IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP (Q34550996)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28186168%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

title

IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP (English)

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2 April 2020

4

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Johanne H Egedal

7

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2 April 2020

Pejman Mohammadi

9

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2 April 2020

Thaneas Prabakaran

10

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Christian K Holm

14

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Mogens Johannsen

16

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Mette Nyegaard

17

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2 April 2020

Mette Nyegaard

18

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2 April 2020

Jacob Giehm Mikkelsen

19

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2 April 2020

author name string

K L Jønsson

1

1 reference

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2 April 2020

A Laustsen

2

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2 April 2020

C Krapp

3

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2 April 2020

K Thavachelvam

5

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2 April 2020

D Hotter

6

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M Kjolby

8

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L K Sørensen

11

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2 April 2020

C Sun

12

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2 April 2020

S B Jensen

13

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2 April 2020

R J Lebbink

15

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2 April 2020

F Kirchhoff

20

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S R Paludan

21

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M R Jakobsen

22

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language of work or name

English

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publication date

10 February 2017

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2 April 2020

published in

Nature Communications

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volume

8

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page(s)

14391

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Creative Commons Attribution 4.0 International

2 April 2020

copyright license

start time

10 February 2017

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5309897/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/ncomms14391

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cites work

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cGAS-mediated stabilization of IFI16 promotes innate signaling during herpes simplex virus infection

7 July 2018

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The interferon-inducible DNA-sensor protein IFI16: a key player in the antiviral response

7 July 2018

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cGAS and Ifi204 cooperate to produce type I IFNs in response to Francisella infection

7 July 2018

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The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.

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Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

7 July 2018

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The E3 ubiquitin ligase AMFR and INSIG1 bridge the activation of TBK1 kinase by modifying the adaptor STING.

7 July 2018

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The ribonuclease activity of SAMHD1 is required for HIV-1 restriction

7 July 2018

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OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids

7 July 2018

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IFI16: At the interphase between innate DNA sensing and genome regulation

7 July 2018

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The mechanism of double-stranded DNA sensing through the cGAS-STING pathway

7 July 2018

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Interferon γ-inducible protein (IFI) 16 transcriptionally regulates type i interferons and other interferon-stimulated genes and controls the interferon response to both DNA and RNA viruses

7 July 2018

1 reference

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Listeria monocytogenes induces IFNβ expression through an IFI16-, cGAS- and STING-dependent pathway

7 July 2018

1 reference

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A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation

7 July 2018

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NF-κB activation induced by hepatitis A virus and Newcastle disease virus occurs by different pathways depending on the structural pattern of viral nucleic acids

7 July 2018

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The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop

7 July 2018

1 reference

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Cooperative assembly of IFI16 filaments on dsDNA provides insights into host defense strategy.

7 July 2018

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Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization

7 July 2018

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Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

7 July 2018

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The capsids of HIV-1 and HIV-2 determine immune detection of the viral cDNA by the innate sensor cGAS in dendritic cells.

7 July 2018

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Human cytomegalovirus tegument protein pUL83 inhibits IFI16-mediated DNA sensing for immune evasion

7 July 2018

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Single nucleotide polymorphisms of human STING can affect innate immune response to cyclic dinucleotides

7 July 2018

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IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication.

7 July 2018

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Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling

7 July 2018

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Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.

7 July 2018

1 reference

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Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects

7 July 2018

1 reference

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The interferon response to intracellular DNA: why so many receptors?

7 July 2018

1 reference

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Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309897

Structural mechanism of cytosolic DNA sensing by cGAS

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309897

cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309897

The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309897

Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309897

STING-dependent recognition of cyclic di-AMP mediates type I interferon responses during Chlamydia trachomatis infection.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309897

STING recognition of cytoplasmic DNA instigates cellular defense

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309897

Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309897

Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309897

Extensive evolutionary and functional diversity among mammalian AIM2-like receptors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309897

Preferential binding of IFI16 protein to cruciform structure and superhelical DNA.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309897

Development of transgenic cloned pig models of skin inflammation by DNA transposon-directed ectopic expression of human β1 and α2 integrin

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309897

Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309897

STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309897

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309897

IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309897

IFI16 is an innate immune sensor for intracellular DNA

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309897

Amelioration of psoriasis by anti-TNF-alpha RNAi in the xenograft transplantation model

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309897

7 July 2018

Identifiers

DOI

10.1038/NCOMMS14391

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28186168%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

2 April 2020

ADS bibcode

2017NatCo...814391J

0 references

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28186168%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

1 reference