Big wheel keeps on turning: apoptosome regulation and its role in chemoresistance (Q36988138)

17 August 2017

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title

Big wheel keeps on turning: apoptosome regulation and its role in chemoresistance (English)

1 reference

17 August 2017

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Fadeel B

1

1 reference

PubMed ID

17975549

17 August 2017

Ottosson A

series ordinal

2

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PubMed ID

17975549

17 August 2017

Pervaiz S

series ordinal

3

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17 August 2017

2 November 2007

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Cell Death & Differentiation

17 August 2017

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17 August 2017

15

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17 August 2017

3

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17 August 2017

443-452

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https://scigraph.springernature.com/pub.10.1038/sj.cdd.4402265

17 August 2017

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cites work

Programmed cell death in animal development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Apoptosis: a basic biological phenomenon with wide-ranging implications in human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Cell death: critical control points

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Apoptosomes: engines for caspase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

21 January 2018

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Alterations in the apoptotic machinery and their potential role in anticancer drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Developmental apoptosis in C. elegans: a complex CEDnario

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

An alternatively spliced C. elegans ced-4 RNA encodes a novel cell death inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Apoptosome: a platform for the activation of initiator caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Pro-apoptotic apoptosis protease-activating factor 1 (Apaf-1) has a cytoplasmic localization distinct from Bcl-2 or Bcl-x(L).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Mechanisms of AIF-mediated apoptotic DNA degradation in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

The role of ARK in stress-induced apoptosis in Drosophila cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Three-dimensional structure of a double apoptosome formed by the Drosophila Apaf-1 related killer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Caspase Activity and a Specific Cytochrome C Are Required for Sperm Differentiation in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Cytochrome c-d regulates developmental apoptosis in the Drosophila retina

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Apaf1 is required for mitochondrial pathways of apoptosis and brain development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Apaf-1 deficiency and neural tube closure defects are found in fog mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Mouse models of cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Decreased apoptosome activity with neuronal differentiation sets the threshold for strict IAP regulation of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Reduced Apaf-1 levels in cardiomyocytes engage strict regulation of apoptosis by endogenous XIAP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

The apoptotic protease-activating factor 1-mediated pathway of apoptosis is dispensable for negative selection of thymocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

A morphologically conserved nonapoptotic program promotes linker cell death in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

The apoptosome pathway to caspase activation in primary human neutrophils exhibits dramatically reduced requirements for cytochrome C

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Injected cytochrome c induces apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Analysis of the composition, assembly kinetics and activity of native Apaf-1 apoptosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Death Domain Assembly Mechanism Revealed by Crystal Structure of the Oligomeric PIDDosome Core Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Mechanisms of cytochrome c release from mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Regulation of cell death protease caspase-9 by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

APAF-1-ALT, a novel alternative splicing form of APAF-1, potentially causes impeded ability of undergoing DNA damage-induced apoptosis in the LNCaP human prostate cancer cell line.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

The adapter protein apoptotic protease-activating factor-1 (Apaf-1) is proteolytically processed during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Plasma membrane sequestration of apoptotic protease-activating factor-1 in human B-lymphoma cells: a novel mechanism of chemoresistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Formation of apoptosome is initiated by cytochrome c-induced dATP hydrolysis and subsequent nucleotide exchange on Apaf-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Intracellular nucleotides act as critical prosurvival factors by binding to cytochrome C and inhibiting apoptosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Physiological concentrations of K+ inhibit cytochrome c-dependent formation of the apoptosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Different mitochondrial intermembrane space proteins are released during apoptosis in a manner that is coordinately initiated but can vary in duration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Regulation of cell death: the calcium-apoptosis link

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

The apoptosome: physiological, developmental, and pathological modes of regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Negative regulation of the Apaf-1 apoptosome by Hsp70

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Heat-shock protein 70 antagonizes apoptosis-inducing factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Hsp27 negatively regulates cell death by interacting with cytochrome c.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Hsp27 functions as a negative regulator of cytochrome c-dependent activation of procaspase-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Hsp27 inhibits release of mitochondrial protein Smac in multiple myeloma cells and confers dexamethasone resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Overexpression of the oncoprotein prothymosin alpha triggers a p53 response that involves p53 acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Enhanced sensitivity to cytochrome c-induced apoptosis mediated by PHAPI in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Control of apoptosis by p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Apaf-1 is a transcriptional target for E2F and p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Apaf-1 is a mediator of E2F-1-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Apaf-1 and caspase-9 do not act as tumor suppressors in myc-induced lymphomagenesis or mouse embryo fibroblast transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Apoptosis protease activator protein-1 expression is dispensable for response of human melanoma cells to distinct proapoptotic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Role of DNA methylation in the suppression of Apaf-1 protein in human leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Silencing of APAF-1 in B-CLL results in poor prognosis in the case of concomitant p53 mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Methylation silencing of the Apaf-1 gene in acute leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Defective cytochrome c-dependent caspase activation in ovarian cancer cell lines due to diminished or absent apoptotic protease activating factor-1 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Increased expression of Apaf-1 and procaspase-3 and the functionality of intrinsic apoptosis apparatus in non-small cell lung carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Positive regulation of apoptosis by HCA66, a new Apaf-1 interacting protein, and its putative role in the physiopathology of NF1 microdeletion syndrome patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Reawakening the cellular death program in neoplasia through the therapeutic blockade of IAP function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Drug insight: cancer therapy strategies based on restoration of endogenous cell death mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Induction of endogenous Bcl-xS through the control of Bcl-x pre-mRNA splicing by antisense oligonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Direct activation of the apoptosis machinery as a mechanism to target cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Activation of mitochondrial pathway is crucial for tumor selective induction of apoptosis by LAQ824.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Cancer gene therapy using a survivin mutant adenovirus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Rational design of shepherdin, a novel anticancer agent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Identification of X-linked inhibitor of apoptosis-associated factor-1 as an interferon-stimulated gene that augments TRAIL Apo2L-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Apoptosis-based therapies and drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

Human skeletal muscle cytosols are refractory to cytochrome c-dependent activation of type-II caspases and lack APAF-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

7 January 2021

Expression and functional analysis of Apaf-1 isoforms. Extra Wd-40 repeat is required for cytochrome c binding and regulated activation of procaspase-9

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

7 January 2021

Nuclear localization of apoptosis protease activating factor-1 predicts survival after tumor resection in early-stage non-small cell lung cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

7 January 2021

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

7 January 2021

Calcium blocks formation of apoptosome by preventing nucleotide exchange in Apaf-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

7 January 2021

Reduced Apaf-1 expression in human cutaneous melanomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

7 January 2021

Lack of apoptotic protease activating factor-1 expression and resistance to hypoxia-induced apoptosis in cervical cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

7 January 2021

Loss of APAF-1 expression is associated with tumour progression and adverse prognosis in colorectal cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

7 January 2021

All along the watchtower: on the regulation of apoptosis regulators.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

7 January 2021

Smac-mediated sensitization of human B-lymphoma cells to staurosporine- and lactacystin-triggered apoptosis is apoptosome-dependent

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

7 January 2021

BCL-2 antisense therapy in patients with non-Hodgkin lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

7 January 2021

p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402265

7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4402265

1 reference

17 August 2017

1 reference

PubMed ID

17975549