Raf-interactome in tuning the complexity and diversity of Raf function (Q27692653)

Yang Y

2

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Ward R

3

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Liu Y

4

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Guo XX

5

1 reference

Xu TR

6

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language of work or name

English

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publication date

January 2015

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282

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issue

1

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page(s)

32-53

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Conferring specificity on the ubiquitous Raf/MEK signalling pathway

cites work

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The RAF proteins take centre stage

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Mechanisms of regulating the Raf kinase family

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RAF protein-serine/threonine kinases: structure and regulation

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Inhibition of doxorubicin-induced autophagy in hepatocellular carcinoma Hep3B cells by sorafenib--the role of extracellular signal-regulated kinase counteraction

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Ras in cancer and developmental diseases

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Mutations of the BRAF gene in human cancer

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BRAF mutations in hairy-cell leukemia

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Guilty as charged: B-RAF is a human oncogene

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Phase II efficacy and pharmacogenomic study of Selumetinib (AZD6244; ARRY-142886) in iodine-131 refractory papillary thyroid carcinoma with or without follicular elements

21 January 2018

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Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

21 January 2018

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Elucidating distinct roles for NF1 in melanomagenesis

21 January 2018

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Melanoma whole-exome sequencing identifies (V600E)B-RAF amplification-mediated acquired B-RAF inhibitor resistance

21 January 2018

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Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma

21 January 2018

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Inhibiting EGF receptor or SRC family kinase signaling overcomes BRAF inhibitor resistance in melanoma

21 January 2018

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COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13113

Selective Raf inhibition in cancer therapy

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13113

Signal transduction: hanging on a scaffold.

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13113

Paradoxical oncogenesis--the long-term effects of BRAF inhibition in melanoma

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13113

"RAF" neighborhood: protein-protein interaction in the Raf/Mek/Erk pathway

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13113

Raf family kinases: old dogs have learned new tricks

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13113

PI3K and cancer: lessons, challenges and opportunities

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13113

Phosphorylation and regulation of Raf by Akt (protein kinase B)

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13113

A novel AKT1 mutant amplifies an adaptive melanoma response to BRAF inhibition

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13113

Structure of the MST4 in complex with MO25 provides insights into its activation mechanism

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13113

Cloning and characterization of MST4, a novel Ste20-like kinase

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13113

The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13113

Group I p21-activated kinases (PAKs) promote tumor cell proliferation and survival through the AKT1 and Raf-MAPK pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

PAK signalling during the development and progression of cancer

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13113

Interaction between active Pak1 and Raf-1 is necessary for phosphorylation and activation of Raf-1

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13113

A human MAP kinase interactome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

p21-activated kinase 1 (PAK1) can promote ERK activation in a kinase-independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

P21-activated kinase 1 (PAK1) as a therapeutic target in BRAF wild-type melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Protein kinase C, an elusive therapeutic target?

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13113

Increased membrane affinity of the C1 domain of protein kinase Cdelta compensates for the lack of involvement of its C2 domain in membrane recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

A single residue in the C1 domain sensitizes novel protein kinase C isoforms to cellular diacylglycerol production

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

The tail wagging the dog--regulation of lipid metabolism by protein kinase C.

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13113

Protein kinase Cε as a cancer marker and target for anticancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Role of diacylglycerol-regulated protein kinase C isotypes in growth factor activation of the Raf-1 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Protein kinase Czeta mediated Raf-1/extracellular-regulated kinase activation by daunorubicin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

14-3-3 Isotypes facilitate coupling of protein kinase C-ζ to Raf-1: negative regulation by 14-3-3 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Taming the Hippo: Raf-1 controls apoptosis by suppressing MST2/Hippo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

SH4-domain-induced plasma membrane dynamization promotes bleb-associated cell motility.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Current status of SRC inhibitors in solid tumor malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Identification of MET and SRC activation in melanoma cell lines showing primary resistance to PLX4032.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

A melanocyte lineage program confers resistance to MAP kinase pathway inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Interferon gamma activation of Raf-1 is Jak1-dependent and p21ras-independent

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

JAK inhibitors: treatment efficacy and safety profile in patients with psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Syk and ZAP-70 mediate recruitment of p56lck/CD4 to the activated T cell receptor/CD3/zeta complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

The protein-tyrosine kinase Lck associates with and is phosphorylated by Cdc2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Activation of T cell Raf-1 at mitosis requires the protein-tyrosine kinase Lck.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Regulation of Raf through phosphorylation and N terminus-C terminus interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Identification of Raf-1 S471 as a novel phosphorylation site critical for Raf-1 and B-Raf kinase activities and for MEK binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Regulation of Raf-1 by direct feedback phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Identification of novel in vivo Raf-1 phosphorylation sites mediating positive feedback Raf-1 regulation by extracellular signal-regulated kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Nuclear Raf-1 kinase regulates the CXCR5 promoter by associating with NFATc3 to drive retinoic acid-induced leukemic cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Protein kinase A blocks Raf-1 activity by stimulating 14-3-3 binding and blocking Raf-1 interaction with Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Regulation of the Raf-1 kinase domain by phosphorylation and 14-3-3 association.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Integrating signals between cAMP and the RAS/RAF/MEK/ERK signalling pathways. Based on the anniversary prize of the Gesellschaft für Biochemie und Molekularbiologie Lecture delivered on 5 July 2003 at the Special FEBS Meeting in Brussels

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Kinase suppressor of Ras is ceramide-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Positive and negative regulation of Raf kinase activity and function by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Reversal of Raf-1 activation by purified and membrane-associated protein phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Ras binding opens c-Raf to expose the docking site for mitogen-activated protein kinase kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Ras signaling: PP2A puts Ksr and Raf in the right place

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Dephosphorylation of Ser-259 regulates Raf-1 membrane association

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Dual-specificity MAP kinase phosphatases (MKPs): shaping the outcome of MAP kinase signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Targeting the disordered C terminus of PTP1B with an allosteric inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Protein tyrosine phosphatases--from housekeeping enzymes to master regulators of signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Usage of tautomycetin, a novel inhibitor of protein phosphatase 1 (PP1), reveals that PP1 is a positive regulator of Raf-1 in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Methylglyoxal downregulates Raf-1 protein through a ubiquitination-mediated mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Threonine 22 phosphorylation attenuates Hsp90 interaction with cochaperones and affects its chaperone activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

HSP90 inhibitors for cancer therapy and overcoming drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Hsp90 inhibitors in breast cancer: a systematic review.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Cdc37 is a molecular chaperone with specific functions in signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

p50(cdc37) binds directly to the catalytic domain of Raf as well as to a site on hsp90 that is topologically adjacent to the tetratricopeptide repeat binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

p21-activated Kinase 1 (Pak1)-dependent phosphorylation of Raf-1 regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Oncogenic B-RafV600E inhibits apoptosis and promotes ERK-dependent inactivation of Bad and Bim.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Bcl-2 targets the protein kinase Raf-1 to mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Apoptosis suppression by Raf-1 and MEK1 requires MEK- and phosphatidylinositol 3-kinase-dependent signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Survival signaling by C-RAF: mitochondrial reactive oxygen species and Ca2+ are critical targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Caspase-independent cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

An old kinase on a new path: Raf and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Inhibitor of apoptosis proteins (IAPs) and their antagonists regulate spontaneous and tumor necrosis factor (TNF)-induced proinflammatory cytokine and chemokine production

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Raf induces NF-kappaB by membrane shuttle kinase MEKK1, a signaling pathway critical for transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Molecular determinants of melanoma malignancy: selecting targets for improved efficacy of chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Protective role of Raf-1 in Salmonella-induced macrophage apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Coordinating ERK/MAPK signalling through scaffolds and inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

KSR modulates signal propagation within the MAPK cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

KSR stimulates Raf-1 activity in a kinase-independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

The molecular scaffold KSR1 regulates the proliferative and oncogenic potential of cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

RAF inhibitor-induced KSR1/B-RAF binding and its effects on ERK cascade signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Regulation of MAP Kinase Signaling Modules by Scaffold Proteins in Mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

CNK1 is a scaffold protein that regulates Src-mediated Raf-1 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

CNK2 couples NGF signal propagation to multiple regulatory cascades driving cell differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

14-3-3 proteins: structure, function, and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

A structural basis for 14-3-3sigma functional specificity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Prohibitin co-localizes with Rb in the nucleus and recruits N-CoR and HDAC1 for transcriptional repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Activation of Raf-1 by 14-3-3 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

14-3-3 is not essential for Raf-1 function: identification of Raf-1 proteins that are biologically activated in a 14-3-3- and Ras-independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

14-3-3 zeta negatively regulates raf-1 activity by interactions with the Raf-1 cysteine-rich domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Regulation of RAF activity by 14-3-3 proteins: RAF kinases associate functionally with both homo- and heterodimeric forms of 14-3-3 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

The role of prohibitin in cell signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Ras-Raf signaling needs prohibitin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Transduction of receptor signals by beta-arrestins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

beta-arrestins: traffic cops of cell signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Mutations of beta-arrestin 2 that limit self-association also interfere with interactions with the beta2-adrenoceptor and the ERK1/2 MAPKs: implications for beta2-adrenoceptor signalling via the ERK1/2 MAPKs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Eukaryotic translation initiation factor 3, subunit a, regulates the extracellular signal-regulated kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

IQGAP1 binds ERK2 and modulates its activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

IQGAP1 and its binding proteins control diverse biological functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

IQGAPs in cancer: a family of scaffold proteins underlying tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

IQGAP1 is a scaffold for mitogen-activated protein kinase signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase-driven tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Phosphorylation of paxillin confers cisplatin resistance in non-small cell lung cancer via activating ERK-mediated Bcl-2 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

RKIP downregulates B-Raf kinase activity in melanoma cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Pivotal roles of snail inhibition and RKIP induction by the proteasome inhibitor NPI-0052 in tumor cell chemoimmunosensitization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Sprouty2 association with B-Raf is regulated by phosphorylation and kinase conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Modulation of signalling by Sprouty: a developing story

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

The scaffold protein Shoc2/SUR-8 accelerates the interaction of Ras and Raf.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Raf-1 regulates Rho signaling and cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

MEK-1 phosphorylation by MEK kinase, Raf, and mitogen-activated protein kinase: analysis of phosphopeptides and regulation of activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

MEKK1 binds raf-1 and the ERK2 cascade components

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Inferring signaling pathway topologies from multiple perturbation measurements of specific biochemical species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113

Requirement of Ras-GTP-Raf Complexes for Activation of Raf-1 by Protein Kinase C

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13113