Pancreatic function, type 2 diabetes, and metabolism in aging (Q35996598)

11 August 2017

Pancreatic function, type 2 diabetes, and metabolism in aging (English)

1 reference

11 August 2017

1 reference

Zhenwei Gong

1

1 reference

PMC publication ID

3362843

11 August 2017

Radhika H Muzumdar

series ordinal

2

1 reference

11 August 2017

17 May 2012

1 reference

International journal of endocrinology

11 August 2017

1 reference

11 August 2017

2012

1 reference

11 August 2017

320482

1 reference

Creative Commons Attribution 3.0 Unported

11 August 2017

start time

1 January 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

1 reference

April 2022 Public Data File from Crossref

cites work

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Age-dependent decline in beta-cell proliferation restricts the capacity of beta-cell regeneration in mice

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Differential expression of GLUT2 in pancreatic islets and kidneys of New and Old World nonhuman primates

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Central insulin action regulates peripheral glucose and fat metabolism in mice

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Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas

2 October 2017

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The role for endoplasmic reticulum stress in diabetes mellitus

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Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice

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beta-cell Regeneration: neogenesis, replication or both?

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Effect of aging on insulin secretory function and expression of beta cell function-related genes of islets

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Reduced eIF2alpha phosphorylation and increased proapoptotic proteins in aging

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p16INK4a induces an age-dependent decline in islet regenerative potential

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Aging correlates with decreased beta-cell proliferative capacity and enhanced sensitivity to apoptosis: a potential role for Fas and pancreatic duodenal homeobox-1

2 October 2017

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Insulin signaling in the central nervous system: learning to survive

2 October 2017

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Diabetes mellitus in the elderly: insulin resistance and/or impaired insulin secretion?

2 October 2017

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Dietary and genetic control of glucose transporter 2 glycosylation promotes insulin secretion in suppressing diabetes

2 October 2017

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Islet neogenesis: a potential therapeutic tool in type 1 diabetes

2 October 2017

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Innate immunity and inflammation in ageing: a key for understanding age-related diseases

2 October 2017

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2 October 2017

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Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth

2 October 2017

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Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes?

2 October 2017

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Ink4a/Arf expression is a biomarker of aging

2 October 2017

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Adipose tissue as an endocrine organ

2 October 2017

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The evolving diabetes burden in the United States

2 October 2017

1 reference

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Bmi1, stem cells, and senescence regulation

2 October 2017

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Obesity is associated with macrophage accumulation in adipose tissue

2 October 2017

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Calorie restriction and aging: review of the literature and implications for studies in humans

2 October 2017

1 reference

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Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number

2 October 2017

1 reference

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Tumor suppression by Ink4a-Arf: progress and puzzles

2 October 2017

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Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

2 October 2017

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Aging and insulin secretion

2 October 2017

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Diabetes mellitus and the central nervous system

2 October 2017

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Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process?

2 October 2017

1 reference

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Effects of age on elements of insulin-signaling pathway in central nervous system of rats

2 October 2017

1 reference

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Macrophage migration inhibitory factor (MIF) sustains macrophage proinflammatory function by inhibiting p53: regulatory role in the innate immune response

2 October 2017

1 reference

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Insights into insulin resistance and type 2 diabetes from knockout mouse models

2 October 2017

1 reference

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Syntaxin 1 interacts with the L(D) subtype of voltage-gated Ca(2+) channels in pancreatic beta cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3362843

Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3362843

Body composition, visceral fat, leptin, and insulin resistance in Asian Indian men.

2 October 2017

2 references

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2 October 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3362843

Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity

14 November 2018

1 reference

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Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3362843

Physical and functional interactions of Doc2 and Munc13 in Ca2+-dependent exocytotic machinery

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3362843

Cloning and sequencing of the pancreatic islet neogenesis associated protein (INGAP) gene and its expression in islet neogenesis in hamsters

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3362843

Glucokinase mutations, insulin secretion, and diabetes mellitus

2 October 2017

1 reference

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Role of insulin resistance in the pathogenesis of NIDDM.

2 October 2017

1 reference

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Mechanism of free fatty acid-induced insulin resistance in humans

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3362843

Soluble N-ethylmaleimide-sensitive-factor attachment protein and N-ethylmaleimide-insensitive factors are required for Ca2+-stimulated exocytosis of insulin.

2 October 2017

1 reference

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Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide.

2 October 2017

1 reference

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Mechanisms of fatty acid-induced inhibition of glucose uptake

2 October 2017

1 reference

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Calcium dependence of the rate of exocytosis in a synaptic terminal

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3362843

SNAP-25 is expressed in islets of Langerhans and is involved in insulin release.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3362843

Identification of synaptic proteins and their isoform mRNAs in compartments of pancreatic endocrine cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3362843

VAMP-2 and cellubrevin are expressed in pancreatic beta-cells and are essential for Ca(2+)-but not for GTP gamma S-induced insulin secretion

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3362843

Effects of fat on glucose uptake and utilization in patients with non-insulin-dependent diabetes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3362843

Impaired growth hormone secretion in the adult population: relation to age and adiposity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3362843

Glucose intolerance and aging

2 October 2017

1 reference

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Characterization of the insulin resistance of aging

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3362843

Subcutaneous and visceral fat distribution according to sex, age, and overweight, evaluated by computed tomography

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3362843

Effects of aging on insulin synthesis and secretion. Differential effects on preproinsulin messenger RNA levels, proinsulin biosynthesis, and secretion of newly made and preformed insulin in the rat

2 October 2017

1 reference

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Banting lecture 1988. Role of insulin resistance in human disease

2 October 2017

1 reference

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Effects of meal ingestion on plasma amylin concentration in NIDDM and nondiabetic humans.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3362843

Effects of fat on insulin-stimulated carbohydrate metabolism in normal men

2 October 2017

1 reference

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Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3362843

Independent influence of age on basal insulin secretion in nondiabetic humans. European Group for the Study of Insulin Resistance

27 July 2018

1 reference

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Arm and leg composition determined by computed tomography in young and elderly men.

27 July 2018

1 reference

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Adaptation of islets of Langerhans to pregnancy: increased islet cell proliferation and insulin secretion correlates with the onset of placental lactogen secretion

27 July 2018

1 reference

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Role of body fat distribution in the decline in insulin sensitivity and glucose tolerance with age

27 July 2018

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Prevalence of diabetes and impaired fasting glucose in adults in the U.S. population: National Health And Nutrition Examination Survey 1999-2002.

27 July 2018

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Pathogenesis of age-related glucose intolerance in man: insulin resistance and decreased beta-cell function.

21 January 2018

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Oxidative stress, beta-cell apoptosis, and decreased insulin secretory capacity in mouse models of hemochromatosis.

21 January 2018

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Linear correlation between beta-cell mass and body weight throughout the lifespan in Lewis rats: role of beta-cell hyperplasia and hypertrophy

21 January 2018

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Functional and molecular defects of pancreatic islets in human type 2 diabetes

21 January 2018

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Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients.

21 January 2018

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ROP, the Drosophila Sec1 homolog, interacts with syntaxin and regulates neurotransmitter release in a dosage-dependent manner.

21 January 2018

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Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets

21 January 2018

1 reference

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Impaired islet turnover in human donor pancreata with aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F320482

The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F320482

In vitro generation of insulin-producing beta cells from adult exocrine pancreatic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F320482

Intramuscular injection of islet neogenesis-associated protein peptide stimulates pancreatic islet neogenesis in healthy dogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F320482

Cellular origins of adult human islet in vitro dedifferentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F320482

Combination therapy with epidermal growth factor and gastrin induces neogenesis of human islet {beta}-cells from pancreatic duct cells and an increase in functional {beta}-cell mass

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F320482

Glucagon-like peptide-1 and exendin-4 stimulate beta-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F320482

Insulin resistance and beta-cell dysfunction in aging: the importance of dietary carbohydrate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F320482

Prevalence of diabetes and impaired glucose tolerance and plasma glucose levels in U.S. population aged 20-74 yr.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F320482

Age or waist as determinant of insulin action?

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F320482

Increased susceptibility to insulin resistance associated with abdominal obesity in aging rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F320482

Intra-abdominal fat is a major determinant of the National Cholesterol Education Program Adult Treatment Panel III criteria for the metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F320482

Association of resistin with visceral fat and muscle insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F320482

Differential gene expression between visceral and subcutaneous fat depots

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F320482

Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F320482

Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F320482

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F320482

Memory improvement following induced hyperinsulinemia in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F320482

Enhancement of memory in Alzheimer disease with insulin and somatostatin, but not glucose.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F320482

Impaired central insulin response in aged Wistar rats: role of adiposity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F320482

The role of leptin resistance in the lipid abnormalities of aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F320482

Determinants of postabsorptive endogenous glucose output in non-diabetic subjects. European Group for the Study of Insulin Resistance (EGIR).

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F320482

Skeletal muscle GLUT4 protein concentration and aging in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F320482

Insulin action and age. European Group for the Study of Insulin Resistance (EGIR).

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F320482

Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-beta in memory-impaired older adults.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3362843

High content of mitochondrial glycerol-3-phosphate dehydrogenase in pancreatic islets and its inhibition by diazoxide.

23 September 2018

1 reference

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Ink4a/Arf expression is a biomarker of aging

23 September 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F320482

"Portal" adipose tissue as a generator of risk factors for cardiovascular disease and diabetes

21 January 2018

1 reference

12 December 2020

Induction of nesidioblastosis will reverse diabetes in Syrian golden hamster

1 reference

12 December 2020

Free fatty acid and glucose metabolism in human aging: evidence for operation of the Randle cycle

1 reference

12 December 2020

Leptin gene expression increases with age independent of increasing adiposity in rats

1 reference

12 December 2020

Circadian and age-dependent expression patterns of GLUT2 and glucokinase in the pancreatic beta-cell of diabetic and nondiabetic rats

1 reference

12 December 2020

Insulin action in aging man: evidence for tissue-specific differences at low physiologic insulin levels

1 reference

12 December 2020

Age changes in body composition revealed by computed tomography

1 reference

12 December 2020

Sexual dimorphism of age-related changes in whole-body fat distribution in the obese

1 reference

12 December 2020

Age-dependent inability of the endocrine pancreas to adapt to pregnancy: a long-term consequence of perinatal malnutrition in the rat

1 reference

12 December 2020

Comparison of body composition in middle-aged and elderly males using computed tomography

1 reference

12 December 2020

The effect of glucose on insulin release and ion movements in isolated pancreatic islets of rats in old age

1 reference

12 December 2020

Diabetes in pregnancy: growth of the fetal pancreatic B cells in the rat

1 reference

12 December 2020

1 reference

12 December 2020

Effect of age on glucose oxidation by isolated rat islets

1 reference

12 December 2020

Cytosolic calcium facilitates release of secretory products after exocytotic vesicle fusion

1 reference

12 December 2020

The Human Visceral Fat Depot Has a Unique Inflammatory Profile

1 reference

12 December 2020

GLUT2 expression and function in beta-cells of GK rats with NIDDM. Dissociation between reductions in glucose transport and glucose-stimulated insulin secretion

1 reference

12 December 2020

Evidence of an age-related decline in mitochondrial glycerophosphate dehydrogenase activity of isolated rat islets

1 reference

12 December 2020

Evaluation of beta-cell replication in mice transgenic for hepatocyte growth factor and placental lactogen: comprehensive characterization of the G1/S regulatory proteins reveals unique involvement of p21cip

1 reference

12 December 2020

Identifiers

DOI

10.1155/2012/320482

1 reference

11 August 2017

1 reference

PMC publication ID

3362843

11 August 2017

PubMed publication ID

22675349

1 reference

PMC publication ID

3362843