New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme (Q34994964)

5 August 2017

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title

New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme (English)

1 reference

5 August 2017

Bo Wang

1

1 reference

5 August 2017

Li-Ping Yang

2

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5 August 2017

Xiao-Zhuang Zhang

3

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5 August 2017

Shui-Qing Huang

4

1 reference

5 August 2017

Mark Bartlam

5

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5 August 2017

Shu-Feng Zhou

6

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5 August 2017

language of work or name

English

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publication date

1 January 2009

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5 August 2017

Drug Metabolism Reviews

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5 August 2017

41

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5 August 2017

4

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5 August 2017

573-643

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Identification of human cytochrome p450 isozymes involved in diphenhydramine N-demethylation.

5 August 2017

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Functional analysis of CYP2D6.31 variant: homology modeling suggests possible disruption of redox partner interaction by Arg440His substitution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Metabolism of ipecac alkaloids cephaeline and emetine by human hepatic microsomal cytochrome P450s, and their inhibitory effects on P450 enzyme activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Donepezil use in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Synergistic use of compound properties and docking scores in neural network modeling of CYP2D6 binding: predicting affinity and conformational sampling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Apparent mechanism-based inhibition of human CYP2D6 in vitro by paroxetine: comparison with fluoxetine and quinidine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

CYP2D6 polymorphisms and the impact on tamoxifen therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Novel reversible inactivation of cytochrome P450 2E1 T303A by tert-butyl acetylene: the role of threonine 303 in proton delivery to the active site of cytochrome P450 2E1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Involvement of CYP2D6 but not CYP2C19 in nicergoline metabolism in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Coordinated intrahepatic and extrahepatic regulation of cytochrome p4502D6 in healthy subjects and in patients after liver transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

The effect of mutation of F87 on the properties of CYP102A1-CYP4C7 chimeras: altered regiospecificity and substrate selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Neurosteroids: biosynthesis and function of these novel neuromodulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Substrate-assisted catalysis in cytochrome P450eryF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Mutations in the CYP11B1 gene causing congenital adrenal hyperplasia and hypertension cluster in exons 6, 7, and 8

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Characterization of novel dihydrothienopyridinium and thienopyridinium metabolites of ticlopidine in vitro: role of peroxidases, cytochromes p450, and monoamine oxidases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Catalytic site prediction and virtual screening of cytochrome P450 2D6 substrates by consideration of water and rescoring in automated docking.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

The gastroprokinetic and antiemetic drug metoclopramide is a substrate and inhibitor of cytochrome P450 2D6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Role of specific cytochrome P450 isoforms in the conversion of phenoxypropoxybiguanide analogs in human liver microsomes to potent antimalarial dihydrotriazines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Chromosomal assignment of human cytochrome P-450 (debrisoquine/sparteine type) to chromosome 22.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Structural basis for ligand promiscuity in cytochrome P450 3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Identification and characterization of a novel protein (p137) which transcytoses bidirectionally in Caco-2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Influence of amino acid residue 374 of cytochrome P-450 2D6 (CYP2D6) on the regio- and enantio-selective metabolism of metoprolol

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Nonhuman primate models of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Functional properties of CYP2D6 1 (wild-type) and CYP2D6 7 (His324Pro) expressed by recombinant baculovirus in insect cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

The role of lipophilicity in the inhibition of polymorphic cytochrome P450IID6 oxidation by beta-blocking agents in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

A brief history of testosterone

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

The decreased in vivo clearance of CYP2D6 substrates by CYP2D6*10 might be caused not only by the low-expression but also by low affinity of CYP2D6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Inhibition of drug metabolism in human liver microsomes by nizatidine, cimetidine and omeprazole

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

The CYP2D6 gene locus in South African Coloureds: unique allele distributions, novel alleles and gene arrangements.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

CYP2D6 is primarily responsible for the metabolism of clomiphene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Metabolism of MPTP by cytochrome P4502D6 and the demonstration of 2D6 mRNA in human foetal and adult brain by in situ hybridization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Characterization of the common genetic defect in humans deficient in debrisoquine metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

A computational procedure for determining energetically favorable binding sites on biologically important macromolecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Identification of human p450 isoforms involved in the metabolism of the antiallergic drug, oxatomide, and its inhibitory effect on enzyme activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Identification of human P450 isoforms involved in the metabolism of the antiallergic drug, oxatomide, and its kinetic parameters and inhibition constants

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Atypical metabolism of deprenyl and its enantiomer, (S)-(+)-N,alpha-dimethyl-N-propynylphenethylamine, by cytochrome P450 2D6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Identification of the main epitope on human cytochrome P450 IID6 recognized by anti-liver kidney microsome antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Role of glutamic acid 216 in cytochrome P450 2D6 substrate binding and catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Diversity in the oxidation of substrates by cytochrome P450 2D6: lack of an obligatory role of aspartate 301-substrate electrostatic bonding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Pivotal role of water in the mechanism of P450BM-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Comparative molecular field analysis and QSAR on substrates binding to cytochrome p450 2D6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

An investigation of the interaction between halofantrine, CYP2D6 and CYP3A4: studies with human liver microsomes and heterologous enzyme expression systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Heterologous expression of cytochrome P450 2D6 mutants, electron transfer, and catalysis of bufuralol hydroxylation: the role of aspartate 301 in structural integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Diversity in mechanisms of substrate oxidation by cytochrome P450 2D6. Lack of an allosteric role of NADPH-cytochrome P450 reductase in catalytic regioselectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

QM/MM modeling of compound I active species in cytochrome P450, cytochrome C peroxidase, and ascorbate peroxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Structure and function of cytochromes P450: a comparative analysis of three crystal structures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Inhibitory effects of H1-antihistamines on CYP2D6- and CYP2C9-mediated drug metabolic reactions in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

The in vitro inhibitory potential of trade herbal products on human CYP2D6-mediated metabolism and the influence of ethanol

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Neurosteroid modulation of synaptic and extrasynaptic GABAA receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Mechanism-based inactivation of CYP2D6 by methylenedioxymethamphetamine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Mechanisms of acetaminophen toxicity: immunochemical detection of drug-protein adducts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Catalytic specificity of CYP2D isoforms in rat and human

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Dopamine formation from tyramine by CYP2D6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Progesterone oxidation by cytochrome P450 2D isoforms in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

X-ray crystal structure and catalytic properties of Thr252Ile mutant of cytochrome P450cam: roles of Thr252 and water in the active center

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Impact of plasticity and flexibility on docking results for cytochrome P450 2D6: a combined approach of molecular dynamics and ligand docking.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Effect of carbonate anion on cytochrome P450 2D6-mediated metabolism in vitro: the potential role of multiple oxygenating species

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Inhibition of cytochrome P450 2D6: structure-activity studies using a series of quinidine and quinine analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

An additional defective allele, CYP2C19*5, contributes to the S-mephenytoin poor metabolizer phenotype in Caucasians

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Uncoupling of the cytochrome P-450cam monooxygenase reaction by a single mutation, threonine-252 to alanine or valine: possible role of the hydroxy amino acid in oxygen activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

A three-dimensional molecular template for substrates of human cytochrome P450 involved in debrisoquine 4-hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Molecular basis of aromatase deficiency in an adult female with sexual infantilism and polycystic ovaries

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

The contribution of the MPTP-treated primate model to the development of new treatment strategies for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Influence of Lipophilicity on the Interactions ofN-Alkyl-4-phenyl-1,2,3,6-tetrahydropyridines and Their Positively Charged N-Alkyl-4-phenylpyridinium Metabolites with Cytochrome P450 2D6

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Metabolic regio- and stereoselectivity of cytochrome P450 2D6 towards 3,4-methylenedioxy-N-alkylamphetamines: in silico predictions and experimental validation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Influence of phenylalanine 120 on cytochrome P450 2D6 catalytic selectivity and regiospecificity: crucial role in 7-methoxy-4-(aminomethyl)-coumarin metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Role of the conserved threonine 309 in mechanism of oxidation by cytochrome P450 2D6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Impact of incorporating the 2C5 crystal structure into comparative models of cytochrome P450 2D6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Cytochrome P450 2D Catalyze Steroid 21-Hydroxylation in the Brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Novel binding mode of the acidic CYP2D6 substrates pactimibe and its metabolite R-125528.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Effects of ketoconazole and quinidine on pharmacokinetics of pactimibe and its plasma metabolite, R-125528, in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

CYP2D6-Mediated metabolism of a novel acyl coenzyme A:cholesterol acyltransferase inhibitor, pactimibe, and its unique plasma metabolite, R-125528.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

The contributions of cytochromes P450 3A4 and 3A5 to the metabolism of the phosphodiesterase type 5 inhibitors sildenafil, udenafil, and vardenafil

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Frequencies of CYP2D6 mutant alleles in a normal Japanese population and metabolic activity of dextromethorphan O-demethylation in different CYP2D6 genotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

An analysis of the role of active site protic residues of cytochrome P-450s: mechanistic and mutational studies on 17alpha-hydroxylase-17,20-lyase (P-45017alpha also CYP17).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzyme-specific probe substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Structures of Prostacyclin Synthase and Its Complexes with Substrate Analog and Inhibitor Reveal a Ligand-specific Heme Conformation Change

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

The role of phenylalanine 483 in cytochrome P450 2D6 is strongly substrate dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Active-site topologies of human CYP2D6 and its aspartate-301 --> glutamate, asparagine, and glycine mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolite formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Comparative in vitro and in vivo inhibition of cytochrome P450 CYP1A2, CYP2D6, and CYP3A by H2-receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

A novel mutant variant of the CYP2D6 gene (CYP2D6*17) common in a black African population: association with diminished debrisoquine hydroxylase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Roles of phenylalanine at position 120 and glutamic acid at position 222 in the oxidation of chiral substrates by cytochrome P450 2D6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Change in enantioselectivity in bufuralol 1''-hydroxylation by the substitution of phenylalanine-120 by alanine in cytochrome P450 2D6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Involvement of multiple human cytochromes P450 in the liver microsomal metabolism of astemizole and a comparison with terfenadine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Two novel CYP2D6*10 haplotypes as possible causes of a poor metabolic phenotype in Japanese

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Chemistry, Pharmacology, Toxicology, and Hepatic Metabolism of Designer Drugs of the Amphetamine (Ecstasy), Piperazine, and Pyrrolidinophenone Types

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Inhibition of recombinant cytochrome P450 isoforms 2D6 and 2C9 by diverse drug-like molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Substrate selectivity of human cytochrome P450 2C9: importance of residues 476, 365, and 114 in recognition of diclofenac and sulfaphenazole and in mechanism-based inactivation by tienilic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Structure conservation in cytochromes P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

The role of human hepatic cytochrome P450 isozymes in the metabolism of racemic 3,4-methylenedioxyethylamphetamine and its single enantiomers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

The molecular mechanisms of two common polymorphisms of drug oxidation--evidence for functional changes in cytochrome P-450 isozymes catalysing bufuralol and mephenytoin oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Neurosteroid modulation of GABAA receptors: molecular determinants and significance in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Differences in antigenic sites, recognized by anti-liver-kidney microsome-1 (LKM-1) autoantibody, between HCV-positive and HCV-negative sera in Japanese patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

A model for human cytochrome P450 2D6 based on homology modeling and NMR studies of substrate binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Desacetyl-diltiazem displays severalfold higher affinity to CYP2D6 compared with CYP3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Functional analysis of phenylalanine residues in the active site of cytochrome P450 2C9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Crystallographic study on the dioxygen complex of wild-type and mutant cytochrome P450cam. Implications for the dioxygen activation mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Enantioselectivity of bunitrolol 4-hydroxylation is reversed by the change of an amino acid residue from valine to methionine at position 374 of cytochrome P450-2D6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Contribution of human hepatic cytochrome P450 isoforms to regioselective hydroxylation of steroid hormones.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Genetic polymorphism of phenformin 4-hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Identification and analysis of conserved sequence motifs in cytochrome P450 family 2. Functional and structural role of a motif 187RFDYKD192 in CYP2B enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Inhibitory effects of amiodarone and its N-deethylated metabolite on human cytochrome P450 activities: prediction of in vivo drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Design, synthesis, and characterization of 7-methoxy-4-(aminomethyl)coumarin as a novel and selective cytochrome P450 2D6 substrate suitable for high-throughput screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Identification of cytochrome P450 enzymes involved in the metabolism of the new designer drug 4'-methyl-alpha-pyrrolidinobutyrophenone

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Structures of human cytochrome P-450 2E1. Insights into the binding of inhibitors and both small molecular weight and fatty acid substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Disposition of lasofoxifene, a next-generation selective estrogen receptor modulator, in healthy male subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

In vitro metabolism of chloroquine: identification of CYP2C8, CYP3A4, and CYP2D6 as the main isoforms catalyzing N-desethylchloroquine formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Crystal structure of the cytochrome P-450CAM active site mutant Thr252Ala

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

A novel intronic mutation, 2988G>A, with high predictivity for impaired function of cytochrome P450 2D6 in white subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Crystal structure of hemoprotein domain of P450BM-3, a prototype for microsomal P450's

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Interactions of two major metabolites of prasugrel, a thienopyridine antiplatelet agent, with the cytochromes P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Summary of information on human CYP enzymes: human P450 metabolism data

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Identification of the human cytochromes P450 responsible for atomoxetine metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Crystal structure of human cytochrome P450 2D6

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

QSAR studies of CYP2D6 inhibitor aryloxypropanolamines using 2D and 3D descriptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Functional characterization of 17 CYP2D6 allelic variants (CYP2D6.2, 10, 14A-B, 18, 27, 36, 39, 47-51, 53-55, and 57).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Identification of the human liver enzymes involved in the metabolism of the antimigraine agent almotriptan

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Pharmacology of dihydroergotamine and evidence for efficacy and safety in migraine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Substrate interaction with cytochrome P-450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Do mammalian cytochrome P450s show multiple ligand access pathways and ligand channelling?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

The catalytic pathway of cytochrome p450cam at atomic resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Determinants of Cytochrome P450 2C8 Substrate Binding: STRUCTURES OF COMPLEXES WITH MONTELUKAST, TROGLITAZONE, FELODIPINE, AND 9-CIS-RETINOIC ACID

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

An open conformation of mammalian cytochrome P450 2B4 at 1.6-Å resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-A resolution: insight into the range of P450 conformations and the coordination of redox partner binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Contribution of cytochrome P450 2D6 to 3,4-methylenedioxymethamphetamine disposition in humans: use of paroxetine as a metabolic inhibitor probe

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Structure of the human lung cytochrome P450 2A13

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

The endocannabinoid anandamide is a substrate for the human polymorphic cytochrome P450 2D6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Polymorphic hydroxylation of perhexiline in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

The effect of enzyme inhibition on the metabolism and activation of tacrine by human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Identification of cytochrome p450 enzymes involved in the metabolism of 4'-methyl-alpha-pyrrolidinopropiophenone, a novel scheduled designer drug, in human liver microsomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Studies on the metabolism and toxicological detection of the new designer drug 4'-methyl-alpha-pyrrolidinopropiophenone in urine using gas chromatography-mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

New designer drug 4′-methyl-α-pyrrolidinohexanophenone: studies on its metabolism and toxicological detection in urine using gas chromatography–mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Binding of 7-methoxy-4-(aminomethyl)-coumarin to wild-type and W128F mutant cytochrome P450 2D6 studied by time-resolved fluorescence spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Cytochrome P450 fluorometric substrates: identification of isoform-selective probes for rat CYP2D2 and human CYP3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Development of a pharmacophore for inhibition of human liver cytochrome P-450 2D6: molecular modeling and inhibition studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Structural analysis of CYP2R1 in complex with vitamin D3

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Ligand-based models for the isoform specificity of cytochrome P450 3A4, 2D6, and 2C9 substrates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Cytochrome P450 isoforms involved in metabolism of the enantiomers of verapamil and norverapamil

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Progesterone biosynthesis and action in the developing neuron

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Alteration in catalytic properties of human CYP2D6 caused by substitution of glycine-42 with arginine, lysine and glutamic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Functional evaluation of cytochrome P450 2D6 with Gly42Arg substitution expressed in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Metabolism of dextrorphan by CYP2D6 in different recombinantly expressed systems and its implications for the in vitro assessment of dextromethorphan metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Topological role of cytochrome P450 2D6 active site residues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Epoxidation of olefins by cytochrome P450: evidence from site-specific mutagenesis for hydroperoxo-iron as an electrophilic oxidant

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Peroxo-iron and oxenoid-iron species as alternative oxygenating agents in cytochrome P450-catalyzed reactions: switching by threonine-302 to alanine mutagenesis of cytochrome P450 2B4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Evaluation of a novel high-throughput assay for cytochrome P450 2D6 using 7-methoxy-4-(aminomethyl)-coumarin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Zolpidem metabolism in vitro: responsible cytochromes, chemical inhibitors, and in vivo correlations

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Microsomal P450 2C3 is expressed as a soluble dimer in Escherichia coli following modification of its N-terminus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

The involvement of CYP3A4 and CYP2C9 in the metabolism of 17 alpha-ethinylestradiol

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Characterization of the CYP2D6*29 allele commonly present in a black Tanzanian population causing reduced catalytic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Structure of a substrate complex of mammalian cytochrome P450 2C5 at 2.3 A resolution: evidence for multiple substrate binding modes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

The structure of human cytochrome P450 2C9 complexed with flurbiprofen at 2.0-A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Crystal structure of human cytochrome P450 2C9 with bound warfarin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Comparison of the dynamics of substrate access channels in three cytochrome P450s reveals different opening mechanisms and a novel functional role for a buried arginine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Interactions of amphetamine analogs with human liver CYP2D6

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Human prostate CYP3A5: identification of a unique 5'-untranslated sequence and characterization of purified recombinant protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05-A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

The roles of CYP2D6 and stereoselectivity in the clinical pharmacokinetics of chlorpheniramine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

The role of Thr268 in oxygen activation of cytochrome P450BM-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Identification of human CYP isoforms involved in the metabolism of propranolol enantiomers--N-desisopropylation is mediated mainly by CYP1A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Indolealkylamines: biotransformations and potential drug-drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Regeneration of serotonin from 5-methoxytryptamine by polymorphic human CYP2D6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

In silico prediction of drug binding to CYP2D6: identification of a new metabolite of metoclopramide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Identification of human liver cytochrome P450 enzymes that metabolize the nonsedating antihistamine loratadine. Formation of descarboethoxyloratadine by CYP3A4 and CYP2D6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Crystal structure of the FMN-binding domain of human cytochrome P450 reductase at 1.93 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: insight into P450 conformational plasticity and membrane interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Drug bioactivation, covalent binding to target proteins and toxicity relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Polymorphism of human cytochrome P450 enzymes and its clinical impact

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Clinical pharmacogenetics and potential application in personalized medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Substrate specificity, inhibitors and regulation of human cytochrome P450 2D6 and implications in drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Molecular Modeling-Guided Site-Directed Mutagenesis of Cytochrome P450 2D6

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Metabolism ofN-substituted 7-methoxy-4-(aminomethyl) -coumarins by cytochrome P450 2D6 mutants and the indication of additional substrate interaction points

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Characterization of Diuron N-Demethylation by Mammalian Hepatic Microsomes and cDNA-Expressed Human Cytochrome P450 Enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Validation of Model of Cytochrome P450 2D6: An in Silico Tool for Predicting Metabolism and Inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine as a Substrate of Cytochrome P450 2D6: Allosteric Effects of NADPH−Cytochrome P450 Reductase†

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530903118729

10.1080/03602530903118729

21 January 2018

Identifiers

DOI

1 reference

5 August 2017

1 reference