Impaired dNTPase activity of SAMHD1 by phosphomimetic mutation of Thr-592 (Q36283619)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26294762%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

title

Impaired dNTPase activity of SAMHD1 by phosphomimetic mutation of Thr-592 (English)

1 reference

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SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1

22 February 2020

main subject

1 reference

defense response to virus

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Li Wu

3

1 reference

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22 February 2020

author name string

Chenxiang Tang

1

1 reference

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22 February 2020

Xiaoyun Ji

2

1 reference

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22 February 2020

Yong Xiong

4

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22 February 2020

language of work or name

English

0 references

publication date

20 August 2015

1 reference

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Journal of Biological Chemistry

22 February 2020

published in

1 reference

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22 February 2020

volume

290

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22 February 2020

issue

44

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22 February 2020

page(s)

26352-26359

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SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activity

22 February 2020

cites work

1 reference

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CyclinA2-Cyclin-dependent Kinase Regulates SAMHD1 Protein Phosphohydrolase Domain

30 September 2017

1 reference

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Structural basis of cellular dNTP regulation by SAMHD1.

30 September 2017

1 reference

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The ribonuclease activity of SAMHD1 is required for HIV-1 restriction

30 September 2017

1 reference

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Cell cycle control and HIV-1 susceptibility are linked by CDK6-dependent CDK2 phosphorylation of SAMHD1 in myeloid and lymphoid cells

30 September 2017

1 reference

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GTP activator and dNTP substrates of HIV-1 restriction factor SAMHD1 generate a long-lived activated state

30 September 2017

1 reference

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Identification of cellular proteins interacting with the retroviral restriction factor SAMHD1

30 September 2017

1 reference

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SAMHD1 prevents autoimmunity by maintaining genome stability

30 September 2017

1 reference

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SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage.

30 September 2017

1 reference

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Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase

30 September 2017

1 reference

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SAMHD1 host restriction factor: a link with innate immune sensing of retrovirus infection

30 September 2017

1 reference

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Mechanism of allosteric activation of SAMHD1 by dGTP

30 September 2017

1 reference

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SAMHD1 restricts herpes simplex virus 1 in macrophages by limiting DNA replication.

30 September 2017

1 reference

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Restriction of virus infection but not catalytic dNTPase activity is regulated by phosphorylation of SAMHD1.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646291

Deoxynucleoside triphosphate (dNTP) synthesis and destruction regulate the replication of both cell and virus genomes.

30 September 2017

1 reference

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GTP is the primary activator of the anti-HIV restriction factor SAMHD1.

30 September 2017

1 reference

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The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells.

30 September 2017

1 reference

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Host factor SAMHD1 restricts DNA viruses in non-dividing myeloid cells

30 September 2017

1 reference

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Phosphorylation of SAMHD1 by cyclin A2/CDK1 regulates its restriction activity toward HIV-1.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646291

The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646291

Restriction of diverse retroviruses by SAMHD1.

30 September 2017

1 reference

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Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646291

Nuclease activity of the human SAMHD1 protein implicated in the Aicardi-Goutieres syndrome and HIV-1 restriction.

30 September 2017

1 reference

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SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646291

Contribution of SAM and HD domains to retroviral restriction mediated by human SAMHD1.

30 September 2017

1 reference

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SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4(+) T-cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646291

SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.

30 September 2017

1 reference

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SAMHD1 is a nucleic-acid binding protein that is mislocalized due to aicardi-goutières syndrome-associated mutations

30 September 2017

1 reference

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SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

30 September 2017

1 reference

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Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646291

SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutières syndrome are highly susceptible to HIV-1 infection

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646291

Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646291

HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646291

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646291

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646291

Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646291

Phasercrystallographic software

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646291

Macromolecular size-and-shape distributions by sedimentation velocity analytical ultracentrifugation.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646291

REFMAC5 dictionary: organization of prior chemical knowledge and guidelines for its use

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646291

Coot: model-building tools for molecular graphics

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646291

Identification of human homologue of mouse IFN-gamma induced protein from human dendritic cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646291

Cyclin-dependent kinases: engines, clocks, and microprocessors

30 September 2017

1 reference

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The role of the alpha-helix dipole in protein function and structure

30 September 2017

1 reference

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30 September 2017

1 reference

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Palbociclib, a selective inhibitor of cyclin-dependent kinase4/6, blocks HIV-1 reverse transcription through the control of sterile α motif and HD domain-containing protein-1 (SAMHD1) activity

30 September 2017

1 reference

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29 June 2018

Identifiers

DOI

10.1074/JBC.M115.677435

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26294762%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26294762%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

PubMed publication ID

26294762

1 reference