Non-caspase proteases: triggers or amplifiers of apoptosis? (Q37695139)

22 August 2017

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title

Non-caspase proteases: triggers or amplifiers of apoptosis? (English)

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22 August 2017

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Karen Schrader

1

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22 August 2017

Jisen Huai

2

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22 August 2017

Lars Jöckel

3

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22 August 2017

Carolin Oberle

4

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22 August 2017

Christoph Borner

5

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22 August 2017

19 February 2010

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Cellular and Molecular Life Sciences

22 August 2017

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22 August 2017

67

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22 August 2017

10

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22 August 2017

1607-1618

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https://scigraph.springernature.com/pub.10.1007/s00018-010-0287-9

22 August 2017

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A novel serine protease predominately expressed in macrophages

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Bcl-2-mediated resistance to apoptosis is associated with glutathione-induced inhibition of AP24 activation of nuclear DNA fragmentation

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Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor

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12 December 2020

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

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Dual contrasting roles of cysteine cathepsins in cancer progression: apoptosis versus tumour invasion.

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Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons

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Defects in regulation of apoptosis in caspase-2-deficient mice

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Protease inhibitors protect macrophages from lipopolysaccharide-induced cytotoxicity: possible role for NF-kappaB.

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DNA degradation in development and programmed cell death

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Caspase-14 protects against epidermal UVB photodamage and water loss

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Caspase activation: the induced-proximity model

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12 December 2020

Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions

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12 December 2020

The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress

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12 December 2020

Caspase-independent cell death: leaving the set without the final cut.

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12 December 2020

Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice

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12 December 2020

A serine protease is involved in the initiation of DNA damage-induced apoptosis

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12 December 2020

Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

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12 December 2020

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

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12 December 2020

HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins

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12 December 2020

Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks

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12 December 2020

A family of serine esterases in lytic granules of cytolytic T lymphocytes

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12 December 2020

Protection from tumor necrosis factor cytotoxicity by protease inhibitors

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12 December 2020

Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activation

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12 December 2020

Differential requirement for caspase 9 in apoptotic pathways in vivo.

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12 December 2020

drICE is an essential caspase required for apoptotic activity in Drosophila cells

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12 December 2020

Cathepsins: key modulators of cell death and inflammatory responses

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12 December 2020

Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule

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12 December 2020

Activation of CPP32-like proteases is not sufficient to trigger apoptosis: inhibition of apoptosis by agents that suppress activation of AP24, but not CPP32-like activity

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12 December 2020

Noncanonical cell death programs in the nematode Caenorhabditis elegans

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Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

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12 December 2020

Regulation of the activity of lysosomal cysteine proteinases by pH-induced inactivation and/or endogenous protein inhibitors, cystatins

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12 December 2020

Caspase-activated DNase (CAD)-independent oligonucleosomal DNA fragmentation in chronic myeloid leukaemia cells; a requirement for serine protease and Mn2+-dependent acidic endonuclease activity

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12 December 2020

Tumor necrosis factor-related apoptosis-inducing ligand activates a lysosomal pathway of apoptosis that is regulated by Bcl-2 proteins

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12 December 2020

A unified model for apical caspase activation

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12 December 2020

Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis

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12 December 2020

Apoptosome-independent activation of the lysosomal cell death pathway by caspase-9.

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12 December 2020

Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE.

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12 December 2020

Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock

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12 December 2020

Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

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12 December 2020

The emerging role of serine proteases in apoptosis

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12 December 2020

A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

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12 December 2020

TNF-alpha-mediated lysosomal permeabilization is FAN and caspase 8/Bid dependent

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12 December 2020

The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism.

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12 December 2020

Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis.

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12 December 2020

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

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12 December 2020

Apoptotic cell death induced by intracellular proteolysis

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12 December 2020

Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity

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12 December 2020

Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria

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12 December 2020

Tumor cell resistance to apoptosis due to a defect in the activation of sphingomyelinase and the 24 kDa apoptotic protease (AP24).

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12 December 2020

The expanding role of mitochondria in apoptosis

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12 December 2020

Caspases in apoptosis and beyond

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12 December 2020

Death by a thousand cuts: granzyme pathways of programmed cell death

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12 December 2020

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

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12 December 2020

Isolation and partial characterization of a protease involved in Fas-induced apoptosis

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12 December 2020

Caspase-6 is the direct activator of caspase-8 in the cytochrome c-induced apoptosis pathway: absolute requirement for removal of caspase-6 prodomain

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12 December 2020

Death receptor signaling

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12 December 2020

Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9

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12 December 2020

Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor

1 reference

12 December 2020

Internucleosomal DNA cleavage triggered by plasma membrane damage during necrotic cell death. Involvement of serine but not cysteine proteases

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12 December 2020

Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins

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12 December 2020

Functional significance of the perforin/granzyme cell death pathway

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12 December 2020

The serpin superfamily of proteinase inhibitors: structure, function, and regulation

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12 December 2020

Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route

1 reference

12 December 2020

Caspase inhibition causes hyperacute tumor necrosis factor-induced shock via oxidative stress and phospholipase A2.

1 reference

12 December 2020

L-DNase II activation by the 24 kDa apoptotic protease (AP24) in TNFalpha-induced apoptosis

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12 December 2020

A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes

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12 December 2020

The CASBAH: a searchable database of caspase substrates

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12 December 2020

Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency

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12 December 2020

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

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12 December 2020

Processing and activation of lysosomal proteinases

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12 December 2020

Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha

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12 December 2020

Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis

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12 December 2020

Human and mouse granzyme A induce a proinflammatory cytokine response.

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12 December 2020

Pyroptosis: host cell death and inflammation

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12 December 2020

Characterization of a serine protease-mediated cell death program activated in human leukemia cells

1 reference

12 December 2020

A common set of engulfment genes mediates removal of both apoptotic and necrotic cell corpses in C. elegans

1 reference

12 December 2020

Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9

1 reference

12 December 2020

Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid.

1 reference

12 December 2020

Cathepsin B mediates TRAIL-induced apoptosis in oral cancer cells.

1 reference

12 December 2020

Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme

1 reference

12 December 2020

Caspase-6 gene disruption reveals a requirement for lamin A cleavage in apoptotic chromatin condensation

1 reference

12 December 2020

Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases

1 reference

12 December 2020

Identification of RIP1 kinase as a specific cellular target of necrostatins

1 reference

12 December 2020

Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation

1 reference

12 December 2020

Genetic control of programmed cell death in the nematode C. elegans.

1 reference

12 December 2020

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

1 reference

12 December 2020

Degradation of Mcl-1 by granzyme B: implications for Bim-mediated mitochondrial apoptotic events

1 reference

12 December 2020

Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 and TNF-alpha

1 reference

12 December 2020

Caspase structure, proteolytic substrates, and function during apoptotic cell death

1 reference

12 December 2020

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

1 reference

12 December 2020

The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta

1 reference

12 December 2020

AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis

1 reference

12 December 2020

Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases

1 reference

12 December 2020

Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A.

1 reference

12 December 2020

Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death

1 reference

12 December 2020

Apoptosis caused by cathepsins does not require Bid signaling in an in vivo model of progressive myoclonus epilepsy (EPM1).

1 reference

12 December 2020

Lysosomal membrane permeabilization induces cell death in a mitochondrion-dependent fashion

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12 December 2020

Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1 reference

12 December 2020

Bid is upstream of lysosome-mediated caspase 2 activation in tumor necrosis factor alpha-induced hepatocyte apoptosis

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12 December 2020

Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice

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12 December 2020

Broad-spectrum caspase inhibitors: from myth to reality?

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12 December 2020

Caspases 3 and 7: key mediators of mitochondrial events of apoptosis

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12 December 2020

A novel Apaf-1-independent putative caspase-2 activation complex

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12 December 2020

A more serine way to die: defining the characteristics of serine protease-mediated cell death cascades

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12 December 2020

Biochemical pathways of apoptosis: nicotinamide adenine dinucleotide-deficient cells are resistant to tumor necrosis factor or ultraviolet light activation of the 24-kD apoptotic protease and DNA fragmentation

1 reference

12 December 2020

DNA-PKcs-PIDDosome: a nuclear caspase-2-activating complex with role in G2/M checkpoint maintenance

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12 December 2020

Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c

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12 December 2020

Inhibition of human caspases by peptide-based and macromolecular inhibitors

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12 December 2020

Endonuclease G is an apoptotic DNase when released from mitochondria

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12 December 2020

A conserved checkpoint pathway mediates DNA damage--induced apoptosis and cell cycle arrest in C. elegans

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12 December 2020

The lysosomal cysteine protease cathepsin L regulates keratinocyte proliferation by control of growth factor recycling.

1 reference

12 December 2020

Caspase-dependant activation of chymotrypsin-like proteases mediates nuclear events during Jurkat T cell apoptosis.

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12 December 2020

Apoptosis induced in Jurkat cells by several agents is preceded by intracellular acidification

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12 December 2020

Non-specific effects of methyl ketone peptide inhibitors of caspases

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12 December 2020

Lysosomal membrane permeabilization in cell death

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12 December 2020

Programmed cell death in animal development

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12 December 2020

Lysosomal membrane permeabilization and cathepsin release is a Bax/Bak-dependent, amplifying event of apoptosis in fibroblasts and monocytes.

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12 December 2020

Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

1 reference

12 December 2020

Serine protease inhibitors suppress cytochrome c-mediatedcaspase-9 activation and apoptosis during hypoxia-reoxygenation

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12 December 2020

Cysteine cathepsins trigger caspase-dependent cell death through cleavage of bid and antiapoptotic Bcl-2 homologues

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12 December 2020

Impaired apoptosis of lymphocytes derived from patient with decreased expression of caspase-8 results in Alps-like phenotype

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12 December 2020

Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila

1 reference

12 December 2020

Emerging roles of cysteine cathepsins in disease and their potential as drug targets.

1 reference

12 December 2020

Death receptors: signaling and modulation

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12 December 2020

The BCL-2 protein family: opposing activities that mediate cell death

1 reference

12 December 2020

The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions

1 reference

12 December 2020

10.1007/S00018-010-0287-9

Identifiers

DOI

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22 August 2017

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