Ras proteins: paradigms for compartmentalised and isoform-specific signalling. (Q36880352)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17628742%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

review article

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title

Ras proteins: paradigms for compartmentalised and isoform-specific signalling (English)

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2 January 2020

3

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2 January 2020

author name string

J Omerovic

series ordinal

1

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2 January 2020

A J Laude

series ordinal

2

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2 January 2020

publication date

1 October 2007

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Cellular and Molecular Life Sciences

2 January 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17628742%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

volume

64

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2 January 2020

issue

19-20

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2 January 2020

page(s)

2575-2589

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https://scigraph.springernature.com/pub.10.1007/s00018-007-7133-8

2 January 2020

exact match

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Live-cell imaging of endogenous Ras-GTP illustrates predominant Ras activation at the plasma membrane

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Replacement of K-Ras with H-Ras supports normal embryonic development despite inducing cardiovascular pathology in adult mice

29 September 2017

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An acylation cycle regulates localization and activity of palmitoylated Ras isoforms

29 September 2017

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29 September 2017

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AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation

29 September 2017

1 reference

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Plasma membrane microdomains: organization, function and trafficking

29 September 2017

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Visualizing Ras signalling in real-time

29 September 2017

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Novel functional interaction between the plasma membrane Ca2+ pump 4b and the proapoptotic tumor suppressor Ras-associated factor 1 (RASSF1).

29 September 2017

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Single-molecule imaging analysis of Ras activation in living cells

29 September 2017

1 reference

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Ras activation in Jurkat T cells following low-grade stimulation of the T-cell receptor is specific to N-Ras and occurs only on the Golgi apparatus.

29 September 2017

1 reference

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Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization

29 September 2017

1 reference

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Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors

29 September 2017

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Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Alternative splicing of the human proto-oncogene c-H-ras renders a new Ras family protein that trafficks to cytoplasm and nucleus

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Exchange factors of the RasGRP family mediate Ras activation in the Golgi

29 September 2017

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Ca2+/calmodulin binds and dissociates K-RasB from membrane

29 September 2017

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The exocytotic trafficking of TC10 occurs through both classical and nonclassical secretory transport pathways in 3T3L1 adipocytes

29 September 2017

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Direct visualization of Ras proteins in spatially distinct cell surface microdomains

29 September 2017

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Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction

29 September 2017

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Identification of a Ras palmitoyltransferase in Saccharomyces cerevisiae.

29 September 2017

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Signal transduction and endocytosis: close encounters of many kinds

29 September 2017

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Structural determinants of Ras-Raf interaction analyzed in live cells

29 September 2017

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H-Ras signaling and K-Ras signaling are differentially dependent on endocytosis

29 September 2017

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Activated K-Ras and H-Ras display different interactions with saturable nonraft sites at the surface of live cells

29 September 2017

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Coordinated traffic of Grb2 and Ras during epidermal growth factor receptor endocytosis visualized in living cells

29 September 2017

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Oncogenic ras and p53 cooperate to induce cellular senescence

29 September 2017

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RasGRP4 is a novel Ras activator isolated from acute myeloid leukemia

29 September 2017

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Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes

29 September 2017

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Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras

29 September 2017

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Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

29 September 2017

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Calmodulin binds to K-Ras, but not to H- or N-Ras, and modulates its downstream signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

Role of the CDC25 homology domain of phospholipase Cepsilon in amplification of Rap1-dependent signaling

29 September 2017

1 reference

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Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

29 September 2017

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Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation

29 September 2017

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GTP-dependent segregation of H-ras from lipid rafts is required for biological activity

29 September 2017

1 reference

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Differential activation of the Rac pathway by Ha-Ras and K-Ras

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal compartment

29 September 2017

1 reference

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Targeted genomic disruption of H-ras and N-ras, individually or in combination, reveals the dispensability of both loci for mouse growth and development

29 September 2017

1 reference

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Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras

29 September 2017

1 reference

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Characterization of RasGRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factor

29 September 2017

1 reference

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Growth factor-dependent activation of the Ras-Raf-MEK-MAPK pathway in the human pancreatic carcinoma cell line PANC-1 carrying activated K-ras: implications for cell proliferation and cell migration

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

GAP1IP4BP contains a novel group I pleckstrin homology domain that directs constitutive plasma membrane association.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

Isoform-specific localization of A-RAF in mitochondria

29 September 2017

1 reference

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H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

A genome-wide survey of RAS transformation targets

29 September 2017

1 reference

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Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

Distinct PI(3)Ks mediate mitogenic signalling and cell migration in macrophages

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

Essential role for oncogenic Ras in tumour maintenance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

Lack of elevated MAP kinase (Erk) activity in pancreatic carcinomas despite oncogenic K-ras expression.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

Raf-1 and B-Raf proteins have similar regional distributions but differential subcellular localization in adult rat brain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

The Ras target AF-6 interacts with ZO-1 and serves as a peripheral component of tight junctions in epithelial cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

K-ras is an essential gene in the mouse with partial functional overlap with N-ras

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

KSR, a novel protein kinase required for RAS signal transduction

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

The murine N-ras gene is not essential for growth and development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

Dynamic fatty acylation of p21N-ras

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

The ras gene family and human carcinogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

ras oncogenes in human cancer: a review

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

Sef is a spatial regulator for Ras/MAP kinase signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

The Sos1-Rac1 signaling. Possible involvement of a vacuolar H(+)-ATPase E subunit.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

Plasma membrane recruitment of RalGDS is critical for Ras-dependent Ral activation

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

Rapid recruitment of p120RasGAP and its associated protein, p190RhoGAP, to the cytoskeleton during integrin mediated cell-substrate interaction

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

Targeting of Tiam1 to the plasma membrane requires the cooperative function of the N-terminal pleckstrin homology domain and an adjacent protein interaction domain

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

Neurofibromin colocalizes with mitochondria in cultured cells

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

Specific association of activated MAP kinase kinase kinase (Raf) with the plasma membranes of ras-transformed retinal cells.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

Nuclear transport of Ras-associated tumor suppressor proteins: different transport receptor binding specificities for arginine-rich nuclear targeting signals.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

Plasma membrane localization of Ras requires class C Vps proteins and functional mitochondria in Saccharomyces cerevisiae.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

Differential modification of Ras proteins by ubiquitination

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

HRAS mutation analysis in Costello syndrome: genotype and phenotype correlation.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

H-Ras dynamically interacts with recycling endosomes in CHO-K1 cells: involvement of Rab5 and Rab11 in the trafficking of H-Ras to this pericentriolar endocytic compartment.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

Mobility of proteins associated with the plasma membrane by interaction with inositol lipids

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

Annexin A6 stimulates the membrane recruitment of p120GAP to modulate Ras and Raf-1 activity

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

A-Raf associates with and regulates platelet-derived growth factor receptor signalling

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysis

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

Galectin-1(L11A) predicted from a computed galectin-1 farnesyl-binding pocket selectively inhibits Ras-GTP.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

Transcriptional basis of KRAS oncogene-mediated cellular transformation in ovarian epithelial cells

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

A designed probe for acidic phospholipids reveals the unique enriched anionic character of the cytosolic face of the mammalian plasma membrane.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

RAS oncogenes: the first 30 years.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

Distinct rates of palmitate turnover on membrane-bound cellular and oncogenic H-ras

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

Ras signalling on the endoplasmic reticulum and the Golgi

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

The linker domain of the Ha-Ras hypervariable region regulates interactions with exchange factors, Raf-1 and phosphoinositide 3-kinase

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

Differential localization of the neurofibromatosis 1 (NF1) gene product, neurofibromin, with the F-actin or microtubule cytoskeleton during differentiation of telencephalic neurons

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

Mouse model for lung tumorigenesis through Cre/lox controlled sporadic activation of the K-Ras oncogene

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

Neurofibromin is enriched in the endoplasmic reticulum of CNS neurons.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

Vav1 Transduces T Cell Receptor Signals to the Activation of the Ras/ERK Pathway via LAT, Sos, and RasGRP1

4 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561238

Lack of constitutive activation of MAP kinase pathway in human acute myeloid leukemia cells with N-Ras mutation

4 December 2018

1 reference

12 December 2020

Transforming growth factor alpha activates Ha-Ras in human pancreatic cancer cells with Ki-ras mutations

1 reference

12 December 2020

K-ras is essential for the development of the mouse embryo

1 reference

12 December 2020

Lipid-binding characteristics of the polybasic carboxy-terminal sequence of K-ras4B

1 reference

12 December 2020

Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase

1 reference

12 December 2020

NGF signaling from clathrin-coated vesicles: evidence that signaling endosomes serve as a platform for the Ras-MAPK pathway

1 reference

12 December 2020

Isolated endosomes from quiescent rat liver contain the signal transduction machinery. Differential distribution of activated Raf-1 and Mek in the endocytic compartment

1 reference

12 December 2020

Structural and functional consequences of c-N-Ras constitutively associated with intact mitochondria

1 reference

12 December 2020

10.1007/S00018-007-7133-8

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17628742%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17628742%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

1 reference