Signaling pathways affecting skeletal health (Q38019847)

27 August 2017

title

Signaling pathways affecting skeletal health (English)

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27 August 2017

Pierre J Marie

1

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27 August 2017

publication date

1 September 2012

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Current osteoporosis reports

27 August 2017

published in

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27 August 2017

volume

10

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27 August 2017

issue

3

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27 August 2017

page(s)

190-198

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Molecular and cellular mechanisms of the anabolic effect of intermittent PTH

27 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

SOST is a target gene for PTH in bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Anabolic and catabolic regimens of human parathyroid hormone 1-34 elicit bone- and envelope-specific attenuation of skeletal effects in Sost-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

PTH receptor signaling in osteocytes governs periosteal bone formation and intracortical remodeling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Suppression of Wnt signaling by Dkk1 attenuates PTH-mediated stromal cell response and new bone formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Silencing of parathyroid hormone (PTH) receptor 1 in T cells blunts the bone anabolic activity of PTH

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Parathyroid hormone signaling through low-density lipoprotein-related protein 6

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Gsα enhances commitment of mesenchymal progenitors to the osteoblast lineage but restrains osteoblast differentiation in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Decreased oxidative stress and greater bone anabolism in the aged, when compared to the young, murine skeleton with parathyroid hormone administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Regulation of bone mass by Wnt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

The two faces of serotonin in bone biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Lrp5 functions in bone to regulate bone mass

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

The serotonin 5-HT2B receptor controls bone mass via osteoblast recruitment and proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Decreased osteoclastogenesis in serotonin-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Wnt10b deficiency results in age-dependent loss of bone mass and progressive reduction of mesenchymal progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Wnt6, Wnt10a and Wnt10b inhibit adipogenesis and stimulate osteoblastogenesis through a β-catenin-dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Mechanical signaling for bone modeling and remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

GSK-3 inhibition by an orally active small molecule increases bone mass in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Modulation of canonical Wnt signaling by the extracellular matrix component biglycan

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

A rate-limiting role for Dickkopf-1 in bone formation and the remediation of bone loss in mouse and primate models of postmenopausal osteoporosis by an experimental therapeutic antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

The role of BMP2 signaling in the skeleton.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Bone morphogenetic protein type IA receptor signaling regulates postnatal osteoblast function and bone remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Wnt inhibitors Dkk1 and Sost are downstream targets of BMP signaling through the type IA receptor (BMPRIA) in osteoblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Conditional deletion of Bmpr1a in differentiated osteoclasts increases osteoblastic bone formation, increasing volume of remodeling bone in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Bone morphogenetic proteins and their antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

WISP-1/CCN4 regulates osteogenesis by enhancing BMP-2 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Transforming growth factor-beta1 to the bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Regulation of osteoblastogenesis and osteoclastogenesis by the other reproductive hormones, Activin and Inhibin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

The activin A-follistatin system: potent regulator of human extracellular matrix mineralization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

A soluble activin receptor Type IIA fusion protein (ACE-011) increases bone mass via a dual anabolic-antiresorptive effect in Cynomolgus monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

The EGFR network in bone biology and pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Epidermal growth factor receptor plays an anabolic role in bone metabolism in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

High cortical bone mass phenotype in betacellulin transgenic mice is EGFR dependent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Normal epidermal growth factor receptor signaling is dispensable for bone anabolic effects of parathyroid hormone

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

FGF/FGFR signaling in bone formation: progress and perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Fibroblast growth factor receptor 2 promotes osteogenic differentiation in mesenchymal cells via ERK1/2 and protein kinase C signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Fibroblast growth factor 2 stimulation of osteoblast differentiation and bone formation is mediated by modulation of the Wnt signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Serum IGF-1 determines skeletal strength by regulating subperiosteal expansion and trait interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Conditional disruption of IGF-I gene in type 1α collagen-expressing cells shows an essential role of IGF-I in skeletal anabolic response to loading

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

The heparin-binding domain of IGFBP-2 has insulin-like growth factor binding-independent biologic activity in the growing skeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Increased EFG- and PDGFalpha-receptor signaling by mutant FGF-receptor 2 contributes to osteoblast dysfunction in Apert craniosynostosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Fibroblast growth factor receptor signaling crosstalk in skeletogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Abrogation of Cbl-PI3K interaction increases bone formation and osteoblast proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

The Loss of Cbl-Phosphatidylinositol 3-Kinase Interaction Perturbs RANKL-mediated Signaling, Inhibiting Bone Resorption and Promoting Osteoclast Survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

The skeleton: a multi-functional complex organ: new insights into osteoblasts and their role in bone formation: the central role of PI3Kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Synergism between Wnt3a and heparin enhances osteogenesis via a phosphoinositide 3-kinase/Akt/RUNX2 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

p85alpha regulates osteoblast differentiation by cross-talking with the MAPK pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Lifelong accumulation of bone in mice lacking Pten in osteoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Selective signaling by Akt1 controls osteoblast differentiation and osteoblast-mediated osteoclast development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Akt induces osteoclast differentiation through regulating the GSK3β/NFATc1 signaling cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Important roles of PI3Kgamma in osteoclastogenesis and bone homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Interactions between extracellular signal-regulated kinase 1/2 and p38 MAP kinase pathways in the control of RUNX2 phosphorylation and transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

p38 regulates expression of osteoblast-specific genes by phosphorylation of osterix

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Neighbor of Brca1 gene (Nbr1) functions as a negative regulator of postnatal osteoblastic bone formation and p38 MAPK activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Essential role of Wnt3a-mediated activation of mitogen-activated protein kinase p38 for the stimulation of alkaline phosphatase activity and matrix mineralization in C3H10T1/2 mesenchymal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

The extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

The calcium-sensing receptor in bone cells: a potential therapeutic target in osteoporosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Osteoblast extracellular Ca2+ -sensing receptor regulates bone development, mineralization, and turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

The calcium-sensing receptor complements parathyroid hormone-induced bone turnover in discrete skeletal compartments in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Strontium ranelate in osteoporosis and beyond: identifying molecular targets in bone cell biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Essential role of nuclear factor of activated T cells (NFAT)-mediated Wnt signaling in osteoblast differentiation induced by strontium ranelate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Strontium ranelate decreases receptor activator of nuclear factor-ΚB ligand-induced osteoclastic differentiation in vitro: involvement of the calcium-sensing receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

The calcium-sensing receptor is involved in strontium ranelate-induced osteoclast apoptosis. New insights into the associated signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Osteoblasts play key roles in the mechanisms of action of strontium ranelate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Bone cell-matrix protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Priming integrin alpha5 promotes human mesenchymal stromal cell osteoblast differentiation and osteogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Mechanical stress-activated integrin α5β1 induces opening of connexin 43 hemichannels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Integrin alpha2beta1 plays a critical role in osteoblast response to micron-scale surface structure and surface energy of titanium substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Directing mesenchymal stem cells to bone to augment bone formation and increase bone mass

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

N-cadherin and cadherin 11 modulate postnatal bone growth and osteoblast differentiation by distinct mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

N-cadherin negatively regulates osteoblast proliferation and survival by antagonizing Wnt, ERK and PI3K/Akt signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

N-cadherin adherens junctions mediate osteogenesis through PI3K signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Cell autonomous requirement of connexin 43 for osteocyte survival: consequences for endocortical resorption and periosteal bone formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Enhanced osteoclastic resorption and responsiveness to mechanical load in gap junction deficient bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Eph and ephrin interactions in bone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Bidirectional signaling through ephrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Suppression of bone formation by osteoclastic expression of semaphorin 4D

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11914-012-0109-0

Role of fibroblast growth factor 2 and Wnt signaling in anabolic effects of parathyroid hormone on bone formation

21 January 2018

1 reference

12 December 2020

Targeted overexpression of insulin-like growth factor I to osteoblasts of transgenic mice: increased trabecular bone volume without increased osteoblast proliferation

1 reference

12 December 2020

Activin receptor signaling: a potential therapeutic target for osteoporosis

1 reference

12 December 2020

Strontium ranelate treatment increases osteoprotegerin serum levels in postmenopausal osteoporotic women

1 reference

12 December 2020

Osteoprotegerin deficiency attenuates strontium-mediated inhibition of osteoclastogenesis and bone resorption

1 reference

12 December 2020

Insulin-like growth factor-I molecular pathways in osteoblasts: potential targets for pharmacological manipulation

1 reference

12 December 2020

Dietary-induced serum phenolic acids promote bone growth via p38 MAPK/β-catenin canonical Wnt signaling

1 reference

12 December 2020

Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization

1 reference

12 December 2020

Calcium sensing receptor-dependent and receptor-independent activation of osteoblast replication and survival by strontium ranelate.

1 reference

12 December 2020

Efficacy of serotonin inhibition in mouse models of bone loss

1 reference

12 December 2020

LRP5, serotonin, and bone: complexity, contradictions, and conundrums

1 reference

12 December 2020

Inhibition of TGF-β signaling by 1D11 antibody treatment increases bone mass and quality in vivo

1 reference

12 December 2020

10.1007/S11914-012-0109-0

Identifiers

DOI

1 reference

Dimensions Publication ID

27 August 2017

1027083264

0 references

1 reference