Pleiotropic cellular functions of PARP1 in longevity and aging: genome maintenance meets inflammation (Q26858894)

language of work or name

1 reference

2012

1 reference

Oxidative medicine and cellular longevity

19 September 2012

2 references

20 August 2019

28 September 2019

3 references

20 August 2019

28 September 2019

2012

1 reference

page(s)

321653

1 reference

Creative Commons Attribution 3.0 Unported

copyright license

start time

1 January 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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April 2022 Public Data File from Crossref

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Deficiency in Poly(ADP-ribose) Polymerase-1 (PARP-1) Accelerates Aging and Spontaneous Carcinogenesis in Mice

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Regulation of poly(ADP-ribose) polymerase 1 activity by the phosphorylation state of the nuclear NAD biosynthetic enzyme NMN adenylyl transferase 1

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Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death

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Cooperation of the Cockayne syndrome group B protein and poly(ADP-ribose) polymerase 1 in the response to oxidative stress.

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Identification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1

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Physical and functional interaction between DNA ligase IIIalpha and poly(ADP-Ribose) polymerase 1 in DNA single-strand break repair

21 March 2017

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Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice

21 March 2017

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XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage

21 March 2017

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Stimulation of intrachromosomal homologous recombination in mammalian cells by an inhibitor of poly(ADP-ribosylation)

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Poly(ADP-ribose) polymerase activity in mononuclear leukocytes of 13 mammalian species correlates with species-specific life span

21 March 2017

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The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks

21 March 2017

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Structural Basis for DNA Damage-Dependent Poly(ADP-ribosyl)ation by Human PARP-1

21 March 2017

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A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation

21 March 2017

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

21 March 2017

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Genome maintenance mechanisms for preventing cancer

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Poly(ADP-ribose) polymerase 2 localizes to mammalian active centromeres and interacts with PARP-1, Cenpa, Cenpb and Bub3, but not Cenpc

21 March 2017

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Centromere proteins Cenpa, Cenpb, and Bub3 interact with poly(ADP-ribose) polymerase-1 protein and are poly(ADP-ribosyl)ated

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Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1

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The enzymatic and DNA binding activity of PARP-1 are not required for NF-kappa B coactivator function

21 March 2017

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Regulation of DNA double-strand break repair pathway choice

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Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation

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Increased poly(ADP-ribose) polymerase activity in lymphoblastoid cell lines from centenarians

21 March 2017

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Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

21 March 2017

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PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase

21 March 2017

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Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos)

21 March 2017

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21 March 2017

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Essential role of limiting telomeres in the pathogenesis of Werner syndrome

21 March 2017

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Poly(ADP-ribose) polymerase null mouse cells synthesize ADP-ribose polymers

21 March 2017

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SIRT1 transgenic mice show phenotypes resembling calorie restriction

21 March 2017

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Shared principles in NF-kappaB signaling

7 April 2017

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PARP inhibition: PARP1 and beyond

7 April 2017

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PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways

7 April 2017

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Telomeres and human disease: ageing, cancer and beyond

7 April 2017

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Understanding the odd science of aging

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Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor

7 April 2017

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Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

7 April 2017

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7 April 2017

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ADP-ribosylhydrolase 3 (ARH3), not poly(ADP-ribose) glycohydrolase (PARG) isoforms, is responsible for degradation of mitochondrial matrix-associated poly(ADP-ribose).

28 September 2017

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28 September 2017

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28 September 2017

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Topoisomerase I poisoning results in PARP-mediated replication fork reversal

28 September 2017

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Poly(ADP-ribosyl)ation of p53 induces gene-specific transcriptional repression of MTA1.

28 September 2017

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The p53 network: cellular and systemic DNA damage responses in aging and cancer

28 September 2017

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Poly(ADP-ribosyl)ation of high mobility group box 1 (HMGB1) protein enhances inhibition of efferocytosis

28 September 2017

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Poly(ADP-ribose) polymerase 1 (PARP-1) binds to 8-oxoguanine-DNA glycosylase (OGG1).

28 September 2017

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Immunoaging induced by hematopoietic stem cell aging.

28 September 2017

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Inflammation and mesenchymal stem cell aging

28 September 2017

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SIRT6 promotes DNA repair under stress by activating PARP1

28 September 2017

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Senescent cells develop a PARP-1 and nuclear factor-{kappa}B-associated secretome (PNAS)

28 September 2017

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Intestinal inflammation induces genotoxicity to extraintestinal tissues and cell types in mice

28 September 2017

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Pharmacological inhibition of NF-κB prolongs lifespan of Drosophila melanogaster.

28 September 2017

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PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation

28 September 2017

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Reactive species and DNA damage in chronic inflammation: reconciling chemical mechanisms and biological fates

28 September 2017

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Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells.

28 September 2017

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Activation of nuclear factor-kappa B signalling promotes cellular senescence

28 September 2017

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Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress

28 September 2017

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A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage

28 September 2017

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High-Affinity Interaction of Poly(ADP-ribose) and the Human DEK Oncoprotein Depends upon Chain Length

28 September 2017

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PARP1 ADP-ribosylates lysine residues of the core histone tails

28 September 2017

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Inflammatory networks during cellular senescence: causes and consequences

28 September 2017

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Inflammation 2010: new adventures of an old flame

28 September 2017

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The central role of chromatin maintenance in aging

28 September 2017

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Poly(ADP-ribose) polymerase 1 at the crossroad of metabolic stress and inflammation in aging

28 September 2017

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Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130.

28 September 2017

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Toward a unified nomenclature for mammalian ADP-ribosyltransferases.

28 September 2017

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A nuclear poly(ADP-ribose)-dependent signalosome confers DNA damage-induced IkappaB kinase activation

28 September 2017

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28 September 2017

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RelA/p65 functions to maintain cellular senescence by regulating genomic stability and DNA repair

28 September 2017

1 reference

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PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination.

28 September 2017

1 reference

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Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion.

28 September 2017

1 reference

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Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites

28 September 2017

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Proteome-wide identification of poly(ADP-ribose) binding proteins and poly(ADP-ribose)-associated protein complexes

28 September 2017

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DNA damage and ageing: new-age ideas for an age-old problem

28 September 2017

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The expanding field of poly(ADP-ribosyl)ation reactions. 'Protein Modifications: Beyond the Usual Suspects' Review Series.

28 September 2017

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SirT1 gain of function increases energy efficiency and prevents diabetes in mice

28 September 2017

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Rapid regulation of telomere length is mediated by poly(ADP-ribose) polymerase-1.

28 September 2017

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The histone subcode: poly(ADP-ribose) polymerase-1 (Parp-1) and Parp-2 control cell differentiation by regulating the transcriptional intermediary factor TIF1beta and the heterochromatin protein HP1alpha

28 September 2017

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Sirt1 protects against high-fat diet-induced metabolic damage

28 September 2017

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CCCTC-binding factor activates PARP-1 affecting DNA methylation machinery.

28 September 2017

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Replicative stress, stem cells and aging

28 September 2017

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Transcriptional control by PARP-1: chromatin modulation, enhancer-binding, coregulation, and insulation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Base excision repair, aging and health span.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

DEK is a poly(ADP-ribose) acceptor in apoptosis and mediates resistance to genotoxic stress

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Depletion of poly(ADP-ribose) polymerase-1 reduces host cell reactivation of a UV-damaged adenovirus-encoded reporter gene in human dermal fibroblasts

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Reciprocal binding of PARP-1 and histone H1 at promoters specifies transcriptional outcomes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

DNA replication stress, genome instability and aging

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Functional localization of two poly(ADP-ribose)-degrading enzymes to the mitochondrial matrix

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Quantitative analysis of the binding affinity of poly(ADP-ribose) to specific binding proteins as a function of chain length

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Feedback-regulated poly(ADP-ribosyl)ation by PARP-1 is required for rapid response to DNA damage in living cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Poly(ADP-ribosyl)ation in mammalian ageing

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Oxidative DNA damage repair and parp 1 and parp 2 expression in Epstein-Barr virus-immortalized B lymphocyte cells from young subjects, old subjects, and centenarians.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Modulation of transcription by PARP-1: consequences in carcinogenesis and inflammation.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Activation of poly(ADP)-ribose polymerase (PARP-1) induces release of the pro-inflammatory mediator HMGB1 from the nucleus

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly(ADP-ribose)-dependent pathway in the early response to DNA-damaging agents

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Single dose treatment with PARP-inhibitor INO-1001 improves aging-associated cardiac and vascular dysfunction

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Poly(ADP-ribose) (PAR) polymer is a death signal

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Unravelling the complexities of the NF-kappaB signalling pathway using mouse knockout and transgenic models.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Free radical theory of aging: an update: increasing the functional life span

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

PARP1 Is a TRF2-associated poly(ADP-ribose)polymerase and protects eroded telomeres

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Identification and characterization of a mammalian 39-kDa poly(ADP-ribose) glycohydrolase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Physiological ageing: role of p53 and PARP-1 tumor suppressors in the regulation of terminal senescence.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Molecular mechanisms of aging-associated inflammation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Cell death independent of caspases: a review.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Anemia of chronic disease.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Poly(ADP-ribose) polymerase 1 regulates both the exonuclease and helicase activities of the Werner syndrome protein

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Human poly(ADP-ribose) glycohydrolase is expressed in alternative splice variants yielding isoforms that localize to different cell compartments

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Poly(ADP-ribosyl)ated chromatin domains: access granted

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Central Role for the Werner Syndrome Protein/Poly(ADP-Ribose) Polymerase 1 Complex in the Poly(ADP-Ribosyl)ation Pathway after DNA Damage

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Poly(ADP-ribosyl)ation accelerates DNA repair in a pathway dependent on Cockayne syndrome B protein

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

1,5-isoquinolinediol increases the frequency of gene targeting by homologous recombination in mouse fibroblasts.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Poly(ADP-ribose) polymerase-1 is a positive regulator of the p53-mediated G1 arrest response following ionizing radiation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Involvement of poly(ADP-Ribose) polymerase 1 and poly(ADP-Ribosyl)ation in regulation of centrosome function

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Null mutation of DNA strand break-binding molecule poly(ADP-ribose) polymerase causes medulloblastomas in p53(-/-) mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

The functional role of poly(ADP-ribose)polymerase 1 as novel coactivator of NF-kappaB in inflammatory disorders

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

PARP-1 modifies the effectiveness of p53-mediated DNA damage response.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Poly(ADP-ribosyl)ation of p53 in vitro and in vivo modulates binding to its DNA consensus sequence

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

DNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Increased susceptibility of poly(ADP-ribose) polymerase-1 knockout mice to nitrosamine carcinogenicity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Poly(ADP-ribose) polymerase localizes to the centrosomes and chromosomes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

New polymorphisms in the human poly(ADP-ribose) polymerase-1 coding sequence: lack of association with longevity or with increased cellular poly(ADP-ribosyl)ation capacity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Negative regulation of alkylation-induced sister-chromatid exchange by poly(ADP-ribose) polymerase-1 activity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Misregulation of gene expression in primary fibroblasts lacking poly(ADP-ribose) polymerase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Resistance to endotoxic shock as a consequence of defective NF-kappaB activation in poly (ADP-ribose) polymerase-1 deficient mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Poly(ADP-ribosyl)ation is required for p53-dependent signal transduction induced by radiation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

DNA repair defect in poly(ADP-ribose) polymerase-deficient cell lines

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

PARP is important for genomic stability but dispensable in apoptosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Multiparametric staining to identify apoptotic human cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

XRCC1 polypeptide interacts with DNA polymerase beta and possibly poly (ADP-ribose) polymerase, and DNA ligase III is a novel molecular 'nick-sensor' in vitro

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

trans-dominant inhibition of poly(ADP-ribosyl)ation sensitizes cells against gamma-irradiation and N-methyl-N'-nitro-N-nitrosoguanidine but does not limit DNA replication of a polyomavirus replicon

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Poly(ADP-ribosyl)ation of polynucleosomes causes relaxation of chromatin structure

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

The second zinc-finger domain of poly(ADP-ribose) polymerase determines specificity for single-stranded breaks in DNA.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Poly ADP-ribosylation: a histone shuttle mechanism in DNA excision repair

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Visualization of a DNA-PK/PARP1 complex.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

AMP-activated protein kinase is a positive regulator of poly(ADP-ribose) polymerase

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Modulation of chromatin superstructure induced by poly(ADP-ribose) synthesis and degradation

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity.

31 May 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F321653

The expanding field of poly(ADP-ribosyl)ation reactions. ‘Protein Modifications: Beyond the Usual Suspects' Review Series.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F321653

Deletion of the nuclear isoform of poly(ADP-ribose) glycohydrolase (PARG) reveals its function in DNA repair, genomic stability and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F321653

Sumoylation of poly(ADP-ribose) polymerase 1 inhibits its acetylation and restrains transcriptional coactivator function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F321653

Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F321653

DNA-independent PARP-1 activation by phosphorylated ERK2 increases Elk1 activity: a link to histone acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F321653

KIF4 motor regulates activity-dependent neuronal survival by suppressing PARP-1 enzymatic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F321653

Ex vivo supplementation with nicotinic acid enhances cellular poly(ADP-ribosyl)ation and improves cell viability in human peripheral blood mononuclear cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F321653

NAD+-dependent modulation of chromatin structure and transcription by nucleosome binding properties of PARP-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F321653

Chromatin loosening by poly(ADP)-ribose polymerase (PARP) at Drosophila puff loci

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F321653

In vivo misregulation of genes involved in apoptosis, development and oxidative stress in mice lacking both functional Werner syndrome protein and poly(ADP-ribose) polymerase-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F321653

Stimulation of the DNA-dependent protein kinase by poly(ADP-ribose) polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F321653

Ablation of PARP-1 does not interfere with the repair of DNA double-strand breaks, but compromises the reactivation of stalled replication forks

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F321653

Poly(ADP-ribose) is required for spindle assembly and structure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F321653

Lentiviral siRNAs targeting multiple highly conserved RNA sequences of human immunodeficiency virus type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F321653

Haploinsufficiency of poly(ADP-ribose) polymerase-1-mediated poly(ADP-ribosyl)ation for centrosome duplication.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F321653

BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F321653

Poly(ADP-ribose) polymerase-1 plays a role in suppressing mammary tumourigenesis in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F321653

Parp-1 deficiency implicated in colon and liver tumorigenesis induced by azoxymethane.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F321653

The ADPRT V762A genetic variant contributes to prostate cancer susceptibility and deficient enzyme function

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F321653

PARP-1 Val762Ala polymorphism, CagA+ H. pylori infection and risk for gastric cancer in Han Chinese population.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F321653

Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F321653

Reversal of aging by NFkappaB blockade

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F321653

The roles of poly(ADP-ribose)-metabolizing enzymes in alkylation-induced cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F321653

PARP1 is required for adhesion molecule expression in atherogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F321653

Functional interplay between Parp-1 and SirT1 in genome integrity and chromatin-based processes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F321653

Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F321653

Inflammatory and age-related pathologies in mice with ectopic expression of human PARP-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F321653

Differential inflammatory responses in aging and disease: TNF-α and IL-6 as possible biomarkers

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F321653

Synergistic role of Ku80 and poly(ADP-ribose) polymerase in suppressing chromosomal aberrations and liver cancer formation

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Function of poly(ADP-ribose) polymerase in response to DNA damage: gene-disruption study in mice.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459245

Enzyme characteristics of recombinant poly(ADP-ribose) polymerases-1 of rat and human origin mirror the correlation between cellular poly(ADP-ribosyl)ation capacity and species-specific life span

28 November 2018

1 reference

12 December 2020

DNA-induced dimerization of poly(ADP-ribose) polymerase-1 triggers its activation

1 reference

12 December 2020

Effect of zinc on cellular poly(ADP-ribosyl)ation capacity

1 reference

12 December 2020

Down-regulation of PARP-1, but not of Ku80 or DNA-PKcs', results in higher gene targeting efficiency

1 reference

12 December 2020

Histone shuttling by poly(ADP-ribosylation)

1 reference

12 December 2020

SET and PARP1 remove DEK from chromatin to permit access by the transcription machinery

1 reference

12 December 2020

A role of poly (ADP-ribose) polymerase in NF-kappaB transcriptional activation

1 reference

12 December 2020

Inhibition of poly(ADP-ribose) polymerase activity accelerates T-cell lymphomagenesis in p53 deficient mice

1 reference

12 December 2020

Poly(ADP-ribose) polymerase mediates the suicide response to massive DNA damage: studies in normal and DNA-repair defective cells

1 reference

12 December 2020

Regulation of p53 sequence-specific DNA-binding by covalent poly(ADP-ribosyl)ation

1 reference

12 December 2020

Biochemical association of poly(ADP-ribose) polymerase-1 and its apoptotic peptide fragments with DNA polymerase beta

1 reference

12 December 2020

Poly(ADP-ribose) polymerase is a catalytic dimer and the automodification reaction is intermolecular

1 reference

12 December 2020

Poly(ADP-ribose) binds to specific domains in DNA damage checkpoint proteins

1 reference

12 December 2020

PARP1 Val762Ala polymorphism reduces enzymatic activity

1 reference

12 December 2020

1 reference

12 December 2020

Functional interactions of p53 with poly(ADP-ribose) polymerase (PARP) during apoptosis following DNA damage: covalent poly(ADP-ribosyl)ation of p53 by exogenous PARP and noncovalent binding of p53 to the M(r) 85,000 proteolytic fragment

1 reference

12 December 2020

Polymorphisms in DNA base excision repair genes ADPRT and XRCC1 and risk of lung cancer

1 reference

12 December 2020

Identifiers

DOI

10.1155/2012/321653

1 reference

release_xt6kbrdmqzbzjgf5azlt5udmum

Fatcat ID

0 references

1 reference

1 reference

PubMed publication ID

23050038

1 reference