September 2017

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Mammalian target of rapamycin regulates Nox4-mediated podocyte depletion in diabetic renal injury.

28 September 2017

1 reference

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Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation

28 September 2017

1 reference

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Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

28 September 2017

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ROS-generating oxidases Nox1 and Nox4 contribute to oncogenic Ras-induced premature senescence

28 September 2017

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DNA damage checkpoints in stem cells, ageing and cancer.

28 September 2017

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Evidence that hyperglycemia after recovery from hypoglycemia worsens endothelial function and increases oxidative stress and inflammation in healthy control subjects and subjects with type 1 diabetes

28 September 2017

1 reference

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New insights into ER stress-induced insulin resistance.

28 September 2017

1 reference

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Endothelium under stress: local and systemic messages

28 September 2017

1 reference

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The number of p16INK4a positive cells in human skin reflects biological age.

28 September 2017

1 reference

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The emerging challenge in diabetes: the "metabolic memory".

28 September 2017

1 reference

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Redox signaling loops in the unfolded protein response

28 September 2017

1 reference

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The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis

28 September 2017

1 reference

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Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP).

28 September 2017

1 reference

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Remodelling of biological parameters during human ageing: evidence for complex regulation in longevity and in type 2 diabetes

28 September 2017

1 reference

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New insights into the roles of ATM and DNA-PKcs in the cellular response to oxidative stress

28 September 2017

1 reference

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Endoplasmic reticulum stress, obesity and diabetes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4908264

Meal-induced increases in C-reactive protein, interleukin-6 and tumour necrosis factor α are attenuated by prandial + basal insulin in patients with Type 2 diabetes.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4908264

p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4908264

The endoplasmic reticulum stress response and diabetic kidney disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4908264

Epigenetics: mechanisms and implications for diabetic complications

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4908264

mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4908264

The essence of senescence

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4908264

Fat tissue, aging, and cellular senescence

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4908264

Inflammatory networks during cellular senescence: causes and consequences

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4908264

The NLRP3 inflammasome: a sensor for metabolic danger?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4908264

Antioxidant anti-inflammatory treatment in type 2 diabetes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4908264

Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4908264

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4908264

Endothelial dysfunction and aging: an update

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4908264

Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4908264

Aging is associated with greater nuclear NF kappa B, reduced I kappa B alpha, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4908264

Stress-response hormesis and aging: "that which does not kill us makes us stronger".

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4908264

p16INK4a induces an age-dependent decline in islet regenerative potential

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4908264

Interleukin-6 in aging and chronic disease: a magnificent pathway

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4908264

Apoptosis signal-regulating kinase 1 mediates cellular senescence induced by high glucose in endothelial cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4908264

Endothelial cell heterogeneity and atherosclerosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4908264

Coordination of ER and oxidative stress signaling: the PERK/Nrf2 signaling pathway

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4908264

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4908264

Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4908264

Structure, function, and inhibition of chemokines

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4908264

Evidence against the involvement of nitric oxide in the modulation of telomerase activity or replicative capacity of human endothelial cells.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4908264

Endothelial dysfunction in aged humans is related with oxidative stress and vascular inflammation

31 May 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F1810327

Are senescence and exhaustion intertwined or unrelated processes that compromise immunity?

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F1810327

Pathogenetic loop between diabetes and cell senescence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F1810327

Leukocyte telomere shortening in elderly Type2DM patients with previous myocardial infarction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F1810327

Accelerated senescence in the kidneys of patients with type 2 diabetic nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F1810327

Effects of interleukin-1β inhibition with canakinumab on hemoglobin A1c, lipids, C-reactive protein, interleukin-6, and fibrinogen: a phase IIb randomized, placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F1810327

Impact of interleukin-1β antibody (canakinumab) on glycaemic indicators in patients with type 2 diabetes mellitus: results of secondary endpoints from a randomized, placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F1810327

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F1810327

Anti-inflammatory effect of ubiquinol-10 on young and senescent endothelial cells via miR-146a modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F1810327

Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F1810327

Yin yang: A balancing act for oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F1810327

Prevention and reversal of premature endothelial cell senescence and vasculopathy in obesity-induced diabetes by ebselen

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F1810327

The pivotal role of high glucose-induced overexpression of PKCβ in the appearance of glucagon-like peptide-1 resistance in endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F1810327

Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F1810327

High-glycemic index carbohydrate increases nuclear factor-kappaB activation in mononuclear cells of young, lean healthy subjects

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4908264

Leukocyte telomere length is associated with complications of Type 2 diabetes mellitus

28 November 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F1810327

Endothelial Cell Senescence and Inflammaging: MicroRNAs as Biomarkers and Innovative Therapeutic Tools

21 January 2018

1 reference

12 December 2020

Enhancing Chemotherapy Efficacy in Pten -Deficient Prostate Tumors by Activating the Senescence-Associated Antitumor Immunity

1 reference

12 December 2020

p53 Mediates the accelerated onset of senescence of endothelial progenitor cells in diabetes

1 reference

12 December 2020

Blockade of the nuclear factor-κB pathway in the endothelium prevents insulin resistance and prolongs life spans

1 reference

12 December 2020

Beta-galactosidase--an indicator of the maturational stage of mouse and human mononuclear phagocytes

1 reference

12 December 2020

Identifiers

DOI

10.1155/2016/1810327

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27340505%20AND%20SRC:MED&resulttype=core&format=json

15 March 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27340505%20AND%20SRC:MED&resulttype=core&format=json

15 March 2020

2 references