Shaping the T‐cell repertoire: a matter of life and death (Q37808101)

23 August 2017

title

Shaping the T-cell repertoire: a matter of life and death (English)

1 reference

https://api.crossref.org/works/10.1038/ICB.2010.127

23 August 2017

Shaping the T‐cell repertoire: a matter of life and death (English)

1 reference

22 August 2024

author name string

Manuel Kaufmann

2

1 reference

23 August 2017

Denise Tischner

3

1 reference

23 August 2017

Andreas Villunger

4

1 reference

23 August 2017

G. Jan Wiegers

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21060321

22 August 2024

language of work or name

1 reference

9 November 2010

1 reference

full work available at URL

23 August 2017

https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1038%2Ficb.2010.127

1 reference

https://api.crossref.org/works/10.1038/ICB.2010.127

https://onlinelibrary.wiley.com/doi/pdf/10.1038/icb.2010.127

22 August 2024

1 reference

https://api.crossref.org/works/10.1038/ICB.2010.127

https://onlinelibrary.wiley.com/doi/full-xml/10.1038/icb.2010.127

22 August 2024

1 reference

https://api.crossref.org/works/10.1038/ICB.2010.127

Immunology & Cell Biology

22 August 2024

published in

1 reference

23 August 2017

volume

89

1 reference

23 August 2017

issue

1

1 reference

23 August 2017

page(s)

33-39

1 reference

Molecular orchestration of differentiation and function of regulatory T cells

23 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

A central role for central tolerance

21 January 2018

1 reference

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Projection of an immunological self shadow within the thymus by the aire protein

21 January 2018

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An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

21 January 2018

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Positional cloning of the APECED gene

21 January 2018

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How defects in central tolerance impinge on a deficiency in regulatory T cells

21 January 2018

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The role of BH3-only proteins in the immune system

21 January 2018

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Bcl-2-regulated cell death signalling in the prevention of autoimmunity

21 January 2018

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The BCL-2 protein family: opposing activities that mediate cell death

21 January 2018

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Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

21 January 2018

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Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand

21 January 2018

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Autoimmune lymphoproliferative syndromes: genetic defects of apoptosis pathways

21 January 2018

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Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

21 January 2018

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NRAS mutation causes a human autoimmune lymphoproliferative syndrome.

21 January 2018

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Antigen presentation in the thymus for positive selection and central tolerance induction

21 January 2018

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Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis.

21 January 2018

1 reference

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Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction

21 January 2018

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Loss of Bim results in abnormal accumulation of mature CD4-CD8-CD44-CD25- thymocytes

21 January 2018

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A central role for thymic emigrants in peripheral T cell homeostasis

21 January 2018

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Thymic progenitor homing and lymphocyte homeostasis are linked via S1P-controlled expression of thymic P-selectin/CCL25

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.127

Thymocyte development is normal in CTLA-4-deficient mice

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.127

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

TCR signaling inhibits glucocorticoid-induced apoptosis in murine thymocytes depending on the stage of development

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.127

Rapid in vivo effects of glucocorticoids on the integrity of rat lymphocyte genomic deoxyribonucleic acid.

21 January 2018

1 reference

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Thymocyte apoptosis induced by elevated endogenous corticosterone levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

THE INFLUENCE OF THE SUPRARENAL GLAND ON THE THYMUS : III. STIMULATION OF THE GROWTH OF THE THYMUS GLAND FOLLOWING DOUBLE SUPRARENALECTOMY IN YOUNG RATS

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

Thymus-derived glucocorticoids are insufficient for normal thymus homeostasis in the adult mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

Thymocyte resistance to glucocorticoids leads to antigen-specific unresponsiveness due to "holes" in the T cell repertoire

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

Intrathymic T cell development and selection proceeds normally in the absence of glucocorticoid receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

Glucocorticoid receptor deficient thymic and peripheral T cells develop normally in adult mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

Disruption of glucocorticoid receptor exon 2 yields a ligand-responsive C-terminal fragment that regulates gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

Thymocyte apoptosis induced by T cell activation is mediated by glucocorticoids in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

Glucocorticoids inhibit activation-induced cell death (AICD) via direct DNA-dependent repression of the CD95 ligand gene by a glucocorticoid receptor dimer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

DNA binding of the glucocorticoid receptor is not essential for survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

Steroid production in the thymus: implications for thymocyte selection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

Thymocyte-synthesized glucocorticoids play a role in thymocyte homeostasis and are down-regulated by adrenocorticotropic hormone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

Thymus-derived glucocorticoids mediate androgen effects on thymocyte homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

Activation of thymic regeneration in mice and humans following androgen blockade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

c-Cbl promotes T cell receptor-induced thymocyte apoptosis by activating the phosphatidylinositol 3-kinase/Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

Signaling by the kinase MINK is essential in the negative selection of autoreactive thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

Apoptosis during lymphoid development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

Bim and Bmf in tissue homeostasis and malignant disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

Negative selection of semimature CD4(+)8(-)HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

Critical roles of Bim in T cell activation and T cell-mediated autoimmune inflammation in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

Bim-mediated apoptosis is not necessary for thymic negative selection to ubiquitous self-antigens.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

A novel TCR transgenic model reveals that negative selection involves an immediate, Bim-dependent pathway and a delayed, Bim-independent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

Complete but curtailed T-cell response to very low-affinity antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

Apoptosis threshold set by Noxa and Mcl-1 after T cell activation regulates competitive selection of high-affinity clones.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

Noxa: at the tip of the balance between life and death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

21 January 2018

Only the strong survive.

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

The Bcl-2 family antagonist ABT-737 significantly inhibits multiple animal models of autoimmunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

Bim-Bcl-2 homology 3 mimetic therapy is effective at suppressing inflammatory arthritis through the activation of myeloid cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

Killing of immature CD4+ CD8+ thymocytes in vivo by anti-CD3 or 5'-(N-ethyl)-carboxamide adenosine is blocked by glucocorticoid receptor antagonist RU-486

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

7 January 2021

A targeted glucocorticoid receptor antisense transgene increases thymocyte apoptosis and alters thymocyte development

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

7 January 2021

Effects of altered glucocorticoid sensitivity in the T cell lineage on thymocyte and T cell homeostasis

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

7 January 2021

T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

7 January 2021

Paracrine glucocorticoid activity produced by mouse thymic epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

7 January 2021

Conditional expression of a glucocorticoid receptor transgene in thymocytes reveals a role for thymic-derived glucocorticoids in thymopoiesis in vivo

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

7 January 2021

Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim.

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.127

7 January 2021

Identifiers

DOI

10.1038/ICB.2010.127

1 reference

23 August 2017

1 reference