The nuclear γ-H2AX apoptotic ring: implications for cancers and autoimmune diseases (Q33656349)

28 July 2017

The nuclear γ-H2AX apoptotic ring: implications for cancers and autoimmune diseases (English)

1 reference

28 July 2017

0 references

2

Yves Pommier

1 reference

28 July 2017

Stéphanie Solier

1

1 reference

28 July 2017

22 January 2014

1 reference

Cellular and Molecular Life Sciences

28 July 2017

1 reference

28 July 2017

71

1 reference

28 July 2017

2289-2297

1 reference

28 July 2017

12

1 reference

https://scigraph.springernature.com/pub.10.1007/s00018-013-1555-2

28 July 2017

0 references

cites work

Clustered DNA damage induces pan-nuclear H2AX phosphorylation mediated by ATM and DNA-PK

1 reference

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Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates.

21 June 2018

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Drugging topoisomerases: lessons and challenges

21 June 2018

1 reference

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STING and the innate immune response to nucleic acids in the cytosol

21 June 2018

1 reference

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Lasonolide A, a potent and reversible inducer of chromosome condensation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

Heat shock protein 90α (HSP90α), a substrate and chaperone of DNA-PK necessary for the apoptotic response

21 June 2018

1 reference

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A novel pathogenetic concept-antiviral immunity in lupus nephritis.

21 June 2018

1 reference

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Use of the γ-H2AX assay to monitor DNA damage and repair in translational cancer research

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

Preclinical study of the DNA repair inhibitor Dbait in combination with chemotherapy in colorectal cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

MDC1 cleavage by caspase-3: a novel mechanism for inactivating the DNA damage response during apoptosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

Histone gammaH2AX and poly(ADP-ribose) as clinical pharmacodynamic biomarkers

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

A minority of foci or pan-nuclear apoptotic staining of gammaH2AX in the S phase after UV damage contain DNA double-strand breaks

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

Monitoring drug-induced gammaH2AX as a pharmacodynamic biomarker in individual circulating tumor cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

Hyperactivation of DNA-PK by double-strand break mimicking molecules disorganizes DNA damage response

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

Human caspases: activation, specificity, and regulation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

The apoptotic ring: a novel entity with phosphorylated histones H2AX and H2B and activated DNA damage response kinases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

Phase 0 clinical trial of the poly (ADP-ribose) polymerase inhibitor ABT-888 in patients with advanced malignancies

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

Histone H2AX phosphorylation in response to changes in chromatin structure induced by altered osmolarity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

Death receptor-induced activation of the Chk2- and histone H2AX-associated DNA damage response pathways

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

The promise of cancer therapeutics targeting the TNF-related apoptosis-inducing ligand and TRAIL receptor pathway

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

Discovery of a new RNA-containing nuclear structure in UVC-induced apoptotic cells by integrated laser electron microscopy

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

Topoisomerase I requirement for death receptor-induced apoptotic nuclear fission

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

Recombinant adeno-associated viral vectors are deficient in provoking a DNA damage response

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

Cytometry of ATM activation and histone H2AX phosphorylation to estimate extent of DNA damage induced by exogenous agents

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

H2AX phosphorylation marks gemcitabine-induced stalled replication forks and their collapse upon S-phase checkpoint abrogation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

Induction of ATM activation, histone H2AX phosphorylation and apoptosis by etoposide: relation to cell cycle phase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

MDC1 accelerates nonhomologous end-joining of dysfunctional telomeres

21 June 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

21 June 2018

https://api.crossref.org/works/10.1007%2FS00018-013-1555-2

Topoisomerase I inhibitors: camptothecins and beyond

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

Cell apoptosis: requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

Cleavage of Cdc6 by caspase-3 promotes ATM/ATR kinase-mediated apoptosis of HeLa cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

H2AX phosphorylation within the G1 phase after UV irradiation depends on nucleotide excision repair and not DNA double-strand breaks

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

DNA-PK phosphorylates histone H2AX during apoptotic DNA fragmentation in mammalian cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

Sequential phosphorylation of Ser-10 on histone H3 and ser-139 on histone H2AX and ATM activation during premature chromosome condensation: relationship to cell-cycle phase and apoptosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

A novel dendritic cell subset involved in tumor immunosurveillance

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

A proteomic snapshot of the human heat shock protein 90 interactome

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

TRAIL and its receptors as targets for cancer therapy

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

Apoptosis and genomic instability

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

Cell death: critical control points

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

MDC1 is a mediator of the mammalian DNA damage checkpoint

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

Megabase chromatin domains involved in DNA double-strand breaks in vivo

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

Human ICE/CED-3 protease nomenclature

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

Programmed cell death and Bcl-2 protection in the absence of a nucleus

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

Induction of a Common Pathway of Apoptosis by Staurosporine

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

Role of nucleases in apoptosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

Nuclear changes in apoptosis.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

Worms, life, and death (Nobel lecture).

21 June 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1555-2

Ionizing radiation induces DNA double-strand breaks in bystander primary human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1555-2

Adeno-associated virus replication induces a DNA damage response coordinated by DNA-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1555-2

Topoisomerase I-DNA complexes contribute to arsenic trioxide-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1555-2

γ-H2AX detection in peripheral blood lymphocytes, splenocytes, bone marrow, xenografts, and skin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1555-2

Compressing drug development timelines in oncology using phase '0' trials.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1555-2

Purification and characterization of a Mg2+-dependent endonuclease (AN34) from etoposide-treated human leukemia HL-60 cells undergoing apoptosis.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032592

Structure and dynamics of hnRNP-labelled nuclear bodies induced by stress treatments

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24448903

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

High titers of autoantibodies to topoisomerase I (Scl-70) in sera from scleroderma patients

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24448903

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The direct interaction between 53BP1 and MDC1 is required for the recruitment of 53BP1 to sites of damage

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24448903

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S00018-013-1555-2

1 reference

28 July 2017

1 reference

28 July 2017

1 reference

PubMed ID

24448903