Fighting neurodegeneration with rapamycin: mechanistic insights (Q28243647)

Nature Reviews Neuroscience

Europe PubMed Central

title

Fighting neurodegeneration with rapamycin: mechanistic insights (English)

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Miquel Vila

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Marta Martinez-vicente

object named as

Marta Martínez-Vicente

series ordinal

2

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author name string

Jordi Bové

series ordinal

1

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language of work or name

English

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publication date

20 July 2011

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published in

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volume

12

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issue

8

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page(s)

437-52

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cites work

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Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss.

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A gene network regulating lysosomal biogenesis and function

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TFEB links autophagy to lysosomal biogenesis

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Neuroprotection of rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement

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Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy

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Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases

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Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

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α-Synuclein Is Degraded by Both Autophagy and the Proteasome

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Genetic clues to the pathogenesis of Parkinson's disease

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Targeting programmed cell death in neurodegenerative diseases

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Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage

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Two molecular pathways initiate mitochondria-dependent dopaminergic neurodegeneration in experimental Parkinson's disease

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Rapamycin pre-treatment protects against apoptosis

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Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster

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Inhibition of mTOR signaling in Parkinson's disease prevents L-DOPA-induced dyskinesia.

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Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy

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A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin.

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A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model.

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Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

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TOR-mediated autophagy regulates cell death in Drosophila neurodegenerative disease

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Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease

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The mTOR kinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6/2 mouse model of Huntington's disease

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Rapamycin inhibits polyglutamine aggregation independently of autophagy by reducing protein synthesis

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Coupling of mammalian target of rapamycin with phosphoinositide 3-kinase signaling pathway regulates protein phosphatase 2A- and glycogen synthase kinase-3 -dependent phosphorylation of Tau

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Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

31 March 2020

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A transient, neuron-wide form of CREB-mediated long-term facilitation can be stabilized at specific synapses by local protein synthesis.

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Rapamycin-sensitive signalling in long-term consolidation of auditory cortex-dependent memory

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Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis

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Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling

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TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model.

31 March 2020

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Rapamycin alleviates toxicity of different aggregate-prone proteins

31 March 2020

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Autophagy protects neuron from Abeta-induced cytotoxicity

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Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease

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Rapamycin promotes beta-amyloid production via ADAM-10 inhibition

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Abeta42-induced neurodegeneration via an age-dependent autophagic-lysosomal injury in Drosophila

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Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

31 March 2020

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Rapamycin treatment augments motor neuron degeneration in SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

31 March 2020

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Degradation of Amyotrophic Lateral Sclerosis-linked Mutant Cu,Zn-Superoxide Dismutase Proteins by Macroautophagy and the Proteasome

31 March 2020

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XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

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Lithium delays progression of amyotrophic lateral sclerosis

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Rapamycin is a neuroprotective treatment for traumatic brain injury.

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mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice.

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Autophagy and amino acid homeostasis are required for chronological longevity in Saccharomyces cerevisiae

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

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Rapamycin extends maximal lifespan in cancer-prone mice

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Recent developments in yeast aging

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Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

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Genetics: influence of TOR kinase on lifespan in C. elegans

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Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

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Activated FOXO-mediated insulin resistance is blocked by reduction of TOR activity.

31 March 2020

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Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

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Genetic links between diet and lifespan: shared mechanisms from yeast to humans

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Aging and survival: the genetics of life span extension by dietary restriction.

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Caloric restriction delays disease onset and mortality in rhesus monkeys

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Overview of caloric restriction and ageing

31 March 2020

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A role for autophagy in the extension of lifespan by dietary restriction in C. elegans

31 March 2020

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TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

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mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex

31 March 2020

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Overview of pharmacology and clinical trials program with the zotarolimus-eluting endeavor stent

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Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma

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Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma

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Consequences of the selective blockage of chaperone-mediated autophagy

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Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization.

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Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma

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Cyclosporine, tacrolimus and sirolimus retain their distinct toxicity profiles despite low doses in the Symphony study

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Neuroinflammation in Parkinson's disease: a target for neuroprotection?

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mTOR regulates memory CD8 T-cell differentiation

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The role of mTOR in memory CD8 T-cell differentiation

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Rapamycin stimulates apoptosis of childhood acute lymphoblastic leukemia cells

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Rapamycin induces apoptosis of JN-DSRCT-1 cells by increasing the Bax : Bcl-xL ratio through concurrent mechanisms dependent and independent of its mTOR inhibitory activity

31 March 2020

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Role of mTOR in physiology and pathology of the nervous system

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Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression.

31 March 2020

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A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus

31 March 2020

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Molecular mechanisms of memory acquisition, consolidation and retrieval

31 March 2020

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Lysosomes: fusion and function

31 March 2020

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The association of AMPK with ULK1 regulates autophagy

31 March 2020

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Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy

31 March 2020

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Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

31 March 2020

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ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

31 March 2020

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ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy

31 March 2020

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FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

31 March 2020

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The role of the Atg1/ULK1 complex in autophagy regulation

31 March 2020

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DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival

31 March 2020

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Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

31 March 2020

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

31 March 2020

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PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

31 March 2020

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Identification of Protor as a novel Rictor-binding component of mTOR complex-2

31 March 2020

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mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s

31 March 2020

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Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

31 March 2020

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Structure of the human mTOR complex I and its implications for rapamycin inhibition.

31 March 2020

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Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

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Targeting mitochondrial dysfunction: role for PINK1 and Parkin in mitochondrial quality control

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Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease

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Lysosomal membrane permeabilization in cell death

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The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice

31 March 2020

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12 December 2020

The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model: a tool to explore the pathogenesis of Parkinson's disease

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12 December 2020

Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.

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12 December 2020

Use of sirolimus in kidney transplantation

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12 December 2020

Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization

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12 December 2020