Enzymatic methods for glyco(diversification/randomization) of drugs and small molecules (Q28247479)

Using simple donors to drive the equilibria of glycosyltransferase-catalyzed reactions

Europe PubMed Central

title

Enzymatic methods for glyco(diversification/randomization) of drugs and small molecules (English)

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author name string

Richard W Gantt

series ordinal

1

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Pauline Peltier-Pain

series ordinal

2

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Jon S Thorson

series ordinal

3

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language of work or name

English

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publication date

October 2011

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published in

Natural Product Reports

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volume

28

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issue

11

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page(s)

1811-53

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cites work

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https://api.crossref.org/works/10.1039%2FC1NP00045D

Kinetic and crystallographic analyses support a sequential-ordered bi bi catalytic mechanism for Escherichia coli glucose-1-phosphate thymidylyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Enhancing the latent nucleotide triphosphate flexibility of the glucose-1-phosphate thymidylyltransferase RmlA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

A practical enzymatic synthesis of UDP sugars and NDP glucoses

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Identification of an extremely thermostable enzyme with dual sugar-1-phosphate nucleotidylyltransferase activities from an acidothermophilic archaeon, Sulfolobus tokodaii strain 7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Phosphomannose isomerase/GDP-mannose pyrophosphorylase from Pyrococcus furiosus: a thermostable biocatalyst for the synthesis of guanidinediphosphate-activated and mannose-containing sugar nucleotides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Expanding pyrimidine diphosphosugar libraries via structure-based nucleotidylyltransferase engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Structure, mechanism and engineering of a nucleotidylyltransferase as a first step toward glycorandomization

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Engineering ribonucleoside triphosphate specificity in a thymidylyltransferase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Expanding the Nucleotide and Sugar 1-Phosphate Promiscuity of Nucleotidyltransferase RmlA via Directed Evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Structure-based enzyme engineering and its impact on in vitro glycorandomization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Flexible enzymatic and chemo-enzymatic approaches to a broad range of uridine-diphospho-sugars.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

The in vitro characterization of polyene glycosyltransferases AmphDI and NysDI

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

UDP-sugar pyrophosphorylase with broad substrate specificity toward various monosaccharide 1-phosphates from pea sprouts

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Leishmania UDP-sugar pyrophosphorylase: the missing link in galactose salvage?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Application of the nucleotidylyltransferase Ep toward the chemoenzymatic synthesis of dTDP-desosamine analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Optimizing glycosyltransferase specificity via "hot spot" saturation mutagenesis presents a catalyst for novobiocin glycorandomization

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Enzymatic synthesis of UDP-GlcNAc/UDP-GalNAc analogs using N-acetylglucosamine 1-phosphate uridyltransferase (GlmU).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Chemoenzymatic synthesis of GDP-azidodeoxymannoses: non-radioactive probes for mannosyltransferase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Enzyme-catalyzed synthesis of isosteric phosphono-analogues of sugar nucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Lipophilic sugar nucleotide synthesis by structure-based design of nucleotidylyltransferase substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

A comparison of sugar indicators enables a universal high-throughput sugar-1-phosphate nucleotidyltransferase assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Surprising bacterial nucleotidyltransferase selectivity in the conversion of carbaglucose-1-phosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Strategies for the chemoenzymatic synthesis of deoxysugar nucleotides: substrate binding versus catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Properties and physiological functions of UDP-sugar pyrophosphorylase in Arabidopsis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Structural basis for the broad substrate range of the UDP-sugar pyrophosphorylase from Leishmania major

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Identification of a novel UDP-sugar pyrophosphorylase with a broad substrate specificity in Trypanosoma cruzi

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

One-step synthesis of labeled sugar nucleotides for protein O-GlcNAc modification studies by chemical function analysis of an archaeal protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Chemoenzymatic synthesis of oligosaccharides and glycoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Synthesis of complex carbohydrates and glycoconjugates: enzyme-based and programmable one-pot strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Combined biosynthetic pathway for de novo production of UDP-galactose: catalysis with multiple enzymes immobilized on agarose beads

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Sugar nucleotide regeneration beads (superbeads): a versatile tool for the practical synthesis of oligosaccharides

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Exploiting the reversibility of natural product glycosyltransferase-catalyzed reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

The in vitro characterization of the iterative avermectin glycosyltransferase AveBI reveals reaction reversibility and sugar nucleotide flexibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

The in vitro characterization of the erythronolide mycarosyltransferase EryBV and its utility in macrolide diversification

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Biochemical and structural insights of the early glycosylation steps in calicheamicin biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Reversible sialylation: synthesis of cytidine 5'-monophospho-N-acetylneuraminic acid from cytidine 5'-monophosphate with alpha2,3-sialyl O-glycan-, glycolipid-, and macromolecule-based donors yields diverse sialylated products.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Single amino acid mutations of Medicago glycosyltransferase UGT85H2 enhance activity and impart reversibility.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Crystal structures of glycosyltransferase UGT78G1 reveal the molecular basis for glycosylation and deglycosylation of (iso)flavonoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Bidirectional N-acetylglucosamine transfer mediated by beta-1,4-N-acetylglucosaminyltransferase III.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Probing the aglycon promiscuity of an engineered glycosyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Recombinant E. coli prototype strains for in vivo glycorandomization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Genetics of Streptomyces fradiae and tylosin biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Production of hybrid glycopeptide antibiotics in vitro and in Streptomyces toyocaensis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Production of the antitumor drug epirubicin (4'-epidoxorubicin) and its precursor by a genetically engineered strain of Streptomyces peucetius

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Large-scale in vivo synthesis of the carbohydrate moieties of gangliosides GM1 and GM2 by metabolically engineered Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Large-scale synthesis of H-antigen oligosaccharides by expressing Helicobacter pylori alpha1,2-fucosyltransferase in metabolically engineered Escherichia coli cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Efficient synthesis of 6'-sialyllactose, 6,6'-disialyllactose, and 6'-KDO-lactose by metabolically engineered E. coli expressing a multifunctional sialyltransferase from the Photobacterium sp. JT-ISH-224.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Bioconversion of 12-, 14-, and 16-membered ring aglycones to glycosylated macrolides in an engineered strain of Streptomyces venezuelae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Engineering the glycosylation of natural products in actinomycetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Reassembled biosynthetic pathway for large-scale carbohydrate synthesis: alpha-Gal epitope producing "superbug".

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Large-scale synthesis of globotriose derivatives through recombinant E. coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Bio-fermentation of modified flavonoids: an example of in vivo diversification of secondary metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Arabidopsis glycosyltransferases as biocatalysts in fermentation for regioselective synthesis of diverse quercetin glucosides

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Glucosylation of flavonols by Escherichia coli expressing glucosyltransferase from rice (Oryza sativa).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Selective detection of sugar phosphates by capillary electrophoresis/mass spectrometry and its application to an engineered E. coli host.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Hallmarks of Cancer: The Next Generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Genetic engineering of antibiotic biosynthesis for the generation of new aminocoumarins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Initial characterization of novobiocic acid noviosyl transferase activity of NovM in biosynthesis of the antibiotic novobiocin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Characterization of the aminocoumarin ligase SimL from the simocyclinone pathway and tandem incubation with NovM,P,N from the novobiocin pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

The biosynthetic gene clusters of aminocoumarin antibiotics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Role of the amino sugar in the DNA binding of disaccharide anthracyclines: crystal structure of the complex MAR70/d(CGATCG).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

A gene cluster from Streptomyces galilaeus involved in glycosylation of aclarubicin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

AknT is an activating protein for the glycosyltransferase AknS in L-aminodeoxysugar transfer to the aglycone of aclacinomycin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Characterization of rhodosaminyl transfer by the AknS/AknT glycosylation complex and its use in reconstituting the biosynthetic pathway of aclacinomycin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Characterization of the glycosyltransferase activity of desVII: analysis of and implications for the biosynthesis of macrolide antibiotics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

AknK is an L-2-deoxyfucosyltransferase in the biosynthesis of the anthracycline aclacinomycin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Inhibition of collagenase by aranciamycin and aranciamycin derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Cloning, purification and characterization of a functional anthracycline glycosyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Insights about the biosynthesis of the avermectin deoxysugar L-oleandrose through heterologous expression of Streptomyces avermitilis deoxysugar genes in Streptomyces lividans

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Identification of a sugar flexible glycosyltransferase from Streptomyces olivaceus, the producer of the antitumor polyketide elloramycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Digitoxosyltetracenomycin C and glucosyltetracenomycin C, two novel elloramycin analogues obtained by exploring the sugar donor substrate specificity of glycosyltransferase ElmGT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Combining sugar biosynthesis genes for the generation of L- and D-amicetose and formation of two novel antitumor tetracenomycins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Glycosylated derivatives of steffimycin: insights into the role of the sugar moieties for the biological activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Inactivation of gilGT, encoding a C-glycosyltransferase, and gilOIII, encoding a P450 enzyme, allows the details of the late biosynthetic pathway to gilvocarcin V to be delineated

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Inactivation of the ketoreductase gilU gene of the gilvocarcin biosynthetic gene cluster yields new analogues with partly improved biological activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

The glycosyltransferase UrdGT2 catalyzes both C- and O-glycosidic sugar transfers

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Understanding and exploiting nature's chemical arsenal: the past, present and future of calicheamicin research.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Antitumor antibiotics: bleomycin, enediynes, and mitomycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

The calicheamicin gene cluster and its iterative type I enediyne PKS

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Glycopeptide and lipoglycopeptide antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Genetic analysis of a high-level vancomycin-resistant isolate of Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Infection with vancomycin-resistant Staphylococcus aureus containing the vanA resistance gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

21 January 2018

Glycopeptide derivatives

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Incorporation of glucose analogs by GtfE and GtfD from the vancomycin biosynthetic pathway to generate variant glycopeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Vancomycin analogues containing monosaccharides exhibit improved antibiotic activity: a combined one-pot enzymatic glycosylation and chemical diversification strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Enzymatic synthesis of vancomycin derivatives using galactosyltransferase and sialyltransferase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Biosynthesis and genetic engineering of lipopeptide antibiotics related to daptomycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Tandem action of glycosyltransferases in the maturation of vancomycin and teicoplanin aglycones: novel glycopeptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Antibiotic optimization via in vitro glycorandomization

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Diversifying vancomycin via chemoenzymatic strategies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

A systematic investigation of the synthetic utility of glycopeptide glycosyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Organization of the teicoplanin gene cluster in Actinoplanes teichomyceticus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Chimeric glycosyltransferases for the generation of hybrid glycopeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Interception of teicoplanin oxidation intermediates yields new antimicrobial scaffolds

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Chemical synthesis of analogs of the glycopeptide contulakin-G, an analgetically active conopeptide from Conus geographus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Follow the leader: the use of leader peptides to guide natural product biosynthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Contulakin-G, an O-glycosylated invertebrate neurotensin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Sublancin is not a lantibiotic but an S-linked glycopeptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Cysteine S-glycosylation, a new post-translational modification found in glycopeptide bacteriocins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Indolocarbazole natural products: occurrence, biosynthesis, and biological activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Deciphering the late steps in the biosynthesis of the anti-tumour indolocarbazole staurosporine: sugar donor substrate flexibility of the StaG glycosyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Deciphering indolocarbazole and enediyne aminodideoxypentose biosynthesis through comparative genomics: insights from the AT2433 biosynthetic locus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

RebG- and RebM-catalyzed indolocarbazole diversification

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Enzymatic approach to unnatural glycosides with diverse aglycon scaffolds using glycosyltransferase VinC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Antibiotics acting on the translational machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Genetic approaches to polyketide antibiotics. 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Translation and protein synthesis: macrolides

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Species-specific antibiotic-ribosome interactions: implications for drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Antibiotics and the ribosome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Anti-inflammatory effects of macrolides--an underappreciated benefit in the treatment of community-acquired respiratory tract infections and chronic inflammatory pulmonary conditions?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Role of glycosylation and deglycosylation in biosynthesis of and resistance to oleandomycin in the producer organism, Streptomyces antibioticus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Two glycosyltransferases and a glycosidase are involved in oleandomycin modification during its biosynthesis by Streptomyces antibioticus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Beta-glucosylation as a part of self-resistance mechanism in methymycin/pikromycin producing strain Streptomyces venezuelae

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Intra-Golgi transport inhibition by megalomicin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Polymorphism and structural maturation of bunyamwera virus in Golgi and post-Golgi compartments

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Linear aglycones are the substrates for glycosyltransferase DesVII in methymycin biosynthesis: analysis and implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Glycosylation of acyclic and cyclic aglycone substrates by macrolide glycosyltransferase DesVII/DesVIII: analysis and implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

TDP-mycaminose biosynthetic pathway revised and conversion of desosamine pathway to mycaminose pathway with one gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Engineered biosynthesis of macrolide derivatives bearing the non-natural deoxysugars 4-epi-D-mycaminose and 3-n-monomethylamino-3-deoxy-D-fucose

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolides

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Engineered biosynthesis of hybrid macrolide polyketides containing D-angolosamine and D-mycaminose moieties

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

High-throughput mass-spectrometry monitoring for multisubstrate enzymes: determining the kinetic parameters and catalytic activities of glycosyltransferases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

The life and times of ivermectin - a success story

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Structural, functional, and genetic analysis of sorangicin inhibition of bacterial RNA polymerase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Polyene macrolide antibiotic biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Polyene macrolide antibiotics and their applications in human therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Interaction of amphotericin B and its selected derivatives with membranes: molecular modeling studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

MFAME, N-methyl-N-D-fructosyl amphotericin B methyl ester, a new amphotericin B derivative of low toxicity: relationship between self-association and effects on red blood cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Biosynthesis of amphotericin derivatives lacking exocyclic carboxyl groups

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Synthesis-enabled functional group deletions reveal key underpinnings of amphotericin B ion channel and antifungal activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Amphotericin biosynthesis in Streptomyces nodosus: deductions from analysis of polyketide synthase and late genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

The biosynthetic gene cluster for the 26-membered ring polyene macrolide pimaricin. A new polyketide synthase organization encoded by two subclusters separated by functionalization genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

A complex multienzyme system encoded by five polyketide synthase genes is involved in the biosynthesis of the 26-membered polyene macrolide pimaricin in Streptomyces natalensis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Organizational and mutational analysis of a complete FR-008/candicidin gene cluster encoding a structurally related polyene complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Analysis of the mycosamine biosynthesis and attachment genes in the nystatin biosynthetic gene cluster of Streptomyces noursei ATCC 11455.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Redesign of polyene macrolide glycosylation: engineered biosynthesis of 19-(O)-perosaminyl-amphoteronolide B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Deciphering biosynthesis of the RNA polymerase inhibitor streptolydigin and generation of glycosylated derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

The impact of enzyme engineering upon natural product glycodiversification

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Structure of a flavonoid glucosyltransferase reveals the basis for plant natural product modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

A pH-sensitive assay for galactosyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Expanding substrate specificity of GT-B fold glycosyltransferase via domain swapping and high-throughput screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Designer enzymes for glycosphingolipid synthesis by directed evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Probing the Breadth of Macrolide Glycosyltransferases: In Vitro Remodeling of a Polyketide Antibiotic Creates Active Bacterial Uptake and Enhances Potency

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Production of ‘hybrid’ antibiotics by genetic engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1NP00045D

Novel Genetically Engineered Tetracenomycins

21 January 2018

1 reference

9 March 2024

https://opencitations.net/index/api/v1/citations/10.1002/ANIE.199511071

The sorangicins, novel and powerful inhibitors of eubacterial RNA polymerase isolated from myxobacteria.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.40.7

Identifiers

DOI

10.1039/C1NP00045D

1 reference

Consolidated OpenCitations Corpus – April 2017

2607987

2607987

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference