Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy (Q27301246)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26858121%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

title

Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26858121%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

1 reference

1 reference

9

1 reference

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7 March 2020

author name string

Erica Barini

1

1 reference

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7 March 2020

Odetta Antico

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26858121%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

Yingjun Zhao

3

1 reference

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7 March 2020

Francesco Asta

4

1 reference

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7 March 2020

Valter Tucci

5

1 reference

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7 March 2020

Tiziano Catelani

6

1 reference

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7 March 2020

Roberto Marotta

7

1 reference

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7 March 2020

Huaxi Xu

8

1 reference

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7 March 2020

language of work or name

English

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publication date

9 February 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26858121%20AND%20SRC:MED&resulttype=core&format=json

Molecular Neurodegeneration

7 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26858121%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

volume

11

1 reference

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7 March 2020

issue

1

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page(s)

16

1 reference

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describes a project that uses

7 March 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4746897/fullTextXML

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1186/s13024-016-0082-7

0 references

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21 March 2017

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Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status

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21 March 2017

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7 April 2017

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7 April 2017

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7 April 2017

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Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis

7 April 2017

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Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer's disease and tauopathies

28 September 2017

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Repurposing diabetes drugs for brain insulin resistance in Alzheimer disease

28 September 2017

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Too little and too much: hypoactivation and disinhibition of medial prefrontal cortex cause attentional deficits.

28 September 2017

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Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2

28 September 2017

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Early detection of Alzheimer's disease using PiB and FDG PET

28 September 2017

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28 September 2017

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Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology

28 September 2017

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Increased risk of cognitive impairment in patients with diabetes is associated with metformin

28 September 2017

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Metformin improves healthspan and lifespan in mice

28 September 2017

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Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.

28 September 2017

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28 September 2017

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28 September 2017

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Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

28 September 2017

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An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers

28 September 2017

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Metformin, other antidiabetic drugs, and risk of Alzheimer's disease: a population-based case-control study

28 September 2017

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Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice

28 September 2017

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Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression.

28 September 2017

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Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer's-like changes

28 September 2017

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Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

28 September 2017

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Cell-mediated neuroprotection in a mouse model of human tauopathy

28 September 2017

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Caspase activation precedes and leads to tangles

28 September 2017

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Characterization of tau fibrillization in vitro

28 September 2017

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Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription.

28 September 2017

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Granular tau oligomers as intermediates of tau filaments

28 September 2017

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Hyperactivation of mammalian target of rapamycin (mTOR) signaling by a gain-of-function mutant of the Rheb GTPase.

28 September 2017

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Efficiency of transduction of highly purified murine hematopoietic stem cells by lentiviral and oncoretroviral vectors under conditions of minimal in vitro manipulation.

28 September 2017

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Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology

28 September 2017

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The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism

28 September 2017

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28 September 2017

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Does insulin dysfunction play a role in Alzheimer's disease?

28 September 2017

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28 September 2017

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Metformin kinetics in healthy subjects and in patients with diabetes mellitus

28 September 2017

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Resting microglia react to Aβ42 fibrils but do not detect oligomers or oligomer-induced neuronal damage

28 September 2017

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Metformin protects against seizures, learning and memory impairments and oxidative damage induced by pentylenetetrazole-induced kindling in mice

31 May 2018

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31 May 2018

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Tau Phosphorylation by GSK3 in Different Conditions

31 May 2018

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Tsc2-Rheb signaling regulates EphA-mediated axon guidance

31 May 2018

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31 May 2018

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Analysis of tau phosphorylation and truncation in a mouse model of human tauopathy

31 May 2018

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S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt.

31 May 2018

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Role of mTOR in the degradation of IRS-1: regulation of PP2A activity

31 May 2018

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Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons.

31 May 2018

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Correlations of synaptic and pathological markers with cognition of the elderly

31 May 2018

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Effects of metformin on learning and memory behaviors and brain mitochondrial functions in high fat diet induced insulin resistant rats.

31 May 2018

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A high-fat-diet-induced cognitive deficit in rats that is not prevented by improving insulin sensitivity with metformin.

21 January 2018

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Novel action of metformin in the prevention of haloperidol-induced catalepsy in mice: Potential in the treatment of Parkinson's disease?

21 January 2018

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21 January 2018

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Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation

21 January 2018

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Clk2 and B56β mediate insulin-regulated assembly of the PP2A phosphatase holoenzyme complex on Akt.

21 January 2018

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Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease.

21 January 2018

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Effects of risperidone on locomotor activity and spatial memory in rats with hippocampal damage.

21 January 2018

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Metformin slows down aging and extends life span of female SHR mice.

21 January 2018

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Metformin therapy in a transgenic mouse model of Huntington's disease.

21 January 2018

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Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404.

21 January 2018

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Quantification of metformin by the HPLC method in brain regions, cerebrospinal fluid and plasma of rats treated with lipopolysaccharide.

21 January 2018

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Fluoro-substituted and 13C-labeled styrylbenzene derivatives for detecting brain amyloid plaques

21 January 2018

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Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology

21 January 2018

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Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein.

21 January 2018

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Anti-ageing pill pushed as bona fide drug

28 November 2018

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Amyloid beta oligomers induce impairment of neuronal insulin receptors

21 January 2018

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12 December 2020

Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly

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Quantitative motor assessment in FALS mice: a longitudinal study

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Insulin transiently increases tau phosphorylation: involvement of glycogen synthase kinase-3beta and Fyn tyrosine kinase

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Identifiers

DOI

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

782752

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26858121%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

7 March 2020

1042328353

0 references

OpenCitations bibliographic resource ID

782752

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26858121%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26858121%20AND%20SRC:MED&resulttype=core&format=json