Parkinson's disease, proteins, and prions: milestones (Q37882593)

24 August 2017

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title

Parkinson's disease, proteins, and prions: milestones (English)

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24 August 2017

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Charles Warren Olanow

series ordinal

1

object named as

C Warren Olanow

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24 August 2017

K McNaught

2

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PubMed ID

21626551

24 August 2017

language of work or name

English

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publication date

1 May 2011

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24 August 2017

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24 August 2017

26

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24 August 2017

6

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24 August 2017

1056-1071

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Staging of brain pathology related to sporadic Parkinson's disease

24 August 2017

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Anti-ubiquitin immunocytochemistry is more sensitive than conventional techniques in the detection of diffuse Lewy body disease

21 January 2018

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alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

21 January 2018

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A critical evaluation of the Braak staging scheme for Parkinson's disease.

21 January 2018

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The Parkinson's complex: parkinsonism is just the tip of the iceberg

21 January 2018

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Protein degradation and protection against misfolded or damaged proteins

21 January 2018

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Autophagy and neurodegeneration: when the cleaning crew goes on strike

21 January 2018

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21 January 2018

The lysosome turns fifty

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Autophagy in the Pathogenesis of Disease

21 January 2018

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21 January 2018

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Mechanisms underlying ubiquitination

21 January 2018

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Proteasomes: machines for all reasons

21 January 2018

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Aggresomes, inclusion bodies and protein aggregation

21 January 2018

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21 January 2018

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Lewy-body formation is an aggresome-related process: a hypothesis

21 January 2018

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Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective

21 January 2018

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

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Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

21 January 2018

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The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

21 January 2018

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Hereditary form of parkinsonism--dementia

21 January 2018

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Fibrillization of alpha-synuclein and tau in familial Parkinson's disease caused by the A53T alpha-synuclein mutation

21 January 2018

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Concurrence of alpha-synuclein and tau brain pathology in the Contursi kindred

21 January 2018

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Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

21 January 2018

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alpha-Synuclein locus triplication causes Parkinson's disease

21 January 2018

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Alpha-synuclein and neurodegenerative diseases

21 January 2018

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Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

21 January 2018

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Interplay of alpha-synuclein binding and conformational switching probed by single-molecule fluorescence.

21 January 2018

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NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

21 January 2018

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Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease.

21 January 2018

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Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

21 January 2018

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Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils

21 January 2018

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Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

21 January 2018

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The alpha-synuclein mutation E46K promotes aggregation in cultured cells

21 January 2018

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Endoproteolytic activity of the proteasome

21 January 2018

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Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway.

21 January 2018

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Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

21 January 2018

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Aggregated and monomeric alpha-synuclein bind to the S6' proteasomal protein and inhibit proteasomal function

21 January 2018

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Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

21 January 2018

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The Parkinson disease protein α-synuclein inhibits autophagy

21 January 2018

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Impairment of the ubiquitin-proteasome system by protein aggregation

21 January 2018

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A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease

21 January 2018

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A Drosophila model of Parkinson's disease

21 January 2018

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Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson's disease

21 January 2018

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Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

21 January 2018

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Olfactory deficits in mice overexpressing human wildtype alpha-synuclein

21 January 2018

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Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions.

21 January 2018

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

21 January 2018

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Association between early-onset Parkinson's disease and mutations in the parkin gene

21 January 2018

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Pathologic and biochemical studies of juvenile parkinsonism linked to chromosome 6q.

21 January 2018

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Immunodetection of Parkin protein in vertebrate and invertebrate brains: a comparative study using specific antibodies

21 January 2018

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Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

21 January 2018

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Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

21 January 2018

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An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

21 January 2018

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Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

21 January 2018

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Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation

21 January 2018

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Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain

21 January 2018

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CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity

21 January 2018

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Protein quality control: U-box-containing E3 ubiquitin ligases join the fold

21 January 2018

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Parkin interacts with the proteasome subunit alpha4

21 January 2018

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Immunohistochemical and subcellular localization of Parkin protein: absence of protein in autosomal recessive juvenile parkinsonism patients

21 January 2018

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Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

21 January 2018

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Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila

21 January 2018

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Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse

21 January 2018

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Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons

21 January 2018

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Parkin-deficient mice are not a robust model of parkinsonism

21 January 2018

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Parkin variants in North American Parkinson's disease: cases and controls.

21 January 2018

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The ubiquitin pathway in Parkinson's disease.

21 January 2018

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The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase

21 January 2018

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Alterations of structure and hydrolase activity of parkinsonism-associated human ubiquitin carboxyl-terminal hydrolase L1 variants

21 January 2018

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Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron

21 January 2018

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Impairment of the ubiquitin-proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures

21 January 2018

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UCHL1 is a Parkinson's disease susceptibility gene.

21 January 2018

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UCHL-1 is not a Parkinson's disease susceptibility gene

21 January 2018

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A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11.2-q13.1.

21 January 2018

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Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

21 January 2018

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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

21 January 2018

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Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

21 January 2018

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Leucine-rich repeat kinase 2 gene-associated disease: redefining genotype-phenotype correlation

21 January 2018

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Leucine-rich repeat kinase 2 is associated with the endoplasmic reticulum in dopaminergic neurons and accumulates in the core of Lewy bodies in Parkinson disease

21 January 2018

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The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

21 January 2018

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Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

21 January 2018

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Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice

21 January 2018

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Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.

21 January 2018

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Failure of the ubiquitin-proteasome system in Parkinson's disease

21 January 2018

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Molecular Pathways of Neurodegeneration in Parkinson's Disease

21 January 2018

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Ubiquitin-proteasome system and Parkinson's disease

21 January 2018

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The expression of mRNAs for the proteasome complex is developmentally regulated in the rat mesencephalon

21 January 2018

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Caretaker or undertaker? The role of the proteasome in aging

21 January 2018

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Proteasomal activity in brain differs between species and brain regions and changes with age.

21 January 2018

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Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?

21 January 2018

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The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease

21 January 2018

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Altered proteasomal function in sporadic Parkinson's disease

21 January 2018

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Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function

21 January 2018

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Brain proteasomal function in sporadic Parkinson's disease and related disorders

21 January 2018

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Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

21 January 2018

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Dopaminergic neurons in rat ventral midbrain cultures undergo selective apoptosis and form inclusions, but do not up-regulate iHSP70, following proteasomal inhibition

21 January 2018

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Proteasome inhibition causes nigral degeneration with inclusion bodies in rats

21 January 2018

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Retrograde dopaminergic neuron degeneration following intrastriatal proteasome inhibition

21 January 2018

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Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease

21 January 2018

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Proteasomal inhibition causes loss of nigral tyrosine hydroxylase neurons.

21 January 2018

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The effects of dose and route of administration of PSI on behavioural and biochemical indices of neuronal degeneration in the rat brain

21 January 2018

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p53 mediates nontranscriptional cell death in dopaminergic cells in response to proteasome inhibition

21 January 2018

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Failure of proteasome inhibitor administration to provide a model of Parkinson's disease in rats and monkeys.

21 January 2018

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Proteasome inhibition and Parkinson's disease modeling

21 January 2018

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Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies.

21 January 2018

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Chaperone-mediated autophagy markers in Parkinson disease brains

21 January 2018

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Pathogenic lysosomal depletion in Parkinson's disease

21 January 2018

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Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species

21 January 2018

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Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress: implications for Parkinson's disease

21 January 2018

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Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death

21 January 2018

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Loss of autophagy in the central nervous system causes neurodegeneration in mice

21 January 2018

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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

21 January 2018

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Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease.

21 January 2018

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Gaucher disease ascertained through a Parkinson's center: imaging and clinical characterization

21 January 2018

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Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease

21 January 2018

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Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

21 January 2018

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Transplanted dopaminergic neurons develop PD pathologic changes: a second case report

21 January 2018

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A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease

21 January 2018

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Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease

21 January 2018

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Intravesicular localization and exocytosis of alpha-synuclein and its aggregates.

21 January 2018

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Assembly-dependent endocytosis and clearance of extracellular alpha-synuclein.

21 January 2018

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Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

21 January 2018

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α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

21 January 2018

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Is Parkinson's disease a prion disorder?

21 January 2018

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21 January 2018

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Structure of membrane-bound alpha-synuclein from site-directed spin labeling and computational refinement

21 January 2018

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Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein

21 January 2018

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Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice

21 January 2018

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Neuroprotection in Parkinson disease: mysteries, myths, and misconceptions

21 January 2018

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Proteasome inhibition in oxidative stress neurotoxicity: implications for heat shock proteins.

21 January 2018

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Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity

21 January 2018

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Proteasomal inhibition by alpha-synuclein filaments and oligomers.

21 January 2018

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Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

21 January 2018

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Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin

21 January 2018

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Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice

21 January 2018

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Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1

21 January 2018

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Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease

21 January 2018

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Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

21 January 2018

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Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease

21 January 2018

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Multiple effects of trehalose on protein folding in vitro and in vivo

21 January 2018

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Geldanamycin induces Hsp70 and prevents alpha-synuclein aggregation and toxicity in vitro

21 January 2018

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Pharmacological prevention of Parkinson disease in Drosophila.

21 January 2018

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Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein

21 January 2018

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Accelerated formation of alpha-synuclein oligomers by concerted action of the 20S proteasome and familial Parkinson mutations

21 January 2018

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Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease

21 January 2018

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Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein

21 January 2018

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Ubiquitin (UbC) expression in muscle cells is increased by glucocorticoids through a mechanism involving Sp1 and MEK1

21 January 2018

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Sensitivity and protein turnover response to glucocorticoids are different in skeletal muscle from adult and old rats. Lack of regulation of the ubiquitin-proteasome proteolytic pathway in aging

21 January 2018

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Identification of ubiquitin ligases required for skeletal muscle atrophy

21 January 2018

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Glucocorticoids regulate mRNA levels for subunits of the 19 S regulatory complex of the 26 S proteasome in fast-twitch skeletal muscles.

21 January 2018

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Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions

21 January 2018

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Mice devoid of PrP are resistant to scrapie

21 January 2018

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Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein

21 January 2018

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Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodies

21 January 2018

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Doxycycline control of prion protein transgene expression modulates prion disease in mice

21 January 2018

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Prion clearance in bigenic mice

21 January 2018

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Autophagy and neurodegeneration

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/MDS.23767

1 reference

24 August 2017

1 reference

PubMed ID

21626551