Can targeting SIRT-1 to treat type 2 diabetes be a good strategy? A review (Q38023959)

27 August 2017

Can targeting SIRT-1 to treat type 2 diabetes be a good strategy? A review (English)

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27 August 2017

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Venkat Koushik Pulla

1

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27 August 2017

Madhu Babu Battu

2

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27 August 2017

Mallika Alvala

3

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27 August 2017

Dharmarajan Sriram

4

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27 August 2017

Perumal Yogeeswari

5

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27 August 2017

language of work or name

English

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publication date

5 July 2012

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Expert Opinion on Therapeutic Targets

27 August 2017

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27 August 2017

16

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27 August 2017

8

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27 August 2017

819-832

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Genetics of type 2 diabetes: pathophysiologic and clinical relevance

27 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

SIRT1 genetic variation and mortality in type 2 diabetes: interaction with smoking and dietary niacin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

New perspectives into the molecular pathogenesis and treatment of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Global prevalence of diabetes: estimates for the year 2000 and projections for 2030

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Conserved enzymatic production and biological effect of O-acetyl-ADP-ribose by silent information regulator 2-like NAD+-dependent deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Phosphorylation of HuR by Chk2 regulates SIRT1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Negative regulation of the deacetylase SIRT1 by DBC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

SIRT1 deacetylase activity and the maintenance of protein homeostasis in response to stress: an overview

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Phosphorylation regulates SIRT1 function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

The role of the liver in metabolic homeostasis: Implications for inborn errors of metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Sirtuin-1 regulation of mammalian metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Nutrient-dependent regulation of PGC-1alpha's acetylation state and metabolic function through the enzymatic activities of Sirt1/GCN5

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Tissue-specific regulation of SIRT1 by calorie restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Beta-cell failure in the pathogenesis of type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Calorie restriction, SIRT1 and metabolism: understanding longevity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Role of uncoupling protein-2 up-regulation and triglyceride accumulation in impaired glucose-stimulated insulin secretion in a beta-cell lipotoxicity model overexpressing sterol regulatory element-binding protein-1c

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Transgenic mice overexpressing nuclear SREBP-1c in pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

SREBPs suppress IRS-2-mediated insulin signalling in the liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Disruption of IRS-2 causes type 2 diabetes in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Independent influences of central fat and skeletal muscle lipids on insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: a mechanism for transcriptional control of muscle glucose metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Sirt1 protects against high-fat diet-induced metabolic damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Metformin increases the PGC-1alpha protein and oxidative enzyme activities possibly via AMPK phosphorylation in skeletal muscle in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Effects of AICAR and exercise on insulin-stimulated glucose uptake, signaling, and GLUT-4 content in rat muscles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Regulation of muscle GLUT4 enhancer factor and myocyte enhancer factor 2 by AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Protein tyrosine phosphatase 1B attenuates growth hormone-mediated JAK2-STAT signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Minireview: The adipocyte--at the crossroads of energy homeostasis, inflammation, and atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Adipose tissue, inflammation, and cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Adiponectin and adiponectin receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

SIRT1 deacetylates and positively regulates the nuclear receptor LXR

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Discovery of oxazolo[4,5-b]pyridines and related heterocyclic analogs as novel SIRT1 activators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Are sirtuins viable targets for improving healthspan and lifespan?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Study of 1,4-dihydropyridine structural scaffold: discovery of novel sirtuin activators and inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

SIRT1 modulation as a novel approach to the treatment of diseases of aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Rev-erb-alpha: an integrator of circadian rhythms and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Nuclear receptors linking circadian rhythms and cardiometabolic control.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

Human sirt-1: molecular modeling and structure-function relationships of an unordered protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.703656

10.1517/14728222.2012.703656

21 January 2018

Identifiers

DOI

1 reference

release_bymmfoqzwbdm3pnk5ko4lpch7a

27 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/bymmfoqzwbdm3pnk5ko4lpch7a

mapped directly with Wikidata item

24 November 2022

based on heuristic

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