Anti-Sclerostin antibody inhibits internalization of Sclerostin and Sclerostin-mediated antagonism of Wnt/LRP6 signaling (Q34701183)

4 August 2017

Anti-Sclerostin antibody inhibits internalization of Sclerostin and Sclerostin-mediated antagonism of Wnt/LRP6 signaling (English)

1 reference

4 August 2017

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Maarten van Dinther

1

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4 August 2017

Juan Zhang

2

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4 August 2017

Stella E Weidauer

3

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4 August 2017

Verena Boschert

4

1 reference

4 August 2017

Eva-Maria Muth

5

1 reference

4 August 2017

Achim Knappik

6

1 reference

4 August 2017

David J J de Gorter

7

1 reference

4 August 2017

Puck B van Kasteren

8

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4 August 2017

Christian Frisch

9

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4 August 2017

Thomas D Mueller

10

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4 August 2017

Peter ten Dijke

11

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4 August 2017

language of work or name

English

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publication date

29 April 2013

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4 August 2017

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4 August 2017

8

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4 August 2017

4

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4 August 2017

e62295

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Creative Commons Attribution 4.0 International

4 August 2017

start time

29 April 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

ImageQuant

object named as

ImageQuant TL

2 references

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3639248/fullTextXML

inferred from PubMed Central ID database lookup

CZ Software Mentions: A large dataset of software mentions in the biomedical literature

cites work

Sclerostin antibody increases bone volume and enhances implant fixation in a rat model

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Signaling pathways affecting skeletal health

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LRP8 mediates Wnt/β-catenin signaling and controls osteoblast differentiation

7 July 2018

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Update on bone anabolics in osteoporosis treatment: rationale, current status, and perspectives

7 July 2018

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Structural Basis of Wnt Signaling Inhibition by Dickkopf Binding to LRP5/6

7 July 2018

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Crystal structures of the extracellular domain of LRP6 and its complex with DKK1

7 July 2018

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Wnt antagonists bind through a short peptide to the first β-propeller domain of LRP5/6

7 July 2018

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New targets for intervention in the treatment of postmenopausal osteoporosis

7 July 2018

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Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function

7 July 2018

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Osteoporosis: now and the future

7 July 2018

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Emerging therapeutic opportunities for skeletal restoration

7 July 2018

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Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways

7 July 2018

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Wnt isoform-specific interactions with coreceptor specify inhibition or potentiation of signaling by LRP6 antibodies

7 July 2018

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Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies

7 July 2018

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Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody

7 July 2018

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Regulation of Lrp6 phosphorylation

7 July 2018

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Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength

7 July 2018

1 reference

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Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6

7 July 2018

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LRP6 is internalized by Dkk1 to suppress its phosphorylation in the lipid raft and is recycled for reuse

7 July 2018

1 reference

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The FOP metamorphogene encodes a novel type I receptor that dysregulates BMP signaling

7 July 2018

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Characterization of the Structural Features and Interactions of Sclerostin: MOLECULAR INSIGHT INTO A KEY REGULATOR OF Wnt-MEDIATED BONE FORMATION

7 July 2018

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NMR structure of the Wnt modulator protein Sclerostin

7 July 2018

1 reference

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Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis

7 July 2018

1 reference

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Wnt3a and Dkk1 regulate distinct internalization pathways of LRP6 to tune the activation of beta-catenin signaling

7 July 2018

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The human combinatorial antibody library HuCAL GOLD combines diversification of all six CDRs according to the natural immune system with a novel display method for efficient selection of high-affinity antibodies.

7 July 2018

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Wnt but not BMP signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formation

7 July 2018

1 reference

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Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity

7 July 2018

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SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor

7 July 2018

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SOST/sclerostin, an osteocyte-derived negative regulator of bone formation

7 July 2018

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Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling

7 July 2018

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Identification of the disease-causing gene in sclerosteosis--discovery of a novel bone anabolic target?

7 July 2018

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Osteocyte control of bone formation via sclerostin, a novel BMP antagonist

7 July 2018

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Mapping Wnt/beta-catenin signaling during mouse development and in colorectal tumors

7 July 2018

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Molecular genetics of too much bone

7 July 2018

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Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins

7 July 2018

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Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling

7 July 2018

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High bone density due to a mutation in LDL-receptor-related protein 5

7 July 2018

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Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway

7 July 2018

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A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait

7 July 2018

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Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

7 July 2018

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Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3639248

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3639248

Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3639248

Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3639248

An LDL-receptor-related protein mediates Wnt signalling in mice

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3639248

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3639248

Subcloning of three osteoblastic cell lines with distinct differentiation phenotypes from the mouse osteoblastic cell line KS-4.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3639248

Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects

7 July 2018

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Amantadine and dansylcadaverine inhibit vesicular stomatitis virus uptake and receptor-mediated endocytosis of alpha 2-macroglobulin

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3639248

A chondrogenic cell line derived from a differentiating culture of AT805 teratocarcinoma cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3639248

Caveolin, a protein component of caveolae membrane coats

7 July 2018

1 reference

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Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength

7 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0062295

Inhibition of sclerostin by monoclonal antibody enhances bone healing and improves bone density and strength of nonfractured bones

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23638027

12 December 2020

inferred from PubMed ID database lookup

Inhibition of sclerostin by systemic treatment with sclerostin antibody enhances healing of proximal tibial defects in ovariectomized rats

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23638027

12 December 2020

inferred from PubMed ID database lookup

Characterization of a membrane receptor for transforming growth factor-beta in normal rat kidney fibroblasts

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23638027

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1371/JOURNAL.PONE.0062295

1 reference

4 August 2017

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1 reference

4 August 2017

1 reference