Subcellular distribution and activity of mechanistic target of rapamycin in aged retinal pigment epithelium (Q34795122)

4 August 2017

Subcellular distribution and activity of mechanistic target of rapamycin in aged retinal pigment epithelium (English)

1 reference

4 August 2017

1 reference

Zhenyang Zhao

3

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author name string

Bo Yu

1

1 reference

4 August 2017

Pei Xu

2

1 reference

4 August 2017

Jiyang Cai

4

1 reference

4 August 2017

Paul Sternberg

5

1 reference

4 August 2017

Yan Chen

6

1 reference

4 August 2017

language of work or name

English

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publication date

9 December 2014

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Investigative Ophthalmology Visual Science

4 August 2017

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4 August 2017

55

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4 August 2017

12

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4 August 2017

8638-8650

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describes a project that uses

4 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4280880/fullTextXML

inferred from PubMed Central ID database lookup

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Analysis of photoreceptor outer segment phagocytosis by RPE cells in culture

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8 July 2018

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The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis

8 July 2018

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8 July 2018

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The role of nuclear lamin B1 in cell proliferation and senescence.

8 July 2018

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mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase

8 July 2018

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Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration

8 July 2018

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Integration of tight junctions and claudins with the barrier functions of the retinal pigment epithelium

8 July 2018

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8 July 2018

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mTOR: from growth signal integration to cancer, diabetes and ageing

8 July 2018

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mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice.

8 July 2018

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The essence of senescence

8 July 2018

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Altered mTOR signaling in senescent retinal pigment epithelium

8 July 2018

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Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

8 July 2018

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The genetics of ageing

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Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

8 July 2018

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Silencing of the CHM gene alters phagocytic and secretory pathways in the retinal pigment epithelium

8 July 2018

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Cigarette smoking, oxidative stress, the anti-oxidant response through Nrf2 signaling, and Age-related Macular Degeneration

8 July 2018

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

8 July 2018

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Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells

8 July 2018

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Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa

8 July 2018

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Regulation of TORC1 by Rag GTPases in nutrient response

8 July 2018

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The aged retinal pigment epithelium/choroid: a potential substratum for the pathogenesis of age-related macular degeneration

8 July 2018

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

8 July 2018

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Characterization of a Bcl-XL-interacting protein FKBP8 and its splice variant in human RPE cells

8 July 2018

1 reference

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Confluent monolayers of cultured human fetal retinal pigment epithelium exhibit morphology and physiology of native tissue.

8 July 2018

1 reference

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Senescence-associated beta-galactosidase is lysosomal beta-galactosidase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280880

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280880

The expression of native and cultured human retinal pigment epithelial cells grown in different culture conditions

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280880

The retinal pigment epithelium in visual function

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280880

Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280880

Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280880

Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280880

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280880

Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280880

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280880

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280880

Downregulation of differentiation specific gene expression by oxidative stress in ARPE-19 cells.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280880

Rb targets histone H3 methylation and HP1 to promoters

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280880

Photocytotoxicity of lipofuscin in human retinal pigment epithelial cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280880

Increase in the advanced glycation end product pentosidine in Bruch's membrane with age.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280880

Endogenous beta-galactosidase activity in continuously nonproliferating cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280880

Human retinal pigment epithelial cell-induced apoptosis in activated T cells.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280880

Phagocytosis of rod outer segments by retinal pigment epithelial cells requires alpha(v)beta5 integrin for binding but not for internalization

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280880

Serum opens tight junctions and reduces ZO-1 protein in retinal epithelial cells.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280880

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280880

NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280880

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280880

Some observations in the fine structure of age changes of the mouse retinal pigment epithelium

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280880

Mitochondrial thioredoxin in regulation of oxidant-induced cell death

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280880

The power and the promise of oncogene-induced senescence markers.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280880

Mitochondrial alterations of retinal pigment epithelium in age-related macular degeneration

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280880

26 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280880

Nrf2-deficient female mice develop lupus-like autoimmune nephritis

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280880

Differentiation between senescence (M1) and crisis (M2) in human fibroblast cultures

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4280880

Is beta-galactosidase staining a marker of senescence in vitro and in vivo?

26 October 2018

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12 December 2020

Rhodopsin content in the outer segment membranes of bovine and frog retinal rods

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12 December 2020

Stereological analysis of liver parenchymal cells from young and old rats

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12 December 2020

Lysosomal activity in the aging rat liver: II. Morphometry of acid phosphatase positive dense bodies

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12 December 2020

Age-dependent alterations in rat ventricular myocardium: a quantitative analysis

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12 December 2020

An improved method for isolation and culture of pigment epithelial cells from rat retina

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12 December 2020

Retinal pigment epithelial cells from dystrophic rats form normal tight junctions in vitro

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12 December 2020

Does pH 6 beta-galactosidase activity indicate cell senescence?

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12 December 2020

Identifiers

DOI

10.1167/IOVS.14-14758

1 reference

4 August 2017

1 reference

4 August 2017

1 reference