The involvement of the wnt signaling pathway and TCF7L2 in diabetes mellitus: The current understanding, dispute, and perspective (Q36309053)

13 August 2017

The involvement of the wnt signaling pathway and TCF7L2 in diabetes mellitus: The current understanding, dispute, and perspective (English)

1 reference

13 August 2017

Wilfred Ip

1

1 reference

13 August 2017

Yu-Ting Alex Chiang

series ordinal

2

1 reference

13 August 2017

Tianru Jin

series ordinal

3

1 reference

13 August 2017

language of work or name

1 reference

14 August 2012

1 reference

13 August 2017

1 reference

13 August 2017

2

1 reference

13 August 2017

28

1 reference

13 August 2017

1

1 reference

https://scigraph.springernature.com/pub.10.1186/2045-3701-2-28

13 August 2017

0 references

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Glucocorticoids and tumor necrosis factor α increase oxidative stress and suppress Wnt protein signaling in osteoblasts

30 September 2017

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30 September 2017

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A novel mechanism for the transcriptional regulation of Wnt signaling in development

30 September 2017

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Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism

30 September 2017

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Unraveling the role of FoxOs in bone--insights from mouse models

30 September 2017

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Osteoporosis: now and the future

30 September 2017

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T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis

30 September 2017

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TCF7L2 splice variants have distinct effects on beta-cell turnover and function

30 September 2017

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Wnt signaling regulates hepatic metabolism

30 September 2017

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Association testing of TCF7L2 polymorphisms with type 2 diabetes in multi-ethnic youth.

30 September 2017

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Wnt signaling and aging-related heart disorders

30 September 2017

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Wnt and incretin connections

30 September 2017

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K-cells and glucose-dependent insulinotropic polypeptide in health and disease

30 September 2017

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The genetics of type 2 diabetes: what have we learned from GWAS?

30 September 2017

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The T-allele of TCF7L2 rs7903146 associates with a reduced compensation of insulin secretion for insulin resistance induced by 9 days of bed rest

30 September 2017

1 reference

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Can the genetics of type 1 and type 2 diabetes shed light on the genetics of latent autoimmune diabetes in adults?

30 September 2017

1 reference

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Regulation of wingless-type MMTV integration site family (WNT) signalling in pancreatic islets from wild-type and obese mice

30 September 2017

1 reference

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Alternative splicing of TCF7L2 gene in omental and subcutaneous adipose tissue and risk of type 2 diabetes

30 September 2017

1 reference

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Organ patterning in the adult stage: the role of Wnt/beta-catenin signaling in liver zonation and beyond

30 September 2017

1 reference

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Increased lipid oxidation causes oxidative stress, increased peroxisome proliferator-activated receptor-gamma expression, and diminished pro-osteogenic Wnt signaling in the skeleton

30 September 2017

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Wnt/beta-catenin signaling: components, mechanisms, and diseases

30 September 2017

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Tissue-specific alternative splicing of TCF7L2.

30 September 2017

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WNT/beta-catenin increases the production of incretins by entero-endocrine cells.

30 September 2017

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Wnt5b stimulates adipogenesis by activating PPARgamma, and inhibiting the beta-catenin dependent Wnt signaling pathway together with Wnt5a

30 September 2017

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Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

30 September 2017

1 reference

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TCF7L2, dietary carbohydrate, and risk of type 2 diabetes in US women

30 September 2017

1 reference

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TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells

30 September 2017

1 reference

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Clinical risk factors, DNA variants, and the development of type 2 diabetes

30 September 2017

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The WNT signalling pathway and diabetes mellitus

30 September 2017

1 reference

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The Wnt signaling pathway effector TCF7L2 and type 2 diabetes mellitus

30 September 2017

1 reference

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Wnt and beyond Wnt: multiple mechanisms control the transcriptional property of beta-catenin

30 September 2017

1 reference

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Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: where are the insulin resistance genes?

30 September 2017

1 reference

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Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians

30 September 2017

1 reference

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Cross talk between the insulin and Wnt signaling pathways: evidence from intestinal endocrine L cells

30 September 2017

1 reference

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Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation

30 September 2017

1 reference

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RETRACTED: Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets

30 September 2017

1 reference

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Regulation of insulin secretion, glucokinase gene transcription and beta cell proliferation by adipocyte-derived Wnt signalling molecules

30 September 2017

1 reference

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TCF4 deficiency expands ventral diencephalon signaling and increases induction of pituitary progenitors

30 September 2017

1 reference

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TCF7L2 is not a major susceptibility gene for type 2 diabetes in Pima Indians: analysis of 3,501 individuals

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

Genome-wide association studies provide new insights into type 2 diabetes aetiology

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

Gone with the Wnts: beta-catenin, T-cell factor, forkhead box O, and oxidative stress in age-dependent diseases of bone, lipid, and glucose metabolism

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

The new type 2 diabetes gene TCF7L2

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

Biology of incretins: GLP-1 and GIP

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

Wnt signaling regulates pancreatic beta cell proliferation

30 September 2017

1 reference

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Wnt/beta-catenin signaling in development and disease

30 September 2017

1 reference

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TCF7L2 variation predicts hyperglycemia incidence in a French general population: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

Polymorphisms of the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with obesity phenotypes in a large family-based association study

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

FOXO transcription factors at the interface between longevity and tumor suppression

30 September 2017

1 reference

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Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase stabilizes beta-catenin through inhibition of its ubiquitination

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

Beta-catenin is essential for pancreatic acinar but not islet development

30 September 2017

1 reference

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Beta-catenin, cancer, and G proteins: not just for frizzleds anymore

30 September 2017

1 reference

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Functional interaction between beta-catenin and FOXO in oxidative stress signaling

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

Wnt10b deficiency promotes coexpression of myogenic and adipogenic programs in myoblasts

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

Association of the gene encoding wingless-type mammary tumor virus integration-site family member 5B (WNT5B) with type 2 diabetes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

FoxOs at the crossroads of cellular metabolism, differentiation, and transformation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

Localization of a susceptibility gene for type 2 diabetes to chromosome 5q34-q35.2.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

Haplotype structure, LD blocks, and uneven recombination within the LRP5 gene.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

Linkage and association mapping of the LRP5 locus on chromosome 11q13 in type 1 diabetes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

Transcriptional activation of the proglucagon gene by lithium and beta-catenin in intestinal endocrine L cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

arrow encodes an LDL-receptor-related protein essential for Wingless signalling

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

Inhibition of adipogenesis by Wnt signaling

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

Linkage of type 2 diabetes mellitus and of age at onset to a genetic location on chromosome 10q in Mexican Americans

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

Cloning of a novel member of the low-density lipoprotein receptor family

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

WNTs modulate cell fate and behavior during vertebrate development

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

A role for glucagon-like peptide-1 in the central regulation of feeding

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

Expression of the transcription factor 7-like 2 gene (TCF7L2) in human adipocytes is down regulated by insulin

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

Type 2 diabetes susceptibility gene TCF7L2 and its role in beta-cell function

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

Association of variants of the TCF7L2 gene with increases in the risk of type 2 diabetes and the proinsulin:insulin ratio in the Spanish population.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor- to forkhead box O-mediated transcription.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

Stabilization of beta-catenin impacts pancreas growth.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

Attenuated Wnt signaling perturbs pancreatic growth but not pancreatic function

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

Wnt10b inhibits development of white and brown adipose tissues.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

Wnt5a and Wnt5b exhibit distinct activities in coordinating chondrocyte proliferation and differentiation.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

Association between oxidative stress and bone mineral density.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3468386

Association Analysis of 6,736 U.K. Subjects Provides Replication and ConfirmsTCF7L2as a Type 2 Diabetes Susceptibility Gene With a Substantial Effect on Individual Risk

22 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2F2045-3701-2-28

Additive Effects of Obesity and TCF7L2 Variants on Risk for Type 2 Diabetes Among Cardiac Patients

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2F2045-3701-2-28

Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2F2045-3701-2-28

Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals

21 January 2018

1 reference

12 December 2020

Cellular mechanisms of wingless/Wnt signal transduction

1 reference

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Association Study of the Genetic Polymorphisms of the Transcription Factor 7-Like 2 (TCF7L2) Gene and Type 2 Diabetes in the Chinese Population

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WNT signalling is both an inducer and effector of glucagon-like peptide-1

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Open chromatin and diabetes risk

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Identifiers

DOI

10.1186/2045-3701-2-28

1 reference

Dimensions Publication ID

13 August 2017

0 references

1 reference

13 August 2017

1 reference