Calcium release channel RyR2 regulates insulin release and glucose homeostasis (Q30654065)

18 October 2017

Calcium release channel RyR2 regulates insulin release and glucose homeostasis (English)

1 reference

18 October 2017

1 reference

2

1 reference

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8 June 2020

Bruno Trimarco

9

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8 June 2020

Wenjun Xie

4

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8 June 2020

Nicola Marziliano

8

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8 June 2020

Alain Lacampagne

11

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8 June 2020

5

Steven Reiken

1 reference

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8 June 2020

author name string

Gaetano Santulli

1

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8 June 2020

Celestino Sardu

3

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8 June 2020

Salvatore Luca D'Ascia

6

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8 June 2020

Michele Cannone

7

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8 June 2020

Andrew R Marks

12

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8 June 2020

Theresa A Guise

10

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8 June 2020

language of work or name

English

0 references

publication date

6 April 2015

1 reference

Journal of Clinical Investigation

18 October 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25844899%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

volume

125

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8 June 2020

page(s)

1968-1978

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8 June 2020

issue

5

1 reference

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Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging

8 June 2020

cites work

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Structure of a mammalian ryanodine receptor

20 June 2018

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Short-coupled polymorphic ventricular tachycardia at rest linked to a novel ryanodine receptor (RyR2) mutation: leaky RyR2 channels under non-stress conditions.

20 June 2018

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Endoplasmic reticulum stress as a novel mechanism in amiodarone-induced destructive thyroiditis

20 June 2018

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Genetically enhancing mitochondrial antioxidant activity improves muscle function in aging

20 June 2018

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Calcium signaling in pancreatic β-cells in health and in Type 2 diabetes.

20 June 2018

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Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism

20 June 2018

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Assessment of β-cell mass and α- and β-cell survival and function by arginine stimulation in human autologous islet recipients

20 June 2018

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A selective microRNA-based strategy inhibits restenosis while preserving endothelial function

20 June 2018

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Gene-lifestyle interaction and type 2 diabetes: the EPIC interact case-cohort study

20 June 2018

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Inhibition of pancreatic β-cell Ca2+/calmodulin-dependent protein kinase II reduces glucose-stimulated calcium influx and insulin secretion, impairing glucose tolerance

20 June 2018

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Calcium co-regulates oxidative metabolism and ATP synthase-dependent respiration in pancreatic beta cells

20 June 2018

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Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

20 June 2018

1 reference

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Calcium efflux from the endoplasmic reticulum leads to β-cell death

20 June 2018

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K(ATP) channels and islet hormone secretion: new insights and controversies

20 June 2018

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Imaging atrial arrhythmic intracellular calcium in intact heart

20 June 2018

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Circulating levels of IL-1B+IL-6 cause ER stress and dysfunction in islets from prediabetic male mice

20 June 2018

1 reference

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Dysfunctional mitochondrial bioenergetics and oxidative stress in Akita(+/Ins2)-derived β-cells

20 June 2018

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Calcium cycling proteins and heart failure: mechanisms and therapeutics

20 June 2018

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CaMK4 Gene Deletion Induces Hypertension

20 June 2018

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Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell-specific abrogation of the glutamate dehydrogenase

20 June 2018

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20 June 2018

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Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes

20 June 2018

1 reference

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A genome-wide association search for type 2 diabetes genes in African Americans

20 June 2018

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Nanospaces between endoplasmic reticulum and mitochondria as control centres of pancreatic β-cell metabolism and survival.

20 June 2018

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Designing calcium release channel inhibitors with enhanced electron donor properties: stabilizing the closed state of ryanodine receptor type 1.

20 June 2018

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Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesis.

20 June 2018

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Mitochondrial signals drive insulin secretion in the pancreatic β-cell

20 June 2018

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Growth hormone receptor regulates β cell hyperplasia and glucose-stimulated insulin secretion in obese mice

20 June 2018

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Disruption of TBP-2 ameliorates insulin sensitivity and secretion without affecting obesity

20 June 2018

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20 June 2018

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Intracardiac injection of AdGRK5-NT reduces left ventricular hypertrophy by inhibiting NF-kappaB-dependent hypertrophic gene expression.

20 June 2018

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Regulation of insulin secretion: role of mitochondrial signalling

20 June 2018

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Calcium signaling in the islets.

20 June 2018

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Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

20 June 2018

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Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy

20 June 2018

1 reference

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Suppression of KATP channel activity protects murine pancreatic beta cells against oxidative stress

20 June 2018

1 reference

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FKBP12.6 disruption impairs glucose-induced insulin secretion

20 June 2018

1 reference

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Remodeling of ryanodine receptor complex causes "leaky" channels: a molecular mechanism for decreased exercise capacity

20 June 2018

1 reference

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Glucose and endoplasmic reticulum calcium channels regulate HIF-1beta via presenilin in pancreatic beta-cells

20 June 2018

1 reference

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R-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretion

20 June 2018

1 reference

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A genome-wide association study identifies novel risk loci for type 2 diabetes

20 June 2018

1 reference

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Fatty acid signaling in the beta-cell and insulin secretion

20 June 2018

1 reference

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Islet beta cell failure in type 2 diabetes

20 June 2018

1 reference

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Glucose-sensing mechanisms in pancreatic beta-cells.

20 June 2018

1 reference

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Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463204

Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak

20 June 2018

1 reference

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Ryanodine receptors in human pancreatic beta cells: localization and effects on insulin secretion.

20 June 2018

1 reference

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Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction.

20 June 2018

1 reference

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Suppression of beta cell energy metabolism and insulin release by PGC-1alpha

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463204

Increased islet apoptosis in Pdx1+/- mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463204

Beta-cell mitochondria and insulin secretion: messenger role of nucleotides and metabolites

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463204

Requirement for the L-type Ca(2+) channel alpha(1D) subunit in postnatal pancreatic beta cell generation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463204

Diet, lifestyle, and the risk of type 2 diabetes mellitus in women

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463204

Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463204

Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463204

Defective pancreatic beta-cell glycolytic signaling in hepatocyte nuclear factor-1alpha-deficient mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463204

Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463204

Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463204

Type 2 diabetes-related genetic risk scores associated with variations in fasting plasma glucose and development of impaired glucose homeostasis in the prospective DESIR study

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463204

Impact of diabetes mellitus on the clinical response to cardiac resynchronization therapy in elderly people

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463204

Disruption and stabilization of β-cell actin microfilaments differently influence insulin secretion triggered by intracellular Ca2+ mobilization or store-operated Ca2+ entry.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463204

Mutations at the same residue (R50) of Kir6.2 (KCNJ11) that cause neonatal diabetes produce different functional effects.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463204

In vivo and in vitro glucose-induced biphasic insulin secretion in the mouse: pattern and role of cytoplasmic Ca2+ and amplification signals in beta-cells

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463204

Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463204

Ryanodine receptors of pancreatic beta-cells mediate a distinct context-dependent signal for insulin secretion.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463204

Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463204

Catecholaminergic polymorphic ventricular tachycardia

25 November 2018

1 reference

12 December 2020

Mitochondria-associated endoplasmic reticulum membranes in insulin signaling

1 reference

12 December 2020

β-Blockers in Diabetic Patients With Heart Failure

1 reference

12 December 2020

Coronary Heart Disease Risk Factors and Mortality

1 reference

12 December 2020

Thrombolysis Outcomes in Acute Ischemic Stroke Patients With Prior Stroke and Diabetes Mellitu

1 reference

12 December 2020

Glucose-induced beta cell dysfunction in vivo in rats: link between oxidative stress and endoplasmic reticulum stress

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI79273

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25844899%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25844899%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25844899%20AND%20SRC:MED&resulttype=core&format=json