The molecular biology of cancer (Q28199928)

Molecular Aspects of Medicine

Europe PubMed Central

title

The molecular biology of cancer (English)

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J S Bertram

1

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language of work or name

English

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publication date

December 2000

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published in

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volume

21

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issue

6

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page(s)

167-223

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cites work

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c-erbB-2 is of independent prognostic relevance in gastric cancer and is associated with the expression of tumor-associated protease systems

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Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays

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Charles S. Mott prize. The detection of environmental mutagens and potential carcinogens

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Tumor suppressor genes studied by cell hybridization and chromosome transfer.

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Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

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Apoptosis control by death and decoy receptors

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Telomerase is active in normal gastrointestinal mucosa and not up-regulated in precancerous lesions

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Downregulation of proapoptotic proteins Bax and Bcl-X(S) in p53 overexpressing hepatocellular carcinomas

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The c-MYC allele that is translocated into the IgH locus undergoes constitutive hypermutation in a Burkitt's lymphoma line

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Platelet-derived growth factor expression and stimulation in human meningiomas

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Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance.

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Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene.

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Monitoring chronic myeloid leukaemia therapy by real-time quantitative PCR in blood is a reliable alternative to bone marrow cytogenetics

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7 January 2021

Retinoblastoma protein recruits histone deacetylase to repress transcription

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7 January 2021

Disruption of p53 in human cancer cells alters the responses to therapeutic agents

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Genetic instability and darwinian selection in tumours

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Increasing complexity of Ras signaling.

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The regulation of anoikis: MEKK-1 activation requires cleavage by caspases

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Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin

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Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis

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Antiangiogenic gene therapy for cancer via systemic administration of adenoviral vectors expressing secretable endostatin

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Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase

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7 January 2021

Emerging roles of BRCA1 in transcriptional regulation and DNA repair

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7 January 2021

Genetic alterations in the adenoma--carcinoma sequence

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7 January 2021

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

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Genomic analysis of metastasis reveals an essential role for RhoC

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Combinatorial roles for pRB, p107, and p130 in E2F-mediated cell cycle control

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7 January 2021

Xeroderma pigmentosum: biochemical and genetic characteristics

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Regulation of p53 stability and activity in response to genotoxic stress.

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Mitochondrion as a novel target of anticancer chemotherapy

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7 January 2021

The catalytic subunit of yeast telomerase

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7 January 2021

Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome

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7 January 2021

The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today

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7 January 2021

Mammalian caspases: structure, activation, substrates, and functions during apoptosis

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7 January 2021

WAF1, a potential mediator of p53 tumor suppression

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7 January 2021

Progress in antiangiogenic gene therapy of cancer

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7 January 2021

Second malignancies following cancer therapy

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Overexpression of enzymes that repair endogenous damage to DNA.

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Cdc25 cell-cycle phosphatase as a target of c-myc

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Rapid induction of senescence in human cervical carcinoma cells

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Mitochondria: execution central

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Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia

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7 January 2021

Gap-junctional protein connexin 43 is expressed in dermis and epidermis of human skin: differential modulation by retinoids

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7 January 2021

Inhibition of telomerase limits the growth of human cancer cells.

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Radiation, DNA damage and cancer

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Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1

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Suppression of Malignancy by Cell Fusion

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7 January 2021

The illusion of cell immortality

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Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL.

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7 January 2021

Approaches to cancer prevention based on an understanding of N-nitrosamine carcinogenesis

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7 January 2021

Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover

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7 January 2021

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

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7 January 2021

The proto-oncogene c-myc and apoptosis

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7 January 2021

Genomic instability in Gadd45a-deficient mice

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7 January 2021

Structures of benzo(a)pyrene–nucleic acid adducts formed in human and bovine bronchial explants

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7 January 2021

The GADD45 inhibition of Cdc2 kinase correlates with GADD45-mediated growth suppression

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7 January 2021

Methylation, mutation and cancer

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7 January 2021

Antiangiogenic therapy of a recurrent giant cell tumor of the mandible with interferon alfa-2a.

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7 January 2021

a controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer

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7 January 2021

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

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7 January 2021

Mutation and childhood cancer: a probabilistic model for the incidence of retinoblastoma

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7 January 2021

Treatment of prostate cancer in vitro and in vivo with 2-5A-anti-telomerase RNA component.

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7 January 2021

Mitochondrial control of apoptosis: an overview

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7 January 2021

2-5A antisense directed against telomerase RNA produces apoptosis in ovarian cancer cells

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7 January 2021

Regulation of p53 in response to DNA damage

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7 January 2021

ATM: the protein encoded by the gene mutated in the radiosensitive syndrome ataxia-telangiectasia

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7 January 2021

DNA as a target of alkylating carcinogens

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7 January 2021

Methylation of DNA by 3H-14C-methyl-labelled N-methyl-N-nitrosourea--evidence for transfer of the intact methyl group.

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7 January 2021

In vivo eradication of human BCR/ABL-positive leukemia cells with an ABL kinase inhibitor

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7 January 2021

Non-Ras targets of farnesyltransferase inhibitors: focus on Rho.

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7 January 2021

Positive selection of candidate tumor-suppressor genes by subtractive hybridization

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7 January 2021

First cytogenetic evidence of homozygosity for the retinoblastoma deletion in chromosome 13

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7 January 2021

p53, the cellular gatekeeper for growth and division

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7 January 2021

c-Myc in breast cancer

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7 January 2021

Rate of depurination of native deoxyribonucleic acid

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7 January 2021

Genomics, gene expression and DNA arrays

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7 January 2021

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

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7 January 2021

Possibilities of hazard from nitrosamines in industry

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7 January 2021

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

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7 January 2021

Constitutively methylated CpG dinucleotides as mutation hot spots in the retinoblastoma gene (RB1).

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7 January 2021

Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling

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7 January 2021

Signal transduction. Why Ras needs Rho.

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7 January 2021

Growth inhibition of transformed cells correlates with their junctional communication with normal cells.

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7 January 2021

Metabolic activation and reactivity of chemical carcinogens

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7 January 2021

Role of N-nitroso compounds (NOC) and N-nitrosation in etiology of gastric, esophageal, nasopharyngeal and bladder cancer and contribution to cancer of known exposures to NOC.

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7 January 2021

MDM2--master regulator of the p53 tumor suppressor protein

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7 January 2021

beta-catenin signaling and cancer

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7 January 2021

Caspase-dependent apoptosis induced by telomere cleavage and TRF2 loss

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7 January 2021

Antisense inhibition of vascular endothelial growth factor in human head and neck squamous cell carcinoma

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7 January 2021

Effects of oncogenic ErbB2 on G1 cell cycle regulators in breast tumour cells

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https://api.crossref.org/works/10.1016%2FS0098-2997%2800%2900007-8

7 January 2021

Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene

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7 January 2021

Altered mechanisms of apoptosis in colon cancer: Fas resistance and counterattack in the tumor-immune conflict.

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7 January 2021

Endostatin: an endogenous inhibitor of angiogenesis and tumor growth

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7 January 2021

Angiostatin induces and sustains dormancy of human primary tumors in mice

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7 January 2021

Microdissection, microchip arrays, and molecular analysis of tumor cells (primary and metastases)

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7 January 2021

Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene

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7 January 2021

Presence of a Kirsten Murine Sarcoma Virus ras Oncogene in Cells Transformed by 3-Methylcholanthrene

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7 January 2021

A Restriction Point for Control of Normal Animal Cell Proliferation

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7 January 2021

The molecular and cellular biology of HER2/neu gene amplification/overexpression and the clinical development of herceptin (trastuzumab) therapy for breast cancer.

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7 January 2021

Molecular portraits of human breast tumours

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7 January 2021

Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer

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7 January 2021

A role for Rho in Ras transformation

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7 January 2021

Progressive increase in telomerase activity from benign melanocytic conditions to malignant melanoma

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https://api.crossref.org/works/10.1016%2FS0098-2997%2800%2900007-8

7 January 2021

Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer

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7 January 2021

Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development

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7 January 2021

Molecular epidemiological study of non-small-cell lung cancer from an environmentally polluted region of Poland

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7 January 2021

Matrix detachment induces caspase-dependent cytochrome c release from mitochondria: inhibition by PKB/Akt but not Raf signalling

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7 January 2021

Is small cell lung cancer the perfect target for anti-telomerase treatment?

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7 January 2021

Activation of hematopoietic growth factor signal transduction pathways by the human oncogene BCR/ABL.

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7 January 2021

The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants

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7 January 2021

Structural mechanism for STI-571 inhibition of abelson tyrosine kinase

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7 January 2021

A phase I study of adenovirus-mediated wild-type p53 gene transfer in patients with advanced non-small cell lung cancer

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7 January 2021

https://api.crossref.org/works/10.1016%2FS0098-2997%2800%2900007-8

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7 January 2021

Understanding Ras: 'it ain't over 'til it's over'.

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7 January 2021

Urinary 8-hydroxy-2'-deoxyguanosine as a biological marker of in vivo oxidative DNA damage

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7 January 2021

Adenovirus-mediated transfer of p53 and Fas ligand drastically enhances apoptosis in gliomas

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7 January 2021

The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway

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7 January 2021

p53-mediated DNA repair responses to UV radiation: studies of mouse cells lacking p53, p21, and/or gadd45 genes

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7 January 2021

Genes expressed in human tumor endothelium

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7 January 2021

Herceptin (trastuzamab) in advanced breast cancer

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7 January 2021

Adenovirus-mediated p53 gene transfer in advanced non-small-cell lung cancer

1 reference

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7 January 2021

Nonfunctional mutants of the retinoblastoma protein are characterized by defects in phosphorylation, viral oncoprotein association, and nuclear tethering

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7 January 2021

Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

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7 January 2021

Apoptosis in the pathogenesis and treatment of disease

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7 January 2021

Apoptotic induction in transformed follicular lymphoma cells by Bcl-2 downregulation.

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7 January 2021

Risk of second cancers after treatment for Hodgkin's disease

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7 January 2021

Telomerase activity in ductal carcinoma in situ and invasive breast cancer

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7 January 2021

Xeroderma pigmentosum and the role of UV-induced DNA damage in skin cancer.

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7 January 2021

TRF2 Protects Human Telomeres from End-to-End Fusions

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7 January 2021

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

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7 January 2021

Alternative pathways for the extension of cellular life span: inactivation of p53/pRb and expression of telomerase

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7 January 2021

Sequential development of an angiogenic phenotype by human fibroblasts progressing to tumorigenicity

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7 January 2021

Ras activation in human breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0098-2997%2800%2900007-8

7 January 2021

Developmental defects and tumor predisposition in Rb mutant mice

1 reference

https://api.crossref.org/works/10.1016%2FS0098-2997%2800%2900007-8

7 January 2021

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS0098-2997%2800%2900007-8

7 January 2021

The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest

1 reference

https://api.crossref.org/works/10.1016%2FS0098-2997%2800%2900007-8

7 January 2021

Induction of wild-type p53 activity in human cancer cells by ribozymes that repair mutant p53 transcripts

1 reference

https://api.crossref.org/works/10.1016%2FS0098-2997%2800%2900007-8

7 January 2021

Mechanism of active transcriptional repression by the retinoblastoma protein

1 reference

https://api.crossref.org/works/10.1016%2FS0098-2997%2800%2900007-8

7 January 2021

Platelet-derived growth factor in human glioma

1 reference

https://api.crossref.org/works/10.1016%2FS0098-2997%2800%2900007-8

7 January 2021

Use of transgenic animals in understanding molecular mechanisms of toxicity.

1 reference

https://api.crossref.org/works/10.1016%2FS0098-2997%2800%2900007-8

7 January 2021

Transcriptional control. Sinful repression

1 reference

https://api.crossref.org/works/10.1016%2FS0098-2997%2800%2900007-8

7 January 2021

Suppression of tumor growth with recombinant murine angiostatin

1 reference

https://api.crossref.org/works/10.1016%2FS0098-2997%2800%2900007-8

7 January 2021

Constitutive tyrosine phosphorylation of ErbB-2 via Jak2 by autocrine secretion of prolactin in human breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0098-2997%2800%2900007-8

7 January 2021

Heregulin selectively upregulates vascular endothelial growth factor secretion in cancer cells and stimulates angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0098-2997%2800%2900007-8

7 January 2021

Rho family proteins and Ras transformation: the RHOad less traveled gets congested.

1 reference

https://api.crossref.org/works/10.1016%2FS0098-2997%2800%2900007-8

7 January 2021

Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0098-2997%2800%2900007-8

7 January 2021

10.1016/S0098-2997(00)00007-8

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

5048313

5048313

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference