Transient dynamics of Aβ contribute to toxicity in Alzheimer's disease (Q26827421)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24803005%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

author name string

E Hubin

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24803005%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

N A J van Nuland

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24803005%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

K Broersen

series ordinal

3

1 reference

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2 June 2020

language of work or name

1 reference

September 2014

1 reference

Cellular and Molecular Life Sciences

1 September 2014

3 references

25 April 2019

20 November 2019

15 December 2019

5 references

25 April 2019

20 November 2019

15 December 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24803005%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

volume

71

2 references

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2 June 2020

issue

18

2 references

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2 June 2020

page(s)

3507-3521

1 reference

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Creative Commons Attribution 4.0 International

2 June 2020

copyright license

start time

7 May 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

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Lipids revert inert Abeta amyloid fibrils to neurotoxic protofibrils that affect learning in mice

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The Alzheimer's peptides Abeta40 and 42 adopt distinct conformations in water: a combined MD / NMR study

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Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue

7 April 2017

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Atomic View of a Toxic Amyloid Small Oligomer

7 April 2017

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Antiparallel -sheet architecture in Iowa-mutant -amyloid fibrils

7 April 2017

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Molecular structural basis for polymorphism in Alzheimer's -amyloid fibrils

7 April 2017

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Atomic structures of amyloid cross-beta spines reveal varied steric zippers

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7 April 2017

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The alpha-to-beta conformational transition of Alzheimer's Abeta-(1-42) peptide in aqueous media is reversible: a step by step conformational analysis suggests the location of beta conformation seeding

7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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Rational design of a structural framework with potential use to develop chemical reagents that target and modulate multiple facets of Alzheimer's disease

28 September 2017

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The triple power of D³: protein intrinsic disorder in degenerative diseases

28 September 2017

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Sleep and Alzheimer disease pathology--a bidirectional relationship

28 September 2017

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Signature amyloid β profiles are produced by different γ-secretase complexes

28 September 2017

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Structural and functional characterization of two alpha-synuclein strains

28 September 2017

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On the subject of rigor in the study of amyloid β-protein assembly

28 September 2017

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The effect of exercise interventions on cognitive outcome in Alzheimer's disease: a systematic review

28 September 2017

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Pulsed hydrogen-deuterium exchange mass spectrometry probes conformational changes in amyloid beta (Aβ) peptide aggregation

28 September 2017

1 reference

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Aβ monomers transiently sample oligomer and fibril-like configurations: ensemble characterization using a combined MD/NMR approach

28 September 2017

1 reference

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Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism

28 September 2017

1 reference

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Intrinsic structural heterogeneity and long-term maturation of amyloid β peptide fibrils

28 September 2017

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Structural insights into Aβ42 oligomers using site-directed spin labeling

28 September 2017

1 reference

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The remarkable conformational plasticity of alpha-synuclein: blessing or curse?

28 September 2017

1 reference

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Polymorph-specific kinetics and thermodynamics of β-amyloid fibril growth

28 September 2017

1 reference

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Environmental novelty activates β2-adrenergic signaling to prevent the impairment of hippocampal LTP by Aβ oligomers.

28 September 2017

1 reference

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Biophysical insights into how surfaces, including lipid membranes, modulate protein aggregation related to neurodegeneration.

28 September 2017

1 reference

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Resolution of oligomeric species during the aggregation of Aβ1-40 using (19)F NMR.

28 September 2017

1 reference

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Single-molecule imaging reveals aβ42:aβ40 ratio-dependent oligomer growth on neuronal processes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Alzheimer's Aβ42 and Aβ40 peptides form interlaced amyloid fibrils

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

The missing link in the amyloid cascade of Alzheimer's disease - metal ions

28 September 2017

1 reference

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Molecular structures of amyloid and prion fibrils: consensus versus controversy

28 September 2017

1 reference

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Alzheimer's disease, cholesterol, and statins: the junctions of important metabolic pathways

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Side-chain dynamics reveals transient association of Aβ(1-40) monomers with amyloid fibers.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Molecular plasticity regulates oligomerization and cytotoxicity of the multipeptide-length amyloid-β peptide pool

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Disruption of the sleep-wake cycle and diurnal fluctuation of β-amyloid in mice with Alzheimer's disease pathology

28 September 2017

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Two-step mechanism of membrane disruption by Aβ through membrane fragmentation and pore formation

28 September 2017

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Dietary polyphenol-derived protection against neurotoxic β-amyloid protein: from molecular to clinical.

28 September 2017

1 reference

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Metals, membranes, and amyloid-β oligomers: key pieces in the Alzheimer's disease puzzle?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Biochemistry of amyloid β-protein and amyloid deposits in Alzheimer disease

28 September 2017

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Direct observation of the interconversion of normal and toxic forms of α-synuclein

28 September 2017

1 reference

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Conformational differences between two amyloid β oligomers of similar size and dissimilar toxicity

28 September 2017

1 reference

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Molecular mechanisms of amyloid oligomers toxicity

28 September 2017

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Metal-associated amyloid-β species in Alzheimer's disease

28 September 2017

1 reference

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The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Structural basis for increased toxicity of pathological aβ42:aβ40 ratios in Alzheimer disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Dynamics of amyloid β fibrils revealed by solid-state NMR.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Atomic-resolution dynamics on the surface of amyloid-β protofibrils probed by solution NMR

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Pyroglutamate amyloid-β (Aβ): a hatchet man in Alzheimer disease

28 September 2017

1 reference

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Effect of zinc binding on β-amyloid structure and dynamics: implications for Aβ aggregation

28 September 2017

1 reference

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Misfolded proteins in Alzheimer's disease and type II diabetes.

28 September 2017

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Membrane and surface interactions of Alzheimer's Aβ peptide--insights into the mechanism of cytotoxicity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Abeta42 neurotoxicity is mediated by ongoing nucleated polymerization process rather than by discrete Abeta42 species

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

The culprit behind amyloid beta peptide related neurotoxicity in Alzheimer's disease: oligomer size or conformation?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Alzheimer's disease: clinical trials and drug development

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Kinetics of amyloid beta monomer-to-oligomer exchange by NMR relaxation.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Neuronutrition and Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Fibril fragmentation in amyloid assembly and cytotoxicity: when size matters

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Alzheimer's disease and amyloid beta-peptide deposition in the brain: a matter of 'aging'?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

The thermodynamic stability of amyloid fibrils studied by differential scanning calorimetry

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Exercise plays a preventive role against Alzheimer's disease

28 September 2017

1 reference

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Size-dependent neurotoxicity of beta-amyloid oligomers.

28 September 2017

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A causative link between the structure of aberrant protein oligomers and their toxicity.

28 September 2017

1 reference

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The recombinant amyloid-beta peptide Abeta1-42 aggregates faster and is more neurotoxic than synthetic Abeta1-42.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Comparison of Alzheimer Abeta(1-40) and Abeta(1-42) amyloid fibrils reveals similar protofilament structures

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Inflammation, microglia, and Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Structural disorder in amyloid fibrils: its implication in dynamic interactions of proteins

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Structure-neurotoxicity relationships of amyloid beta-protein oligomers

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

The role of apolipoprotein E in Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Structural polymorphism of Alzheimer Abeta and other amyloid fibrils

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Converging concepts of protein folding in vitro and in vivo

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Distinct conformations of in vitro and in vivo amyloids of huntingtin-exon1 show different cytotoxicity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Chaperone signalling complexes in Alzheimer's disease.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

The interaction of beta-amyloid protein with cellular membranes stimulates its own production

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Interprotofilament interactions between Alzheimer's Abeta1-42 peptides in amyloid fibrils revealed by cryoEM

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Linking folding and binding

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Annular protofibrils are a structurally and functionally distinct type of amyloid oligomer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Protein aggregation kinetics, mechanism, and curve-fitting: a review of the literature.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Structural classification of toxic amyloid oligomers

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Paired beta-sheet structure of an Abeta(1-40) amyloid fibril revealed by electron microscopy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Amyloid-a state in many guises: survival of the fittest fibril fold

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

28 September 2017

Amyloid-beta aggregation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Solution state characterization of amyloid beta-derived diffusible ligands

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Hydrogen/deuterium exchange mass spectrometry--a window into amyloid structure

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Anti-amyloidogenic therapies: strategies for prevention and treatment of Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Structural disorder throws new light on moonlighting

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

The aluminium-amyloid cascade hypothesis and Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Hydrogen exchange-mass spectrometry analysis of beta-amyloid peptide structure

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Specific Compositions of Amyloid-β Peptides as the Determinant of Toxic β-Aggregation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Interaction of intracellular beta amyloid peptide with chaperone proteins

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Highly conserved and disease-specific patterns of carboxyterminally truncated Abeta peptides 1-37/38/39 in addition to 1-40/42 in Alzheimer's disease and in patients with chronic neuroinflammation.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

NMR studies in aqueous solution fail to identify significant conformational differences between the monomeric forms of two Alzheimer peptides with widely different plaque-competence, A beta(1-40)(ox) and A beta(1-42)(ox).

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Nucleated conformational conversion and the replication of conformational information by a prion determinant

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Abnormal tau-containing filaments in neurodegenerative diseases

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Studies on the in vitro assembly of a beta 1-40: implications for the search for a beta fibril formation inhibitors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Alzheimer's disease amyloid propagation by a template-dependent dock-lock mechanism

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Solution structures of micelle-bound amyloid beta-(1-40) and beta-(1-42) peptides of Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Common core structure of amyloid fibrils by synchrotron X-ray diffraction.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Characterization of beta-amyloid peptide from human cerebrospinal fluid

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Advanced glycation end products contribute to amyloidosis in Alzheimer disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Amyloid-beta aggregation: selective inhibition of aggregation in mixtures of amyloid with different chain lengths

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Racemization: its biological significance on neuropathogenesis of Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Structural characterization and inhibition of toxic amyloid-β oligomeric intermediates

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Abeta(1-40) forms five distinct amyloid structures whose beta-sheet contents and fibril stabilities are correlated

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Abeta(1-40) fibril polymorphism implies diverse interaction patterns in amyloid fibrils.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

On the nucleation of amyloid beta-protein monomer folding

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Structural diversity of ex vivo amyloid fibrils studied by cryo-electron microscopy

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

The toxicity of the Alzheimer's beta-amyloid peptide correlates with a distinct fiber morphology.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Aggregation and secondary structure of synthetic amyloid beta A4 peptides of Alzheimer's disease.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Neuritic pathology and dementia in Alzheimer's disease.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment.

31 May 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1634-Z

Deposition of monomeric, not oligomeric, Abeta mediates growth of Alzheimer's disease amyloid plaques in human brain preparations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1634-Z

Preparation and characterization of toxic Abeta aggregates for structural and functional studies in Alzheimer's disease research.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1634-Z

Solution NMR studies of the A beta(1-40) and A beta(1-42) peptides establish that the Met35 oxidation state affects the mechanism of amyloid formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1634-Z

Structure of the 21-30 fragment of amyloid beta-protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1634-Z

Abeta42 is more rigid than Abeta40 at the C terminus: implications for Abeta aggregation and toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1634-Z

Structural and dynamic features of Alzheimer's Abeta peptide in amyloid fibrils studied by site-directed spin labeling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1634-Z

A new structural model of Aβ40 fibrils.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1634-Z

Hydrogen-deuterium (H/D) exchange mapping of Abeta 1-40 amyloid fibril secondary structure using nuclear magnetic resonance spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1634-Z

The solvent protection of alzheimer amyloid-beta-(1-42) fibrils as determined by solution NMR spectroscopy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1634-Z

Analysis of the secondary structure of beta-amyloid (Abeta42) fibrils by systematic proline replacement

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1634-Z

Mapping abeta amyloid fibril secondary structure using scanning proline mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1634-Z

Solid-state NMR spectroscopic investigation of Aβ protofibrils: implication of a β-sheet remodeling upon maturation into terminal amyloid fibrils.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1634-Z

Evidence for age-dependent in vivo conformational rearrangement within Aβ amyloid deposits.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1634-Z

Effect of different salt ions on the propensity of aggregation and on the structure of Alzheimer's abeta(1-40) amyloid fibrils.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1634-Z

Clinicopathologic studies in cognitively healthy aging and Alzheimer's disease: relation of histologic markers to dementia severity, age, sex, and apolipoprotein E genotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1634-Z

Amyloid fibril composition is related to the phenotype of hereditary transthyretin V30M amyloidosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1634-Z

Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1634-Z

Antiparallel beta-sheet: a signature structure of the oligomeric amyloid beta-peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1634-Z

Transformation of amyloid β(1-40) oligomers into fibrils is characterized by a major change in secondary structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1634-Z

Toxic prefibrillar α-synuclein amyloid oligomers adopt a distinctive antiparallel β-sheet structure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1634-Z

ANS binding reveals common features of cytotoxic amyloid species

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1634-Z

Aβ42 oligomers, but not fibrils, simultaneously bind to and cause damage to ganglioside-containing lipid membranes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1634-Z

Beta-amyloid racemized at the Ser26 residue in the brains of patients with Alzheimer disease: implications in the pathogenesis of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1634-Z

Irreversible dimerization/tetramerization and post-translational modifications inhibit proteolytic degradation of A beta peptides of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1634-Z

Phosphorylation of amyloid-beta at the serine 26 residue by human cdc2 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1634-Z

Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1634-Z

Simulations of monomeric amyloid β-peptide (1-40) with varying solution conditions and oxidation state of Met35: implications for aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1634-Z

Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1634-Z

Methylene blue inhibits amyloid Abeta oligomerization by promoting fibrillization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1634-Z

Synaptic dysfunction in hippocampus of transgenic mouse models of Alzheimer's disease: a multi-electrode array study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1634-Z

Structure and intermolecular dynamics of aggregates populated during amyloid fibril formation studied by hydrogen/deuterium exchange.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1634-Z

Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1634-Z

Nucleation-dependent polymerization is an essential component of amyloid-mediated neuronal cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1634-Z

Preserving cognition, quality of life, physical health and functional ability in Alzheimer's disease: the effect of physical exercise (ADEX trial): rationale and design.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1634-Z

Copper binding to the amyloid-beta (Abeta) peptide associated with Alzheimer's disease: folding, coordination geometry, pH dependence, stoichiometry, and affinity of Abeta-(1-28): insights from a range of complementary spectroscopic techniques

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1634-Z

Heat shock protein 70 participates in the neuroprotective response to intracellularly expressed beta-amyloid in neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1634-Z

Heat shock proteins 70 and 90 inhibit early stages of amyloid beta-(1-42) aggregation in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1634-Z

The BRICHOS domain, amyloid fibril formation, and their relationship

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1634-Z

The common architecture of cross-beta amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1634-Z

Modification of amyloid-β1-42 fibril structure by methionine-35 oxidation

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Amyloid-β peptide fibrils induce nitro-oxidative stress in neuronal cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143600

Abeta40 protects non-toxic Abeta42 monomer from aggregation

28 November 2018

1 reference

12 December 2020

Multiple assembly pathways underlie amyloid-beta fibril polymorphisms

1 reference

12 December 2020

Structural features of the Abeta amyloid fibril elucidated by limited proteolysis

1 reference

12 December 2020

Real-time amyloid aggregation monitoring with a photonic crystal-based approach

1 reference

12 December 2020

Quaternary structure of a mature amyloid fibril from Alzheimer's Abeta(1-40) peptide

1 reference

12 December 2020

Structural differences in Abeta amyloid protofibrils and fibrils mapped by hydrogen exchange--mass spectrometry with on-line proteolytic fragmentation

1 reference

12 December 2020

10.1007/S00018-014-1634-Z

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24803005%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

2 June 2020

1045749261

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24803005%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24803005%20AND%20SRC:MED&resulttype=core&format=json