β-thalassemias: paradigmatic diseases for scientific discoveries and development of innovative therapies (Q28086960)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25828088%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

review article

1 reference

title

β-thalassemias: paradigmatic diseases for scientific discoveries and development of innovative therapies (English)

2 references

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4 March 2020

1

1 reference

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4 March 2020

author name string

S. Rivella

series ordinal

1

1 reference

Crossref

language of work or name

1 reference

1 April 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25828088%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25828088%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

volume

100

2 references

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4 March 2020

page(s)

418-430

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4 March 2020

issue

4

2 references

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The complex transcription regulatory landscape of our genome: control in three dimensions

4 March 2020

cites work

1 reference

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Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice

20 March 2017

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Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia

20 March 2017

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Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin

20 March 2017

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VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5

20 March 2017

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Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)

20 March 2017

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Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia

20 March 2017

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20 March 2017

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Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

20 March 2017

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Locus control regions

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Hepcidin, a urinary antimicrobial peptide synthesized in the liver

20 March 2017

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The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors

20 March 2017

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The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins

20 March 2017

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A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Krüppel family of nuclear proteins

20 March 2017

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The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin

20 March 2017

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Identification of erythroferrone as an erythroid regulator of iron metabolism

20 March 2017

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Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle

20 March 2017

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Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor

20 March 2017

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Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis

20 March 2017

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Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy

20 March 2017

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The serine protease TMPRSS6 is required to sense iron deficiency

20 March 2017

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ZFP36L2 is required for self-renewal of early burst-forming unit erythroid progenitors

20 March 2017

1 reference

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Multiple functions of Ldb1 required for beta-globin activation during erythroid differentiation

20 March 2017

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BMP4 and Madh5 regulate the erythroid response to acute anemia

20 March 2017

1 reference

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The active spatial organization of the beta-globin locus requires the transcription factor EKLF

20 March 2017

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Interactions between LIM domains and the LIM domain-binding protein Ldb1

20 March 2017

1 reference

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Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene

20 March 2017

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Therapeutic hemoglobin levels after gene transfer in β-thalassemia mice and in hematopoietic cells of β-thalassemia and sickle cells disease patients

20 March 2017

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Enhanced erythropoiesis in Hfe-KO mice indicates a role for Hfe in the modulation of erythroid iron homeostasis

20 March 2017

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Combinatorial and distinct roles of α₅ and α₄ integrins in stress erythropoiesis in mice

20 March 2017

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SCL and associated proteins distinguish active from repressive GATA transcription factor complexes

20 March 2017

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Activin type IIA and IIB receptors mediate Gdf11 signaling in axial vertebral patterning

20 March 2017

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Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice

20 March 2017

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A mouse model for beta 0-thalassemia

20 March 2017

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Position-independent, high-level expression of the human beta-globin gene in transgenic mice

20 March 2017

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Genomic discovery of potent chromatin insulators for human gene therapy

7 April 2017

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Combination therapy with a Tmprss6 RNAi-therapeutic and the oral iron chelator deferiprone additively diminishes secondary iron overload in a mouse model of β-thalassemia intermedia.

29 September 2017

1 reference

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Dexamethasone targeted directly to macrophages induces macrophage niches that promote erythroid expansion

29 September 2017

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The second transferrin receptor regulates red blood cell production in mice

29 September 2017

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Myeloproliferative neoplasms: JAK2 signaling pathway as a central target for therapy.

29 September 2017

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Isolation and transcriptome analyses of human erythroid progenitors: BFU-E and CFU-E

29 September 2017

1 reference

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Induction of fetal hemoglobin through enhanced translation efficiency of γ-globin mRNA

29 September 2017

1 reference

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Reactivation of developmentally silenced globin genes by forced chromatin looping.

29 September 2017

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The IRP/IRE system in vivo: insights from mouse models

29 September 2017

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Genetic studies reveal an unexpected negative regulatory role for Jak2 in thrombopoiesis

29 September 2017

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29 September 2017

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KLF1 mutations are relatively more common in a thalassemia endemic region and ameliorate the severity of β-thalassemia

29 September 2017

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Modified activin receptor IIB ligand trap mitigates ineffective erythropoiesis and disease complications in murine β-thalassemia

29 September 2017

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An activin receptor IIA ligand trap corrects ineffective erythropoiesis in β-thalassemia

29 September 2017

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29 September 2017

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29 September 2017

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Manipulating nuclear architecture

29 September 2017

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Safe mobilization of CD34+ cells in adults with β-thalassemia and validation of effective globin gene transfer for clinical investigation.

29 September 2017

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Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia

29 September 2017

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Systemic iron homeostasis

29 September 2017

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Updates of the HbVar database of human hemoglobin variants and thalassemia mutations

29 September 2017

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An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level.

29 September 2017

1 reference

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In vivo mapping of notch pathway activity in normal and stress hematopoiesis

29 September 2017

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Non-transfusion-dependent thalassemias

29 September 2017

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The gut in iron homeostasis: role of HIF-2 under normal and pathological conditions

29 September 2017

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Ldb1-nucleated transcription complexes function as primary mediators of global erythroid gene activation

29 September 2017

1 reference

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Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice

29 September 2017

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CD169⁺ macrophages provide a niche promoting erythropoiesis under homeostasis and stress

29 September 2017

1 reference

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Macrophages support pathological erythropoiesis in polycythemia vera and β-thalassemia

29 September 2017

1 reference

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Isolation and functional characterization of human erythroblasts at distinct stages: implications for understanding of normal and disordered erythropoiesis in vivo

29 September 2017

1 reference

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The IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption

29 September 2017

1 reference

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Deletion of iron regulatory protein 1 causes polycythemia and pulmonary hypertension in mice through translational derepression of HIF2α.

29 September 2017

1 reference

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Gene therapy for hemoglobinopathies: progress and challenges

29 September 2017

1 reference

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Clinical experience with fetal hemoglobin induction therapy in patients with β-thalassemia.

29 September 2017

1 reference

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Regulation of erythropoiesis by hypoxia-inducible factors

29 September 2017

1 reference

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Advances in stem cell transplantation and gene therapy in the β-hemoglobinopathies.

29 September 2017

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An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(-/-) mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia

29 September 2017

1 reference

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Hypercoagulability in β-thalassemia: a status quo.

29 September 2017

1 reference

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Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis

29 September 2017

1 reference

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Stat5 signaling specifies basal versus stress erythropoietic responses through distinct binary and graded dynamic modalities.

29 September 2017

1 reference

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EPO-mediated expansion of late-stage erythroid progenitors in the bone marrow initiates recovery from sublethal radiation stress

29 September 2017

1 reference

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Cerebral infarction in β-thalassemia intermedia: breaking the silence.

29 September 2017

1 reference

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The emerging role of fetal hemoglobin induction in non-transfusion-dependent thalassemia

29 September 2017

1 reference

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Iron overload in non-transfusion-dependent thalassemia: a clinical perspective

29 September 2017

1 reference

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Chromatin loop formation in the β-globin locus and its role in globin gene transcription

29 September 2017

1 reference

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The expression of the glucocorticoid receptor in human erythroblasts is uniquely regulated by KIT ligand: implications for stress erythropoiesis.

29 September 2017

1 reference

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Deletion of TMPRSS6 attenuates the phenotype in a mouse model of β-thalassemia.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Targeted therapeutic strategies for fetal hemoglobin induction

29 September 2017

1 reference

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Contrasting dynamic responses in vivo of the Bcl-xL and Bim erythropoietic survival pathways

29 September 2017

1 reference

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Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing

29 September 2017

1 reference

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SWAP-70 regulates erythropoiesis by controlling α4 integrin

29 September 2017

1 reference

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Non-transferrin bound iron: a key role in iron overload and iron toxicity

29 September 2017

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Identification and analysis of mouse erythroid progenitors using the CD71/TER119 flow-cytometric assay.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Activin receptor signaling: a potential therapeutic target for osteoporosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

β-thalassemia: a model for elucidating the dynamic regulation of ineffective erythropoiesis and iron metabolism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Negative autoregulation by Fas stabilizes adult erythropoiesis and accelerates its stress response

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Pathophysiology of beta thalassaemia.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Hypoxia-inducible factor-2α mediates the adaptive increase of intestinal ferroportin during iron deficiency in mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Stress erythropoiesis: new signals and new stress progenitor cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Compound heterozygosity for KLF1 mutations associated with remarkable increase of fetal hemoglobin and red cell protoporphyrin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

The population genetics and dynamics of the thalassemias

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Murine erythroid short-term radioprotection requires a BMP4-dependent, self-renewing population of stress erythroid progenitors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Matriptase-2- and proprotein convertase-cleaved forms of hemojuvelin have different roles in the down-regulation of hepcidin expression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Sotatercept, a soluble activin receptor type 2A IgG-Fc fusion protein for the treatment of anemia and bone loss

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Essential role for focal adhesion kinase in regulating stress hematopoiesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

The erythroid niche: molecular processes occurring within erythroblastic islands

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

beta-Thalassemia: HiJAKing Ineffective Erythropoiesis and Iron Overload

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Advances in the understanding of haemoglobin switching

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

The genome-wide dynamics of the binding of Ldb1 complexes during erythroid differentiation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Resolving the distinct stages in erythroid differentiation based on dynamic changes in membrane protein expression during erythropoiesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Interaction between the glucocorticoid and erythropoietin receptors in human erythroid cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Discovering the genetics underlying foetal haemoglobin production in adults.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Maintenance of the BMP4-dependent stress erythropoiesis pathway in the murine spleen requires hedgehog signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Erythroblastic islands: niches for erythropoiesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in beta-thalassemia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Inhibition of the TGF-beta receptor I kinase promotes hematopoiesis in MDS.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Gene regulation in the third dimension

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Negative autoregulation by FAS mediates robust fetal erythropoiesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Alpha4beta1 integrin and erythropoietin mediate temporally distinct steps in erythropoiesis: integrins in red cell development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Liver iron concentrations and urinary hepcidin in beta-thalassemia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

BMP4, SCF, and hypoxia cooperatively regulate the expansion of murine stress erythroid progenitors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Erythroblastic islands: specialized microenvironmental niches for erythropoiesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Proximity among distant regulatory elements at the beta-globin locus requires GATA-1 and FOG-1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Identification of a TAL1 Target Gene Reveals a Positive Role for the LIM Domain-Binding Protein Ldb1 in Erythroid Gene Expression and Differentiation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Splicing and 3' end formation in the definition of nonsense-mediated decay-competent human beta-globin mRNPs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

The importance of non-transferrin bound iron in disorders of iron metabolism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Mechanisms of developmental control of transcription in the murine alpha- and beta-globin loci

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Mouse model of human beta zero thalassemia: targeted deletion of the mouse beta maj- and beta min-globin genes in embryonic stem cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Processing of human beta-globin mRNA precursor to mRNA is defective in three patients with beta+-thalassemia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Beta Thalassemia and Translation of Globin Messenger RNA

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Induction of colonies of hemoglobin-synthesizing cells by erythropoietin in vitro

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

A distant gene deletion affects beta-globin gene function in an atypical gamma delta beta-thalassemia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Gamma delta beta-thalassemia due to a de novo mutation deleting the 5' beta-globin gene activation-region hypersensitive sites

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Oxidative denaturation of red blood cells in thalassemia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Human beta-globin locus control region: analysis of the 5' DNase I hypersensitive site HS 2 in transgenic mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Human gamma- to beta-globin gene switching using a mini construct in transgenic mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Chromosomal localization of human β globin gene on human chromosome 11 in somatic cell hybrids

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Amplification and characterization of a β-globin gene synthesized in vitro

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

An ingredient for the elixir of youth

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Transforming growth factor-β superfamily ligand trap ACE-536 corrects anemia by promoting late-stage erythropoiesis

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

A combined approach for β-thalassemia based on gene therapy-mediated adult hemoglobin (HbA) production and fetal hemoglobin (HbF) induction

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Stem cell factor modulates avidity of alpha 4 beta 1 and alpha 5 beta 1 integrins expressed on hematopoietic cell lines.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Hemoglobin and the origins of the concept of allosterism.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

A deletion of the human beta-globin locus activation region causes a major alteration in chromatin structure and replication across the entire beta-globin locus.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Human gamma- to beta-globin gene switching in transgenic mice.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Erythroid progenitors in mouse bone marrow detected by macroscopic colony formation in culture

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Non-specific serum iron in thalassaemia: an abnormal serum iron fraction of potential toxicity

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Combination of Tmprss6- ASO and the iron chelator deferiprone improves erythropoiesis and reduces iron overload in a mouse model of beta-thalassemia intermedia

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Iron and hepcidin: a story of recycling and balance.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Combining gene therapy and fetal hemoglobin induction for treatment of β-thalassemia

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2α mRNA translation.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Polymeric IgA1 controls erythroblast proliferation and accelerates erythropoiesis recovery in anemia

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

LIM Domain Binding Proteins 1 and 2 Have Different Oligomeric States

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Transferrin therapy ameliorates disease in beta-thalassemic mice.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Hereditary persistence of fetal hemoglobin: a study of 79 affected persons in 15 Negro families in Baltimore

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

A novel murine model of Cooley anemia and its rescue by lentiviral-mediated human beta-globin gene transfer

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Cross-talk between alpha(4)beta(1)/alpha(5)beta(1) and c-Kit results in opposing effect on growth and survival of hematopoietic cells via the activation of focal adhesion kinase, mitogen-activated protein kinase, and Akt signaling pathways

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Each hypersensitive site of the human beta-globin locus control region confers a different developmental pattern of expression on the globin genes.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

Transcription complex stability and chromatin dynamics in vivo.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380714

γ-β-Thalassaemia studies showing that deletion of the γ- and δ-genes influences β-globin gene expression in man

27 November 2018

1 reference

12 December 2020

A mouse model for β-thalassemia

1 reference

12 December 2020

Separation of the erythropoietin-responsive progenitors BFU-E and CFU-E in mouse bone marrow by unit gravity sedimentation

1 reference

12 December 2020

mRNA expression of iron regulatory genes in β-thalassemia intermedia and β-thalassemia major mouse models

1 reference

12 December 2020

Isolation, characterization, and immunoprecipitation studies of immune complexes from membranes of beta-thalassemic erythrocytes

1 reference

12 December 2020

β-Globin gene inactivation by DNA translocation in γβ-thalassaemi

1 reference

12 December 2020

Decreased hepcidin mRNA expression in thalassemic mice

1 reference

12 December 2020

10.3324/HAEMATOL.2014.114827

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25828088%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25828088%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

2 references