Targeting protein-protein interactions for therapeutic intervention: a challenge for the future. (Q33852396)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21426071%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

review article

1 reference

title

Targeting protein-protein interactions for therapeutic intervention: a challenge for the future (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21426071%20AND%20SRC:MED&resulttype=core&format=json

protein-protein interaction

26 January 2020

main subject

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21426071%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

author name string

David E Thurston

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21426071%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

publication date

1 April 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21426071%20AND%20SRC:MED&resulttype=core&format=json

Future Medicinal Chemistry

26 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21426071%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

volume

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21426071%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

page(s)

65-93

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21426071%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21426071%20AND%20SRC:MED&resulttype=core&format=json

Protein networks in disease

26 January 2020

cites work

1 reference

Protein-protein interactions in human disease

21 January 2018

1 reference

Inhibiting protein-protein interactions as an emerging paradigm for drug discovery.

21 January 2018

1 reference

Drugs targeting protein-protein interactions

21 January 2018

1 reference

The challenge of drugging undruggable targets in cancer: lessons learned from targeting BCL-2 family members

21 January 2018

1 reference

Targeting protein-protein interactions: lessons from p53/MDM2.

21 January 2018

1 reference

Disruption of protein-protein interactions: towards new targets for chemotherapy

21 January 2018

1 reference

Small molecule modulators of transcription

21 January 2018

1 reference

Principles of protein-protein interactions: what are the preferred ways for proteins to interact?

21 January 2018

1 reference

The chemical biology of apoptosis. Exploring protein-protein interactions and the life and death of cells with small molecules

21 January 2018

1 reference

Chemical genetics to chemical genomics: small molecules offer big insights

21 January 2018

1 reference

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

21 January 2018

1 reference

CASTp: computed atlas of surface topography of proteins with structural and topographical mapping of functionally annotated residues

21 January 2018

1 reference

Targeting protein-protein interactions for cancer therapy

21 January 2018

1 reference

Bcl-2 inhibitors: small molecules with a big impact on cancer therapy

21 January 2018

1 reference

Promoting apoptosis as a strategy for cancer drug discovery

21 January 2018

1 reference

The Bcl2 family: regulators of the cellular life-or-death switch

21 January 2018

1 reference

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

21 January 2018

1 reference

Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapy.

21 January 2018

1 reference

BCL-2 family antagonists for cancer therapy

21 January 2018

1 reference

Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL

21 January 2018

1 reference

Apoptosis-based dual molecular targeting by INNO-406, a second-generation Bcr-Abl inhibitor, and ABT-737, an inhibitor of antiapoptotic Bcl-2 proteins, against Bcr-Abl-positive leukemia

21 January 2018

1 reference

BH3 mimetic ABT-737 neutralizes resistance to FLT3 inhibitor treatment mediated by FLT3-independent expression of BCL2 in primary AML blasts.

21 January 2018

1 reference

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

21 January 2018

1 reference

Discovery of an orally bioavailable small molecule inhibitor of prosurvival B-cell lymphoma 2 proteins

21 January 2018

1 reference

Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program

21 January 2018

1 reference

Mutational spectrum of p53 mutations in primary breast and ovarian tumors.

21 January 2018

1 reference

Restoration of p53 function leads to tumour regression in vivo

21 January 2018

1 reference

Modeling the therapeutic efficacy of p53 restoration in tumors

21 January 2018

1 reference

MDM2 and human malignancies: expression, clinical pathology, prognostic markers, and implications for chemotherapy

21 January 2018

1 reference

MDM2 inhibitors for cancer therapy

21 January 2018

1 reference

Small molecular weight protein-protein interaction antagonists: an insurmountable challenge?

21 January 2018

1 reference

Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy

21 January 2018

1 reference

Specificity in signal transduction: from phosphotyrosine-SH2 domain interactions to complex cellular systems

21 January 2018

1 reference

Characterization and prediction of protein-protein interactions within and between complexes

21 January 2018

1 reference

Strategies to search and design stabilizers of protein-protein interactions: a feasibility study

21 January 2018

1 reference

Strategies for targeting protein-protein interactions with synthetic agents.

21 January 2018

1 reference

Computational identification of inhibitors of protein-protein interactions.

21 January 2018

1 reference

Extended disordered proteins: targeting function with less scaffold

21 January 2018

1 reference

21 January 2018

1 reference

Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase

21 January 2018

1 reference

VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

21 January 2018

1 reference

Predicting protein interaction sites: binding hot-spots in protein-protein and protein-ligand interfaces.

21 January 2018

1 reference

Hot regions in protein--protein interactions: the organization and contribution of structurally conserved hot spot residues.

21 January 2018

1 reference

Allostery: absence of a change in shape does not imply that allostery is not at play

21 January 2018

1 reference

Allosteric regulation and catalysis emerge via a common route.

21 January 2018

1 reference

Targeting protein-protein interactions with small molecules: challenges and perspectives for computational binding epitope detection and ligand finding

21 January 2018

1 reference

A hot spot of binding energy in a hormone-receptor interface

21 January 2018

1 reference

Structure-based maximal affinity model predicts small-molecule druggability.

21 January 2018

1 reference

Protein-protein interactions: hot spots and structurally conserved residues often locate in complemented pockets that pre-organized in the unbound states: implications for docking.

21 January 2018

1 reference

Hot spots--a review of the protein-protein interface determinant amino-acid residues

21 January 2018

1 reference

Spatial chemical conservation of hot spot interactions in protein-protein complexes

21 January 2018

1 reference

Automated clustering of probe molecules from solvent mapping of protein surfaces: new algorithms applied to hot-spot mapping and structure-based drug design.

21 January 2018

1 reference

Identification of hot spots within druggable binding regions by computational solvent mapping of proteins.

21 January 2018

1 reference

Wnt and beyond Wnt: multiple mechanisms control the transcriptional property of beta-catenin

21 January 2018

1 reference

Crystal structure of a beta-catenin/Tcf complex

21 January 2018

1 reference

Structure of a human Tcf4-beta-catenin complex

21 January 2018

1 reference

Allosteric inhibitors of Akt1 and Akt2: discovery of [1,2,4]triazolo[3,4-f][1,6]naphthyridines with potent and balanced activity

21 January 2018

1 reference

Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry

21 January 2018

1 reference

Allosteric Inhibition of the Protein-Protein Interaction between the Leukemia-Associated Proteins Runx1 and CBFβ

21 January 2018

1 reference

Allosteric drugs: thinking outside the active-site box.

21 January 2018

1 reference

Core binding factor acute myeloid leukemia

21 January 2018

1 reference

Altered affinity of CBF beta-SMMHC for Runx1 explains its role in leukemogenesis

21 January 2018

1 reference

Solution structure of core binding factor beta and map of the CBF alpha binding site

21 January 2018

1 reference

21 January 2018

Engineered antibodies

1 reference

Peptidomimetics, a synthetic tool of drug discovery

21 January 2018

1 reference

Protein-protein interactions as targets for small molecule drug discovery

21 January 2018

1 reference

Emerging classes of protein-protein interaction inhibitors and new tools for their development

21 January 2018

1 reference

Modulation of protein-protein interactions with small organic molecules

21 January 2018

1 reference

Inhibition of protein-protein association by small molecules: approaches and progress

21 January 2018

1 reference

Design and structure of peptide and peptidomimetic antagonists of protein-protein interaction.

21 January 2018

1 reference

Synthetic non-peptide mimetics of alpha-helices

21 January 2018

1 reference

21 January 2018

1 reference

Synthesis of amino acid-derived cyclic acyl amidines for use in beta-strand peptidomimetics

21 January 2018

1 reference

Design of beta-turn based therapeutic agents

21 January 2018

1 reference

Scaffolds for blocking protein-protein interactions

21 January 2018

1 reference

Terphenyl-Based Bak BH3 alpha-helical proteomimetics as low-molecular-weight antagonists of Bcl-xL.

21 January 2018

1 reference

The design of drugs for HIV and HCV

21 January 2018

1 reference

Inhibiting protein-protein interactions using designed molecules

21 January 2018

1 reference

Small-molecule dimerization inhibitors of wild-type and mutant HIV protease: a focused library approach

21 January 2018

1 reference

Rapid synthesis and in situ screening of potent HIV-1 protease dimerization inhibitors

21 January 2018

1 reference

Switching between allosteric and dimerization inhibition of HIV-1 protease

21 January 2018

1 reference

New constrained "molecular tongs" designed to dissociate HIV-1 protease dimer

21 January 2018

1 reference

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix

21 January 2018

1 reference

Penetratin and related cell-penetrating cationic peptides can translocate across lipid bilayers in the presence of a transbilayer potential

21 January 2018

1 reference

Cell transduction pathways of transportans

21 January 2018

1 reference

The partial retro-inverso modification: a road traveled together

21 January 2018

1 reference

Transcriptional regulation and transformation by Myc proteins

21 January 2018

1 reference

Myc goes global: new tricks for an old oncogene.

21 January 2018

1 reference

The world according to MYC. Conference on MYC and the transcriptional control of proliferation and oncogenesis

21 January 2018

1 reference

The MYC oncogene as a cancer drug target

21 January 2018

1 reference

Natural products as leads to potential drugs: an old process or the new hope for drug discovery?

21 January 2018

1 reference

Natural products as a robust source of new drugs and drug leads: past successes and present day issues

21 January 2018

1 reference

The impact of natural products upon modern drug discovery.

21 January 2018

1 reference

The evolving role of natural products in drug discovery

21 January 2018

1 reference

Drug discovery beyond the 'rule-of-five'.

21 January 2018

1 reference

Therapeutic potential of natural product signal transduction agents

21 January 2018

1 reference

Drug development from marine natural products

21 January 2018

1 reference

Natural-product-like spiroketals and fused bicyclic acetals as potential therapeutic agents for B-cell chronic lymphocytic leukaemia

21 January 2018

1 reference

Chemical variation of natural-product-like scaffolds: design, synthesis, and biological activity of fused bicyclic acetal derivatives

21 January 2018

1 reference

Natural products as an inspiration in the diversity-oriented synthesis of bioactive compound libraries

21 January 2018

1 reference

Exploring new chemical space by stereocontrolled diversity-oriented synthesis

21 January 2018

1 reference

Synthesis of natural-product-like molecules with over eighty distinct scaffolds

21 January 2018

1 reference

Mining and engineering natural-product biosynthetic pathways

21 January 2018

1 reference

Between a rock and a hard place?

21 January 2018

1 reference

Hypoxia, drug therapy and toxicity

21 January 2018

1 reference

Tumor hypoxia and cancer progression.

21 January 2018

1 reference

HIF-1 as a target for drug development

21 January 2018

1 reference

Hypoxia: a key regulator of angiogenesis in cancer

21 January 2018

1 reference

Natural product-based inhibitors of hypoxia-inducible factor-1 (HIF-1).

21 January 2018

1 reference

The magic of the hypoxia-signaling cascade

21 January 2018

1 reference

Inhibiting hypoxia-inducible factor 1 for cancer therapy

21 January 2018

1 reference

Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway

21 January 2018

1 reference

Drug delivery systems: entering the mainstream

21 January 2018

1 reference

Protein-protein interaction inhibitors: small molecules from screening techniques

21 January 2018

1 reference

Discovery of inhibitors of protein-protein interactions from combinatorial libraries

21 January 2018

1 reference

High-affinity mu opioid receptor ligands discovered by the screening of an exhaustively stereodiversified library of 1,5-enediols

21 January 2018

1 reference

Extensively stereodiversified scaffolds for use in diversity-oriented library synthesis

21 January 2018

1 reference

Synthetic strategy toward skeletal diversity via solid-supported, otherwise unstable reactive intermediates

21 January 2018

1 reference

Exploring skeletal diversity via ring contraction of glycal-derived scaffolds.

21 January 2018

1 reference

Fluorescent biosensors of protein function

21 January 2018

1 reference

Single-bead, single-molecule, single-cell fluorescence: technologies for drug screening and target validation

21 January 2018

1 reference

Displacement of protein-bound aptamers with small molecules screened by fluorescence polarization

21 January 2018

1 reference

A convenient, high-throughput assay for measuring the relative cell permeability of synthetic compounds

21 January 2018

1 reference

Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity

21 January 2018

1 reference

A novel platinum compound inhibits constitutive Stat3 signaling and induces cell cycle arrest and apoptosis of malignant cells

21 January 2018

1 reference

Strongylophorines: natural product inhibitors of hypoxia-inducible factor-1 transcriptional pathway

21 January 2018

1 reference

Integration of NMR and high-throughput screening

21 January 2018

1 reference

The application of FAST-NMR for the identification of novel drug discovery targets

21 January 2018

1 reference

SPR-based fragment screening: advantages and applications

21 January 2018

1 reference

Label-free primary screening and affinity ranking of fragment libraries using parallel analysis of protein panels

21 January 2018

1 reference

The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription

21 January 2018

1 reference

Design and properties of a Myc derivative that efficiently homodimerizes

21 January 2018

1 reference

Selective inhibition of c-Myc/Max dimerization and DNA binding by small molecules

21 January 2018

1 reference

Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts

21 January 2018

1 reference

A credit-card library approach for disrupting protein-protein interactions

21 January 2018

1 reference

Selective inhibition of c-Myc/Max dimerization by a pyrazolo[1,5-a]pyrimidine.

21 January 2018

1 reference

A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia

21 January 2018

1 reference

Improved low molecular weight Myc-Max inhibitors

21 January 2018

1 reference

Structural rationale for the coupled binding and unfolding of the c-Myc oncoprotein by small molecules

21 January 2018

1 reference

CBP/p300 TAZ1 domain forms a structured scaffold for ligand binding

21 January 2018

1 reference

Interaction of the TAZ1 domain of the CREB-binding protein with the activation domain of CITED2: regulation by competition between intrinsically unstructured ligands for non-identical binding sites

21 January 2018

1 reference

Three conformational states of the p300 CH1 domain define its functional properties

21 January 2018

1 reference

Computationally designed peptide inhibitors of protein-protein interactions in membranes

21 January 2018

1 reference

Role of Stat3 in suppressing anti-tumor immunity

21 January 2018

1 reference

Targeting Stat3 in cancer therapy

21 January 2018

1 reference

Signal transducers and activators of transcription (STATs): Novel targets of chemopreventive and chemotherapeutic drugs

21 January 2018

1 reference

21 January 2018

1 reference

Three-dimensional structure of the Stat3beta homodimer bound to DNA

21 January 2018

1 reference

Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

21 January 2018

1 reference

A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells

21 January 2018

1 reference

Alternate protein frameworks for molecular recognition

21 January 2018

1 reference

Designing DNA-binding proteins on the surface of filamentous phage

21 January 2018

1 reference

Methodology for optimizing functional miniature proteins based on avian pancreatic polypeptide using phage display

21 January 2018

1 reference

Concerted evolution of structure and function in a miniature protein

21 January 2018

1 reference

Design and Evolution of a Miniature Bcl-2 Binding Protein We thank the HHMI Biopolymer/Keck Foundation Biotechnology Resource Laboratory (Yale University School of Medicine, New Haven, CT) for oligonucleotide and peptide synthesis and amino acid ana

21 January 2018

1 reference

Molecular Recognition of Protein Surfaces: High Affinity Ligands for the CBP KIX Domain

21 January 2018

1 reference

Binding mode and transcriptional activation potential of high affinity ligands for the CBP KIX domain

21 January 2018

1 reference

Miniature protein ligands for EVH1 domains: interplay between affinity, specificity, and cell motility

21 January 2018

1 reference

Encodable activators of SRC family kinases

21 January 2018

1 reference

Increasing the kinase specificity of k252a by protein surface recognition.

21 January 2018

1 reference

Minimally cationic cell-permeable miniature proteins via alpha-helical arginine display

21 January 2018

1 reference

Scorpion toxins as natural scaffolds for protein engineering

21 January 2018

1 reference

Rational engineering of a miniprotein that reproduces the core of the CD4 site interacting with HIV-1 envelope glycoprotein

21 January 2018

1 reference

Rational design of a CD4 mimic that inhibits HIV-1 entry and exposes cryptic neutralization epitopes

21 January 2018

1 reference

Olefin-metathesis catalysts for the preparation of molecules and materials (Nobel Lecture).

21 January 2018

1 reference

A stapled BID BH3 helix directly binds and activates BAX

21 January 2018

1 reference

A cell-penetrating helical peptide as a potential HIV-1 inhibitor

21 January 2018

1 reference

A highly stable short alpha-helix constrained by a main-chain hydrogen-bond surrogate

21 January 2018

1 reference

A hydrogen bond surrogate approach for stabilization of short peptide sequences in alpha-helical conformation

21 January 2018

1 reference

Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP

21 January 2018

1 reference

Stabilization of p53 by CP-31398 inhibits ubiquitination without altering phosphorylation at serine 15 or 20 or MDM2 binding.

21 January 2018

1 reference

X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex

21 January 2018

1 reference

Brefeldin A acts to stabilize an abortive ARF-GDP-Sec7 domain protein complex: involvement of specific residues of the Sec7 domain

21 January 2018

1 reference

Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)).

21 January 2018

1 reference

Design and Applications of Bifunctional Small Molecules: Why Two Heads Are Better Than One.

21 January 2018

1 reference

Progress in modeling of protein structures and interactions

21 January 2018

1 reference

Monitoring ligand modulation of protein-protein interactions by mass spectrometry: estrogen receptor alpha-SRC1.

21 January 2018

1 reference

Binding affinity and kinetic analysis of nuclear receptor/co-regulator interactions using surface plasmon resonance.

21 January 2018

1 reference

Biomolecular interaction analysis in drug discovery using surface plasmon resonance technology

21 January 2018

1 reference

High affinity, paralog-specific recognition of the Mena EVH1 domain by a miniature protein

21 January 2018

1 reference

Chemical variation of natural product-like scaffolds: design and synthesis of spiroketal derivatives

21 January 2018

1 reference

Computational alanine scanning mutagenesis--an improved methodological approach

21 January 2018

1 reference

Exploiting domino enyne metathesis mechanisms for skeletal diversity generation

21 January 2018

1 reference

Skeletal diversity construction via a branching synthetic strategy

21 January 2018

1 reference