Order and disorder in large multi-site docking proteins of the Gab family--implications for signalling complex formation and inhibitor design strategies (Q28248627)

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English	Order and disorder in large multi-site docking proteins of the Gab family--implications for signalling complex formation and inhibitor design strategies	scientific article

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Order and disorder in large multi-site docking proteins of the Gab family--implications for signalling complex formation and inhibitor design strategies (English)

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Philip C Simister

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Stephan M Feller

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publication date

January 2012

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Molecular BioSystems

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8

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1

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33-46

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Function, regulation and pathological roles of the Gab/DOS docking proteins

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Expression and function of the insulin receptor substrate proteins in cancer

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Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins

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CAS proteins in normal and pathological cell growth control

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21 January 2018

Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2

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21 January 2018

Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor

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21 January 2018

Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses

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21 January 2018

Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation

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21 January 2018

Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins

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21 January 2018

The "Gab" in signal transduction.

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21 January 2018

The gift of Gab.

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21 January 2018

Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein

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21 January 2018

Essential role of Gab1 for signaling by the c-Met receptor in vivo

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21 January 2018

Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation

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21 January 2018

Gab3-deficient mice exhibit normal development and hematopoiesis and are immunocompetent

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21 January 2018

Essential role for Gab2 in the allergic response

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21 January 2018

Requirement of Gab2 for mast cell development and KitL/c-Kit signaling

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21 January 2018

The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis

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21 January 2018

Abnormal hematopoiesis in Gab2 mutant mice

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21 January 2018

Concerted functions of Gab1 and Shp2 in liver regeneration and hepatoprotection

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21 January 2018

Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action

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21 January 2018

Grb-2-associated binder 1 (Gab1) regulates postnatal ischemic and VEGF-induced angiogenesis through the protein kinase A-endothelial NOS pathway

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21 January 2018

Docking protein Gab1 is an essential component of postnatal angiogenesis after ischemia via HGF/c-met signaling.

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21 January 2018

Endothelial Grb2-associated binder 1 is crucial for postnatal angiogenesis

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21 January 2018

Distinct requirements for Gab1 in Met and EGF receptor signaling in vivo

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21 January 2018

The Pfam protein families database

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21 January 2018

SMART 6: recent updates and new developments

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21 January 2018

Self-organization and regulation of intrinsically disordered proteins with folded N-termini

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21 January 2018

ELM: the status of the 2010 eukaryotic linear motif resource

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21 January 2018

Short Linear Motifs recognized by SH2, SH3 and Ser/Thr Kinase domains are conserved in disordered protein regions

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21 January 2018

Protein structure prediction servers at University College London

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21 January 2018

Proteins without 3D structure: definition, detection and beyond

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The mysterious unfoldome: structureless, underappreciated, yet vital part of any given proteome

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21 January 2018

Sequence complexity of disordered protein

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21 January 2018

RONN: the bio-basis function neural network technique applied to the detection of natively disordered regions in proteins

1 reference

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21 January 2018

Prediction of disordered regions in proteins based on the meta approach

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PONDR-FIT: a meta-predictor of intrinsically disordered amino acids

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Improved disorder prediction by combination of orthogonal approaches

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The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization

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IUPred: web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy content

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Flavors of protein disorder

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21 January 2018

A new mechanism for the regulation of Gab1 recruitment to the plasma membrane.

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21 January 2018

Close encounters of the third kind: disordered domains and the interactions of proteins.

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The consensus coding sequences of human breast and colorectal cancers

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Binding of the cSH3 domain of Grb2 adaptor to two distinct RXXK motifs within Gab1 docker employs differential mechanisms

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21 January 2018

Prediction of protein binding regions in disordered proteins

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21 January 2018

Intrinsic disorder in scaffold proteins: getting more from less

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21 January 2018

The structure of "unstructured" regions in peptides and proteins: role of the polyproline II helix in protein folding and recognition

1 reference

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A tetrapeptide-based method for polyproline II-type secondary structure prediction

1 reference

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Context-dependent resistance to proteolysis of intrinsically disordered proteins

1 reference

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21 January 2018

The C-terminal SH3 domain of CRKL as a dynamic dimerization module transiently exposing a nuclear export signal

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Role of intrinsic flexibility in signal transduction mediated by the cell cycle regulator, p27 Kip1.

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p27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding

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Tracking the ends: a dynamic protein network controls the fate of microtubule tips

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Conformational changes in CLIP-170 regulate its binding to microtubules and dynactin localization

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Self-recognition by an intrinsically disordered protein

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21 January 2018

Helicobacter pylori CagA--a potential bacterial oncoprotein that functionally mimics the mammalian Gab family of adaptor proteins

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A transgenic Drosophila model demonstrates that the Helicobacter pylori CagA protein functions as a eukaryotic Gab adaptor

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Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion

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Helicobacter exploits integrin for type IV secretion and kinase activation

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Helicobacter pylori type IV secretion apparatus exploits beta1 integrin in a novel RGD-independent manner

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Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo.

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Phosphorylation of Helicobacter pylori CagA by c-Abl leads to cell motility

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Grb2 is a key mediator of helicobacter pylori CagA protein activities

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21 January 2018

Role of the cag-pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis

1 reference

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21 January 2018

DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila.

1 reference

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21 January 2018

SH3 domain-mediated binding of the Drk protein to Dos is an important step in signaling of Drosophila receptor tyrosine kinases

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Helicobacter pylori cytotoxin-associated gene A (CagA) subverts the apoptosis-stimulating protein of p53 (ASPP2) tumor suppressor pathway of the host

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Helicobacter pylori CagA induces a transition from polarized to invasive phenotypes in MDCK cells

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A novel inhibitory domain of Helicobacter pylori protein CagA reduces CagA effects on host cell biology.

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Purpose of recently detected inhibitory domain of the Helicobacter pylori protein CagA.

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Recruitment of the protein tyrosine phosphatase CSW by DOS is an essential step during signaling by the sevenless receptor tyrosine kinase

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Helicobacter pylori CagA inhibits PAR1-MARK family kinases by mimicking host substrates

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The docking protein Gab2 is overexpressed and estrogen regulated in human breast cancer

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A role for the scaffolding adapter GAB2 in breast cancer

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Gab2-mediated signaling promotes melanoma metastasis

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Critical role for Gab2 in transformation by BCR/ABL

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Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations.

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Gab1 is required for cell cycle transition, cell proliferation, and transformation induced by an oncogenic met receptor.

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Novel therapeutic inhibitors of the c-Met signaling pathway in cancer

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Apc deficiency is associated with increased Egfr activity in the intestinal enterocytes and adenomas of C57BL/6J-Min/+ mice

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Distinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cells

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Intrinsic disorder is a common feature of hub proteins from four eukaryotic interactomes

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Identifying hubs in protein interaction networks

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Interactome networks and human disease

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Evidence for dynamically organized modularity in the yeast protein-protein interaction network

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A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells

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Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics

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Elevated PI3K signaling drives multiple breast cancer subtypes

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Characterization of phospholipase C gamma enzymes with gain-of-function mutations

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The road less traveled: modulating signal transduction enzymes by inhibiting their protein-protein interactions

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The rules of disorder or why disorder rules

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The FRS2 family of docking/scaffolding adaptor proteins as therapeutic targets of cancer treatment

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The interplay between structure and function in intrinsically unstructured proteins.

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Function and structure of inherently disordered proteins

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Limitations of induced folding in molecular recognition by intrinsically disordered proteins

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Brefeldin A acts to stabilize an abortive ARF-GDP-Sec7 domain protein complex: involvement of specific residues of the Sec7 domain

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Crystal structure of ARF1*Sec7 complexed with Brefeldin A and its implications for the guanine nucleotide exchange mechanism

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Structure of the human ADP-ribosylation factor 1 complexed with GDP

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Structure of Arf6-GDP suggests a basis for guanine nucleotide exchange factors specificity

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SAXS and X-ray crystallography suggest an unfolding model for the GDP/GTP conformational switch of the small GTPase Arf6

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Improved structural characterizations of the drkN SH3 domain unfolded state suggest a compact ensemble with native-like and non-native structure

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Sequence determinants of compaction in intrinsically disordered proteins

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Drugs targeting protein-protein interactions

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A high-affinity Arg-X-X-Lys SH3 binding motif confers specificity for the interaction between Gads and SLP-76 in T cell signaling

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Designing focused chemical libraries enriched in protein-protein interaction inhibitors using machine-learning methods

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UCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction blocking drug

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Synthetic mimetics of protein secondary structure domains

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Protein-peptide interactions adopt the same structural motifs as monomeric protein folds

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Regulation of cell division by intrinsically unstructured proteins: intrinsic flexibility, modularity, and signaling conduits

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Structural signature of the MYPT1-PP1 interaction.

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Jalview Version 2--a multiple sequence alignment editor and analysis workbench

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21 January 2018

GAB2 is a novel target of 11q amplification in AML/MDS

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