Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex (Q36143620)

12 August 2017

Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex (English)

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12 August 2017

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12 August 2017

Oliver T Fackler

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Andrea Imle

object named as

Andrea Imle

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Libin Abraham

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object named as

Libin Abraham

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12 August 2017

Nikolaos Tsopoulidis

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12 August 2017

Bernard Hoflack

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12 August 2017

language of work or name

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8 September 2015

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6

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e01309-15

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describes a project that uses

12 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4600113/fullTextXML

inferred from PubMed Central ID database lookup

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Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action

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2 October 2017

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Adult AIDS-like disease in a novel inducible human immunodeficiency virus type 1 Nef transgenic mouse model: CD4+ T-cell activation is Nef dependent and can occur in the absence of lymphophenia

2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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HIV-1 Nef binds PACS-2 to assemble a multikinase cascade that triggers major histocompatibility complex class I (MHC-I) down-regulation: analysis using short interfering RNA and knock-out mice.

2 October 2017

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HIV-1 Nef disrupts the podocyte actin cytoskeleton by interacting with diaphanous interacting protein

2 October 2017

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HIV-1 Nef employs two distinct mechanisms to modulate Lck subcellular localization and TCR induced actin remodeling

2 October 2017

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Association of Nef with p21-activated kinase 2 is dispensable for efficient human immunodeficiency virus type 1 replication and cytopathicity in ex vivo-infected human lymphoid tissue

2 October 2017

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Dynamin 2 is required for the enhancement of HIV-1 infectivity by Nef.

2 October 2017

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Regulation of T-cell activation by the cytoskeleton

2 October 2017

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Specific and distinct determinants mediate membrane binding and lipid raft incorporation of HIV-1(SF2) Nef.

2 October 2017

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Nef-Mediated Suppression of T Cell Activation Was Lost in a Lentiviral Lineage that Gave Rise to HIV-1

2 October 2017

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A hydrophobic binding surface on the human immunodeficiency virus type 1 Nef core is critical for association with p21-activated kinase 2.

2 October 2017

1 reference

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Proteomic analysis of adaptor protein 1A coats selectively assembled on liposomes

2 October 2017

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Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef.

2 October 2017

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Nef associates with p21-activated kinase 2 in a p21-GTPase-dependent dynamic activation complex within lipid rafts.

2 October 2017

1 reference

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Human immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid rafts

2 October 2017

1 reference

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HIV-1 Nef binds the DOCK2-ELMO1 complex to activate rac and inhibit lymphocyte chemotaxis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600113

Ral GTPases regulate exocyst assembly through dual subunit interactions

2 October 2017

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Cdc42/Rac1-mediated activation primes PAK2 for superactivation by tyrosine phosphorylation

2 October 2017

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Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1

2 October 2017

1 reference

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The exocyst complex binds the small GTPase RalA to mediate filopodia formation

2 October 2017

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A natural variability in the proline-rich motif of Nef modulates HIV-1 replication in primary T cells.

2 October 2017

1 reference

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Structure--function relationships in HIV-1 Nef.

2 October 2017

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Human immunodeficiency virus type 1 Nef selectively associates with a catalytically active subpopulation of p21-activated kinase 2 (PAK2) independently of PAK2 binding to Nck or beta-PIX

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600113

p21-activated kinase 1 plays a critical role in cellular activation by Nef.

2 October 2017

1 reference

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HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4600113

Identification of the Nef-associated kinase as p21-activated kinase 2

2 October 2017

1 reference

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Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions

2 October 2017

1 reference

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HIV-1 Nef increases T cell activation in a stimulus-dependent manner

2 October 2017

1 reference

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Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking

2 October 2017

1 reference

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Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity

2 October 2017

1 reference

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Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4

2 October 2017

1 reference

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The Exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae

2 October 2017

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Human immunodeficiency virus type 1 Nef associates with a member of the p21-activated kinase family

2 October 2017

1 reference

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Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein

2 October 2017

1 reference

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Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene.

2 October 2017

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Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection

2 October 2017

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Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis

2 October 2017

1 reference

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Human immunodeficiency virus type 1 Nef increases the efficiency of reverse transcription in the infected cell

2 October 2017

1 reference

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Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients

2 October 2017

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Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

2 October 2017

1 reference

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HIV-1 Nef disrupts membrane-microdomain-associated anterograde transport for plasma membrane delivery of selected Src family kinases

2 October 2017

1 reference

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HIV-1 Nef inhibits ruffles, induces filopodia, and modulates migration of infected lymphocytes

2 July 2018

1 reference

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Inhibition of T-cell receptor-induced actin remodeling and relocalization of Lck are evolutionarily conserved activities of lentiviral Nef proteins

2 July 2018

1 reference

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Human immunodeficiency virus type 1 Nef recruits the guanine exchange factor Vav1 via an unexpected interface into plasma membrane microdomains for association with p21-activated kinase 2 activity

2 July 2018

1 reference

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The HIV-1 pathogenicity factor Nef interferes with maturation of stimulatory T-lymphocyte contacts by modulation of N-Wasp activity

2 July 2018

1 reference

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HIV-1 Nef limits communication between linker of activated T cells and SLP-76 to reduce formation of SLP-76-signaling microclusters following TCR stimulation.

2 July 2018

1 reference

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HIV-1 Nef compensates for disorganization of the immunological synapse by inducing trans-Golgi network-associated Lck signaling

23 September 2018

1 reference

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Exo70 interacts with the Arp2/3 complex and regulates cell migration

23 September 2018

1 reference

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Human immunodeficiency virus type-1 infection impairs the formation of the immunological synapse

23 September 2018

1 reference

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The Nef protein of human immunodeficiency virus establishes superinfection immunity by a dual strategy to downregulate cell-surface CCR5 and CD4.

23 September 2018

1 reference

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Hyper-responsiveness to stimulation of human immunodeficiency virus-infected CD4+ T cells requires Nef and Tat virus gene products and results from higher NFAT, NF-kappaB, and AP-1 induction

23 September 2018

1 reference

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HIV Nef inhibits T cell migration.

23 September 2018

1 reference

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HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes.

23 September 2018

1 reference

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Massive Secretion by T Cells Is Caused by HIV Nef in Infected Cells and by Nef Transfer to Bystander Cells

23 September 2018

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12 December 2020

Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice

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12 December 2020

The exocyst is a Ral effector complex

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12 December 2020

Attenuated retrovirus vaccines and AIDS

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12 December 2020

The N-Terminus of Nef from HIV-1/SIV Associates with a Protein Complex Containing Lck and a Serine Kinase

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12 December 2020

Identifiers

DOI

10.1128/MBIO.01309-15

1 reference

12 August 2017

1 reference

12 August 2017

PubMed publication ID

26350970

1 reference