Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response (Q28297156)

SH2 domains recognize specific phosphopeptide sequences

20 April 2017

1 reference

Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms

20 April 2017

1 reference

Regulating mammalian checkpoints through Cdc25 inactivation

20 April 2017

1 reference

Activation of Raf-1 by 14-3-3 proteins

20 April 2017

1 reference

Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation

20 April 2017

1 reference

Interaction of the protein kinase Raf-1 with 14-3-3 proteins

20 April 2017

1 reference

Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine

20 April 2017

1 reference

Structural analysis of 14-3-3 phosphopeptide complexes identifies a dual role for the nuclear export signal of 14-3-3 in ligand binding

20 April 2017

1 reference

Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer

20 April 2017

1 reference

Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways

20 April 2017

1 reference

Crystal structure of the zeta isoform of the 14-3-3 protein

20 April 2017

1 reference

14-3-3 Isotypes facilitate coupling of protein kinase C-ζ to Raf-1: negative regulation by 14-3-3 phosphorylation

20 April 2017

1 reference

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

20 April 2017

1 reference

Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulation

20 April 2017

1 reference

JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage

20 April 2017

1 reference

Lysine acetylation targets protein complexes and co-regulates major cellular functions

20 April 2017

1 reference

Cdc25B and Cdc25C differ markedly in their properties as initiators of mitosis

20 April 2017

1 reference

Plk1 promotes nuclear translocation of human Cdc25C during prophase

20 April 2017

1 reference

Dual phosphorylation controls Cdc25 phosphatases and mitotic entry

20 April 2017

1 reference

Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

20 April 2017

1 reference

Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry

20 April 2017

1 reference

Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery

20 April 2017

1 reference

SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response

20 April 2017

1 reference

A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint

20 April 2017

1 reference

Identification and characterization of a novel cell cycle-regulated internal ribosome entry site

20 April 2017

1 reference

The regulated assembly of a PKCepsilon complex controls the completion of cytokinesis

20 April 2017

1 reference

Aurora B and 14-3-3 coordinately regulate clustering of centralspindlin during cytokinesis

20 April 2017

1 reference

Central spindle assembly and cytokinesis require a kinesin-like protein/RhoGAP complex with microtubule bundling activity

20 April 2017

1 reference

An ECT2-centralspindlin complex regulates the localization and function of RhoA

20 April 2017

1 reference

The WW domain: a signalling site in dystrophin?

20 April 2017

1 reference

Structural analysis of WW domains and design of a WW prototype

20 April 2017

1 reference

A human peptidyl-prolyl isomerase essential for regulation of mitosis

20 April 2017

1 reference

The mitotic peptidyl-prolyl isomerase, Pin1, interacts with Cdc25 and Plx1

20 April 2017

1 reference

The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins

20 April 2017

1 reference

Identification of a novel kinesin-related protein, KRMP1, as a target for mitotic peptidyl-prolyl isomerase Pin1

20 April 2017

1 reference

Function of WW domains as phosphoserine- or phosphothreonine-binding modules

20 April 2017

1 reference

Structural basis for phosphoserine-proline recognition by group IV WW domains

20 April 2017

1 reference

The decision to enter mitosis: feedback and redundancy in the mitotic entry network

20 April 2017

1 reference

Stk10, a new member of the polo-like kinase kinase family highly expressed in hematopoietic tissue

20 April 2017

1 reference

The chromosomal passenger complex activates Polo kinase at centromeres

20 April 2017

1 reference

Pfam: multiple sequence alignments and HMM-profiles of protein domains

20 April 2017

1 reference

Cloning of cDNAs for M-phase phosphoproteins recognized by the MPM2 monoclonal antibody and determination of the phosphorylated epitope

20 April 2017

1 reference

Plk1-dependent and -independent roles of an ODF2 splice variant, hCenexin1, at the centrosome of somatic cells

20 April 2017

1 reference

Self-regulated mechanism of Plk1 localization to kinetochores: lessons from the Plk1-PBIP1 interaction

20 April 2017

1 reference

Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1

20 April 2017

1 reference

Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis

20 April 2017

1 reference

Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody

20 April 2017

1 reference

How do so few control so many?

20 April 2017

1 reference

F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex

20 April 2017

1 reference

Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex

20 April 2017

1 reference

The SCF ubiquitin ligase: insights into a molecular machine

20 April 2017

1 reference

Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase

20 April 2017

1 reference

Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase

20 April 2017

1 reference

Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

20 April 2017

1 reference

The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27

20 April 2017

1 reference

Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1

20 April 2017

1 reference

Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase

20 April 2017

1 reference

Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase

20 April 2017

1 reference

Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex

20 April 2017

1 reference

E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)

20 April 2017

1 reference

Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex

20 April 2017

1 reference

Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines

20 April 2017

1 reference

SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase

20 April 2017

1 reference

Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer

20 April 2017

1 reference

M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP

20 April 2017

1 reference

Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts

20 April 2017

1 reference

Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress

20 April 2017

1 reference

Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage

20 April 2017

1 reference

Cancer susceptibility and the functions of BRCA1 and BRCA2

20 April 2017

1 reference

Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response

20 April 2017

1 reference

Involvement of Brca2 in DNA repair

20 April 2017

1 reference

Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair

20 April 2017

1 reference

Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

20 April 2017

1 reference

Structure of an XRCC1 BRCT domain: a new protein-protein interaction module

20 April 2017

1 reference

The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression

20 April 2017

1 reference

Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure

20 April 2017

1 reference

BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

20 April 2017

1 reference

The BRCT Domain Is a Phospho-Protein Binding Domain

20 April 2017

1 reference

BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function

20 April 2017

1 reference

Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer

20 April 2017

1 reference

Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains

20 April 2017

1 reference

Phospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damage

20 April 2017

1 reference

Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation

20 April 2017

1 reference

Phosphopeptide Binding Specificities of BRCA1 COOH-terminal (BRCT) Domains

20 April 2017

1 reference

MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

20 April 2017

1 reference

WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity

20 April 2017

1 reference

Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1

20 April 2017

1 reference

The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms

20 April 2017

1 reference

The many substrates and functions of ATM

20 April 2017

1 reference

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

20 April 2017

1 reference

The DNA damage response: ten years after

20 April 2017

1 reference

Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2

20 April 2017

1 reference

Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain

20 April 2017

1 reference

Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase

20 April 2017

1 reference

MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals

20 April 2017

1 reference

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

20 April 2017

1 reference

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

20 April 2017

1 reference

Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

20 April 2017

1 reference

RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly

20 April 2017

1 reference

Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response

20 April 2017

1 reference

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

20 April 2017

1 reference

MDC1 is a mediator of the mammalian DNA damage checkpoint

20 April 2017

1 reference

MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

20 April 2017

1 reference

MDC1 is required for the intra-S-phase DNA damage checkpoint

20 April 2017

1 reference

Nbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and Repair

20 April 2017

1 reference

A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage

20 April 2017

1 reference

Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage

20 April 2017

1 reference

Solution structure of the Set2-Rpb1 interacting domain of human Set2 and its interaction with the hyperphosphorylated C-terminal domain of Rpb1

20 April 2017

1 reference

FF domains of CA150 bind transcription and splicing factors through multiple weak interactions

20 April 2017

1 reference

The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain

20 April 2017

1 reference

Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase

20 April 2017

1 reference

The structural basis for 14-3-3:phosphopeptide binding specificity

20 April 2017

1 reference

Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates

20 April 2017

1 reference

Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism

20 April 2017

1 reference

Brca1 controls homology-directed DNA repair

20 April 2017

1 reference

Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage

20 April 2017

1 reference

Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

20 April 2017

1 reference

TopBP1 activates the ATR-ATRIP complex

20 April 2017

1 reference

Binding of Transforming Protein, P47 gag-crk , to a Broad Range of Phosphotyrosine-containing Proteins

20 April 2017

1 reference

SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases

31 March 2020

1 reference

31 March 2020

Protein Phosphorylation

1 reference

Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2.

31 March 2020

1 reference

The CDK subunit CKS2 counteracts CKS1 to control cyclin A/CDK2 activity in maintaining replicative fidelity and neurodevelopment.

31 March 2020

1 reference

How protein kinases co-ordinate mitosis in animal cells.

31 March 2020

1 reference

CDK inhibitors: cell cycle regulators and beyond

31 March 2020

1 reference

Demonstration of the phosphorylation-dependent interaction of tryptophan hydroxylase with the 14-3-3 protein

31 March 2020

1 reference

Brainstem deficiency of the 14-3-3 regulator of serotonin synthesis: a proteomics analysis in the sudden infant death syndrome

31 March 2020

1 reference

The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development

31 March 2020

1 reference

C-terminal recognition by 14-3-3 proteins for surface expression of membrane receptors

31 March 2020

1 reference

Functional specificity in 14-3-3 isoform interactions through dimer formation and phosphorylation. Chromosome location of mammalian isoforms and variants

31 March 2020

1 reference

A structural basis for 14-3-3sigma functional specificity.

31 March 2020

1 reference

Oligomeric structure of 14-3-3 protein: what do we know about monomers?

31 March 2020

1 reference

Structural determinants of 14-3-3 binding specificities and regulation of subcellular localization of 14-3-3-ligand complexes: a comparison of the X-ray crystal structures of all human 14-3-3 isoforms

31 March 2020

1 reference

14-3-3 isotypes facilitate coupling of protein kinase C-zeta to Raf-1: negative regulation by 14-3-3 phosphorylation

31 March 2020

1 reference

14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport

31 March 2020

1 reference

How do 14-3-3 proteins work?-- Gatekeeper phosphorylation and the molecular anvil hypothesis

31 March 2020

1 reference

Evolution of signal multiplexing by 14-3-3-binding 2R-ohnologue protein families in the vertebrates.

31 March 2020

1 reference

NMR spectroscopy of 14-3-3ζ reveals a flexible C-terminal extension: differentiation of the chaperone and phosphoserine-binding activities of 14-3-3ζ.

31 March 2020

1 reference

Post-translationally modified 14-3-3 isoforms and inhibition of protein kinase C

31 March 2020

1 reference

14-3-3 is phosphorylated by casein kinase I on residue 233. Phosphorylation at this site in vivo regulates Raf/14-3-3 interaction

31 March 2020

1 reference

A novel sphingosine-dependent protein kinase (SDK1) specifically phosphorylates certain isoforms of 14-3-3 protein

31 March 2020

1 reference

Proteomic identification of 14-3-3zeta as a mitogen-activated protein kinase-activated protein kinase 2 substrate: role in dimer formation and ligand binding

31 March 2020

1 reference

JNK antagonizes Akt-mediated survival signals by phosphorylating 14-3-3.

31 March 2020

1 reference

JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins

31 March 2020

1 reference

The Giardia duodenalis 14-3-3 protein is post-translationally modified by phosphorylation and polyglycylation of the C-terminal tail

31 March 2020

1 reference

Four-dimensional control of the cell cycle

31 March 2020

1 reference

CDC25 phosphatases in cancer cells: key players? Good targets?

31 March 2020

1 reference

A dual-specificity phosphatase Cdc25B is an unstable protein and triggers p34(cdc2)/cyclin B activation in hamster BHK21 cells arrested with hydroxyurea.

31 March 2020

1 reference

Regulation of Cdc25C by ERK-MAP kinases during the G2/M transition

31 March 2020

1 reference

Elimination of cdc2 phosphorylation sites in the cdc25 phosphatase blocks initiation of M-phase

31 March 2020

1 reference

14-3-3 proteins act as negative regulators of the mitotic inducer Cdc25 in Xenopus egg extracts

31 March 2020

1 reference

Localization of human Cdc25C is regulated both by nuclear export and 14-3-3 protein binding.

31 March 2020

1 reference

Binding of 14-3-3 proteins and nuclear export control the intracellular localization of the mitotic inducer Cdc25.

31 March 2020

1 reference

Regulation of CDC25B phosphatases subcellular localization

31 March 2020

1 reference

Cdc25B activity is regulated by 14-3-3.

31 March 2020

1 reference

Checking on DNA damage in S phase

31 March 2020

1 reference

PP1 control of M phase entry exerted through 14-3-3-regulated Cdc25 dephosphorylation

31 March 2020

1 reference

Mitotic phosphorylation of Cdc25B Ser321 disrupts 14-3-3 binding to the high affinity Ser323 site

31 March 2020

1 reference

Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis

31 March 2020

1 reference

Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase

31 March 2020

1 reference

DNA damage signaling in response to double-strand breaks during mitosis

31 March 2020

1 reference

14-3-3sigma controls mitotic translation to facilitate cytokinesis

31 March 2020

1 reference

CDK11(p58) is required for the maintenance of sister chromatid cohesion

31 March 2020

1 reference

Normalization of nomenclature for peptide motifs as ligands of modular protein domains

31 March 2020

1 reference

WW domain sequence activity relationships identified using ligand recognition propensities of 42 WW domains

31 March 2020

1 reference

Requirement of the prolyl isomerase Pin1 for the replication checkpoint.

31 March 2020

1 reference

The xenopus Suc1/Cks protein promotes the phosphorylation of G(2)/M regulators

31 March 2020

1 reference

p13(SUC1) and the WW domain of PIN1 bind to the same phosphothreonine-proline epitope

31 March 2020

1 reference

Pin1 acts catalytically to promote a conformational change in Cdc25.

31 March 2020

1 reference

Pin1-dependent prolyl isomerization regulates dephosphorylation of Cdc25C and tau proteins

31 March 2020

1 reference

Mechanism for inactivation of the mitotic inhibitory kinase Wee1 at M phase

31 March 2020

1 reference

Pin1 stabilizes Emi1 during G2 phase by preventing its association with SCF(betatrcp).

31 March 2020

1 reference

Polo-like kinases: conservation and divergence in their functions and regulation

31 March 2020

1 reference

Phosphorylation of threonine 210 and the role of serine 137 in the regulation of mammalian polo-like kinase

31 March 2020

1 reference

Cell cycle-regulated phosphorylation of the Xenopus polo-like kinase Plx1.

31 March 2020

1 reference

Plk1 activation by Ste20-like kinase (Slk) phosphorylation and polo-box phosphopeptide binding assayed with the substrate translationally controlled tumor protein (TCTP).

31 March 2020

1 reference

Purification and cloning of a protein kinase that phosphorylates and activates the polo-like kinase Plx1.

31 March 2020

1 reference

Ste20-like kinase (SLK), a regulatory kinase for polo-like kinase (Plk) during the G2/M transition in somatic cells

31 March 2020

1 reference

A feedback loop in the polo-like kinase activation pathway

31 March 2020

1 reference

The mouse Plk gene: structural characterization, chromosomal localization and identification of a processed Plk pseudogene.

31 March 2020

1 reference

Purification and molecular cloning of Plx1, a Cdc25-regulatory kinase from Xenopus egg extracts

31 March 2020

1 reference

Mutation of the polo-box disrupts localization and mitotic functions of the mammalian polo kinase Plk.

31 March 2020

1 reference

The polo-box-dependent induction of ectopic septal structures by a mammalian polo kinase, plk, in Saccharomyces cerevisiae

31 March 2020

1 reference

A spindle checkpoint arrest and a cytokinesis failure by the dominant-negative polo-box domain of Plk1 in U-2 OS cells.

31 March 2020

1 reference

A novel function of Saccharomyces cerevisiae CDC5 in cytokinesis

31 March 2020

1 reference

Structure and function of Polo-like kinases

31 March 2020

1 reference

Proteomic screen defines the Polo-box domain interactome and identifies Rock2 as a Plk1 substrate.

31 March 2020

1 reference

Monoclonal antibodies to mitotic cells

31 March 2020

1 reference

The cyclin-ubiquitin ligase activity of cyclosome/APC is jointly activated by protein kinases Cdk1-cyclin B and Plk.

31 March 2020

1 reference

PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2.

31 March 2020

1 reference

Phosphorylation by Cdk1 induces Plk1-mediated vimentin phosphorylation during mitosis

31 March 2020

1 reference

Functional dynamics of Polo-like kinase 1 at the centrosome.

31 March 2020

1 reference

Different Plk1 functions show distinct dependencies on Polo-Box domain-mediated targeting

31 March 2020

1 reference

Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation

31 March 2020

1 reference

Polo-like kinase-1 is a target of the DNA damage checkpoint

31 March 2020

1 reference

Activation of Cdc2/cyclin B and inhibition of centrosome amplification in cells depleted of Plk1 by siRNA.

31 March 2020

1 reference

Polo-like kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells

31 March 2020

1 reference

Mechanisms and function of substrate recruitment by F-box proteins.

31 March 2020

1 reference

Kip1 meets SKP2: new links in cell-cycle control

31 March 2020

1 reference

Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins

31 March 2020

1 reference

A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.

31 March 2020

1 reference

Cell cycle regulation of a Xenopus Wee1-like kinase

31 March 2020

1 reference

Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways

31 March 2020

1 reference

p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage

31 March 2020

1 reference

Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.

31 March 2020

1 reference

GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers.

31 March 2020

1 reference

Molecular functions of BRCA1 in the DNA damage response

31 March 2020

1 reference

BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a brca1 transgene.

31 March 2020

1 reference

Human pescadillo induces large-scale chromatin unfolding

31 March 2020

1 reference

BRCA1 induces DNA damage recognition factors and enhances nucleotide excision repair.

31 March 2020

1 reference

Fanconi anemia is associated with a defect in the BRCA2 partner PALB2.

31 March 2020

1 reference

BRCA1 and BRCA2: 1994 and beyond

31 March 2020

1 reference

Duplicated region of sequence similarity to the human XRCC1 DNA repair gene in the Schizosaccharomyces pombe rad4/cut5 gene

31 March 2020

1 reference

XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage

31 March 2020

1 reference

Structure and function of mammalian DNA ligases

31 March 2020

1 reference

The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR.

31 March 2020

1 reference

The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1.

31 March 2020

1 reference

The FHA domain: a putative nuclear signalling domain found in protein kinases and transcription factors

31 March 2020

1 reference

14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response

31 March 2020

1 reference

PhosphoThr peptide binding globally rigidifies much of the FHA domain from Arabidopsis receptor kinase-associated protein phosphatase

31 March 2020

1 reference

The use of in vitro peptide-library screens in the analysis of phosphoserine/threonine-binding domain structure and function

31 March 2020

1 reference

Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1.

31 March 2020

1 reference

CHK2 kinase--a busy messenger.

31 March 2020

1 reference

The hCds1 (Chk2)-FHA domain is essential for a chain of phosphorylation events on hCds1 that is induced by ionizing radiation

31 March 2020

1 reference

Chk2 activation and phosphorylation-dependent oligomerization

31 March 2020

1 reference

Structure of the BRCT repeat domain of MDC1 and its specificity for the free COOH-terminal end of the gamma-H2AX histone tail

31 March 2020

1 reference

Homozygous deficiency of ubiquitin-ligase ring-finger protein RNF168 mimics the radiosensitivity syndrome of ataxia-telangiectasia

31 March 2020

1 reference

Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin

31 March 2020

1 reference

Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin

31 March 2020

1 reference

The FHA domain is a modular phosphopeptide recognition motif.

31 March 2020

1 reference

The molecular architecture of the mammalian DNA repair enzyme, polynucleotide kinase

31 March 2020

1 reference

Arrestins as multi-functional signaling adaptors

31 March 2020

1 reference

Inhibition of polo-like kinase 1 by blocking polo-box domain-dependent protein-protein interactions

31 March 2020

1 reference

Caged phosphopeptides reveal a temporal role for 14-3-3 in G1 arrest and S-phase checkpoint function.

31 March 2020

1 reference

14-3-3 Integrates prosurvival signals mediated by the AKT and MAPK pathways in ZNF198-FGFR1-transformed hematopoietic cells

31 March 2020

1 reference

Regulation of the Chk2 protein kinase by oligomerization-mediated cis- and trans-phosphorylation

31 March 2020

1 reference

12 December 2020

Cytoplasmic accumulation of cdc25B phosphatase in mitosis triggers centrosomal microtubule nucleation in HeLa cells

1 reference

12 December 2020

Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation

1 reference

12 December 2020

Protein-protein interactions define specificity in signal transduction

1 reference

12 December 2020

Phosphorylation and activation of human cdc25-C by cdc2--cyclin B and its involvement in the self-amplification of MPF at mitosis

1 reference

12 December 2020

The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation

1 reference

12 December 2020

Protein Phosphorylation and Hormone Action

1 reference

12 December 2020

Homology-directed dna repair, mitomycin-c resistance, and chromosome stability is restored with correction of a Brca1 mutation

1 reference

12 December 2020

BRCA1 and BRCA2 are necessary for the transcription-coupled repair of the oxidative 8-oxoguanine lesion in human cells.

1 reference

12 December 2020

Cell cycle analysis and chromosomal localization of human Plk1, a putative homologue of the mitotic kinases Drosophila polo and Saccharomyces cerevisiae Cdc5.

1 reference

12 December 2020

The breast cancer susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA cross-linking agent cisplatin

1 reference

12 December 2020

The Drosophila orthologue of xPlkk1 is not essential for Polo activation and is necessary for proper contractile ring formation.

1 reference

12 December 2020

Hormonal Control of Glycogen Metabolism

1 reference

12 December 2020