Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and presenilin (Q37961473)

26 August 2017

title

Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and presenilin (English)

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26 August 2017

Johannes Prox

1

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26 August 2017

Andrea Rittger

series ordinal

2

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26 August 2017

Paul Saftig

series ordinal

3

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26 August 2017

publication date

27 November 2011

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26 August 2017

number of pages

11

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Experimental Brain Research

inferred from page(s)

published in

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26 August 2017

volume

217

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26 August 2017

issue

3-4

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26 August 2017

page(s)

331-341

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Not(ch) just development: Notch signalling in the adult brain

26 August 2017

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Constitutive activation of metalloproteinase ADAM10 in mantle cell lymphoma promotes cell growth and activates the TNFα/NFκB pathway

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Expression analysis of BACE2 in brain and peripheral tissues

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The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations

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Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease

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Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

21 January 2018

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BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice

21 January 2018

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The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein

21 January 2018

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Novel research horizons for presenilins and γ-secretases in cell biology and disease

21 January 2018

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

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A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

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The secretases: enzymes with therapeutic potential in Alzheimer disease

21 January 2018

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Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice

21 January 2018

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SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.

21 January 2018

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The role of ADAMs in disease pathophysiology

21 January 2018

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The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages: modulation of APLP-1 processing by n-glycosylation

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Blocking ADAM10 synaptic trafficking generates a model of sporadic Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

SFRPs act as negative modulators of ADAM10 to regulate retinal neurogenesis.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Expression of L1-CAM and ADAM10 in human colon cancer cells induces metastasis.

21 January 2018

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ADAM10 overexpression shifts lympho- and myelopoiesis by dysregulating site 2/site 3 cleavage products of Notch

21 January 2018

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Filling the gaps in the abeta cascade hypothesis of Alzheimer's disease

21 January 2018

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Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide

21 January 2018

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Presenilin-1 deficiency leads to loss of Cajal-Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Molecular mechanisms and therapeutic application of NSAIDs and derived compounds in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Increased processing of APLP2 and APP with concomitant formation of APP intracellular domains in BDNF and retinoic acid-differentiated human neuroblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Bace1 modulates myelination in the central and peripheral nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

BACE1 deficiency causes altered neuronal activity and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Non-proteolytic effect of beta-site APP-cleaving enzyme 1 (BACE1) on sodium channel function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

β-Site APP-cleaving enzyme 1 (BACE1) cleaves cerebellar Na+ channel β4-subunit and promotes Purkinje cell firing by slowing the decay of resurgent Na+ current.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Therapeutic intervention for Alzheimer's disease with γ-secretase inhibitors: still a viable option?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Gamma-secretase and the intramembrane proteolysis of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Metalloprotease-disintegrin (ADAM) genes are widely and differentially expressed in the adult CNS

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

BACE1 regulates voltage-gated sodium channels and neuronal activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Characterization of alpha 2,6-sialyltransferase cleavage by Alzheimer's beta -secretase (BACE1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

In vivo cleavage of alpha2,6-sialyltransferase by Alzheimer beta-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Gamma-secretase: proteasome of the membrane?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

The canonical Notch signaling pathway: unfolding the activation mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Regulated intramembrane proteolysis--lessons from amyloid precursor protein processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Synaptic localization and activity of ADAM10 regulate excitatory synapses through N-cadherin cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Synapse-associated protein-97 mediates alpha-secretase ADAM10 trafficking and promotes its activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Presenilin-dependent regulated intramembrane proteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Notch signaling: from the outside in

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

BACE (beta-secretase) modulates the processing of APLP2 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Alzheimer's disease beta-amyloid peptides are released in association with exosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Regulated ADAM10-dependent ectodomain shedding of gamma-protocadherin C3 modulates cell-cell adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Downregulation of PS1 expression in neurons decreases beta-amyloid production: a biochemical link between the two major familial Alzheimer's disease genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

The function of presenilin-1 in amyloid beta-peptide generation and brain development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Neuregulin 1 and susceptibility to schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Intramembrane proteolysis by gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Beta-galactoside alpha2,6-sialyltransferase I cleavage by BACE1 enhances the sialylation of soluble glycoproteins. A novel regulatory mechanism for alpha2,6-sialylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Eliciting the T cell fate with Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Up-regulation of the alpha-secretase ADAM10 by retinoic acid receptors and acitretin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Secretase inhibitors and modulators for Alzheimer's disease treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Presenilins: members of the gamma-secretase quartets, but part-time soloists too.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Phosphorylation regulates intracellular trafficking of beta-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Mice lacking the metalloprotease-disintegrin MDC9 (ADAM9) have no evident major abnormalities during development or adult life.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Control of peripheral nerve myelination by the beta-secretase BACE1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Function, regulation and therapeutic properties of beta-secretase (BACE1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2952-0

Activity-dependent alpha-cleavage of nectin-1 is mediated by a disintegrin and metalloprotease 10 (ADAM10).

21 January 2018

1 reference

12 December 2020

Genomic structure and functional characterization of the human ADAM10 promoter

1 reference

12 December 2020

Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase

1 reference

12 December 2020

The Role of the anti-amyloidogenic secretase ADAM10 in shedding the APP-like proteins

1 reference

12 December 2020

Deletion of Adam10 in endothelial cells leads to defects in organ-specific vascular structures

1 reference

12 December 2020

Alzheimer's disease: genes, proteins, and therapy

1 reference

12 December 2020

γ-Secretase modulators as potential disease modifying anti-Alzheimer's drugs

1 reference

12 December 2020

10.1007/S00221-011-2952-0

Identifiers

DOI

1 reference

26 August 2017

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