Comparison of rapamycin schedules in mice on high-fat diet (Q36189078)

12 August 2017

Comparison of rapamycin schedules in mice on high-fat diet (English)

1 reference

12 August 2017

1 reference

3

Mikhail V Blagosklonny

1 reference

12 August 2017

Olga V Leontieva

1

1 reference

PMCID

4614913

12 August 2017

Geraldine M Paszkiewicz

series ordinal

2

1 reference

12 August 2017

1 January 2014

1 reference

12 August 2017

1 reference

12 August 2017

13

1 reference

12 August 2017

3350-3356

1 reference

12 August 2017

21

1 reference

Fasting levels of hepatic p-S6 are increased in old mice

12 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Rapamycin-induced metabolic defects are reversible in both lean and obese mice

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Contact inhibition and high cell density deactivate the mammalian target of rapamycin pathway, thus suppressing the senescence program

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Rapamycin reverses insulin resistance (IR) in high-glucose medium without causing IR in normoglycemic medium

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Beneficial metabolic effects of rapamycin are associated with enhanced regulatory cells in diet-induced obese mice

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Weekly administration of rapamycin improves survival and biomarkers in obese male mice on high-fat diet

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Lifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses of rapamycin

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

BMAL1-dependent regulation of the mTOR signaling pathway delays aging

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Immunostimulatory activity of lifespan-extending agents.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

eRapa restores a normal life span in a FAP mouse model.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Metformin: do we finally have an anti-aging drug?

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Rapamycin enhances long-term hematopoietic reconstitution of ex vivo expanded mouse hematopoietic stem cells by inhibiting senescence

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Increased mammalian target of rapamycin complex 2 signaling promotes age-related decline in CD4 T cell signaling and function

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Rapamycin extends life- and health span because it slows aging

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Metformin improves healthspan and lifespan in mice

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

M(o)TOR of aging: MTOR as a universal molecular hypothalamus

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Rapamycin extends murine lifespan but has limited effects on aging

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Late-life rapamycin treatment reverses age-related heart dysfunction.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Rapamycin extends life and health in C57BL/6 mice

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Common drugs and treatments for cancer and age-related diseases: revitalizing answers to NCI's provocative questions

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Rapamycin extends life span of Rb1+/- mice by inhibiting neuroendocrine tumors

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Resveratrol potentiates rapamycin to prevent hyperinsulinemia and obesity in male mice on high fat diet

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

mTOR in aging, metabolism, and cancer

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Genetics of longevity in model organisms: debates and paradigm shifts

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/- mice

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53-/- mice by delaying carcinogenesis

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Sarcopenia, obesity, and natural killer cell immune senescence in aging: altered cytokine levels as a common mechanism

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

How to save Medicare: the anti-aging remedy

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Alternative Perspectives on Aging in Caenorhabditis elegans: Reactive Oxygen Species or Hyperfunction?

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Hypoxia suppresses conversion from proliferative arrest to cellular senescence

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Caveolin-1 and accelerated host aging in the breast tumor microenvironment: chemoprevention with rapamycin, an mTOR inhibitor and anti-aging drug

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Once again on rapamycin-induced insulin resistance and longevity: despite of or owing to.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Metformin in obesity, cancer and aging: addressing controversies

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Rapamycin slows aging in mice

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Of mice and men: the benefits of caloric restriction, exercise, and mimetics.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

mTORC1 controls fasting-induced ketogenesis and its modulation by ageing.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Regression of left ventricular hypertrophy in kidney transplant recipients: the potential role for inhibition of mammalian target of rapamycin

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Metformin for aging and cancer prevention

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Paradoxical suppression of cellular senescence by p53

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Rapamycin extends maximal lifespan in cancer-prone mice

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Growth and aging: a common molecular mechanism

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Mammalian target of rapamycin and diabetes: what does the current evidence tell us?

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Role of visceral adipose tissue in aging

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Growth stimulation leads to cellular senescence when the cell cycle is blocked

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Aging, stem cells, and mammalian target of rapamycin: a prospect of pharmacologic rejuvenation of aging stem cells

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Rapamycin in preventive (very low) doses

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Rapamycin prolongs female reproductive lifespan

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Chemoprevention of age-related macular regeneration (AMD) with rapamycin

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Obesity increases vascular senescence and susceptibility to ischemic injury through chronic activation of Akt and mTOR.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4614913

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice.

2 July 2018

1 reference

https://api.crossref.org/works/10.4161%2F15384101.2014.970491

Rapamycin as longevity enhancer and cancer preventative agent in the context of p53 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2F15384101.2014.970491

Prolonged rapamycin treatment led to beneficial metabolic switch

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2F15384101.2014.970491

A double whammy for aging? Rapamycin extends lifespan and inhibits cancer in inbred female mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2F15384101.2014.970491

Long-term administration of rapamycin reduces adiposity, but impairs glucose tolerance in high-fat diet-fed KK/HlJ mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2F15384101.2014.970491

Rapamycin protects against high fat diet-induced obesity in C57BL/6J mice

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2F15384101.2014.970491

Effect of mTOR inhibitor on body weight: from an experimental rat model to human transplant patients

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2F15384101.2014.970491

Treatment with sirolimus is associated with less weight gain after kidney transplantation.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2F15384101.2014.970491

Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2F15384101.2014.970491

Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2F15384101.2014.970491

Metformin, aging and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2F15384101.2014.970491

Obesity accelerates ovarian follicle development and follicle loss in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2F15384101.2014.970491

M(o)TOR of pseudo-hypoxic state in aging: rapamycin to the rescue

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2F15384101.2014.970491

Activation of mammalian target of rapamycin complex 1 and insulin resistance induced by palmitate in hepatocytes.

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25485580

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The Mammalian target of rapamycin pathway regulates nutrient-sensitive glucose uptake in man

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25485580

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Rapamycin slows aging in mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25485580

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.4161/15384101.2014.970491

1 reference

12 August 2017

1 reference

12 August 2017

1 reference

PMCID

4614913