Role of the polycytin-primary cilia complex in bone development and mechanosensing (Q34074649)

30 July 2017

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title

Role of the polycytin-primary cilia complex in bone development and mechanosensing (English)

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30 July 2017

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Z S Xiao

1

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30 July 2017

L D Quarles

series ordinal

2

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30 July 2017

language of work or name

English

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publication date

1 March 2010

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Annals of the New York Academy of Sciences

30 July 2017

published in

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30 July 2017

volume

1192

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30 July 2017

page(s)

410-421

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The polycystic kidney disease 1 (Pkd1) gene is required for the responses of osteochondroprogenitor cells to midpalatal suture expansion in mice

30 July 2017

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Growth of cranial synchondroses and sutures requires polycystin-1.

5 July 2018

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Polycystin-1 C-terminal tail associates with beta-catenin and inhibits canonical Wnt signaling

5 July 2018

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Polycystin-1 regulates skeletogenesis through stimulation of the osteoblast-specific transcription factor RUNX2-II.

5 July 2018

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Autosomal dominant polycystic kidney disease is associated with an increased prevalence of radiographic bronchiectasis

5 July 2018

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Polycystic kidney disease and renal injury repair: common pathways, fluid flow, and the function of polycystin-1.

5 July 2018

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Polycystin-2 cation channel function is under the control of microtubular structures in primary cilia of renal epithelial cells.

5 July 2018

1 reference

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Cilia-like structures and polycystin-1 in osteoblasts/osteocytes and associated abnormalities in skeletogenesis and Runx2 expression.

5 July 2018

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Polycystin-1, STAT6, and P100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease

5 July 2018

1 reference

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Molecular pathways mediating mechanical signaling in bone

5 July 2018

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Oral-facial-digital type I protein is required for primary cilia formation and left-right axis specification

5 July 2018

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Selective Runx2-II deficiency leads to low-turnover osteopenia in adult mice

5 July 2018

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WNT and beta-catenin signalling: diseases and therapies

5 July 2018

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Polycystins, calcium signaling, and human diseases.

5 July 2018

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Calcium restriction allows cAMP activation of the B-Raf/ERK pathway, switching cells to a cAMP-dependent growth-stimulated phenotype

5 July 2018

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Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

5 July 2018

1 reference

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Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations.

5 July 2018

1 reference

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The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia

5 July 2018

1 reference

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PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2

5 July 2018

1 reference

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Expression of PKD1 and PKD2 transcripts and proteins in human embryo and during normal kidney development

5 July 2018

1 reference

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Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene

5 July 2018

1 reference

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The Caenorhabditis elegans autosomal dominant polycystic kidney disease gene homologs lov-1 and pkd-2 act in the same pathway

5 July 2018

1 reference

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Reconstructing the skeleton with intermittent parathyroid hormone

5 July 2018

1 reference

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Polycystin 1 is required for the structural integrity of blood vessels

5 July 2018

1 reference

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Genetic evidence for a trans-heterozygous model for cystogenesis in autosomal dominant polycystic kidney disease.

5 July 2018

1 reference

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The polycystic kidney disease 1 gene product modulates Wnt signaling

5 July 2018

1 reference

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Somatic mutation in individual liver cysts supports a two-hit model of cystogenesis in autosomal dominant polycystic kidney disease.

5 July 2018

1 reference

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Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation

5 July 2018

1 reference

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Intraflagellar transport is essential for endochondral bone formation.

5 July 2018

1 reference

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Osteocytes: a proposed multifunctional bone cell.

28 October 2018

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Primary cilium—is it an osteocyte's strain‐sensing flowmeter?

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924156

The molecular basis of focal cyst formation in human autosomal dominant polycystic kidney disease type I.

28 October 2018

1 reference

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Loss of Polycystin-1 in Human Cyst-Lining Epithelia Leads to Ciliary Dysfunction

28 October 2018

1 reference

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Treatment of postmenopausal osteoporosis

28 October 2018

1 reference

12 December 2020

The PKD1 gene product, "polycystin-1," is a tyrosine-phosphorylated protein that colocalizes with alpha2beta1-integrin in focal clusters in adherent renal epithelia

1 reference

12 December 2020

Pathogenic sequence for dissecting aneurysm formation in a hypomorphic polycystic kidney disease 1 mouse model

1 reference

12 December 2020

Rational proteomics of PKD1. I. Modeling the three dimensional structure and ligand specificity of the C_lectin binding domain of Polycystin-1

1 reference

12 December 2020

Bone cell cilia: vestigial or functional organelles?

1 reference

12 December 2020

10.1111/J.1749-6632.2009.05239.X

Identifiers

DOI

1 reference

release_h6kkyfbi4vb4lnedg3gidkp7by

30 July 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/h6kkyfbi4vb4lnedg3gidkp7by

24 November 2022

mapped directly with Wikidata item

PMC publication ID

2924156

1 reference

30 July 2017

1 reference