Intracellular trafficking of the β-secretase and processing of amyloid precursor protein (Q37915426)

25 August 2017

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title

Intracellular trafficking of the β-secretase and processing of amyloid precursor protein (English)

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25 August 2017

Paul A Gleeson

2

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author name string

Pei Zhi Cheryl Chia

series ordinal

1

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25 August 2017

publication date

10 August 2011

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25 August 2017

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25 August 2017

volume

63

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25 August 2017

issue

9

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25 August 2017

page(s)

721-729

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Traffic jam: a compendium of human diseases that affect intracellular transport processes

25 August 2017

cites work

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New insights into membrane trafficking and protein sorting.

21 January 2018

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The trans Golgi network: sorting at the exit site of the Golgi complex.

21 January 2018

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Endocytosis and signaling. an inseparable partnership

21 January 2018

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Retrograde traffic in the biosynthetic-secretory route: pathways and machinery

21 January 2018

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The trans-Golgi network: a late secretory sorting station

21 January 2018

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Regulation of microtubule-dependent recycling at the trans-Golgi network by Rab6A and Rab6A'

21 January 2018

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Pathways and mechanisms of endocytic recycling

21 January 2018

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Tracing the retrograde route in protein trafficking.

21 January 2018

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Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

21 January 2018

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Amyloid plaque core protein in Alzheimer disease and Down syndrome

21 January 2018

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Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

21 January 2018

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Potentially Amyloidogenic, Carboxyl-Terminal Derivatives of the Amyloid Protein Precursor

21 January 2018

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Secretion of β-amyloid precursor protein cleaved at the amino terminus of the β-amyloid peptide

21 January 2018

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A beta oligomers - a decade of discovery

21 January 2018

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Presenilin: running with scissors in the membrane

21 January 2018

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Cleavage of amyloid beta peptide during constitutive processing of its precursor

21 January 2018

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Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease

21 January 2018

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

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Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

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aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

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The role of presenilin cofactors in the gamma-secretase complex

21 January 2018

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Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

21 January 2018

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Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

21 January 2018

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Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

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Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

21 January 2018

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BACE1 (beta-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time

21 January 2018

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Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

21 January 2018

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Expression analysis of BACE2 in brain and peripheral tissues

21 January 2018

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Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes

21 January 2018

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BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

21 January 2018

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BACE2 functions as an alternative alpha-secretase in cells

21 January 2018

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Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production

21 January 2018

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A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase

21 January 2018

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Processing of beta-secretase by furin and other members of the proprotein convertase family

21 January 2018

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Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties

21 January 2018

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Analysis of N-linked oligosaccharides: progress towards the characterisation of glycoprotein-linked carbohydrates

21 January 2018

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The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate

21 January 2018

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Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

21 January 2018

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Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts

21 January 2018

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Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein

21 January 2018

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Efficient inhibition of the Alzheimer's disease beta-secretase by membrane targeting

21 January 2018

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Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts

21 January 2018

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Cleavage of Alzheimer's amyloid precursor protein by alpha-secretase occurs at the surface of neuronal cells

21 January 2018

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Beta-amyloid precursor protein cleavage by a membrane-bound protease

21 January 2018

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Inhibition of Receptor-mediated Endocytosis Demonstrates Generation of Amyloid β-Protein at the Cell Surface

21 January 2018

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Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes

21 January 2018

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Alzheimer's disease beta-amyloid peptides are released in association with exosomes

21 January 2018

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Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis

21 January 2018

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Amyloidogenic processing of beta-amyloid precursor protein in intracellular compartments

21 January 2018

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BACE is degraded via the lysosomal pathway

21 January 2018

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GGA proteins mediate the recycling pathway of memapsin 2 (BACE).

21 January 2018

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GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network

21 January 2018

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Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex

21 January 2018

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Signals for sorting of transmembrane proteins to endosomes and lysosomes

21 January 2018

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Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes

21 January 2018

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A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein

21 January 2018

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The X11 proteins, Abeta production and Alzheimer's disease.

21 January 2018

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Mints as adaptors. Direct binding to neurexins and recruitment of munc18

21 January 2018

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Mint3/X11gamma is an ADP-ribosylation factor-dependent adaptor that regulates the traffic of the Alzheimer's Precursor protein from the trans-Golgi network

21 January 2018

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A structural explanation for the recognition of tyrosine-based endocytotic signals

21 January 2018

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The carboxyl-terminus of BACE contains a sorting signal that regulates BACE trafficking but not the formation of total A(beta).

21 January 2018

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A structural explanation for the binding of endocytic dileucine motifs by the AP2 complex

21 January 2018

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The GGA proteins: adaptors on the move

21 January 2018

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Demonstration of BACE (beta-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy

21 January 2018

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Phosphorylation regulates intracellular trafficking of beta-secretase

21 January 2018

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Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity

21 January 2018

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GGA1 acts as a spatial switch altering amyloid precursor protein trafficking and processing.

21 January 2018

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Interactions of GGA3 with the ubiquitin sorting machinery

21 January 2018

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Ubiquitin regulates GGA3-mediated degradation of BACE1

21 January 2018

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Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor

21 January 2018

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Identification of different itineraries and retromer components for endosome-to-Golgi transport of TGN38 and Shiga toxin

21 January 2018

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The retromer complex and clathrin define an early endosomal retrograde exit site.

21 January 2018

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Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer

21 January 2018

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The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor

21 January 2018

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A sorting nexin-1 homologue, Vps5p, forms a complex with Vps17p and is required for recycling the vacuolar protein-sorting receptor

21 January 2018

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A membrane coat complex essential for endosome-to-Golgi retrograde transport in yeast

21 January 2018

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Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides

21 January 2018

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Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors

21 January 2018

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Recycle your receptors with retromer

21 January 2018

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The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network

21 January 2018

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The structure and function of the retromer protein complex.

21 January 2018

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Model-guided microarray implicates the retromer complex in Alzheimer's disease

21 January 2018

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The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

21 January 2018

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Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation

21 January 2018

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Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated

21 January 2018

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Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein

21 January 2018

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Sorting by the cytoplasmic domain of the amyloid precursor protein binding receptor SorLA.

21 January 2018

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The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments

21 January 2018

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Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex

21 January 2018

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Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing.

21 January 2018

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BACE1 retrograde trafficking is uniquely regulated by the cytoplasmic domain of sortilin

21 January 2018

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Isoaspartate-containing amyloid precursor protein-derived peptides alter efficacy and specificity of potential beta-secretases

21 January 2018

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A portrait of Alzheimer secretases--new features and familiar faces

21 January 2018

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Neurotoxic traffic: uncovering the mechanics of amyloid production in Alzheimer's disease

21 January 2018

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Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons

21 January 2018

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Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis

21 January 2018

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Inhibitors and modulators of beta- and gamma-secretase

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IUB.512

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25 August 2017

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