The ever-expanding role of HIF in tumour and stromal biology (Q28079015)

Amato J. Giaccia

series ordinal

2

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language of work or name

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April 2016

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1 reference

18

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issue

4

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page(s)

356-65

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Structural integration in hypoxia-inducible factors

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Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

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Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

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Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

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The Intercellular Metabolic Interplay between Tumor and Immune Cells

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RETRACTED: Lysyl oxidase is essential for hypoxia-induced metastasis

20 March 2017

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The hypoxia-inducible microRNA cluster miR-199a∼214 targets myocardial PPARδ and impairs mitochondrial fatty acid oxidation

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Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion

7 April 2017

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Activation of a metabolic gene regulatory network downstream of mTOR complex 1

7 April 2017

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Macrophage diversity enhances tumor progression and metastasis

7 April 2017

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Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

7 April 2017

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Regulation of immune responses by L-arginine metabolism

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The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies

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Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

7 April 2017

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Neutrophils in the activation and regulation of innate and adaptive immunity

7 April 2017

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Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN

7 April 2017

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HIF-1alpha is essential for myeloid cell-mediated inflammation

7 April 2017

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Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics

7 April 2017

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Modeling Alveolar Soft Part Sarcomagenesis in the Mouse: A Role for Lactate in the Tumor Microenvironment

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Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

24 May 2017

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The Complex Role of Neutrophils in Tumor Angiogenesis and Metastasis

24 May 2017

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Neutrophils Oppose Uterine Epithelial Carcinogenesis via Debridement of Hypoxic Tumor Cells

29 September 2017

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Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis

29 September 2017

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Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses.

29 September 2017

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The Cancer Cell Oxygen Sensor PHD2 Promotes Metastasis via Activation of Cancer-Associated Fibroblasts

29 September 2017

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Suppression of PGC-1α Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma

29 September 2017

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TCR-Signaling Events in Cellular Metabolism and Specialization

29 September 2017

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E3 Ubiquitin Ligase VHL Regulates Hypoxia-Inducible Factor-1α to Maintain Regulatory T Cell Stability and Suppressive Capacity.

29 September 2017

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High resolution imaging of intracellular oxygen concentration by phosphorescence lifetime.

29 September 2017

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The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase.

29 September 2017

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Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis

29 September 2017

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Fatty acid carbon is essential for dNTP synthesis in endothelial cells

29 September 2017

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A novel HIF-1α-integrin-linked kinase regulatory loop that facilitates hypoxia-induced HIF-1α expression and epithelial-mesenchymal transition in cancer cells

29 September 2017

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Targeting vascular pericytes in hypoxic tumors increases lung metastasis via angiopoietin-2.

29 September 2017

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VHL, the story of a tumour suppressor gene

29 September 2017

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Aberrant IDH3α expression promotes malignant tumor growth by inducing HIF-1-mediated metabolic reprogramming and angiogenesis.

29 September 2017

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Tissue injury and hypoxia promote malignant progression of prostate cancer by inducing CXCL13 expression in tumor myofibroblasts

29 September 2017

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Fatty acid uptake and lipid storage induced by HIF-1α contribute to cell growth and survival after hypoxia-reoxygenation

29 September 2017

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HIF-1-mediated suppression of acyl-CoA dehydrogenases and fatty acid oxidation is critical for cancer progression.

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation

29 September 2017

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Increased metabolites of 5-lipoxygenase from hypoxic ovarian cancer cells promote tumor-associated macrophage infiltration

29 September 2017

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The multifaceted von Hippel-Lindau tumour suppressor protein

29 September 2017

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Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1α.

29 September 2017

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Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth

29 September 2017

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29 September 2017

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The role of reactive oxygen species and metabolism on cancer cells and their microenvironment

29 September 2017

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A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells

29 September 2017

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Granzyme B degradation by autophagy decreases tumor cell susceptibility to natural killer-mediated lysis under hypoxia

29 September 2017

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Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology

29 September 2017

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Loss of prolyl hydroxylase-2 in myeloid cells and T-lymphocytes impairs tumor development.

29 September 2017

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R-2-hydroxyglutarate as the key effector of IDH mutations promoting oncogenesis

29 September 2017

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Arginase II expressed in cancer-associated fibroblasts indicates tissue hypoxia and predicts poor outcome in patients with pancreatic cancer

29 September 2017

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29 September 2017

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29 September 2017

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Oxygen versus Reactive Oxygen in the Regulation of HIF-1α: The Balance Tips

29 September 2017

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Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells

29 September 2017

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Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa

29 September 2017

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Metabolic reprogramming and two-compartment tumor metabolism: opposing role(s) of HIF1α and HIF2α in tumor-associated fibroblasts and human breast cancer cells

29 September 2017

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Reciprocal metabolic reprogramming through lactate shuttle coordinately influences tumor-stroma interplay

29 September 2017

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Primary tumor hypoxia recruits CD11b+/Ly6Cmed/Ly6G+ immune suppressor cells and compromises NK cell cytotoxicity in the premetastatic niche.

29 September 2017

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Loss of fibroblast HIF-1α accelerates tumorigenesis.

29 September 2017

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Semaphorin 3A overcomes cancer hypoxia and metastatic dissemination induced by antiangiogenic treatment in mice

29 September 2017

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Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis.

29 September 2017

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Endothelial HIF-2α regulates murine pathological angiogenesis and revascularization processes

29 September 2017

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Role of reactive oxygen species in the regulation of HIF-1 by prolyl hydroxylase 2 under mild hypoxia

29 September 2017

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The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity

29 September 2017

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Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase

29 September 2017

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Dietary obesity-associated Hif1α activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD+ system.

29 September 2017

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Pericyte depletion results in hypoxia-associated epithelial-to-mesenchymal transition and metastasis mediated by met signaling pathway

29 September 2017

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Endothelial cell HIF-1α and HIF-2α differentially regulate metastatic success

29 September 2017

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Metabolic symbiosis in cancer: refocusing the Warburg lens

29 September 2017

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Cancer associated fibroblasts: the dark side of the coin.

29 September 2017

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Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells.

29 September 2017

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HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

29 September 2017

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Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases

29 September 2017

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Stromal endothelial cells directly influence cancer progression.

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898054

From vessel sprouting to normalization: role of the prolyl hydroxylase domain protein/hypoxia-inducible factor oxygen-sensing machinery.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898054

HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898054

Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898054

Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898054

Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898054

Hypoxia, inflammation, and the tumor microenvironment in metastatic disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898054

Differential activation and antagonistic function of HIF-{alpha} isoforms in macrophages are essential for NO homeostasis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898054

The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898054

Signalling cross talk of the HIF system: involvement of the FIH protein.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898054

mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898054

Hypoxia-inducible factor 2 regulates hepatic lipid metabolism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898054

Endothelial deletion of hypoxia-inducible factor-2alpha (HIF-2alpha) alters vascular function and tumor angiogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898054

The cooperative induction of hypoxia-inducible factor-1 alpha and STAT3 during hypoxia induced an impairment of tumor susceptibility to CTL-mediated cell lysis.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898054

Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898054

PGC-1alpha is coupled to HIF-1alpha-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898054

A role for VEGF as a negative regulator of pericyte function and vessel maturation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898054

NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898054

HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898054

Mitochondrial oxygen sensing: regulation of hypoxia-inducible factor by mitochondrial generated reactive oxygen species

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898054

A2A adenosine receptor protects tumors from antitumor T cells.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898054

Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898054

Galectin-1: a link between tumor hypoxia and tumor immune privilege

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898054

Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898054

Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898054

Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898054

Foxp3 expressing CD4+CD25(high) regulatory T cells are overrepresented in human metastatic melanoma lymph nodes and inhibit the function of infiltrating T cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898054

Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898054

Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898054

Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898054

Regulation of the chemokine receptor CXCR4 by hypoxia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898054

BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898054

Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898054

Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898054

Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3)

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898054

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898054

Regulation of EMAP II by hypoxia

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898054

Proceedings: Tumor angiogenesis factor

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898054

TSC2 regulates VEGF through mTOR-dependent and -independent pathways

2 June 2018

1 reference

TCR engagement increases hypoxia-inducible factor-1 alpha protein synthesis via rapamycin-sensitive pathway under hypoxic conditions in human peripheral T cells

21 January 2018

1 reference

Hypoxic gene activation by lipopolysaccharide in macrophages: implication of hypoxia-inducible factor 1alpha

21 January 2018

1 reference

Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells

21 January 2018

1 reference

Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations

21 January 2018

1 reference

Metabolic reprogramming of cancer-associated fibroblasts by IDH3α downregulation.

21 January 2018

1 reference

Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis.

21 January 2018

1 reference

Adipocyte-derived fibroblasts promote tumor progression and contribute to the desmoplastic reaction in breast cancer.

21 January 2018

1 reference

Bone marrow contribution to tumor-associated myofibroblasts and fibroblasts.

21 January 2018

1 reference

Impeding macrophage entry into hypoxic tumor areas by Sema3A/Nrp1 signaling blockade inhibits angiogenesis and restores antitumor immunity.

21 January 2018

1 reference

Low-dose irradiation programs macrophage differentiation to an iNOS⁺/M1 phenotype that orchestrates effective T cell immunotherapy

21 January 2018

1 reference

Tumor hypoxia does not drive differentiation of tumor-associated macrophages but rather fine-tunes the M2-like macrophage population.

21 January 2018

1 reference

Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis

21 January 2018

1 reference

Tumor-Promoting Effects of Myeloid-Derived Suppressor Cells Are Potentiated by Hypoxia-Induced Expression of miR-210.

21 January 2018

1 reference

Hypoxia controls CD4+CD25+ regulatory T-cell homeostasis via hypoxia-inducible factor-1alpha

21 January 2018

1 reference

Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4898054

Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1α (HIF1A) and result in differential HIF1A-dependent gene expression

27 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/27027486

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Anoxia/reoxygenation-induced neutrophil adherence to cultured endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/27027486

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCB3330

1 reference

Dimensions Publication ID

813906

1048342056

0 references

813906

1 reference

1 reference

1 reference