Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease (Q34366768)

1 August 2017

title

Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease (English)

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1 August 2017

Frank M Longo

1

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1 August 2017

Stephen M Massa

series ordinal

2

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1 August 2017

publication date

1 July 2013

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Nature Reviews Drug Discovery

1 August 2017

published in

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1 August 2017

volume

12

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1 August 2017

issue

7

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1 August 2017

page(s)

507-525

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Neurotrophins and their receptors: a convergence point for many signalling pathways

1 August 2017

cites work

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Neurotrophin-regulated signalling pathways

21 January 2018

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Clinical relevance of the neurotrophins and their receptors

21 January 2018

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Neurotrophin signalling in health and disease

21 January 2018

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Permeability at the blood-brain and blood-nerve barriers of the neurotrophic factors: NGF, CNTF, NT-3, BDNF.

21 January 2018

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Intracranial delivery of recombinant nerve growth factor: release kinetics and protein distribution for three delivery systems

21 January 2018

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The precursor pro-nerve growth factor is the predominant form of nerve growth factor in brain and is increased in Alzheimer's disease

21 January 2018

1 reference

Hippocampal proNGF signaling pathways and β-amyloid levels in mild cognitive impairment and Alzheimer disease

21 January 2018

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Ligand-dependent TrkA activity in brain differentially affects spatial learning and long-term memory

21 January 2018

1 reference

Taking pain out of NGF: a "painless" NGF mutant, linked to hereditary sensory autonomic neuropathy type V, with full neurotrophic activity

21 January 2018

1 reference

An agonistic TrkB mAb causes sustained TrkB activation, delays RGC death, and protects the retinal structure in optic nerve axotomy and in glaucoma

21 January 2018

1 reference

The function neutralizing anti-TrkA antibody MNAC13 reduces inflammatory and neuropathic pain

21 January 2018

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TrkB and TrkC agonist antibodies improve function, electrophysiologic and pathologic features in Trembler J mice.

21 January 2018

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Neurotrophin-3 gradients established by lentiviral gene delivery promote short-distance axonal bridging beyond cellular grafts in the injured spinal cord.

21 January 2018

1 reference

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

21 January 2018

1 reference

Long-term neuroprotection achieved with latency-associated promoter-driven herpes simplex virus gene transfer to the peripheral nervous system

21 January 2018

1 reference

Mechanisms, locations, and kinetics of synaptic BDNF secretion: an update.

21 January 2018

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Regulation of local translation at the synapse by BDNF.

21 January 2018

1 reference

Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling?: Neuronal life, growth and death signalling are crucially regulated by intra-membrane proteolysis and trafficking of p75(NTR).

21 January 2018

1 reference

Truncated TrkB: beyond a dominant negative receptor

21 January 2018

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Neurotrophin secretion: current facts and future prospects

21 January 2018

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Activity-dependent release of precursor nerve growth factor, conversion to mature nerve growth factor, and its degradation by a protease cascade

21 January 2018

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Molecular and Structural Insight into proNGF Engagement of p75NTR and Sortilin

21 January 2018

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The p75 neurotrophin receptor activates Akt (protein kinase B) through a phosphatidylinositol 3-kinase-dependent pathway

21 January 2018

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Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75.

21 January 2018

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Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75.

21 January 2018

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p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway

21 January 2018

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Oxygen-dependent cleavage of the p75 neurotrophin receptor triggers stabilization of HIF-1α.

21 January 2018

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Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor

21 January 2018

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Structural and functional properties of the TRK family of neurotrophin receptors

21 January 2018

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Trk receptors: roles in neuronal signal transduction

21 January 2018

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Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity

21 January 2018

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Trk receptor expression and inhibition in neuroblastomas

21 January 2018

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A signaling organelle containing the nerve growth factor-activated receptor tyrosine kinase, TrkA.

21 January 2018

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Retrograde neurotrophin signaling: Trk-ing along the axon

21 January 2018

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p75 reduces TrkB tyrosine autophosphorylation in response to brain-derived neurotrophic factor and neurotrophin 4/5.

21 January 2018

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High affinity not in the vicinity?

21 January 2018

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TrkA receptor activation by nerve growth factor induces shedding of the p75 neurotrophin receptor followed by endosomal gamma-secretase-mediated release of the p75 intracellular domain

21 January 2018

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The p75NTR intracellular domain generated by neurotrophin-induced receptor cleavage potentiates Trk signaling

21 January 2018

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Structure of nerve growth factor complexed with the shared neurotrophin receptor p75

21 January 2018

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Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors

21 January 2018

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Structural model for p75(NTR)-TrkA intracellular domain interaction: a combined FRET and bioinformatics study.

21 January 2018

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An intracellular domain fragment of the p75 neurotrophin receptor (p75(NTR)) enhances tropomyosin receptor kinase A (TrkA) receptor function

21 January 2018

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Ligand-independent signaling by disulfide-crosslinked dimers of the p75 neurotrophin receptor

21 January 2018

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Sortilin is essential for proNGF-induced neuronal cell death

21 January 2018

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The nerve growth factor precursor proNGF exhibits neurotrophic activity but is less active than mature nerve growth factor

21 January 2018

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Biological activity of nerve growth factor precursor is dependent upon relative levels of its receptors

21 January 2018

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Status epilepticus induces a TrkB to p75 neurotrophin receptor switch and increases brain-derived neurotrophic factor interaction with p75 neurotrophin receptor: an initial event in neuronal injury induction

21 January 2018

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Interaction of survival and death signaling in basal forebrain neurons: roles of neurotrophins and proneurotrophins.

21 January 2018

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Neurotrophic activity of proNGF in vivo.

21 January 2018

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p75 nerve growth factor receptor immunoreactivity in the human brainstem and spinal cord

21 January 2018

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NGF receptor (p75)-immunoreactivity in the developing primate basal ganglia

21 January 2018

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Upregulation of p75 neurotrophin receptor after stroke in mice does not contribute to differential vulnerability of striatal neurons

21 January 2018

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ProNGF induces p75-mediated death of oligodendrocytes following spinal cord injury

21 January 2018

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Secreted proNGF is a pathophysiological death-inducing ligand after adult CNS injury

21 January 2018

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Oral administration of a small molecule targeted to block proNGF binding to p75 promotes myelin sparing and functional recovery after spinal cord injury

21 January 2018

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Overexpression of neurotrophin receptor p75 contributes to the excitotoxin-induced cholinergic neuronal death in rat basal forebrain

21 January 2018

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p75 NTR expression is induced in isolated neurons of the penumbra after ischemia by cortical devascularization

21 January 2018

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Activation of p75NTR by proBDNF facilitates hippocampal long-term depression

21 January 2018

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Efficient copackaging and cotransport yields postsynaptic colocalization of neuromodulators associated with synaptic plasticity

21 January 2018

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Neuronal growth cone retraction relies on proneurotrophin receptor signaling through Rac.

21 January 2018

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Role of pro-brain-derived neurotrophic factor (proBDNF) to mature BDNF conversion in activity-dependent competition at developing neuromuscular synapses

21 January 2018

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Of proneurotrophins and their antineurotrophic effects

21 January 2018

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Neurotrophins Redirect p75NTR from a clathrin-independent to a clathrin-dependent endocytic pathway coupled to axonal transport

21 January 2018

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Age-dependent alterations in nerve growth factor (NGF)-related proteins, sortilin, and learning and memory in rats

21 January 2018

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Increased proNGF levels in subjects with mild cognitive impairment and mild Alzheimer disease

21 January 2018

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Effects of proNGF on neuronal viability, neurite growth and amyloid-beta metabolism

21 January 2018

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Matrix metalloproteinase-7 regulates cleavage of pro-nerve growth factor and is neuroprotective following kainic acid-induced seizures

21 January 2018

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Cholinergic involvement in Alzheimer's disease. A link with NGF maturation and degradation

21 January 2018

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Identification of a linear epitope in sortilin that partakes in pro-neurotrophin binding.

21 January 2018

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Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor

21 January 2018

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Specificity in Trk receptor:neurotrophin interactions: the crystal structure of TrkB-d5 in complex with neurotrophin-4/5

21 January 2018

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TrkA immunoglobulin-like ligand binding domains inhibit spontaneous activation of the receptor

21 January 2018

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TrkB dimerization during development of the prefrontal cortex of the macaque

21 January 2018

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Nerve growth factor signals via preexisting TrkA receptor oligomers

21 January 2018

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Nerve growth factor receptor TrkA exists as a preformed, yet inactive, dimer in living cells

21 January 2018

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Brain-derived neurotrophic factor receptor TrkB exists as a preformed dimer in living cells.

21 January 2018

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The TrkC receptor induces apoptosis when the dependence receptor notion meets the neurotrophin paradigm.

21 January 2018

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Expression of nerve growth factor, p75, and trk in the somatosensory and motor cortices of mature rats: evidence for local trophic support circuits

21 January 2018

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Immunohistochemical localization of the high-affinity NGF receptor (gp140-trkA) in the adult human dorsal root and sympathetic ganglia and in the nerves and sensory corpuscles supplying digital skin.

21 January 2018

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Decreased TrkA gene expression in cholinergic neurons of the striatum and basal forebrain of patients with Alzheimer's disease

21 January 2018

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Nerve growth factor signaling, neuroprotection, and neural repair

21 January 2018

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Neurotrophins as synaptic modulators

21 January 2018

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Brain-Derived Neurotrophic Factor/TrkB Signaling in Memory Processes

21 January 2018

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Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents

21 January 2018

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Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR).

21 January 2018

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The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death

21 January 2018

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Induction of apoptosis by the low-affinity NGF receptor

21 January 2018

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p75NTR and the concept of cellular dependence: seeing how the other half die.

21 January 2018

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Neurotrophin signaling through the p75 neurotrophin receptor

21 January 2018

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Small molecule modulation of p75 neurotrophin receptor functions

21 January 2018

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The cytoplasmic and transmembrane domains of the p75 and Trk A receptors regulate high affinity binding to nerve growth factor.

21 January 2018

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TrkA mediates developmental sympathetic neuron survival in vivo by silencing an ongoing p75NTR-mediated death signal

21 January 2018

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Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptor

21 January 2018

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The p75 neurotrophin receptor enhances TrkA signalling by binding to Shc and augmenting its phosphorylation

21 January 2018

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p75 neurotrophin receptor is implicated in the ability of neurotrophin-3 to negatively modulate activated ERK1/2 signaling in TrkA-expressing adult sensory neurons.

21 January 2018

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LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex

21 January 2018

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A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein

21 January 2018

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P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp

21 January 2018

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Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules

21 January 2018

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The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression

21 January 2018

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Brain-derived neurotrophic factor over-expression in the forebrain ameliorates Huntington's disease phenotypes in mice

21 January 2018

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Bdnf overexpression in hippocampal neurons prevents dendritic atrophy caused by Rett-associated MECP2 mutations

21 January 2018

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Pericontusion axon sprouting is spatially and temporally consistent with a growth-permissive environment after traumatic brain injury.

21 January 2018

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TrkB inhibition as a therapeutic target for CNS-related disorders.

21 January 2018

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Conditional deletion of TrkB but not BDNF prevents epileptogenesis in the kindling model

21 January 2018

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Injury-induced axonal sprouting in the hippocampus is initiated by activation of trkB receptors

21 January 2018

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Nerve growth factor-mediated regulation of pain signalling and proposed new intervention strategies in clinical pain management

21 January 2018

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Low molecular weight, non-peptidic agonists of TrkA receptor with NGF-mimetic activity.

21 January 2018

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Structural, biological, and pharmacological strategies for the inhibition of nerve growth factor

21 January 2018

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Receptor signaling: when dimerization is not enough

21 January 2018

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Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation

21 January 2018

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Activation of the Leptin Receptor by a Ligand-induced Conformational Change of Constitutive Receptor Dimers

21 January 2018

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EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization

21 January 2018

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Signal transduction. Autoinhibition control

21 January 2018

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The biotin repressor: thermodynamic coupling of corepressor binding, protein assembly, and sequence-specific DNA binding

21 January 2018

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Ligand-induced formation of transient dimers of mammalian 12/15-lipoxygenase: a key to allosteric behavior of this class of enzymes?

21 January 2018

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A novel mutation within the extracellular domain of TrkA causes constitutive receptor activation

21 January 2018

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A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone.

21 January 2018

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Deoxygedunin, a natural product with potent neurotrophic activity in mice

21 January 2018

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Small, nonpeptide p75NTR ligands induce survival signaling and inhibit proNGF-induced death.

21 January 2018

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NGF and neurotrophin-3 both activate TrkA on sympathetic neurons but differentially regulate survival and neuritogenesis

21 January 2018

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Point mutation in trkB causes loss of NT4-dependent neurons without major effects on diverse BDNF responses.

21 January 2018

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Neurotrophin small-molecule mimetics

21 January 2018

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Small molecule Trk receptor agonists and other neurotrophic factor mimetics

21 January 2018

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Small molecule peptidomimetic ligands of neurotrophin receptors, identifying binding sites, activation sites and regulatory sites

21 January 2018

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Disruption of the low affinity receptor-binding site in NGF allows neuronal survival and differentiation by binding to the trk gene product

21 January 2018

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p75 Neurotrophin receptor antagonist retards apoptosis-driven hair follicle involution (catagen).

21 January 2018

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Differential actions of nerve growth factor receptors TrkA and p75NTR in a rat model of epileptogenesis

21 January 2018

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Inhibition of p75(NTR) in glia potentiates TrkA-mediated survival of injured retinal ganglion cells

21 January 2018

1 reference

Genuine Monovalent Ligands of TrkA Nerve Growth Factor Receptors Reveal a Novel Pharmacological Mechanism of Action

21 January 2018

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Nerve growth factor (NGF) loop 4 dimeric mimetics activate ERK and AKT and promote NGF-like neurotrophic effects

21 January 2018

1 reference

Long-lasting rescue of age-associated deficits in cognition and the CNS cholinergic phenotype by a partial agonist peptidomimetic ligand of TrkA.

21 January 2018

1 reference

A new nerve growth factor-mimetic peptide active on neuropathic pain in rats

21 January 2018

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Neurogenic and neurotrophic effects of BDNF peptides in mouse hippocampal primary neuronal cell cultures

21 January 2018

1 reference

Design of a conformationally defined and proteolytically stable circular mimetic of brain-derived neurotrophic factor.

21 January 2018

1 reference

A small peptide mimetic of brain-derived neurotrophic factor promotes peripheral myelination.

21 January 2018

1 reference

Cyclotraxin-B, the first highly potent and selective TrkB inhibitor, has anxiolytic properties in mice

21 January 2018

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New templates for syntheses of ring-fused, C(10) beta-turn peptidomimetics leading to the first reported small-molecule mimic of neurotrophin-3.

21 January 2018

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Dimeric beta-turn peptidomimetics as ligands for the neurotrophin receptor TrkC.

21 January 2018

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Neuroprotection by small molecule activators of the nerve growth factor receptor.

21 January 2018

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Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death

21 January 2018

1 reference

Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic activity

21 January 2018

1 reference

Requirements for binding and signaling of the kinase domain receptor for vascular endothelial growth factor

21 January 2018

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A hot spot of binding energy in a hormone-receptor interface

21 January 2018

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A combinatorial method for solution-phase synthesis of labeled bivalent beta-turn mimics.

21 January 2018

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Antioxidant activity of 7,8-dihydroxyflavone provides neuroprotection against glutamate-induced toxicity

21 January 2018

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7,8-dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's disease

21 January 2018

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Effect of 7,8-dihydroxyflavone, a small-molecule TrkB agonist, on emotional learning

21 January 2018

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7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilization stress in rats

21 January 2018

1 reference

Epigenetic enhancement of BDNF signaling rescues synaptic plasticity in aging

21 January 2018

1 reference

Vulnerability to depression: from brain neuroplasticity to identification of biomarkers.

21 January 2018

1 reference

A Synthetic 7,8-Dihydroxyflavone Derivative Promotes Neurogenesis and Exhibits Potent Antidepressant Effect

21 January 2018

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Optimization of a small tropomyosin-related kinase B (TrkB) agonist 7,8-dihydroxyflavone active in mouse models of depression

21 January 2018

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7,8-dihydroxyflavone exhibits therapeutic efficacy in a mouse model of Rett syndrome

21 January 2018

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Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents

21 January 2018

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A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome

21 January 2018

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Delayed administration of a small molecule tropomyosin-related kinase B ligand promotes recovery after hypoxic-ischemic stroke

21 January 2018

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Targets for preventing epilepsy following cortical injury

21 January 2018

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Identification of a low-molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice

21 January 2018

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TrkB receptor signaling in the nucleus tractus solitarius mediates the food intake-suppressive effects of hindbrain BDNF and leptin

21 January 2018

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Effects of TrkB agonist 7,8-dihydroxyflavone on sensory gating deficits in mice after administration of methamphetamine.

21 January 2018

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N-acetylserotonin activates TrkB receptor in a circadian rhythm

21 January 2018

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N-acetyl serotonin derivatives as potent neuroprotectants for retinas

21 January 2018

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Bivalent peptidomimetic ligands of TrkC are biased agonists and selectively induce neuritogenesis or potentiate neurotrophin-3 trophic signals

21 January 2018

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Synthetic NGF peptide derivatives prevent neuronal death via a p75 receptor-dependent mechanism.

21 January 2018

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Modulation of p75-dependent motor neuron death by a small non-peptidyl mimetic of the neurotrophin loop 1 domain

21 January 2018

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Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment

21 January 2018

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Small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model.

21 January 2018

1 reference

Brain-derived neurotrophic factor is neuroprotective against human immunodeficiency virus-1 envelope proteins

21 January 2018

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Suppression of immunodeficiency virus-associated neural damage by the p75 neurotrophin receptor ligand, LM11A-31, in an in vitro feline model

21 January 2018

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Signaling through Rho GTPase pathway as viable drug target

21 January 2018

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Anti-cancer drug induced neurotoxicity and identification of Rho pathway signaling modulators as potential neuroprotectants

21 January 2018

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Chronic and Acute Models of Retinal Neurodegeneration TrkA Activity Are Neuroprotective whereas p75NTR Activity Is Neurotoxic through a Paracrine Mechanism

21 January 2018

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Neurotrophins: from enthusiastic expectations through sobering experiences to rational therapeutic approaches

21 January 2018

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Intracerebroventricular infusion of nerve growth factor in three patients with Alzheimer's disease

21 January 2018

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A role for nerve growth factor in sympathetic sprouting in rat dorsal root ganglia

21 January 2018

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Noradrenergic pain modulation

21 January 2018

1 reference

A double-blind placebo-controlled clinical trial of recombinant human brain-derived neurotrophic factor (rhBDNF) in diabetic polyneuropathy

21 January 2018

1 reference

Long-term treatment with recombinant nerve growth factor for HIV-associated sensory neuropathy.

21 January 2018

1 reference

Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease.

21 January 2018

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Amyloid beta binds trimers as well as monomers of the 75-kDa neurotrophin receptor and activates receptor signaling

21 January 2018

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Characterization of the signaling pathway downstream p75 neurotrophin receptor involved in beta-amyloid peptide-dependent cell death.

21 January 2018

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Postsynaptic Receptors for Amyloid-β Oligomers as Mediators of Neuronal Damage in Alzheimer's Disease

21 January 2018

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Alzheimer's disease: synaptic dysfunction and Abeta

21 January 2018

1 reference

An NGF mimetic, MIM-D3, stimulates conjunctival cell glycoconjugate secretion and demonstrates therapeutic efficacy in a rat model of dry eye.

21 January 2018

1 reference

Solid-state NMR reveals structural changes in phospholamban accompanying the functional regulation of Ca2+-ATPase

21 January 2018

1 reference

Discovery of a Small Molecule Insulin Mimetic with Antidiabetic Activity in Mice

21 January 2018

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Intradermal recombinant human nerve growth factor induces pressure allodynia and lowered heat-pain threshold in humans

21 January 2018

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Nerve growth factor evokes hyperalgesia in mice lacking the low-affinity neurotrophin receptor p75

31 March 2020

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Neurotrophin binding to the p75 receptor modulates Rho activity and axonal outgrowth

31 March 2020

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Ligand-induced internalization of the p75 neurotrophin receptor: a slow route to the signaling endosome

31 March 2020

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Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex

31 March 2020

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Low-affinity nerve growth factor receptor (p75NGFR)- and choline acetyltransferase (ChAT)-immunoreactive axons in the cerebral cortex and hippocampus of adult macaque monkeys and humans

31 March 2020

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Emerging themes in structural biology of neurotrophic factors

31 March 2020

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Expression and coexpression of Trk receptors in subpopulations of adult primary sensory neurons projecting to identified peripheral targets

31 March 2020

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Competitive signaling between TrkA and p75 nerve growth factor receptors determines cell survival.

31 March 2020

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Nerve growth factor and associated nerve sprouting contribute to local mechanical hyperalgesia in a rat model of bone injury

31 March 2020

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Increase in BDNF-mediated TrkB signaling promotes epileptogenesis in a mouse model of mesial temporal lobe epilepsy

31 March 2020

1 reference

Erythropoietin receptor activation by a ligand-induced conformation change

31 March 2020

1 reference

PD 90780, a non peptide inhibitor of nerve growth factor's binding to the P75 NGF receptor

31 March 2020

1 reference

A TrkA-selective, fast internalizing nerve growth factor-antibody complex induces trophic but not neuritogenic signals

31 March 2020

1 reference

Small peptide mimics of nerve growth factor bind TrkA receptors and affect biological responses

31 March 2020

1 reference

Neurotrophic rationale in glaucoma: a TrkA agonist, but not NGF or a p75 antagonist, protects retinal ganglion cells in vivo

31 March 2020

1 reference

Efficacy and safety of recombinant human nerve growth factor in patients with diabetic polyneuropathy: A randomized controlled trial. rhNGF Clinical Investigator Group

31 March 2020

1 reference

A phase II trial of nerve growth factor for sensory neuropathy associated with HIV infection. AIDS Clinical Trials Group Team 291

31 March 2020

1 reference

A controlled trial of recombinant methionyl human BDNF in ALS: The BDNF Study Group (Phase III)

31 March 2020

1 reference

Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins

31 March 2020

1 reference

The in vitro biological effect of nerve growth factor is inhibited by synthetic peptides

31 March 2020

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12 December 2020

Neurite outgrowth can be modulated in vitro using a tetracycline-repressible gene therapy vector expressing human nerve growth factor

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12 December 2020

Design of Potent Peptide Mimetics of Brain-derived Neurotrophic Factor

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12 December 2020

Structure-activity relationships of conformationally constrained peptide analogues of loop 2 of brain-derived neurotrophic factor

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12 December 2020

Epilepsy following cortical injury: cellular and molecular mechanisms as targets for potential prophylaxis

1 reference

12 December 2020

A designed peptidomimetic agonistic ligand of TrkA nerve growth factor receptors.

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12 December 2020

A cyclic peptide that binds p75(NTR) protects neurones from beta amyloid (1-40)-induced cell death.

1 reference

12 December 2020

An agonistic mAb directed to the TrkC receptor juxtamembrane region defines a trophic hot spot and interactions with p75 coreceptors

1 reference

12 December 2020

Association of protein kinases ERK1 and ERK2 with p75 nerve growth factor receptors

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12 December 2020

Neurotrophins, neuroprotection and the blood-brain barrier

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12 December 2020

Human ProNGF: biological effects and binding profiles at TrkA, P75NTR and sortilin

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRD4024

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1 August 2017

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