The ribosomal peptidyl transferase center: structure, function, evolution, inhibition (Q36300790)

13 August 2017

1 reference

title

The ribosomal peptidyl transferase center: structure, function, evolution, inhibition (English)

1 reference

13 August 2017

Norbert Polacek

1

1 reference

PubMed ID

16257828

13 August 2017

Alexander S Mankin

series ordinal

2

1 reference

13 August 2017

1 September 2005

1 reference

Critical Reviews in Biochemistry and Molecular Biology

13 August 2017

1 reference

13 August 2017

40

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13 August 2017

5

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13 August 2017

285-311

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Ribosomal crystallography: a flexible nucleotide anchoring tRNA translocation, facilitates peptide-bond formation, chirality discrimination and antibiotics synergism

13 August 2017

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

The complete atomic structure of the large ribosomal subunit at 2.4 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

From peptide-bond formation to cotranslational folding: dynamic, regulatory and evolutionary aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Structural basis of the ribosomal machinery for peptide bond formation, translocation, and nascent chain progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

A conformational change in the ribosomal peptidyl transferase center upon active/inactive transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

The A2453-C2499 wobble base pair in Escherichia coli 23S ribosomal RNA is responsible for pH sensitivity of the peptidyltransferase active site conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

A novel site of antibiotic action in the ribosome: interaction of evernimicin with the large ribosomal subunit.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

The G2447A mutation does not affect ionization of a ribosomal group taking part in peptide bond formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Structural Insight into the Antibiotic Action of Telithromycin against Resistant Mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Different nucleotide changes in the large rRNA gene of the mitochondrial DNA confer chloramphenicol resistance on two human cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

23S rRNA positions essential for tRNA binding in ribosomal functional sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

RNA aptamers to the peptidyl transferase inhibitor chloramphenicol

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

The comparative RNA web (CRW) site: an online database of comparative sequence and structure information for ribosomal, intron, and other RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Hydrolysis of fMet-tRNA by peptidyl transferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

In vitro splicing of the ribosomal RNA precursor of tetrahymena: Involvement of a guanosine nucleotide in the excision of the intervening sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Cross-linking in the Living Cell Locates the Site of Action of Oxazolidinone Antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Cooperative and Antagonistic Interactions of Peptidyl-tRNA and Antibiotics with Bacterial Ribosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Histidine 229 in protein L2 is apparently essential for 50S peptidyl transferase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

The origin of the genetic code

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Antibiotics and polyribosomes. II. Some effects of lincomycin, spiramycin, and streptogramin A in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

How antibiotic-producing organisms avoid suicide

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

In vitro protein folding by ribosomes from Escherichia coli, wheat germ and rat liver: the role of the 50S particle and its 23S rRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

What are antibiotics? Archaic functions for modern activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Role of 5S RNA in assembly and function of the 50S subunit from Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Mononucleotide derivatives as ribosomal P-site substrates reveal an important contribution of the 2'-OH to activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

The Effects of Tiamulin, a Semisynthetic Pleuromutilin Derivative, on Bacterial Polypeptide Chain Initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

The chemical repertoire of natural ribozymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Functional interactions within 23S rRNA involving the peptidyltransferase center.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

RNA structure comparison, motif search and discovery using a reduced representation of RNA conformational space

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

21 January 2018

Ribozyme speed limits

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Chemical engineering of the peptidyl transferase center reveals an important role of the 2'-hydroxyl group of A2451

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Ribosome-catalyzed ester formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Mutations in the highly conserved GGQ motif of class 1 polypeptide release factors abolish ability of human eRF1 to trigger peptidyl-tRNA hydrolysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Binding site of macrolide antibiotics on the ribosome: new resistance mutation identifies a specific interaction of ketolides with rRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Origin of life: The RNA world

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Ribosomes and translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Mutations in the peptidyl transferase region of E. coli 23S rRNA affecting translational accuracy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Structural insights into peptide bond formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

The structures of four macrolide antibiotics bound to the large ribosomal subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

The macrolide-ketolide antibiotic binding site is formed by structures in domains II and V of 23S ribosomal RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

High resolution structure of the large ribosomal subunit from a mesophilic eubacterium

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Alterations at the peptidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Isomeric phenylalanyl-tRNAs. Position of the aminoacyl moiety during protein biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Exploration of the conserved A+C wobble pair within the ribosomal peptidyl transferase center using affinity purified mutant ribosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Decoding at the ribosomal A site: antibiotics, misreading and energy of aminoacyl-tRNA binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Important contribution to catalysis of peptide bond formation by a single ionizing group within the ribosome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Altered ribosomal RNA genes in mitochondria from mammalian cells with chloramphenicol resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Effect of antibiotics on large ribosomal subunit assembly reveals possible function of 5 S rRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Characterization of functionally active subribosomal particles from Thermus aquaticus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Peptidyl transferase activity catalyzed by protein-free 23S ribosomal RNA remains elusive.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Movement of the 3'-end of tRNA through the peptidyl transferase centre and its inhibition by antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Visualization of release factor 3 on the ribosome during termination of protein synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

The kink-turn: a new RNA secondary structure motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

The contribution of metal ions to the structural stability of the large ribosomal subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Resistance mutations in 23 S rRNA identify the site of action of the protein synthesis inhibitor linezolid in the ribosomal peptidyl transferase center

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Role for the highly conserved region of domain IV of 23S-like rRNA in subunit-subunit interactions at the peptidyl transferase centre

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

The origins of RNA catalysis in ribozymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Recombination Proficiency Influences Frequency and Locus of Mutational Resistance to Linezolid in Enterococcus faecalis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Ribosome-Catalyzed Peptidyl Transfer. Effects of Cations and pH Value

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Gene regulation by riboswitches

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Chloramphenicol resistance mutations in the single 23S rRNA gene of the archaeon Halobacterium halobium

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Inactivation and reactivation of ribosomal subunits: The peptidyl transferase activity of the 50 s subunit of Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Chloramphenicol, erythromycin, carbomycin and vernamycin B protect overlapping sites in the peptidyl transferase region of 23S ribosomal RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Interaction of tRNA with 23S rRNA in the ribosomal A, P, and E sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Ribosome-catalyzed peptidyl transfer: substrate specificity at the P-site

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Stop codon recognition and interactions with peptide release factor RF3 of truncated and chimeric RF1 and RF2 from Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Identification of the chloramphenicol-binding protein in Escherichia coli ribosomes by partial reconstitution

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

The structural basis of ribosome activity in peptide bond synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

RNA tertiary interactions in the large ribosomal subunit: the A-minor motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Peptidyl transferase: protein, ribonucleoprotein, or RNA?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

The driving force for molecular evolution of translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Unusual resistance of peptidyl transferase to protein extraction procedures

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Nuclear MRP genes and mitochondrial disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Genetic probes of ribosomal RNA function

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Mutations at U2555, a tRNA-protected base in 23S rRNA, affect translational fidelity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Evidence against stabilization of the transition state oxyanion by a pKa-perturbed RNA base in the peptidyl transferase center

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Peptidyl-Puromycin Synthesis on Polyribosomes from Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Antibiotics as probes of ribosome structure: binding of chloramphenicol and erythromycin to polyribosomes; effect of other antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

23S rRNA base pair 2057-2611 determines ketolide susceptibility and fitness cost of the macrolide resistance mutation 2058A-->G.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Metal ion probing of rRNAs: evidence for evolutionarily conserved divalent cation binding pockets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Ribosomal peptidyl transferase can withstand mutations at the putative catalytic nucleotide

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

SPARK--a novel method to monitor ribosomal peptidyl transferase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

The critical role of the universally conserved A2602 of 23S ribosomal RNA in the release of the nascent peptide during translation termination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

The pleuromutilin drugs tiamulin and valnemulin bind to the RNA at the peptidyl transferase centre on the ribosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Inhibition of the ribosomal peptidyl transferase reaction by the mycarose moiety of the antibiotics carbomycin, spiramycin and tylosin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Resistance to linezolid: characterization of mutations in rRNA and comparison of their occurrences in vancomycin-resistant enterococci

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

A cryo-electron microscopic study of ribosome-bound termination factor RF2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

A base pair between tRNA and 23S rRNA in the peptidyl transferase centre of the ribosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Ribosomal and non-ribosomal resistance to oxazolidinones: species-specific idiosyncrasy of ribosomal alterations

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Mapping functionally important motifs SPF and GGQ of the decoding release factor RF2 to the Escherichia coli ribosome by hydroxyl radical footprinting. Implications for macromolecular mimicry and structural changes in RF2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Structural basis for the antibiotic activity of ketolides and azalides

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Class-1 translation termination factors: invariant GGQ minidomain is essential for release activity and ribosome binding but not for stop codon recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Mechanism of action of the oxazolidinone antibacterial agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

The ribosome as an entropy trap

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

The crystal structure of human eukaryotic release factor eRF1--mechanism of stop codon recognition and peptidyl-tRNA hydrolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

On the structural basis of peptide-bond formation and antibiotic resistance from atomic structures of the large ribosomal subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

RNA, the first macromolecular catalyst: the ribosome is a ribozyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Oligonucleotide-directed peptide synthesis in a ribosome- and ribozyme-free system

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Translational termination: "stop" for protein synthesis or "pause" for regulation of gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

The mechanism of action of macrolides, lincosamides and streptogramin B reveals the nascent peptide exit path in the ribosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Site-directed mutagenesis of Escherichia coli 23 S ribosomal RNA at position 1067 within the GTP hydrolysis centre

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Analysis of mutations at residues A2451 and G2447 of 23S rRNA in the peptidyltransferase active site of the 50S ribosomal subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

The protein synthesis inhibitors, oxazolidinones and chloramphenicol, cause extensive translational inaccuracy in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Macrolide resistance conferred by base substitutions in 23S rRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Bacterial polypeptide release factor RF2 is structurally distinct from eukaryotic eRF1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Possible involvement of peptidyl transferase in the termination step of protein biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Substrate-assisted catalysis of peptide bond formation by the ribosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Mutation of a highly conserved base in the yeast mitochondrial 21S rRNA restricts ribosomal frameshifting.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

An inhibitor of ribosomal peptidyl transferase using transition-state analogy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Coenzymes as fossils of an earlier metabolic state

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

The ribosomal binding and peptidyl-tRNA hydrolysis functions of Escherichia coli release factor 2 are linked through residue 246

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Protein synthesis at atomic resolution: mechanistics of translation in the light of highly resolved structures for the ribosome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Structure of the 30S ribosomal subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Mode of action of chloramphenicol IX. Effects of chloramphenicol upon a ribosomal amino acid polymerization system and its binding to bacterial ribosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Ribosomal protein L27 participates in both 50 S subunit assembly and the peptidyl transferase reaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Oxazolidinone resistance mutations in 23S rRNA of Escherichia coli reveal the central region of domain V as the primary site of drug action.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

A ketolide resistance mutation in domain II of 23S rRNA reveals the proximity of hairpin 35 to the peptidyl transferase centre

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Binding site of the bridged macrolides in the Escherichia coli ribosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

The active site of the ribosome is composed of two layers of conserved nucleotides with distinct roles in peptide bond formation and peptide release

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Crystal structure of the ribosome at 5.5 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Release of peptide promoted by the GGQ motif of class 1 release factors regulates the GTPase activity of RF3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Peptide bond formation by in vitro selected ribozymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

Peptidyl-transferase ribozymes: trans reactions, structural characterization and ribosomal RNA-like features

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230500326334

10.1080/10409230500326334

21 January 2018

Identifiers

DOI

1 reference

13 August 2017

1 reference

PubMed ID

16257828