Selective neuronal degeneration in Huntington's disease (Q36597920)

15 August 2017

1 reference

title

Selective neuronal degeneration in Huntington's disease (English)

1 reference

15 August 2017

0 references

Lynn A Raymond

2

0 references

author name string

Catherine M Cowan

series ordinal

1

1 reference

15 August 2017

1 January 2006

1 reference

Current Topics in Developmental Biology

15 August 2017

1 reference

15 August 2017

75

1 reference

15 August 2017

25-71

1 reference

Selective neurodegeneration in Huntington's disease

15 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Alternative excitotoxic hypotheses

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

The functional anatomy of basal ganglia disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Abnormalities of striatal projection neurons and N-methyl-D-aspartate receptors in presymptomatic Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Preproenkephalin messenger RNA?containing neurons in striatum of patients with symptomatic and presymptomatic huntington's disease: An in situ hybridization study

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Preferential loss of striato-external pallidal projection neurons in presymptomatic Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Complex I defect in muscle from patients with Huntington's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Striatal potassium channel dysfunction in Huntington's disease transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Neuronal vulnerability in mouse models of Huntington's disease: membrane channel protein changes

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

CAG expansion affects the expression of mutant Huntingtin in the Huntington's disease brain

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Reduction in enkephalin and substance P messenger RNA in the striatum of early grade Huntington's disease: a detailed cellular in situ hybridization study

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Aging, energy, and oxidative stress in neurodegenerative diseases.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Mitochondria take center stage in aging and neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Chronic quinolinic acid lesions in rats closely resemble Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Proteasome impairment does not contribute to pathogenesis in R6/2 Huntington's disease mice: exclusion of proteasome activator REGgamma as a therapeutic target

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Increased vulnerability to 3-nitropropionic acid in an animal model of Huntington's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Genome-wide expression profiling of human blood reveals biomarkers for Huntington's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Regional mitochondrial respiratory activity in Huntington's disease brain

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Increased susceptibility of striatal mitochondria to calcium-induced permeability transition

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Normal huntingtin function: an alternative approach to Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

NMDA receptor function in mouse models of Huntington disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Transient and progressive electrophysiological alterations in the corticostriatal pathway in a mouse model of Huntington's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Transcriptional dysregulation in Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Subtype-dependence of NMDA receptor channel open probability.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Subtype-specific enhancement of NMDA receptor currents by mutant huntingtin

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Polyglutamine aggregation behavior in vitro supports a recruitment mechanism of cytotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Amyloid-like features of polyglutamine aggregates and their assembly kinetics

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Huntington's disease age-of-onset linked to polyglutamine aggregation nucleation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Mutant huntingtin represses CBP, but not p300, by binding and protein degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Lesion of striatal neurons with kainic acid provides a model for Huntington's chorea

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Oxidative stress, glutamate, and neurodegenerative disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Degeneration of pyramidal projection neurons in Huntington's disease cortex

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

1 reference

7 January 2021

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Subcellular localization of the Huntington's disease gene product in cell lines by immunofluorescence and biochemical subcellular fractionation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

1 reference

7 January 2021

Differential loss of striatal projection systems in Huntington's disease: a quantitative immunohistochemical study

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Excitotoxic injury of the neostriatum: a model for Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Nuclear targeting sequences--a consensus?

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Early changes in Huntington's disease patient brains involve alterations in cytoskeletal and synaptic elements

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Analysis of the subcellular localization of huntingtin with a set of rabbit polyclonal antibodies in cultured mammalian cells of neuronal origin: comparison with the distribution of huntingtin in Huntington's disease autopsy brain

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Inactivation of the mouse Huntington's disease gene homolog Hdh

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Expression of mutant huntingtin blocks exocytosis in PC12 cells by depletion of complexin II

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Selective sparing of a class of striatal neurons in Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Morphologic and histochemical characteristics of a spared subset of striatal neurons in Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Excitotoxin lesions in primates as a model for Huntington's disease: histopathologic and neurochemical characterization

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Calpain activation in Huntington's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Specific progressive cAMP reduction implicates energy deficit in presymptomatic Huntington's disease knock-in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Synthetic peptides as nuclear localization signals

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Nucleocytoplasmic transport

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Evidence for degenerative and regenerative changes in neostriatal spiny neurons in Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Characterization of the excitotoxic potential of the reversible succinate dehydrogenase inhibitor malonate

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Inhibition of succinate dehydrogenase by malonic acid produces an "excitotoxic" lesion in rat striatum

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Mitochondrial defect in Huntington's disease caudate nucleus

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Early degenerative changes in transgenic mice expressing mutant huntingtin involve dendritic abnormalities but no impairment of mitochondrial energy production

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Disruption of Axonal Transport by Loss of Huntingtin or Expression of Pathogenic PolyQ Proteins in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Huntingtin: a single bait hooks many species

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

The cellular and subcellular localization of huntingtin-associated protein 1 (HAP1): comparison with huntingtin in rat and human.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

The influence of huntingtin protein size on nuclear localization and cellular toxicity.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Transgenic mice expressing a Huntington's disease mutation are resistant to quinolinic acid-induced striatal excitotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Resistance to NMDA toxicity correlates with appearance of nuclear inclusions, behavioural deficits and changes in calcium homeostasis in mice transgenic for exon 1 of the huntington gene

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

A primate model of Huntington's disease: behavioral and anatomical studies of unilateral excitotoxic lesions of the caudate-putamen in the baboon

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Caspase and calpain function in cell death: bridging the gap between apoptosis and necrosis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Neuronal loss in layers V and VI of cerebral cortex in Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Cortical and striatal neurone number in Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Cloned glutamate receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Inefficient degradation of truncated polyglutamine proteins by the proteasome

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Regulation of proteins affecting NMDA receptor-induced excitotoxicity in a Huntington's mouse model

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Evidence for impairment of energy metabolism in vivo in Huntington's disease using localized 1H NMR spectroscopy

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Ionotropic and metabotropic glutamate receptor structure and pharmacology

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Mutant huntingtin expression in clonal striatal cells: dissociation of inclusion formation and neuronal survival by caspase inhibition.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Electrophysiological and morphological changes in striatal spiny neurons in R6/2 Huntington's disease transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Energy metabolism defects in Huntington's disease and effects of coenzyme Q10.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Huntington's disease gene: regional and cellular expression in brain of normal and affected individuals

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

NMDA receptor subunit mRNA expression by projection neurons and interneurons in rat striatum.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Wild-type huntingtin protects neurons from excitotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Brain energy metabolism and dopaminergic function in Huntington's disease measured in vivo using positron emission tomography

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Huntingtin aggregate-associated axonal degeneration is an early pathological event in Huntington's disease mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Abnormal association of mutant huntingtin with synaptic vesicles inhibits glutamate release

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Role of NR2B-type NMDA receptors in selective neurodegeneration in Huntington disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Enhanced striatal NR2B-containing N-methyl-D-aspartate receptor-mediated synaptic currents in a mouse model of Huntington disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Interaction of huntingtin-associated protein with dynactin P150Glued

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Cellular defects and altered gene expression in PC12 cells stably expressing mutant huntingtin

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

A huntingtin-associated protein enriched in brain with implications for pathology

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Abnormal phosphorylation of synapsin I predicts a neuronal transmission impairment in the R6/2 Huntington's disease transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Neurological abnormalities in a knock-in mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

The toxic effect of sodium L-glutamate on the inner layers of the retina.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Analysis of Huntingtin-associated protein 1 in mouse brain and immortalized striatal neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

CREB-binding protein sequestration by expanded polyglutamine

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Duplication of biochemical changes of Huntington's chorea by intrastriatal injections of glutamic and kainic acids

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Early motor dysfunction and striosomal distribution of huntingtin microaggregates in Huntington's disease knock-in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

HIP1 functions in clathrin-mediated endocytosis through binding to clathrin and adaptor protein 2

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Disruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor trafficking

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Heteromeric NMDA receptors: molecular and functional distinction of subtypes

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Progressive depletion of complexin II in a transgenic mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

A combination drug therapy improves cognition and reverses gene expression changes in a mouse model of Huntington's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Nuclear localization of a non-caspase truncation product of atrophin-1, with an expanded polyglutamine repeat, increases cellular toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

CRE-mediated transcription is increased in Huntington's disease transgenic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Clinical markers of early disease in persons near onset of Huntington's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Glutamine repeats as polar zippers: their possible role in inherited neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Huntingtin spheroids and protofibrils as precursors in polyglutamine fibrilization

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Preferential loss of preproenkephalin versus preprotachykinin neurons from the striatum of Huntington's disease patients

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

The messenger RNAs for the N-methyl-D-aspartate receptor subunits show region-specific expression of different subunit composition in the human brain

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Nuclear membrane indentations in Huntington's chorea

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's disease and related disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Mitochondrial impairment in patients and asymptomatic mutation carriers of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

The quinolinic acid model of Huntington's disease: locomotor abnormalities

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Postnatal developmental changes in AMPA and NMDA receptors in the rat vestibular nuclei.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Huntingtin localization in brains of normal and Huntington's disease patients

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Correction of hemophilia B in canine and murine models using recombinant adeno-associated viral vectors

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

II. Excitotoxic models for neurodegenerative disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

HD CAG repeat implicates a dominant property of huntingtin in mitochondrial energy metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Widespread expression of Huntington's disease gene (IT15) protein product

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

A Huntington's disease CAG expansion at the murine Hdh locus is unstable and associated with behavioural abnormalities in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Early transcriptional profiles in huntingtin-inducible striatal cells by microarray analyses

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Morphometric analysis of the prefrontal cortex in Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Biochemical abnormalities in Huntington's chorea brains

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Expression of NMDA glutamate receptor subunit mRNAs in neurochemically identified projection and interneurons in the striatum of the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Alterations in N-methyl-D-aspartate receptor sensitivity and magnesium blockade occur early in development in the R6/2 mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

SUMO modification of Huntingtin and Huntington's disease pathology

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

The synaptic vesicle cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Transcriptional abnormalities in Huntington disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Decreased cAMP response element-mediated transcription: an early event in exon 1 and full-length cell models of Huntington's disease that contributes to polyglutamine pathogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Neuropathogenic forms of huntingtin and androgen receptor inhibit fast axonal transport

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Biochemical abnormalities and excitotoxicity in Huntington's disease brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Nuclear relocation of normal huntingtin

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Aberrant histone acetylation, altered transcription, and retinal degeneration in a Drosophila model of polyglutamine disease are rescued by CREB-binding protein

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Impaired synaptic plasticity in mice carrying the Huntington's disease mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Selective degeneration and nuclear localization of mutant huntingtin in the YAC128 mouse model of Huntington disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Wild-type and mutant huntingtins function in vesicle trafficking in the secretory and endocytic pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

CREB-binding protein and p300 in transcriptional regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

1 reference

7 January 2021

HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Striatal D1 and D2 dopamine receptor loss in asymptomatic mutation carriers of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Of molecular interactions, mice and mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Early phenotypes that presage late-onset neurodegenerative disease allow testing of modifiers in Hdh CAG knock-in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Polyglutamine expansions cause decreased CRE-mediated transcription and early gene expression changes prior to cell death in an inducible cell model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Huntingtin contains a highly conserved nuclear export signal

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

NMDA receptor losses in putamen from patients with Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Mutant huntingtin enhances excitotoxic cell death.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Potentiation of NMDA receptor-mediated excitotoxicity linked with intrinsic apoptotic pathway in YAC transgenic mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Morphometric demonstration of atrophic changes in the cerebral cortex, white matter, and neostriatum in Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Studies on brain biopsies of patients with Huntington's chorea

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

Neuropathological classification of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2806%2975002-5

7 January 2021

10.1016/S0070-2153(06)75002-5

Identifiers

DOI

1 reference

15 August 2017

1 reference

PubMed ID

16984809