The mTOR signaling pathway in the brain: focus on epilepsy and epileptogenesis (Q38028872)

27 August 2017

title

The mTOR signaling pathway in the brain: focus on epilepsy and epileptogenesis (English)

1 reference

27 August 2017

2

Rita Citraro

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Giovambattista De Sarro

4

object named as

Giovambattista De Sarro

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author name string

Emilio Russo

1

1 reference

27 August 2017

Rita Citraro

2

1 reference

27 August 2017

Andrew Constanti

3

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27 August 2017

Giovambattista De Sarro

4

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27 August 2017

publication date

24 July 2012

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27 August 2017

published in

Molecular Neurobiology

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27 August 2017

volume

46

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27 August 2017

issue

3

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27 August 2017

page(s)

662-681

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Mammalian target of rapamycin: a signaling kinase for every aspect of cellular life

27 August 2017

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis

21 January 2018

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PIKE GTPase signaling and function

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Lipid signaling in experimental epilepsy

21 January 2018

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21 January 2018

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Growing roles for the mTOR pathway

21 January 2018

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TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity

21 January 2018

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Oncogenic EGFR signaling activates an mTORC2-NF-κB pathway that promotes chemotherapy resistance

21 January 2018

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Activation of mTORC2 by association with the ribosome

21 January 2018

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AKT/PKB signaling: navigating downstream

21 January 2018

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PKC-eta mediates glioblastoma cell proliferation through the Akt and mTOR signaling pathways

21 January 2018

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Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

21 January 2018

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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

21 January 2018

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(Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms

21 January 2018

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mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

21 January 2018

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Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1

21 January 2018

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Amino acids and mTOR signalling in anabolic function

21 January 2018

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mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

21 January 2018

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Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

21 January 2018

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Signalling and autophagy regulation in health, aging and disease

21 January 2018

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21 January 2018

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Quantitative visualization of autophagy induction by mTOR inhibitors

21 January 2018

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Time-restricted role for dendritic activation of the mTOR-p70 S6K pathway in the induction of late-phase long-term potentiation in the CA1

21 January 2018

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Control of dendritic arborization by the phosphoinositide-3'-kinase-Akt-mammalian target of rapamycin pathway.

21 January 2018

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Hypothalamic mTOR signaling regulates food intake

21 January 2018

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Regulation of dendritic morphogenesis by Ras-PI3K-Akt-mTOR and Ras-MAPK signaling pathways.

21 January 2018

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Signaling mechanisms underlying dendrite formation

21 January 2018

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Dendritic mRNA: transport, translation and function

21 January 2018

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Activity- and mTOR-dependent suppression of Kv1.1 channel mRNA translation in dendrites.

21 January 2018

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A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus

21 January 2018

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BDNF activates mTOR to regulate GluR1 expression required for memory formation

21 January 2018

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Forskolin induction of late-LTP and up-regulation of 5' TOP mRNAs translation via mTOR, ERK, and PI3K in hippocampal pyramidal cells

21 January 2018

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Translational regulatory mechanisms in persistent forms of synaptic plasticity

21 January 2018

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Local protein synthesis mediates a rapid increase in dendritic elongation factor 1A after induction of late long-term potentiation.

21 January 2018

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Mitogen-activated protein kinase upregulates the dendritic translation machinery in long-term potentiation by controlling the mammalian target of rapamycin pathway

21 January 2018

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The growing role of mTOR in neuronal development and plasticity.

21 January 2018

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BDNF regulates the translation of a select group of mRNAs by a mammalian target of rapamycin-phosphatidylinositol 3-kinase-dependent pathway during neuronal development.

21 January 2018

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Roles of glutamate receptors and the mammalian target of rapamycin (mTOR) signaling pathway in activity-dependent dendritic protein synthesis in hippocampal neurons

21 January 2018

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Regulation of protein kinase Mzeta synthesis by multiple kinases in long-term potentiation.

21 January 2018

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Insulin stimulates postsynaptic density-95 protein translation via the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway

21 January 2018

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Molecular mechanisms of memory acquisition, consolidation and retrieval

21 January 2018

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Spatial memory formation and memory-enhancing effect of glucose involves activation of the tuberous sclerosis complex-Mammalian target of rapamycin pathway

21 January 2018

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Removal of FKBP12 enhances mTOR-Raptor interactions, LTP, memory, and perseverative/repetitive behavior

21 January 2018

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Translational control via the mammalian target of rapamycin pathway is critical for the formation and stability of long-term fear memory in amygdala neurons.

21 January 2018

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Dopaminergic modulation of auditory cortex-dependent memory consolidation through mTOR.

21 January 2018

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Rapamycin-sensitive signalling in long-term consolidation of auditory cortex-dependent memory

21 January 2018

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Biphasic activation of the mTOR pathway in the gustatory cortex is correlated with and necessary for taste learning.

21 January 2018

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Role of the phosphoinositide 3-kinase-Akt-mammalian target of the rapamycin signaling pathway in long-term potentiation and trace fear conditioning memory in rat medial prefrontal cortex

21 January 2018

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From mTOR to cognition: molecular and cellular mechanisms of cognitive impairments in tuberous sclerosis

21 January 2018

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Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis

21 January 2018

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Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling

21 January 2018

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Mediobasal hypothalamic p70 S6 kinase 1 modulates the control of energy homeostasis

21 January 2018

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Critical roles for the TSC-mTOR pathway in β-cell function

21 January 2018

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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

The mammalian target of rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system.

21 January 2018

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Dysregulation of the TSC-mTOR pathway in human disease

21 January 2018

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Targeting mammalian target of rapamycin (mTOR) for health and diseases.

21 January 2018

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Rapamycin for treating Tuberous sclerosis and Autism spectrum disorders

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Therapeutic approaches to epileptogenesis--hope on the horizon

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Oncogenes on my mind: ERK and MTOR signaling in cognitive diseases

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Molecular pathways to neurodegeneration

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Rapamycin alleviates toxicity of different aggregate-prone proteins

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain

21 January 2018

1 reference

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Activated mTOR and PKR kinases in lymphocytes correlate with memory and cognitive decline in Alzheimer's disease

21 January 2018

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mTOR-dependent signalling in Alzheimer's disease

21 January 2018

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Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

21 January 2018

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TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model.

21 January 2018

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The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway

21 January 2018

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RTP801 is elevated in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson's disease by a mechanism involving mammalian target of rapamycin inactivation.

21 January 2018

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Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease

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L-DOPA activates ERK signaling and phosphorylates histone H3 in the striatonigral medium spiny neurons of hemiparkinsonian mice

21 January 2018

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mTOR regulation of autophagy

21 January 2018

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The role of the phosphatidylinositide 3-kinase-protein kinase B pathway in schizophrenia

21 January 2018

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The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder

21 January 2018

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mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists

21 January 2018

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Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer

21 January 2018

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Effects of immunosuppressive drugs on the cognitive functioning of renal transplant recipients: a pilot study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Common toxicities of mammalian target of rapamycin inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

No major neurologic complications with sirolimus use in heart transplant recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Targeting SGK1 in diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Depression in epilepsy: a critical review from a clinical perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Determinants of health-related quality of life in pharmacoresistant epilepsy: results from a large multicenter study of consecutively enrolled patients using validated quantitative assessments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Comorbidity between epilepsy and sleep disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Clinical comparability of the new antiepileptic drugs in refractory partial epilepsy: a systematic review and meta-analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Whole transcriptome analysis of the hippocampus: toward a molecular portrait of epileptogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Epilepsy genetics--past, present, and future

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Molecular genetic advances in tuberous sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Tsc2 null murine neuroepithelial cells are a model for human tuber giant cells, and show activation of an mTOR pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

The tuberous sclerosis complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Enhanced episodic-like memory and kindling epilepsy in a rat model of tuberous sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Morphology of cerebral lesions in the Eker rat model of tuberous sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Therapeutic value of prenatal rapamycin treatment in a mouse brain model of tuberous sclerosis complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Impaired glial glutamate transport in a mouse tuberous sclerosis epilepsy model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Regulation of cell death and epileptogenesis by the mammalian target of rapamycin (mTOR): a double-edged sword?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

GABAergic interneuron development and function is modulated by the Tsc1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Rapamycin suppresses axon sprouting by somatostatin interneurons in a mouse model of temporal lobe epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Inhibition of the mammalian target of rapamycin blocks epilepsy progression in NS-Pten conditional knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Bcl-2 phosphorylation and apoptosis activated by damaged microtubules require mTOR and are regulated by Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Post-treatment with rapamycin does not prevent epileptogenesis in the amygdala stimulation model of temporal lobe epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Pentylenetetrazole-induced seizures cause acute, but not chronic, mTOR pathway activation in rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

mTOR cascade activation distinguishes tubers from focal cortical dysplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Rapamycin for treatment of epilepsy: antiseizure, antiepileptogenic, both, or neither?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Activation of mammalian target of rapamycin in cytomegalic neurons of human cortical dysplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Pi3K-mTOR signaling and AMOG expression in epilepsy-associated glioneuronal tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

The ketogenic diet inhibits the mammalian target of rapamycin (mTOR) pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Effects of rapamycin on gene expression, morphology, and electrophysiological properties of rat hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

A role for the mTOR pathway in surface expression of AMPA receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Kainic acid induces early and transient autophagic stress in mouse hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Autophagy is upregulated in rats with status epilepticus and partly inhibited by Vitamin E

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

The role of inflammation in epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Inflammation in epilepsy: clinical observations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Rapamycin inhibits GM-CSF-induced neutrophil migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

The multiple facets of mTOR in immunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Involvement of mTOR kinase in cytokine-dependent microglial activation and cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

The TSC-mTOR signaling pathway regulates the innate inflammatory response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

FKBP family proteins: immunophilins with versatile biological functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

From cell death to viral replication: the diverse functions of the membrane-associated FKBP38.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Hypoxia signalling through mTOR and the unfolded protein response in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

21 January 2018

The double life of Irs.

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

21 January 2018

Targeting PDK1 in cancer

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Present and future of PI3K pathway inhibition in cancer: perspectives and limitations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Regulation of PTEN function as a PIP3 gatekeeper through membrane interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

PTEN loss in the continuum of common cancers, rare syndromes and mouse models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Activation of mTORC1 in two steps: Rheb-GTP activation of catalytic function and increased binding of substrates to raptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

TSC1/TSC2 signaling in the CNS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Regulation of microtubule-dependent protein transport by the TSC2/mammalian target of rapamycin pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Eukaryotic elongation factor-2 (eEF2): its regulation and peptide chain elongation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Ornithine decarboxylase mRNA is stabilized in an mTORC1-dependent manner in Ras-transformed cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Regulation of mTOR and S6K1 activation by the nPKC isoforms, PKCepsilon and PKCdelta, in adult cardiac muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Neuroprotectin D1 induces neuronal survival and downregulation of amyloidogenic processing in Alzheimer's disease cellular models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Negative regulation of ASK1 by p21Cip1 involves a small domain that includes Serine 98 that is phosphorylated by ASK1 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Levels of p27 sensitize to dual PI3K/mTOR inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

Retinoblastoma protein phosphorylation via PI 3-kinase and mTOR pathway regulates adipocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8314-5

mTOR Signaling and Entrainment of the Mammalian Circadian Clock.

21 January 2018

1 reference

12 December 2020

mTOR in tuberous sclerosis and other neurological disorders

1 reference

12 December 2020

Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants

1 reference

12 December 2020

Preventing and treating posttraumatic seizures: the human experience

1 reference

12 December 2020

Malformative and neoplastic glioneuronal lesions in patients with chronic pharmacoresistant epilepsies.

1 reference

12 December 2020

Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes

1 reference

12 December 2020

Novel inhibitors of mTORC1 and mTORC2.

1 reference

12 December 2020

Mammalian target of rapamycin (mTOR): pro- and anti-apoptotic

1 reference

12 December 2020

Insulin signaling in health and disease

1 reference

12 December 2020

A new link in the chain from amino acids to mTORC1 activation

1 reference

12 December 2020

10.1007/S12035-012-8314-5

Identifiers

DOI

1 reference

Dimensions Publication ID

27 August 2017

1026322072

0 references

1 reference