The RING finger protein RNF8 ubiquitinates Nbs1 to promote DNA double-strand break repair by homologous recombination (Q34309225)

1 August 2017

The RING finger protein RNF8 ubiquitinates Nbs1 to promote DNA double-strand break repair by homologous recombination (English)

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1 August 2017

protein ubiquitination

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Chi-Sheng Lu

1

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1 August 2017

Lan N Truong

2

1 reference

1 August 2017

Aaron Aslanian

3

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1 August 2017

Linda Z Shi

4

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1 August 2017

Yongjiang Li

5

1 reference

1 August 2017

Patty Yi-Hwa Hwang

6

1 reference

1 August 2017

Kwi Hye Koh

7

1 reference

1 August 2017

Tony Hunter

8

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1 August 2017

John R Yates

9

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1 August 2017

Michael W Berns

10

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1 August 2017

Xiaohua Wu

11

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1 August 2017

language of work or name

English

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publication date

31 October 2012

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Journal of Biological Chemistry

1 August 2017

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1 August 2017

287

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1 August 2017

52

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1 August 2017

43984-43994

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describes a project that uses

1 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3527981/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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CtIP protein dimerization is critical for its recruitment to chromosomal DNA double-stranded breaks

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Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1.

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Double-strand break end resection and repair pathway choice

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HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes

6 July 2018

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Role of mammalian Mre11 in classical and alternative nonhomologous end joining

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RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

6 July 2018

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The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

6 July 2018

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PCNA is ubiquitinated by RNF8

6 July 2018

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Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation

6 July 2018

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6 July 2018

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MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks

6 July 2018

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6 July 2018

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Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage

6 July 2018

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Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin

6 July 2018

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Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin

6 July 2018

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Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair.

6 July 2018

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Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage

6 July 2018

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Activation and regulation of ATM kinase activity in response to DNA double-strand breaks

6 July 2018

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Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

6 July 2018

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RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly

6 July 2018

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RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

6 July 2018

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The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response

6 July 2018

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The Mre11 complex mediates the S-phase checkpoint through an interaction with replication protein A.

6 July 2018

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The Mre11-Rad50-Nbs1 complex acts both upstream and downstream of ataxia telangiectasia mutated and Rad3-related protein (ATR) to regulate the S-phase checkpoint following UV treatment.

6 July 2018

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Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response

6 July 2018

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RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites

6 July 2018

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Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response

6 July 2018

1 reference

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Exploration of new chromophore structures leads to the identification of improved blue fluorescent proteins.

6 July 2018

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Structural complexity in ubiquitin recognition.

6 July 2018

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MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

6 July 2018

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ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

6 July 2018

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6 July 2018

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Ubiquitin-binding domains

6 July 2018

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MS1, MS2, and SQT-three unified, compact, and easily parsed file formats for the storage of shotgun proteomic spectra and identifications.

6 July 2018

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Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527981

SV40 T antigen interacts with Nbs1 to disrupt DNA replication control.

6 July 2018

1 reference

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Mass spectrometric and mutational analyses reveal Lys-6-linked polyubiquitin chains catalyzed by BRCA1-BARD1 ubiquitin ligase

6 July 2018

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Requirement of the MRN complex for ATM activation by DNA damage

6 July 2018

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The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin

6 July 2018

1 reference

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Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

6 July 2018

1 reference

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Evaluation of multidimensional chromatography coupled with tandem mass spectrometry (LC/LC-MS/MS) for large-scale protein analysis: the yeast proteome

6 July 2018

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DTASelect and Contrast: tools for assembling and comparing protein identifications from shotgun proteomics

6 July 2018

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The Mre11 complex: at the crossroads of dna repair and checkpoint signalling

6 July 2018

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Structure of a BRCA1-BARD1 heterodimeric RING-RING complex

6 July 2018

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N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527981

The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527981

ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527981

Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527981

The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527981

The RING finger protein RNF8 recruits UBC13 for lysine 63-based self polyubiquitylation

6 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M112.421545

A backup DNA repair pathway moves to the forefront

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23115235

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M112.421545

1 reference

1 August 2017

1 reference

1 August 2017

1 reference