Small-molecule chromatin-modifying agents: therapeutic applications (Q37961728)

26 August 2017

title

Small-molecule chromatin-modifying agents: therapeutic applications (English)

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26 August 2017

Antonello Mai

1

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publication date

1 April 2010

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26 August 2017

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26 August 2017

volume

2

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26 August 2017

issue

2

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26 August 2017

page(s)

307-324

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Epigenetics: a landscape takes shape

26 August 2017

cites work

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Epi-drugs to fight cancer: from chemistry to cancer treatment, the road ahead

21 January 2018

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The therapeutic uses of chromatin-modifying agents

21 January 2018

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Histone acetyltransferase inhibitors and preclinical studies

21 January 2018

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Non-cancer uses of histone deacetylase inhibitors: effects on infectious diseases and beta-hemoglobinopathies

21 January 2018

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The emerging therapeutic potential of histone methyltransferase and demethylase inhibitors

21 January 2018

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Cancer treatment of the future: inhibitors of histone methyltransferases

21 January 2018

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The many roles of histone deacetylases in development and physiology: implications for disease and therapy

21 January 2018

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Histone acetyl transferases as emerging drug targets.

21 January 2018

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Histone deacetylase inhibitors and neurodegenerative disorders: holding the promise

21 January 2018

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Chromatin modifications and their function

21 January 2018

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Acetylation and chromosomal functions.

21 January 2018

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Histone acetylation in chromatin structure and transcription

21 January 2018

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Enhanced histone acetylation and transcription: a dynamic perspective

21 January 2018

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Functions of site-specific histone acetylation and deacetylation

21 January 2018

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Multivalent engagement of chromatin modifications by linked binding modules

21 January 2018

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Deacetylase enzymes: biological functions and the use of small-molecule inhibitors

21 January 2018

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Histone deacetylation in epigenetics: an attractive target for anticancer therapy

21 January 2018

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Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression

21 January 2018

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Class II histone deacetylases: versatile regulators

21 January 2018

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Class IIa histone deacetylases: regulating the regulators

21 January 2018

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Histone deacetylase inhibitors: Potential in cancer therapy

21 January 2018

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HDAC family: What are the cancer relevant targets?

21 January 2018

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MEF2: a calcium-dependent regulator of cell division, differentiation and death

21 January 2018

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HDAC6 is a microtubule-associated deacetylase

21 January 2018

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The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance

21 January 2018

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Anticancer activities of histone deacetylase inhibitors

21 January 2018

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Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer

21 January 2018

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Histone deacetylases and cancer

21 January 2018

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Histone deacetylase inhibitors: mechanisms and clinical significance in cancer: HDAC inhibitor-induced apoptosis

21 January 2018

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Retinoic acid induces proteasome-dependent degradation of retinoic acid receptor alpha (RARalpha) and oncogenic RARalpha fusion proteins

21 January 2018

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PIC-1/SUMO-1-modified PML-retinoic acid receptor alpha mediates arsenic trioxide-induced apoptosis in acute promyelocytic leukemia

21 January 2018

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The PML-RARalpha fusion protein and targeted therapy for acute promyelocytic leukemia

21 January 2018

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Retinoic acid (RA) and As2O3 treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RARalpha and PLZF-RARalpha oncoproteins

21 January 2018

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Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia

21 January 2018

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Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO.

21 January 2018

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Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

21 January 2018

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Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases

21 January 2018

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Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor

21 January 2018

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Crystal structure of a bacterial class 2 histone deacetylase homologue

21 January 2018

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Structural and functional analysis of the human HDAC4 catalytic domain reveals a regulatory structural zinc-binding domain

21 January 2018

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Residues in the 11 A channel of histone deacetylase 1 promote catalytic activity: implications for designing isoform-selective histone deacetylase inhibitors

21 January 2018

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On the function of the 14 A long internal cavity of histone deacetylase-like protein: implications for the design of histone deacetylase inhibitors

21 January 2018

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Sodium butyrate induces human colon carcinoma HT-29 cell apoptosis through a mitochondrial pathway

21 January 2018

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Valproic acid causes dose- and time-dependent changes in nuclear structure in prostate cancer cells in vitro and in vivo

21 January 2018

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Phase II trial of the histone deacetylase inhibitor pivaloyloxymethyl butyrate (Pivanex, AN-9) in advanced non-small cell lung cancer

21 January 2018

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Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors

21 January 2018

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Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents

21 January 2018

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Clinical studies of histone deacetylase inhibitors.

21 January 2018

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Epigenetic modifiers: basic understanding and clinical development.

21 January 2018

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N-hydroxy-3-phenyl-2-propenamides as novel inhibitors of human histone deacetylase with in vivo antitumor activity: discovery of (2E)-N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide (NVP-LAQ824).

21 January 2018

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A phase 1 pharmacokinetic and pharmacodynamic study of the histone deacetylase inhibitor belinostat in patients with advanced solid tumors

21 January 2018

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A phase II multiple dose clinical trial of histone deacetylase inhibitor ITF2357 in patients with relapsed or progressive multiple myeloma

21 January 2018

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Isoform-selective histone deacetylase inhibitors.

21 January 2018

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Romidepsin for the treatment of cutaneous T-cell lymphoma

21 January 2018

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Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma

21 January 2018

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Synthesis and histone deacetylase inhibitory activity of new benzamide derivatives

21 January 2018

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The histone deacetylase inhibitor MS-275 induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia cells

21 January 2018

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Antitumor activity of the histone deacetylase inhibitor MS-275 in prostate cancer models

21 January 2018

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Phase I study of MGCD0103 given as a three-times-per-week oral dose in patients with advanced solid tumors

21 January 2018

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Phase 1 study of the oral isotype specific histone deacetylase inhibitor MGCD0103 in leukemia

21 January 2018

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Phase II study of the histone deacetylase inhibitor MGCD0103 in patients with previously treated chronic lymphocytic leukaemia

21 January 2018

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New pyrrole-based histone deacetylase inhibitors: binding mode, enzyme- and cell-based investigations

21 January 2018

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Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides

21 January 2018

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Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC-MEF2 complexes

21 January 2018

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Specific activity of class II histone deacetylases in human breast cancer cells

21 January 2018

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The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species

21 January 2018

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Induction of apoptosis in U937 human leukemia cells by suberoylanilide hydroxamic acid (SAHA) proceeds through pathways that are regulated by Bcl-2/Bcl-XL, c-Jun, and p21CIP1, but independent of p53

21 January 2018

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Histone deacetylase inhibitors in cancer therapy: is transcription the primary target?

21 January 2018

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Inhibitors of histone deacetylation downregulate the expression of endothelial nitric oxide synthase and compromise endothelial cell function in vasorelaxation and angiogenesis

21 January 2018

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Targeting tumor angiogenesis with histone deacetylase inhibitors: the hydroxamic acid derivative LBH589.

21 January 2018

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Cancer cells become susceptible to natural killer cell killing after exposure to histone deacetylase inhibitors due to glycogen synthase kinase-3-dependent expression of MHC class I-related chain A and B.

21 January 2018

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Histone deacetylase (HDAC) inhibitor LBH589 increases duration of gamma-H2AX foci and confines HDAC4 to the cytoplasm in irradiated non-small cell lung cancer

21 January 2018

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HDAC inhibitors: clinical update and mechanism-based potential.

21 January 2018

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Enhancing the apoptotic and therapeutic effects of HDAC inhibitors

21 January 2018

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Histone deacetylase inhibitors in cancer therapy

21 January 2018

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Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect

21 January 2018

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Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase

21 January 2018

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Anti-malarial effect of histone deacetylation inhibitors and mammalian tumour cytodifferentiating agents

21 January 2018

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Potent antimalarial activity of histone deacetylase inhibitor analogues.

21 January 2018

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Antimalarial activity of phenylthiazolyl-bearing hydroxamate-based histone deacetylase inhibitors

21 January 2018

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A series of potent and selective, triazolylphenyl-based histone deacetylases inhibitors with activity against pancreatic cancer cells and Plasmodium falciparum

21 January 2018

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Histone Deacetylase Inhibitors

21 January 2018

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Candidaemia in Europe: epidemiology and resistance

21 January 2018

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Histone deacetylase inhibitors enhance Candida albicans sensitivity to azoles and related antifungals: correlation with reduction in CDR and ERG upregulation

21 January 2018

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Discovery of uracil-based histone deacetylase inhibitors able to reduce acquired antifungal resistance and trailing growth in Candida albicans

21 January 2018

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Histone deacetylase inhibitors may reduce pathogenicity and virulence in Candida albicans

21 January 2018

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Activity of MGCD290, a Hos2 histone deacetylase inhibitor, in combination with azole antifungals against opportunistic fungal pathogens.

21 January 2018

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Administration of HDAC inhibitors to reactivate HIV-1 expression in latent cellular reservoirs: implications for the development of therapeutic strategies

21 January 2018

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The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention

21 January 2018

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NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation

21 January 2018

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c-Myc and Sp1 contribute to proviral latency by recruiting histone deacetylase 1 to the human immunodeficiency virus type 1 promoter

21 January 2018

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Depletion of latent HIV-1 infection in vivo: a proof-of-concept study

21 January 2018

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"Shock and kill" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence

21 January 2018

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Reactivation of DNA viruses in association with histone deacetylase inhibitor therapy: a case series report

21 January 2018

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Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

21 January 2018

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Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease.

21 January 2018

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Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity.

21 January 2018

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The benzamide MS-275 is a potent, long-lasting brain region-selective inhibitor of histone deacetylases.

21 January 2018

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Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease

21 January 2018

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The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice

21 January 2018

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Histone deacetylase inhibitors that target tubulin

21 January 2018

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HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS

21 January 2018

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Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain alpha-synuclein immunoreactivity

21 January 2018

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Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity

21 January 2018

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Endogenous alpha-synuclein is induced by valproic acid through histone deacetylase inhibition and participates in neuroprotection against glutamate-induced excitotoxicity.

21 January 2018

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Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia.

21 January 2018

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Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases

21 January 2018

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HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model

21 January 2018

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Chemical probes identify a role for histone deacetylase 3 in Friedreich's ataxia gene silencing

21 January 2018

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Sirtuins in mammals: insights into their biological function

21 January 2018

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Recent progress in the biology and physiology of sirtuins

21 January 2018

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The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase

21 January 2018

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SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis

21 January 2018

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The Sir2 family of protein deacetylases

21 January 2018

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Acetylation inactivates the transcriptional repressor BCL6.

21 January 2018

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hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

21 January 2018

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Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors.

21 January 2018

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Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation

21 January 2018

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Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase

21 January 2018

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Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening

21 January 2018

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Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors

21 January 2018

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Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect.

21 January 2018

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Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1.

21 January 2018

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Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage

21 January 2018

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Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes

21 January 2018

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Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator.

21 January 2018

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Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease

21 January 2018

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Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective

21 January 2018

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Opposing activities protect against age-onset proteotoxicity

21 January 2018

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Mammalian Sir2-related protein (SIRT) 2-mediated modulation of resistance to axonal degeneration in slow Wallerian degeneration mice: a crucial role of tubulin deacetylation

21 January 2018

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A century of Alzheimer's disease

21 January 2018

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Therapeutic role of sirtuins in neurodegenerative disease.

21 January 2018

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SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis

21 January 2018

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Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides.

21 January 2018

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Paths of convergence: sirtuins in aging and neurodegeneration

21 January 2018

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SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling

21 January 2018

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SIRT1 negatively regulates HDAC1-dependent transcriptional repression by the RBP1 family of proteins

21 January 2018

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Trans-regulation of histone deacetylase activities through acetylation

21 January 2018

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Inhibition of Histone Deacetylase Class I but not Class II Is Critical for the Sensitization of Leukemic Cells to Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Induced Apoptosis

21 January 2018

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Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells

21 January 2018

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Synthesis and Biological Properties of Novel, Uracil-Containing Histone Deacetylase Inhibitors

21 January 2018

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Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway

21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/EPI.10.7

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release_itrdk7u6x5ffjhekgh2uy4cw4u

26 August 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/itrdk7u6x5ffjhekgh2uy4cw4u

mapped directly with Wikidata item

24 November 2022

based on heuristic

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