Closing in on the amyloid cascade: recent insights into the cell biology of Alzheimer's disease (Q34286933)

1 August 2017

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title

Closing in on the amyloid cascade: recent insights into the cell biology of Alzheimer's disease (English)

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1 August 2017

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Huse JT

1

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1 August 2017

Doms RW

series ordinal

2

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1 August 2017

publication date

1 August 2000

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1 August 2017

published in

Molecular Neurobiology

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1 August 2017

volume

22

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1 August 2017

issue

1-3

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1 August 2017

page(s)

81-98

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Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties

1 August 2017

cites work

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12 December 2020

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

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12 December 2020

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

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12 December 2020

Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer's disease gene ALG-3

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12 December 2020

Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene

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12 December 2020

Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix

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12 December 2020

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

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12 December 2020

Generation and regulation of beta-amyloid peptide variants by neurons.

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12 December 2020

Protein topology of presenilin 1

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12 December 2020

Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

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12 December 2020

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

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12 December 2020

Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation

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12 December 2020

Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavage

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12 December 2020

Purification and cloning of amyloid precursor protein beta-secretase from human brain

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12 December 2020

Amyloid beta-protein precursor is associated with extracellular matrix

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12 December 2020

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

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12 December 2020

Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide.

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12 December 2020

Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network

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12 December 2020

beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms.

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12 December 2020

Secretion of β-amyloid precursor protein cleaved at the amino terminus of the β-amyloid peptide

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12 December 2020

Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation

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12 December 2020

Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response

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12 December 2020

Amino-terminal Deletions Enhance Aggregation of β-Amyloid Peptides in Vitro

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12 December 2020

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

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12 December 2020

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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12 December 2020

Endogenous presenilin-1 targets to endocytic rather than biosynthetic compartments

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12 December 2020

Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

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12 December 2020

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

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12 December 2020

The regulation of amyloid beta protein precursor secretion and its modulatory role in cell adhesion

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12 December 2020

Novel β-Secretase Cleavage of β-Amyloid Precursor Protein in the Endoplasmic Reticulum/Intermediate Compartment of NT2N Cells

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12 December 2020

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

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12 December 2020

Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells

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12 December 2020

Accumulation of murine amyloidbeta42 in a gene-dosage-dependent manner in PS1 'knock-in' mice.

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12 December 2020

Cell-type and amyloid precursor protein-type specific inhibition of A beta release by bafilomycin A1, a selective inhibitor of vacuolar ATPases

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12 December 2020

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

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12 December 2020

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

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12 December 2020

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

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12 December 2020

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors

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12 December 2020

Increased apoptosis arising from increased expression of the Alzheimer's disease-associated presenilin-2 mutation (N141I).

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12 December 2020

Evidence for a six-transmembrane domain structure of presenilin 1.

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12 December 2020

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

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12 December 2020

A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth

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12 December 2020

The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity

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12 December 2020

Translating cell biology into therapeutic advances in Alzheimer's disease

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12 December 2020

Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.

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12 December 2020

Presenilin 1 suppresses the function of c-Jun homodimers via interaction with QM/Jif-1

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12 December 2020

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein

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12 December 2020

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12 December 2020

Presenilin 1 facilitates the constitutive turnover of beta-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway

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12 December 2020

beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

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12 December 2020

The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II.

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12 December 2020

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

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12 December 2020

The seven-transmembrane spanning topography of the Alzheimer disease-related presenilin proteins in the plasma membranes of cultured cells

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12 December 2020

Notch1 is required for the coordinate segmentation of somites

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12 December 2020

Maturation and pro-peptide cleavage of beta-secretase

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12 December 2020

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

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12 December 2020

Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels

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12 December 2020

The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region

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12 December 2020

Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

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12 December 2020

Endoproteolytic Processing and Stabilization of Wild-type and Mutant Presenilin

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12 December 2020

Amyloid plaque core protein in Alzheimer disease and Down syndrome

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12 December 2020

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

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12 December 2020

Nuclear access and action of notch in vivo

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12 December 2020

Alzheimer's Aβ(1–42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

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12 December 2020

An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos.

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12 December 2020

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

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12 December 2020

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

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12 December 2020

Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins

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12 December 2020

Posttranslational modification and plasma membrane localization of the Drosophila melanogaster presenilin.

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12 December 2020

Expression of the Alzheimer amyloid precursor gene transcripts in the human brain.

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12 December 2020

Cleavage of amyloid beta peptide during constitutive processing of its precursor

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12 December 2020

The protease inhibitory properties of the Alzheimer's beta-amyloid precursor protein.

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12 December 2020

Secreted form of amyloid beta protein precursor is involved in the growth regulation of fibroblasts.

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12 December 2020

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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12 December 2020

A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease

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12 December 2020

Tripartite management of unfolded proteins in the endoplasmic reticulum

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12 December 2020

Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF.

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12 December 2020

Solution Structures of β Peptide and Its Constituent Fragments: Relation to Amyloid Deposition

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12 December 2020

Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase

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12 December 2020

Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease.

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12 December 2020

Presenilin 1 mutations linked to familial Alzheimer's disease increase the intracellular levels of amyloid beta-protein 1-42 and its N-terminally truncated variant(s) which are generated at distinct sites.

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12 December 2020

Interaction of presenilins with the filamin family of actin-binding proteins

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12 December 2020

The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth

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12 December 2020

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

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12 December 2020

Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin 1 and presenilin 2 complexes

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12 December 2020

Skeletal and CNS defects in Presenilin-1-deficient mice

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12 December 2020

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

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12 December 2020

A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase

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12 December 2020

Presenilin 1 interaction in the brain with a novel member of the Armadillo family

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12 December 2020

Alzheimer Presenilins in the Nuclear Membrane, Interphase Kinetochores, and Centrosomes Suggest a Role in Chromosome Segregation

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12 December 2020

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

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12 December 2020

Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus

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12 December 2020

Down patients: extracellular preamyloid deposits precede neuritic degeneration and senile plaques.

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12 December 2020

Cell-surface beta-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner

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12 December 2020

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

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12 December 2020

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

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12 December 2020

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

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12 December 2020

Modeling of substrate specificity of the Alzheimer's disease amyloid precursor protein beta-secretase.

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12 December 2020

Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation

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12 December 2020

Generation of amyloid β protein from its precursor is sequence specific

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12 December 2020

The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome

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12 December 2020

Detection of a novel intraneuronal pool of insoluble amyloid beta protein that accumulates with time in culture

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12 December 2020

Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage

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12 December 2020

Effects of PS1 deficiency on membrane protein trafficking in neurons

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12 December 2020

Amyloid of neurofibrillary tangles of Guamanian parkinsonism-dementia and Alzheimer disease share identical amino acid sequence

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12 December 2020

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

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12 December 2020

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

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12 December 2020

Genetic risk factors in Alzheimer's disease

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12 December 2020

Presenilin is required for activity and nuclear access of Notch in Drosophila

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12 December 2020

The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

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12 December 2020

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

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12 December 2020

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

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12 December 2020

Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau

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12 December 2020

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

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12 December 2020

Expression analysis of BACE2 in brain and peripheral tissues

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12 December 2020

Protease nexin-II, a potent antichymotrypsin, shows identity to amyloid beta-protein precursor

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12 December 2020

Amyloid beta-peptide is produced by cultured cells during normal metabolism

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12 December 2020

From differentiation to proliferation: the secretory amyloid precursor protein as a local mediator of growth in thyroid epithelial cells

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12 December 2020

Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites

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12 December 2020

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

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12 December 2020

Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment

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12 December 2020

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

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12 December 2020

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

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12 December 2020

A myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 protein

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12 December 2020

Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease

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12 December 2020

An antibody to beta amyloid and the amyloid precursor protein inhibits cell-substratum adhesion in many mammalian cell types

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12 December 2020

The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation

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12 December 2020

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

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12 December 2020

BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

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12 December 2020

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

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12 December 2020

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

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12 December 2020

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

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12 December 2020

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

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12 December 2020

Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts

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12 December 2020

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

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12 December 2020

Membrane topology of the C. elegans SEL-12 presenilin

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12 December 2020

Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells

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12 December 2020

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

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12 December 2020

Amyloid, the presenilins and Alzheimer's disease

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12 December 2020

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

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12 December 2020

Notch1 is essential for postimplantation development in mice.

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12 December 2020

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

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12 December 2020

Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch

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12 December 2020

Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins

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12 December 2020

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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12 December 2020

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

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12 December 2020

Mice lacking both presenilin genes exhibit early embryonic patterning defects

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12 December 2020

Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression

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12 December 2020

A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response

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12 December 2020

The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology

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12 December 2020

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

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12 December 2020

Beta amyloid precursor protein mediates neuronal cell-cell and cell-surface adhesion

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12 December 2020

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

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12 December 2020

A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase

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12 December 2020

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

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12 December 2020

Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins

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12 December 2020

Identifiers

DOI

10.1385/MN:22:1-3:081

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Dimensions Publication ID

1 August 2017

1044519191

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