Escape from p53-mediated tumor surveillance in neuroblastoma: switching off the p14(ARF)-MDM2-p53 axis. (Q37603053)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19779493%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

review article

1 reference

title

Escape from p53-mediated tumor surveillance in neuroblastoma: switching off the p14(ARF)-MDM2-p53 axis (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19779493%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference

2

1 reference

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8 February 2020

Ali Rihani

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19779493%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

author name string

T Van Maerken

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19779493%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

A De Paepe

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19779493%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

F Speleman

5

1 reference

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8 February 2020

publication date

25 September 2009

1 reference

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Cell Death & Differentiation

8 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19779493%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

volume

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19779493%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

issue

12

1 reference

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8 February 2020

page(s)

1563-1572

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19779493%20AND%20SRC:MED&resulttype=core&format=json

p53 is nuclear and functional in both undifferentiated and differentiated neuroblastoma

8 February 2020

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Molecular interaction map of the p53 and Mdm2 logic elements, which control the Off-On switch of p53 in response to DNA damage

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7 January 2021

Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity

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7 January 2021

MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation

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7 January 2021

Hdm2 recruits a hypoxia-sensitive corepressor to negatively regulate p53-dependent transcription

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7 January 2021

Yin Yang 1 is a negative regulator of p53.

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MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation

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7 January 2021

The pathological response to DNA damage does not contribute to p53-mediated tumour suppression

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7 January 2021

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

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7 January 2021

Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

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7 January 2021

P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

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7 January 2021

Nucleolar Arf sequesters Mdm2 and activates p53

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7 January 2021

An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor

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7 January 2021

p53- and Mdm2-Independent Repression of NF-κB Transactivation by the ARF Tumor Suppressor

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7 January 2021

Cytogenetic evolution of mycn and mdm2 amplification in the neuroblastoma ls tumour and its cell line

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7 January 2021

Identification of two distinct chromosome 12-derived amplification units in neuroblastoma cell line NGP

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7 January 2021

High-resolution array copy number analyses for detection of deletion, gain, amplification and copy-neutral LOH in primary neuroblastoma tumors: four cases of homozygous deletions of the CDKN2A gene

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7 January 2021

The p16 (CDKN2A) gene is involved in the growth of neuroblastoma cells and its expression is associated with prognosis of neuroblastoma patients

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

MYCN-directed centrosome amplification requires MDM2-mediated suppression of p53 activity in neuroblastoma cells

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7 January 2021

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7 January 2021

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7 January 2021

Oncogene MYCN regulates localization of NKT cells to the site of disease in neuroblastoma

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7 January 2021

Targeted expression of MYCN causes neuroblastoma in transgenic mice

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7 January 2021

MycN and IFNgamma cooperate in apoptosis of human neuroblastoma cells.

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7 January 2021

MycN sensitizes neuroblastoma cells for drug-induced apoptosis

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7 January 2021

MycN sensitizes neuroblastoma cells for drug-triggered apoptosis

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7 January 2021

N-Myc overexpression leads to decreased beta1 integrin expression and increased apoptosis in human neuroblastoma cells

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7 January 2021

The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.

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7 January 2021

Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis

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7 January 2021

Phosphoregulation of Twist1 provides a mechanism of cell fate control

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Regulation of histone acetyltransferases p300 and PCAF by the bHLH protein twist and adenoviral oncoprotein E1A

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7 January 2021

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7 January 2021

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The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

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7 January 2021

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7 January 2021

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7 January 2021

Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation

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7 January 2021

Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways

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7 January 2021

Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging

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7 January 2021

Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E mu-myc transgenic mice.

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7 January 2021

Perturbation of B and T cell development and predisposition to lymphomagenesis in EμBmi1 transgenic mice require the Bmi1 RING finger

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7 January 2021

Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

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7 January 2021

Bmi-1 cooperates with H-Ras to transform human mammary epithelial cells via dysregulation of multiple growth-regulatory pathways.

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7 January 2021

Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control.

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7 January 2021

E2F proteins regulate MYCN expression in neuroblastomas

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7 January 2021

Bmi-1 regulates the differentiation and clonogenic self-renewal of I-type neuroblastoma cells in a concentration-dependent manner.

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7 January 2021

Definition and characterization of a region of 1p36.3 consistently deleted in neuroblastoma

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7 January 2021

Expression and sequence analysis of candidates for the 1p36.31 tumor suppressor gene deleted in neuroblastomas

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7 January 2021

CHD5, a tumor suppressor gene deleted from 1p36.31 in neuroblastomas

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7 January 2021

CHD5, a new member of the chromodomain gene family, is preferentially expressed in the nervous system

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7 January 2021

CHD5 is a tumor suppressor at human 1p36

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7 January 2021

Gain of chromosome arm 17q and adverse outcome in patients with neuroblastoma

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7 January 2021

Unequivocal delineation of clinicogenetic subgroups and development of a new model for improved outcome prediction in neuroblastoma

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7 January 2021

Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23

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7 January 2021

Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity

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7 January 2021

The serine-threonine protein phosphatase PPM1D is frequently activated through amplification in aggressive primary breast tumours

1 reference

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7 January 2021

Genomic and protein expression profiling identifies CDK6 as novel independent prognostic marker in medulloblastoma

1 reference

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7 January 2021

Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1D

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.138

7 January 2021

Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner

1 reference

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7 January 2021

p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation

1 reference

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7 January 2021

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

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7 January 2021

Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase

1 reference

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7 January 2021

Intrinsic kinase activity and SQ/TQ domain of Chk2 kinase as well as N-terminal domain of Wip1 phosphatase are required for regulation of Chk2 by Wip1.

1 reference

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7 January 2021

The Wip1 phosphatase (PPM1D) antagonizes activation of the Chk2 tumour suppressor kinase

1 reference

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7 January 2021

Wip1 Phosphatase Modulates ATM-Dependent Signaling Pathways

1 reference

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7 January 2021

Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.138

7 January 2021

The Wip1 phosphatase PPM1D dephosphorylates SQ/TQ motifs in checkpoint substrates phosphorylated by PI3K-like kinases

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.138

7 January 2021

The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.138

7 January 2021

Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.138

7 January 2021

Augmented cancer resistance and DNA damage response phenotypes in PPM1D null mice.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.138

7 January 2021

The role of the MKK6/p38 MAPK pathway in Wip1-dependent regulation of ErbB2-driven mammary gland tumorigenesis.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.138

7 January 2021

Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.138

7 January 2021

Evidence that wild-type p53 in neuroblastoma cells is in a conformation refractory to integration into the transcriptional complex

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.138

7 January 2021

Parc: a cytoplasmic anchor for p53.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.138

7 January 2021

Effects on normal fibroblasts and neuroblastoma cells of the activation of the p53 response by the nuclear export inhibitor leptomycin B.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.138

7 January 2021

Hyperubiquitylation of wild-type p53 contributes to cytoplasmic sequestration in neuroblastoma

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.138

7 January 2021

Nitric oxide promotes p53 nuclear retention and sensitizes neuroblastoma cells to apoptosis by ionizing radiation

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.138

7 January 2021

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.138

7 January 2021

Nuclear exclusion of p53 in a subset of tumors requires MDM2 function

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.138

7 January 2021

Human polyomavirus BK (BKV) and neuroblastoma: mechanisms of oncogenic action and possible strategy for novel treatment

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.138

7 January 2021

Negative cross-talk between p53 and the glucocorticoid receptor and its role in neuroblastoma cells

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.138

7 January 2021

Cytoplasmic tethering is involved in synergistic inhibition of p53 by Mdmx and Mdm2.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.138

7 January 2021

Cytoplasmically "sequestered" wild type p53 protein is resistant to Mdm2-mediated degradation

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.138

7 January 2021

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.138

7 January 2021

Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.138

7 January 2021

Distinct E2F-mediated transcriptional program regulates p14ARF gene expression

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.138

7 January 2021

MDM2 inhibition sensitizes neuroblastoma to chemotherapy-induced apoptotic cell death

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.138

7 January 2021

Antitumor activity of the selective MDM2 antagonist nutlin-3 against chemoresistant neuroblastoma with wild-type p53.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.138

7 January 2021